Pretreatment Neurofilament Light Chain Serum Levels, Early Disease Severity, and Treatment Response in Pediatric Multiple Sclerosis

Article Clinical Neurology

Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial

Jens Kuhle et al.

Summary: The TERIKIDS study demonstrated that teriflunomide is effective and safe in children with relapsing multiple sclerosis (RMS). Teriflunomide treatment is associated with significantly reduced pNfL levels in children with RMS.

MULTIPLE SCLEROSIS JOURNAL (2023)

添加到收藏夹

Article Clinical Neurology

Serum neurofilament light-chain levels in children with monophasic myelin oligodendrocyte glycoprotein-associated disease, multiple sclerosis, and other acquired demyelinating syndrome

Eva-Maria Wendel et al.

Summary: This study assessed the diagnostic and prognostic potential of serum neurofilament light chain (sNfL) in children with first acquired demyelinating syndrome (ADS). The results showed that sNfL levels were significantly elevated in all three studied pediatric ADS subtypes, particularly in children with an acute disseminated encephalomyelitis (ADEM)-like magnetic resonance imaging (MRI) pattern or longitudinally extensive myelitis. In pediatric MS, elevated sNfL levels were associated with higher numbers of cerebral and spinal MRI lesions at baseline and predicted a higher number of relapses.

MULTIPLE SCLEROSIS JOURNAL (2022)

添加到收藏夹

Article Immunology

Prognostic Value of Serum Neurofilament Light Chain for Disease Activity and Worsening in Patients With Relapsing Multiple Sclerosis: Results From the Phase 3 ASCLEPIOS I and II Trials

Tjalf Ziemssen et al.

Summary: This study confirms the prognostic value of baseline serum neurofilament light chain (sNfL) for lesion formation and brain atrophy in patients with relapsing multiple sclerosis (RMS). It highlights the importance of using sNfL as a biomarker for predicting disease activity and worsening.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring

Peter A. Calabresi et al.

Summary: The study aimed to explore the use of sNfL as a prognostic biomarker in MS, and results showed that sNfL could predict brain volume change and development of new T2 lesions over 4 years. Patients treated with peginterferon beta-1a showed significant improvements in clinical and MRI outcomes when sNfL levels decreased. sNfL levels were higher and more variable in patients with evidence of active MS.

MULTIPLE SCLEROSIS JOURNAL (2021)

添加到收藏夹

Article Clinical Neurology

Plasma neurofilament light chain levels are predictors of disease activity in multiple sclerosis as measured by four-domain NEDA status, including brain volume loss

Jarmila Szilasiova et al.

Summary: The study investigated the relationship between plasma neurofilament light chain (pNfL) levels and disease activity in MS patients. Results showed that pNfL levels predict NEDA-3 and NEDA-BVL status, suggesting it is a useful biomarker for disease activity in RRMS patients.

MULTIPLE SCLEROSIS JOURNAL (2021)

添加到收藏夹

Article Clinical Neurology

Serum neurofilament light chain in pediatric spinal muscular atrophy patients and healthy children

Elisa Nitz et al.

Summary: The study identified pediatric reference values that can be used to evaluate disease activity in children with spinal muscular atrophy. Neurofilament light chain was found to be a suitable biomarker for disease activity in young children with different types of SMA.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis

Kristen M. Krysko et al.

ANNALS OF NEUROLOGY (2020)

添加到收藏夹

Review Clinical Neurology

Neurofilaments: neurobiological foundations for biomarker applications

Arie R. Gafson et al.

BRAIN (2020)

添加到收藏夹

Article Clinical Neurology

Clinical characteristics and use of disease modifying therapy in the nationwide Danish cohort of paediatric onset multiple sclerosis

Julie Laub Erdal et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Ali Manouchehrinia et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis

Mattia Rosso et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

Stefan Bittner et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Clinical Neurology