4.7 Article

Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum

Sergi Ferre et al.

Summary: Adenosine plays a significant role in modulating striatal neurotransmission, which is mediated by A1 and A2A receptors. The modulation involves different components of the striatal microcircuit and the formation of heteromers. These heteromers have unique properties and provide fine-tune modulation of striatal glutamate release. Targeting these adenosine receptor heteromers may be important for drug development in neuropsychiatric disorders.

NEUROPHARMACOLOGY (2023)

Article Cell Biology

Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex

Vanessa Jorge Henriques et al.

Summary: In this study, optogenetics and 2-photon Ca2+ imaging experiments were used to investigate the signaling between Somatostatin (SST)-releasing GABAergic interneurons and astrocytes in brain slice preparations from the visual cortex. It was found that intense stimulation of SST interneurons evokes Ca2+ elevations in astrocytes depending on GABA(B) receptor activation, with this response modulated by the neuropeptide somatostatin. Additionally, after episodes of SST interneuron hyperactivity, a long-lasting reduction of inhibitory postsynaptic current (IPSC) onto pyramidal neurons was observed, which was counterbalanced by the activation of astrocytes that upregulate SST interneuron-evoked IPSC amplitude through the release of ATP and conversion to adenosine.
Review Neurosciences

NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling

Jacek Szymanski et al.

Summary: The time-sensitive shift of GABA from excitatory to inhibitory is crucial for early neural circuit development and relies on the expression of cation-chloride cotransporters NKCC1 and KCC2. BDNF-TrkB signaling plays a role in controlling the expression of NKCC1 and the GABA shift during hippocampal circuit formation. Deletion of Ntrk2/Trkb affects the integration and maturation of immature mouse hippocampal granule cells and reduces Nkcc1 expression in their target region, resulting in premature GABA shift.

BRAIN SCIENCES (2022)

Review Clinical Neurology

Astrocytes in the initiation and progression of epilepsy

Annamaria Vezzani et al.

Summary: Epilepsy affects millions of people worldwide, and current antiseizure medications have limitations in controlling seizures. This review highlights the important role of astrocytes in the development and progression of epilepsy, and explores strategies to modify their dysfunction for potential therapeutic interventions.

NATURE REVIEWS NEUROLOGY (2022)

Article Neurosciences

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sa et al.

Summary: Research suggests that administration of A(2A) receptor antagonists can improve motor deficits in an Angelman syndrome mouse model and correct synaptic alterations in the cerebellum and striatum.

MOLECULAR NEUROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Structure and function of adenosine receptor heteromers

Rafael Franco et al.

Summary: This review discusses the occurrence of heteromers formed by different adenosine receptors in mammals, emphasizing the tetrameric structural arrangements and functional diversity they provide to adenosinergic signaling.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Neurosciences

Caffeine Improves GABA Transport in the Striatum of Spontaneously Hypertensive Rats (SHR)

Regina Celia Cussa Kubrusly et al.

Summary: The spontaneously hypertensive rat (SHR) exhibits defective striatal GABA transport system, while caffeine can improve GABA transport through regulating A1R-cAMP-PKA signaling. These findings suggest that caffeine may have therapeutic potential in disorders with impaired GABA transport system.

NEUROTOXICITY RESEARCH (2021)

Article Multidisciplinary Sciences

Convergence of adenosine and GABA signaling for synapse stabilization during development

Ferran Gomez-Castro et al.

Summary: The research demonstrates that activation of adenosine A(2A) receptors is essential for stabilizing GABAergic synapses during neural circuit development. The synergistic action of GABAAR- and A(2A)R-dependent signaling pathways leads to the production of adenosine 3',5'-monophosphate. The stabilization of pre- and postsynaptic GABAergic elements involves the interaction between gephyrin and the synaptogenic membrane protein Slitrk3.

SCIENCE (2021)

Review Neurosciences

The Multifaceted Roles of KCC2 in Cortical Development

Mari A. Virtanen et al.

Summary: KCC2 is a multifunctional molecule that can regulate the strength and polarity of GABAergic currents and cytoskeletal dynamics. Its various splice variants play roles in controlling early network events and the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions is evident in mature neurons during plasticity, disease, and aging, making it one of the most important molecules shaping the overall neuronal phenotype.

TRENDS IN NEUROSCIENCES (2021)

Article Neurosciences

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation

Sofia Alcada-Morais et al.

Summary: The study found that A(2A)R controls the radial migration of cortical projection neurons, not just the tangential migration of somatostatin(+) interneurons. Furthermore, A(2A)R plays a crucial role in the multipolar-bipolar transition and axon formation of the latter.

CEREBRAL CORTEX (2021)

Article Neurosciences

Dynamic interplay between GABAergic networks and developing neurons in the adult hippocampus

Mariela F. Trinchero et al.

Summary: Neurogenesis is a powerful mechanism for structural and functional remodeling in restricted areas of the adult brain, with GABA playing a key role in regulating neural stem cell quiescence to neuronal maturation. The complexity is further enhanced by feedback and feedforward networks that impact the development and function of new neurons. Ultimately, newly generated granule cells connect with input and output partners in a manner largely influenced by local circuit activity.

CURRENT OPINION IN NEUROBIOLOGY (2021)

Review Pharmacology & Pharmacy

The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons

Dasiel O. Borroto-Escuela et al.

Summary: The interaction between A2AR and STEP in neurons has been discussed in relation to AMPA receptor phosphorylation and synaptic downregulation. Experimental findings suggest that A2AR overexpression can affect neuronal environment through interactions with mGluR5, leading to the activation of STEP.

PHARMACOLOGICAL REPORTS (2021)

Article Cell & Tissue Engineering

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

Filipa F. Ribeiro et al.

Summary: The activation of A(2A) receptors promotes neural stem cell self-renewal, protects committed neuronal cells from cell death, and increases the density of immature and mature neuronal cells. Furthermore, the endogenous activation of A(2A) receptors is essential for BDNF-mediated cell proliferation and neuronal differentiation.

STEM CELLS (2021)

Article Biochemistry & Molecular Biology

Caffeine exposure ameliorates acute ischemic cell death in avian developing retina

D. Pereira-Figueiredo et al.

PURINERGIC SIGNALLING (2020)

Article Multidisciplinary Sciences

Negative feedback control of neuronal activity by microglia

Ana Badimon et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmission at the hippocampus

Robertta S. Martins et al.

PURINERGIC SIGNALLING (2020)

Review Pharmacology & Pharmacy

Adenosine receptor signalling: Probing the potential pathways for the ministration of neuropathic pain

Sneha Shaw et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain

Fabrizio Vincenzi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

A2B Adenosine Receptors: When Outsiders May Become an Attractive Target to Treat Brain Ischemia or Demyelination

Elisabetta Coppi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Neurosciences

Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors

Michael Lazarus et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Caffeine regulates GABA transport via A1R blockade and cAMP signaling

Vladimir Pedro Peralva Borges-Martins et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Article Pharmacology & Pharmacy

Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons

Francisco M. Mouro et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Hippocampal GABAergic transmission: a new target for adenosine control of excitability

Diogo M. Rombo et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Neurosciences

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity

Ursula S. Sandau et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Neurosciences

Purinergic signalling in brain ischemia

Felicita Pedata et al.

NEUROPHARMACOLOGY (2016)

Review Neurosciences

Purine nucleosides in neuroregeneration and neuroprotection

Filipa F. Ribeiro et al.

NEUROPHARMACOLOGY (2016)

Review Neurosciences

Adenosinergic signaling in epilepsy

Detlev Boison

NEUROPHARMACOLOGY (2016)

Article Cardiac & Cardiovascular Systems

NTS adenosine A2a receptors inhibit the cardiopulmonary chemoreflex control of regional sympathetic outputs via a GABAergic mechanism

Zeljka Minic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Pharmacology & Pharmacy

Modulation of adenosinergic system and its application for the treatment of epilepsy

Mariusz J. Swiader et al.

PHARMACOLOGICAL REPORTS (2014)

Article Biochemistry & Molecular Biology

A1R-A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

Sofia Cristovao-Ferreira et al.

PURINERGIC SIGNALLING (2013)

Article Cell Biology

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

Carla G. Silva et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Review Neurosciences

Adenosine: setting the stage for plasticity

Raquel B. Dias et al.

TRENDS IN NEUROSCIENCES (2013)

Article Neurosciences

Adenosine Release during Seizures Attenuates GABAA Receptor-Mediated Depolarization

Andrei Ilie et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Neurosciences

Receptor-mediated modulation of activity-dependent adenosine release in rat cerebellum

Boris P. Klyuch et al.

NEUROPHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1

Sofia Cristovao-Ferreira et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Multidisciplinary Sciences

Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABAA receptors microtransplanted to Xenopus oocytes

Cristina Roseti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Adenosine A1 receptors inhibit GABAergic transmission in rat tuberomammillary nucleus neurons

D. -S. Yum et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Multidisciplinary Sciences

Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors

Cristina Roseti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor

Lane Bekar et al.

NATURE MEDICINE (2008)

Review Biochemistry & Molecular Biology

Adenosine, an endogenous distress signal, modulates tissue damage and repair

B. B. Fredholm

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus

Bruno G. Frenguelli et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Review Physiology

Physiology and pathophysiology of purinergic neurotransmission

Geoffrey Burnstock

PHYSIOLOGICAL REVIEWS (2007)

Review Neurosciences

Targeting adenosine A2A receptors in Parkinson's disease

Michael A. Schwarzschild et al.

TRENDS IN NEUROSCIENCES (2006)

Article Pharmacology & Pharmacy

Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus

Isabel R. Fragata et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

Article Neurosciences

Adenosine A1 receptors are crucial in keeping an epileptic focus localized

Denise E. Fedele et al.

EXPERIMENTAL NEUROLOGY (2006)

Article Biochemistry & Molecular Biology

Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors

S. V. Conde et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Physiology

Adenosine A(2A) receptors mediate GABAergic inhibition of respiration in immature rats

CA Mayer et al.

JOURNAL OF APPLIED PHYSIOLOGY (2006)

Article Neurosciences

Adenosine suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons

H Li et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2004)

Article Physiology

Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets

CG Wilson et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2004)

Article Pharmacology & Pharmacy

GABA transporters as drug targets for modulation of GABAergic activity

A Schousboe et al.

BIOCHEMICAL PHARMACOLOGY (2004)

Review Neurosciences

Tonically active GABAA receptors:: modulating gain and maintaining the tone

A Semyanov et al.

TRENDS IN NEUROSCIENCES (2004)

Article Multidisciplinary Sciences

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

B Johansson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Neurosciences

A role for adenosine in modulating cardio-respiratory responses: A mini-review

KM Spyer et al.

BRAIN RESEARCH BULLETIN (2000)