相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Systematic discovery of complex insertions and deletions in human cancers
Kai Ye et al.
NATURE MEDICINE (2016)
Context-dependent actions of Polycomb repressors in cancer
M. Koppens et al.
ONCOGENE (2016)
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor
Lorna H. Mitchell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs
Gerard L. Brien et al.
CANCER CELL (2016)
MiR-502/SET8 regulatory circuit in pathobiology of breast cancer
Ben Liu et al.
CANCER LETTERS (2016)
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes
Junjian Wang et al.
CANCER LETTERS (2016)
The role of PRDMs in cancer: one family, two sides
Slim Mzoughi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal et al.
NATURE (2016)
Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status
Marie Schoumacher et al.
NATURE MEDICINE (2016)
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
George P. Souroullas et al.
NATURE MEDICINE (2016)
Targeting EZH2 in cancer
Kimberly H. Kim et al.
NATURE MEDICINE (2016)
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
Pratiksha I. Thakore et al.
NATURE METHODS (2016)
Single-molecule decoding of combinatorially modified nucleosomes
Efrat Shema et al.
SCIENCE (2016)
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets
Glenn S. Van Aller et al.
STRUCTURE (2016)
Applications of CRISPR Genome Engineering in Cell Biology
Fangyuan Wang et al.
TRENDS IN CELL BIOLOGY (2016)
Histone Modifications and Cancer
James E. Audia et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
Andrew Keniry et al.
EPIGENETICS & CHROMATIN (2016)
Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy
Masaru Katoh
EPIGENOMICS (2016)
G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
Xi Zhang et al.
NATURE COMMUNICATIONS (2016)
A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer
Ben Liu et al.
ONCOTARGET (2016)
Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer
Xuejiao Song et al.
SCIENTIFIC REPORTS (2016)
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1
Yanyan Gao et al.
SCIENTIFIC REPORTS (2016)
ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
Zineb Mounir et al.
ELIFE (2016)
A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
H. Uemit Kaniskan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Epigenetic mechanisms and therapeutic targets of chemotherapy resistance in epithelial ovarian cancer
Jane Borley et al.
ANNALS OF MEDICINE (2015)
Genomic Profiling of Advanced-Stage, Metaplastic Breast Carcinoma by Next-Generation Sequencing Reveals Frequent, Targetable Genomic Abnormalities and Potential New Treatment Options
Jeffrey S. Ross et al.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2015)
Dysfunction of the Reciprocal Feedback Loop between GATA3-and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis
Wenzhe Si et al.
CANCER CELL (2015)
An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis
Smita Matkar et al.
CANCER CELL (2015)
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Jesse G. Zalatan et al.
CELL (2015)
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Giovanni Ciriello et al.
CELL (2015)
The interplay of histone modifications - writers that read
Tianyi Zhang et al.
EMBO REPORTS (2015)
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
Lauren R. Polstein et al.
GENOME RESEARCH (2015)
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2
Hannah Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth
Alessia Peserico et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions
Jian Xu et al.
MOLECULAR CELL (2015)
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Elayne Chan-Penebre et al.
NATURE CHEMICAL BIOLOGY (2015)
Genomic landscapes of breast fibroepithelial tumors
Jing Tan et al.
NATURE GENETICS (2015)
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
Kimberly H. Kim et al.
NATURE MEDICINE (2015)
Loss of BAP1 function leads to EZH2-dependent transformation
Lindsay M. LaFave et al.
NATURE MEDICINE (2015)
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
Benjamin G. Bitler et al.
NATURE MEDICINE (2015)
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
Pratiksha I. Thakore et al.
NATURE METHODS (2015)
DNA methylation pathways and their crosstalk with histone methylation
Jiamu Du et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer
S. Stolzenburg et al.
ONCOGENE (2015)
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Lorna H. Mitchell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
The NSD family of protein methyltransferases in human cancer
Theodore Vougiouklakis et al.
EPIGENOMICS (2015)
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
Min-Hyung Cho et al.
NATURE COMMUNICATIONS (2015)
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
Daniel Zingg et al.
NATURE COMMUNICATIONS (2015)
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
Dong Hu et al.
NATURE COMMUNICATIONS (2015)
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression
R. Mitchell Baldwin et al.
ONCOTARGET (2015)
Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression
Nienke A. de Vries et al.
CELL REPORTS (2015)
Functional role of G9a histone methyltransferase in cancer
Francesco Casciello et al.
FRONTIERS IN IMMUNOLOGY (2015)
Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer
Tal Salz et al.
MOLECULAR CANCER RESEARCH (2015)
The Methyltransferase EZH2 is not Required for Mammary Cancer Development, Although High EZH2 and Low H3K27me3 Correlate With Poor Prognosis of ER-Positive Breast Cancers
Woo Kyun Bae et al.
MOLECULAR CARCINOGENESIS (2015)
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer
Lanxin Liu et al.
ONCOTARGET (2015)
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Rajesh C. Rao et al.
NATURE REVIEWS CANCER (2015)
Role of somatic cancer mutations in human protein lysine methyltransferases
Srikanth Kudithipudi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)
PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Ruosi Yao et al.
CANCER RESEARCH (2014)
UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Jae-Hwan Kim et al.
CANCER RESEARCH (2014)
Protein arginine methylation of non-histone proteins and its role in diseases
Han Wei et al.
CELL CYCLE (2014)
EZH2 Inhibitor Efficacy in Non-Hodgkin's Lymphoma Does Not Require Suppression of H3K27 Monomethylation
William D. Bradley et al.
CHEMISTRY & BIOLOGY (2014)
Ezh2 is required for neural crest-derived cartilage and bone formation
Daniel Schwarz et al.
DEVELOPMENT (2014)
SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells
Daniel J. O'Neill et al.
EPIGENETICS (2014)
Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells
Sheng Liu et al.
GENES & DEVELOPMENT (2014)
Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer
Woo Kyun Bae et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)
The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis
Kuo-Tai Hua et al.
MOLECULAR CANCER (2014)
Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma
Kai-Chun Li et al.
MOLECULAR CANCER (2014)
Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Sarah K. Knutson et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
Fang Cao et al.
MOLECULAR CELL (2014)
PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes
Tae Gyu Oh et al.
MOLECULAR ENDOCRINOLOGY (2014)
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
Pawel K. Mazur et al.
NATURE (2014)
Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein
J. Zhong et al.
ONCOGENE (2014)
Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets
Ying Chen et al.
PLOS ONE (2014)
EZH2 expands breast stem cells through activation of NOTCH1 signaling
Maria E. Gonzalez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Integrated analysis of germline and somatic variants in ovarian cancer
Krishna L. Kanchi et al.
NATURE COMMUNICATIONS (2014)
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer
Li Zhang et al.
ONCOTARGET (2014)
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity
Yuhki Yokoyama et al.
BREAST CANCER RESEARCH (2014)
Overexpression of multiple myeloma SET domain (MMSET) is associated with advanced tumor aggressiveness and poor prognosis in serous ovarian carcinoma
Shanshan Yang et al.
BIOMARKERS (2013)
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle et al.
BLOOD (2013)
The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer
Hany Onsy Habashy et al.
BREAST CANCER RESEARCH AND TREATMENT (2013)
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)
Brandi L. Carofino et al.
DISEASE MODELS & MECHANISMS (2013)
Expression of Polycomb Targets Predicts Breast Cancer Prognosis
Alba Jene-Sanz et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Towards Sustained Silencing of HER2/neu in Cancer By Epigenetic Editing
Fahimeh Falahi et al.
MOLECULAR CANCER RESEARCH (2013)
Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
Irfan A. Asangani et al.
MOLECULAR CELL (2013)
Mutational landscape and significance across 12 major cancer types
Cyriac Kandoth et al.
NATURE (2013)
Pan-cancer patterns of somatic copy number alteration
Travis I. Zack et al.
NATURE GENETICS (2013)
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Stine Jorgensen et al.
NUCLEIC ACIDS RESEARCH (2013)
Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells
N. Chapman-Rothe et al.
ONCOGENE (2013)
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Sarah K. Knutson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Regulation of estrogen receptor a by histone methyltransferase SMYD2-mediated protein methylation
Xi Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Polycomb Group Gene Ezh2 Regulates Mammary Gland Morphogenesis and Maintains the Luminal Progenitor Pool
Ewa Malgorzata Michalak et al.
STEM CELLS (2013)
Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2
Bhupinder Pal et al.
CELL REPORTS (2013)
Protein arginine methyltransferases and cancer
Yanzhong Yang et al.
NATURE REVIEWS CANCER (2013)
An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients
F. Crea et al.
ANNALS OF ONCOLOGY (2012)
Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest
Isabel Hidalgo et al.
CELL STEM CELL (2012)
Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes
Dennis H. Dowhan et al.
ENDOCRINE-RELATED CANCER (2012)
Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma
Jing Zhong et al.
FEBS JOURNAL (2012)
Identification of a functional estrogen-responsive enhancer element in the promoter 2 of PRDM2 gene in breast cancer cell lines
Ciro Abbondanza et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
Chenfang Dong et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes
Karolina Holm et al.
MOLECULAR ONCOLOGY (2012)
Chromatin-modifying enzymes as modulators of reprogramming
Tamer T. Onder et al.
NATURE (2012)
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Michael T. McCabe et al.
NATURE (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis et al.
NATURE (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
Understanding the language of Lys36 methylation at histone H3
Eric J. Wagner et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
Mathieu Neault et al.
NUCLEIC ACIDS RESEARCH (2012)
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
Sameer Phalke et al.
NUCLEIC ACIDS RESEARCH (2012)
The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes
Claudia Stein et al.
NUCLEIC ACIDS RESEARCH (2012)
Chromatin landscape and endocrine response in breast cancer
Luca Magnani et al.
EPIGENOMICS (2012)
A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer
Cuiju Wang et al.
CANCER GENETICS (2012)
Decreased expression of EZH2 is associated with upregulation of ER and favorable outcome to tamoxifen in advanced breast cancer
E. A. Reijm et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4
Matthew A. Powers et al.
CANCER RESEARCH (2011)
CARM1 Is an Important Determinant of ERα-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells
Mariam Al-Dhaheri et al.
CANCER RESEARCH (2011)
H3K9 methyltransferase G9a and the related molecule GLP
Yoichi Shinkai et al.
GENES & DEVELOPMENT (2011)
The diverse functions of Dot1 and H3K79 methylation
Anh Tram Nguyen et al.
GENES & DEVELOPMENT (2011)
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
Elena Ezhkova et al.
GENES & DEVELOPMENT (2011)
NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming
Alex J. Kuo et al.
MOLECULAR CELL (2011)
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation
Jung-Mao Hsu et al.
NATURE CELL BIOLOGY (2011)
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi et al.
NATURE CHEMICAL BIOLOGY (2011)
Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22
J. B. Patel et al.
ONCOGENE (2011)
Clinical evaluation of PRMT1 gene expression in breast cancer
Konstantina Mathioudaki et al.
TUMOR BIOLOGY (2011)
Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
Lovorka Stojic et al.
EPIGENETICS & CHROMATIN (2011)
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a
Yanqi Chang et al.
NATURE COMMUNICATIONS (2011)
Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer
Zeng-Quan Yang et al.
CANCER RESEARCH (2010)
Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
Wee-Wei Tee et al.
GENES & DEVELOPMENT (2010)
Methylation of the Retinoblastoma Tumor Suppressor by SMYD2
Louis A. Saddic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
CLLD8/KMT1F Is a Lysine Methyltransferase That Is Important for Chromosome Segregation
Claire Falandry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53
Jing Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Genetic Polymorphisms in the Polycomb Group Gene EZH2 and the Risk of Lung Cancer
Kyong-Ah Yoon et al.
JOURNAL OF THORACIC ONCOLOGY (2010)
Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes
Cathy B. Moelans et al.
MODERN PATHOLOGY (2010)
Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion
Jiakun Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
Lifeng Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Protein arginine methylation in estrogen signaling and estrogen-related cancers
Catherine Teyssier et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia
Xin Li et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
MMSET is overexpressed in cancers: Link with tumor aggressiveness
Alboukadel Kassambara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis
Mads Thomassen et al.
BREAST CANCER RESEARCH AND TREATMENT (2009)
Identification of Smyd4 as a Potential Tumor Suppressor Gene Involved in Breast Cancer Development
Liping Hu et al.
CANCER RESEARCH (2009)
Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription
Hyunjung Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation
Zhenbao Yu et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
RelB NF-κB Represses Estrogen Receptor α Expression via Induction of the Zinc Finger Protein Blimp1
Xiaobo Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome
Keisuke Nimura et al.
NATURE (2009)
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim et al.
NATURE MEDICINE (2009)
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
Quan Zhao et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1
M. E. Gonzalez et al.
ONCOGENE (2009)
Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells
Justin Wray et al.
PLOS ONE (2009)
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
Julian Puppe et al.
BREAST CANCER RESEARCH (2009)
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
Yongkun Wei et al.
MOLECULAR CARCINOGENESIS (2008)
Regulation of estrogen rapid signaling through arginine methylation by PRMT1
Muriel Le Romancer et al.
MOLECULAR CELL (2008)
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
Raphael Margueron et al.
MOLECULAR CELL (2008)
EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
Xiaohua Shen et al.
MOLECULAR CELL (2008)
Arginine methylation regulates the p53 response
Martin Jansson et al.
NATURE CELL BIOLOGY (2008)
Protein lysine methyltransferase G9a acts on non-histone targets
Philipp Rathert et al.
NATURE CHEMICAL BIOLOGY (2008)
The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
Brendan Jones et al.
PLOS GENETICS (2008)
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
John W. Edmunds et al.
EMBO JOURNAL (2008)
Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization
Isabelle Goulet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
Ernesto Guccione et al.
NATURE (2007)
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Antonis Kirmizis et al.
NATURE (2007)
Gene amplification and overexpression of PRDM14 in breast cancers
Noriko Nishikawa et al.
CANCER RESEARCH (2007)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
Nathaniel D. Heintzman et al.
NATURE GENETICS (2007)
5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3K9 di-methylation levels are linked to tumor suppressor gene reactivation
R. J. Wozniak et al.
ONCOGENE (2007)
Protein arginine methyltransferases: Evolution and assessment of their pharmacological and therapeutic potential
Christopher D. Krause et al.
PHARMACOLOGY & THERAPEUTICS (2007)
Profile of histone lysine methylation across transcribed mammalian chromatin
Christopher R. Vakoc et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Repression of p53 activity by Smyd2-mediated methylation
Jing Huang et al.
NATURE (2006)
Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast
Lei Ding et al.
CANCER RESEARCH (2006)
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene
Selma El Messaoudi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Suz12 binds to silenced regions of the genome in a cell-type-specific manner
Sharon L. Squazzo et al.
GENOME RESEARCH (2006)
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
Katia Ancelin et al.
NATURE CELL BIOLOGY (2006)
Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
Farin Kamangar et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
L Pasqualucci et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
K Collett et al.
CLINICAL CANCER RESEARCH (2006)
Enhanced SMYD3 expression is essential for the growth of breast cancer cells
R Hamamoto et al.
CANCER SCIENCE (2006)
Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation
P Gazzerro et al.
EXPERIMENTAL CELL RESEARCH (2006)
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
IM Bachmann et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide
B Rao et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The diverse functions of histone lysine methylation
C Martin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Global histone modification patterns predict risk of prostate cancer recurrence
DB Seligson et al.
NATURE (2005)
hDOT1L links histone methylation to leukemogenesis
Y Okada et al.
CELL (2005)
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
MF Fraga et al.
NATURE GENETICS (2005)
PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
I Gyory et al.
NATURE IMMUNOLOGY (2004)
PRDM5 is silenced in human cancers and has growth suppressive activities
QD Deng et al.
ONCOGENE (2004)
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
G Schotta et al.
GENES & DEVELOPMENT (2004)
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
NSD1 is essential for early post-implantation development and has a catalytically active SET domain
GV Rayasam et al.
EMBO JOURNAL (2003)
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
FM Raaphorst et al.
NEOPLASIA (2003)
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
M Tachibana et al.
GENES & DEVELOPMENT (2002)
Gene expression profiling predicts clinical outcome of breast cancer
LJ van't Veer et al.
NATURE (2002)
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
AHFM Peters et al.
CELL (2001)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
T Sorlie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The Polycomb-group gene Ezh2 is required for early mouse development
D O'Carroll et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Molecular portraits of human breast tumours
CM Perou et al.
NATURE (2000)
Transcriptional repression by Blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
J Yu et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)