4.7 Article

Clinical Value of Longitudinal Serum Neurofilament Light Chain in Prodromal Genetic Frontotemporal Dementia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers

Elizabeth Finger et al.

Summary: This study investigates the hypothesis that genetic mutations causing frontotemporal dementia (FTD) have neurodevelopmental consequences. The researchers examined brain structure and function in young adult mutation carriers and found differences between preclinical mutation carriers and familial non-carriers at a mean age of 26 years. These findings have implications for therapeutic interventions and further studies on early pathophysiologic processes in FTD.
Article Clinical Neurology

Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia

Alberto Benussi et al.

Summary: The presymptomatic stages of frontotemporal dementia (FTD) have not been clearly defined, indicating a need for a consensus lexicon to comprehensively describe the stages that anticipate dementia and to formulate a better strategy for characterizing these disease stages.

ALZHEIMERS & DEMENTIA (2022)

Article Clinical Neurology

Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study

Carlo Wilke et al.

Summary: This study provides a biomarker cascade for the conversion stage in presymptomatic frontotemporal dementia, using serum neurofilament levels to stratify individuals in different stages and potentially identify those converting to symptomatic disease. The biomarker cascade may pave the way towards a biomarker-based precision medicine approach to genetic FTD.

ANNALS OF NEUROLOGY (2022)

Article Clinical Neurology

A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia

Emma L. van der Ende et al.

Summary: This study aimed to model the sequence of biomarker abnormalities in genetic frontotemporal dementia and determine the disease stages of patients. The results showed that NPTX2 and neurofilament light chain were the earliest biomarkers to change. This model could help select suitable patients for pharmaceutical trials and improve patient stratification and tracking of therapeutic interventions.
Article Clinical Neurology

Proposed research criteria for prodromal behavioural variant frontotemporal dementia

Megan S. Barker et al.

Summary: Currently, there are no research criteria for diagnosing prodromal behavioural variant frontotemporal dementia (bvFTD), but early detection is highly important for research purposes. This study aimed to develop and validate a proposed set of research criteria for prodromal bvFTD called 'mild behavioural and/or cognitive impairment in bvFTD' (MBCI-FTD). The criteria included seven core features and supportive features, and showed high accuracy in classifying prodromal bvFTD.
Article Biochemistry & Molecular Biology

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Adam M. Staffaroni et al.

Summary: This study developed multimodal models for familial frontotemporal dementia (f-FTD) progression and found that the temporal ordering of clinical and biomarker progression differed by genotype. In prevention-trial simulations, atrophy and NfL were identified as the best endpoints, with clinical measures potential endpoints in early symptomatic trials.

NATURE MEDICINE (2022)

Article Clinical Neurology

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia

Jackie M. Poos et al.

Summary: Research in presymptomatic genetic FTD patients showed that brain atrophy rates accelerate at different ages and diverge from normal aging effects, depending on the gene group.

NEUROLOGY (2022)

Article Clinical Neurology

Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface

Lisa Vermunt et al.

Summary: Interpretation of axonal damage biomarker NfL concentrations is challenging due to the lack of age-specific and disease-specific reference values. We developed an interactive interface to provide reference values and support clinicians in interpreting individual patient results in human body fluids.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

Article Cell Biology

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

Tania F. Gendron et al.

Summary: Blood neurofilament light (NfL) shows promise as a biomarker for frontotemporal dementia (FTD), aiding in early diagnosis, participant selection for prevention or early treatment trials, and improving patient care and treatment outcome estimations.

CELL REPORTS MEDICINE (2022)

Article Clinical Neurology

Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia

Jessica L. Panman et al.

Summary: Degeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-GRN, with presymptomatic carriers distinguishable from symptomatic carriers through biomarker cascade analysis, and behavioral variant FTD showing more heterogeneous disease progression than non-fluent variant primary progressive aphasia.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Article Clinical Neurology

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

Julio C. Rojas et al.

Summary: Plasma neurofilament light chain (NfL) can identify asymptomatic carriers of FTLD-causing mutations at risk of disease progression, providing potential for selecting participants in prevention clinical trials.

NEUROLOGY (2021)

Article Clinical Neurology

Plasma NfL levels and longitudinal change rates in C9orf72 and GRN-associated diseases: from tailored references to clinical applications

Dario Saracino et al.

Summary: The study found that plasma neurofilament light chain levels increased with age in controls, and were higher in patients with gene-specific trajectories such as C9orf72 and GRN cohorts; repeating pNfL measurements and considering ARC as a prognostic marker of disease progression are important for predicting disease progression in genetic FTD/ALS.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Article Clinical Neurology

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

Julio C. Rojas et al.

Summary: Plasma neurofilament light chain (NfL) can identify asymptomatic carriers of FTLD-causing mutations at risk of disease progression. Higher baseline NfL levels are associated with worse clinical progression, neuropsychological function, and brain atrophy.

NEUROLOGY (2021)

Article Biochemical Research Methods

Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study

Vania Tavares et al.

JOURNAL OF NEUROSCIENCE METHODS (2020)

Article Clinical Neurology

Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis

Antti Cajanus et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Article Clinical Neurology

An update on genetic frontotemporal dementia

Caroline Greaves et al.

JOURNAL OF NEUROLOGY (2019)

Review Clinical Neurology

Neurofilament light chain as a biomarker in neurological disorders

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Review Clinical Neurology

Therapeutic trial design for frontotemporal dementia and related disorders

Philippe Desmarais et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Clinical Neurology

Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis

Federico Verde et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Clinical Neurology

Imaging and fluid biomarkers in frontotemporal dementia

Lieke H. Meeter et al.

NATURE REVIEWS NEUROLOGY (2017)

Letter Clinical Neurology

Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum

Carlo Wilke et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Article Clinical Neurology

Neurofilament light chain: a biomarker for genetic frontotemporal dementia

Lieke H. Meeter et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

Review Medicine, General & Internal

Frontotemporal dementia

Jason D. Warren et al.

BMJ-BRITISH MEDICAL JOURNAL (2013)

Article Biochemical Research Methods

pROC: an open-source package for R and S plus to analyze and compare ROC curves

Xavier Robin et al.

BMC BIOINFORMATICS (2011)

Review Clinical Neurology

Classification of primary progressive aphasia and its variants

M. L. Gorno-Tempini et al.

NEUROLOGY (2011)

Article Clinical Neurology

El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

BR Brooks et al.

AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2000)