☆ 4.5 Review

The potential role of cholesterol in Parkinson's disease neuropathology: perpetrator or victim

NEUROLOGICAL SCIENCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Clinical Neurology

High-cholesterol diet promotes depression- and anxiety-like behaviors in mice by impact gut microbe and neuroinflammation

Lili Zou et al.

Summary: Neuropsychiatric disorders, such as anxiety and depression, are common mental illnesses worldwide. This study found that a high-cholesterol diet can induce anxiety and depression-like behaviors in mice, and the dysbiosis of gut microbiota further promotes neuroinflammation.

JOURNAL OF AFFECTIVE DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease?

Madia Lozupone et al.

Summary: This article discusses the role of human apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), describing its impact on brain homeostasis, neuroinflammation, blood-brain barrier permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta deposition, and tau-mediated neurodegeneration. It also provides updates on different therapeutic approaches targeting apoE in AD treatment.

ALZHEIMERS & DEMENTIA (2023)

添加到收藏夹

Review Immunology

SIRT1 pathway in Parkinson's disease: a faraway snapshot but so close

Gaber El-Saber Batiha et al.

Summary: SIRT1 plays a crucial role in the neuropathology of Parkinson's disease by regulating inflammatory reactions and oxidative stress, thereby reducing neuronal cell death and the progression of degenerative brain diseases.

INFLAMMOPHARMACOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Impact of dyslipidemia in the development of cardiovascular complications: Delineating the potential therapeutic role of coenzyme

Sinenhlanhla X. H. Mthembu et al.

Summary: Dyslipidemia is a major risk factor for cardiovascular disease in type 2 diabetes patients. Statin drugs can lower cholesterol and reduce the risk of CVD. However, statins also inhibit the synthesis of coenzyme Q10, which is crucial for mitochondrial function and antioxidant properties. Therefore, researchers are exploring alternative approaches to block cholesterol synthesis while maintaining CoQ10 levels to protect against the destructive complications of dyslipidemia.

BIOCHIMIE (2023)

添加到收藏夹

Review Immunology

A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects

Mohammed Alrouji et al.

Summary: Parkinson's disease (PD) is a degenerative disorder caused by the damage to certain neurons in the brain. The use of non-steroidal anti-inflammatory drugs (NSAIDs) to treat musculoskeletal problems in PD patients can have both beneficial and harmful effects on the progression of the disease. NSAIDs can potentially prevent the development of PD by reducing neuroinflammation, but they may also inhibit neuroprotective mechanisms and worsen neuroinflammation. In conclusion, the effect of NSAIDs on PD neuropathology is still uncertain and further research is needed.

INFLAMMOPHARMACOLOGY (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

Hayder M. M. Al-kuraishy et al.

Summary: Parkinson's disease (PD) is the second most common neurodegenerative brain disease after Alzheimer's disease (AD). Statins are commonly used lipid-lowering agents for managing dyslipidemia and preventing cardiovascular diseases (CVD). There is a controversial point regarding the role of serum lipids in the development of PD. This review aims to clarify the precise role of statins in PD based on published studies.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2023)

添加到收藏夹

Article Immunology

Lowering blood cholesterol does not affect neuroinflammation in experimental autoimmune encephalomyelitis

Solenne Vigne et al.

Summary: This study investigated the effect of circulating cholesterol levels on multiple sclerosis (MS) using a mouse model. The results showed that blood cholesterol level does not have a direct role in neuro-inflammatory diseases, and the protective effects of statins in MS are not related to circulating cholesterol.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Review Neurosciences

Brain cell type-specific cholesterol metabolism and implications for learning and memory

Dingfeng Li et al.

Summary: Cholesterol homeostasis plays a vital role in brain function, with locally synthesized cholesterol and its transfer between different cell types having implications for brain aging and Alzheimer's disease.

TRENDS IN NEUROSCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models

Jung-Eun Park et al.

Summary: This study examined the anti-inflammatory and neuroprotective effects of GTS-21, a selective alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) agonist, in neuroinflammation and Parkinson's disease (PD) mouse models. GTS-21 inhibited inflammation by reducing the expression of pro-inflammatory cytokines and activating anti-inflammatory signaling pathways. It also showed neuroprotective properties by reducing microglial activation and protecting dopaminergic neurons.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Intravenous 2-hydroxypropyl-β-cyclodextrin (Trappsol® Cyclo™) demonstrates biological activity and impacts cholesterol metabolism in the central nervous system and peripheral tissues in adult subjects with Niemann-Pick Disease Type C1: Results of a phase 1 trial

Caroline Hastings et al.

Summary: This study evaluated the safety, pharmacokinetics, and pharmacodynamics of HP beta CD in adult subjects with NPC1. Results showed that HP beta CD cleared cholesterol from the liver and improved peripheral biomarkers of cholesterol homeostasis, while also demonstrating pharmacological activity in the CNS.

MOLECULAR GENETICS AND METABOLISM (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

Dong-Yong Hong et al.

Summary: This review summarizes the important role of low-density lipoprotein receptor in brain cholesterol metabolism and its association with cognitive deficits and neurodegenerative brain diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice

Tao Wang et al.

Summary: Cholesterol and its derivative 27-OHC play a role in the pathogenesis of Alzheimer's disease, and phosphorylated tau is involved. Experimental results show that dietary cholesterol impairs learning and memory, and impaired autophagy is related to this effect.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

添加到收藏夹

Article Cell Biology

Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines

Soo-Yeon Woo et al.

Summary: 27HC, an oxygenated derivative of cholesterol, regulates the quantity and function of various cell populations in the bone marrow and may serve as a new therapeutic target for hematological malignancies. Exogenous 27HC treatment induces oxidative stress and apoptosis in the bone marrow.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease

Janelle Drouin-Ouellet et al.

Summary: We have developed an efficient approach to generate functional induced dopaminergic neurons from adult human dermal fibroblasts and could specifically detect disease-relevant pathology in patient cells. These patient-derived neurons can serve as a cellular model to study age-related pathology relevant to Parkinson's disease.

STEM CELL REPORTS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Liver X Receptor Regulation of Glial Cell Functions in the CNS

Xiaoyu Song et al.

Summary: This review discusses the role of liver X receptors (LXRs) in glial cells in the central nervous system (CNS). LXRs regulate genes involved in cholesterol homeostasis, inflammatory responses, and glutamate homeostasis. Studies on LXR knockout mice have shown that LXR beta is crucial for the health of various types of neurons in both CNS and peripheral nervous system. LXRs are also important for cerebrospinal fluid homeostasis. Despite the neurological deficits observed in LXR-deficient rodents, defective LXR signaling has only been identified in multiple sclerosis among human neurodegenerative diseases. Targeting LXRs in glial cells may hold potential for treating neurodegenerative diseases and disorders caused by abnormal neuronal migration during development.

BIOMEDICINES (2022)

添加到收藏夹

Review Cell Biology

Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease

Shwetha Nanjundaiah et al.

Summary: Cholesterol, a crucial component of the cell membrane, plays a significant role in the brain by influencing synaptic transmission, neuronal signaling, and neurodegenerative diseases. Dysregulation of cholesterol trafficking is linked to increased production of hyperphosphorylated Tau and Amyloid-beta protein, leading to Alzheimer's disease. Understanding the regulation of cholesterol metabolism and Tau phosphorylation is essential for managing the pathogenesis of Alzheimer's disease.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Clinical Neurology

The Non-Motor Symptoms Scale in Parkinson's disease: Validation and use

Daniel J. van Wamelen et al.

Summary: The NMSS, developed in 2007, is the first instrument for comprehensively assessing a range of non-motor symptoms in Parkinson's disease. Over the past 13 years, it has been extensively validated and utilized in over 100 clinical studies, showing strong correlations with health-related quality of life measures. The scale has proven capable of detecting longitudinal changes in non-motor symptoms and has become a key outcome measure in several randomized clinical trials.

ACTA NEUROLOGICA SCANDINAVICA (2021)

添加到收藏夹

Review Cell Biology

Lipid metabolism in astrocytic structure and function

James A. K. Lee et al.

Summary: Astrocytes in the central nervous system play crucial roles in metabolic homeostasis, blood brain barrier regulation, and neuronal crosstalk; Lipids are fundamental for astrocyte function, including energy generation, membrane fluidity, and cell to cell signaling; Disruption in lipid metabolism, structure, and signaling in astrocytes can lead to pathogenic mechanisms associated with various neurological disorders.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Neurosciences

The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer's Disease

Tapan Behl et al.

Summary: The review highlights the importance of ABC transporters in Alzheimer's disease (AD) pathogenesis, as they play a crucial role in regulating cholesterol metabolism and Aβ peptide load, while also exerting protective effects against neurotoxic substrates and xenobiotics. Research targeting these proteins may provide a new approach and target for treating AD.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Clinical Neurology

The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease

Patricia Garcia-Sanz et al.

Summary: Parkinson's disease is a progressive neurodegenerative disease associated with dopaminergic neuron loss and alpha-synuclein. The disease develops from interactions between multiple factors, with mutations in the GBA1 gene being a major genetic risk factor. Cholesterol plays a role in PD pathology, particularly in relation to disturbed cellular cholesterol metabolism.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Visceral adipose tissue had a causal, independent role in lowering the risk of Parkinson's disease: A mendelian randomization study

Yaozhong Liu et al.

Summary: Genetic evidence suggests that visceral adipose tissue may have a causal, independent role in lowering the risk of Parkinson's disease, but further studies are needed to explore the underlying mechanism.

PARKINSONISM & RELATED DISORDERS (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation

Federica Bono et al.

Summary: Mutations in the LRRK2 gene can lead to abnormal membrane localization of dopamine receptors and nicotinic acetylcholine receptors, potentially contributing to the vulnerability of dopaminergic neurons.

NEUROBIOLOGY OF AGING (2021)

添加到收藏夹

Review Geriatrics & Gerontology

Effects of statins on mitochondrial pathways

Hamid Mollazadeh et al.

Summary: Statins, commonly used for treating hyperlipidaemia, have pleiotropic effects on atherosclerosis, but can also lead to adverse reactions like myopathy. Studies indicate that statins impact mitochondrial function in various ways, potentially contributing to the onset of additional pathological conditions.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

添加到收藏夹

Article Neurosciences

Cholesterol-recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB

Cecilia Cannarozzo et al.

Summary: The study identified the presence of cholesterol-recognition amino acid consensus (CRAC) and its inverted version (CARC) in different species, with CARC only found in vertebrates. TRKB, a member of the RTK family, may play a crucial role in neuronal plasticity and exhibits a CARC motif in its transmembrane region. Molecular dynamics simulations showed that cholesterol interaction with the TRKB CARC motif mainly occurs at the central Y433 residue. The study suggests that CARC/CRAC motifs may be involved in the function of the RTK family transmembrane region.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

添加到收藏夹

Review Medicine, General & Internal

Parkinson's disease

Bastiaan R. Bloem et al.

Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.

LANCET (2021)

添加到收藏夹

Article Neurosciences

The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury

Erin M. Triplet et al.

Summary: The study identified the thrombin receptor PAR1 as a key regulator of neuronal cholesterol metabolism and neurite growth after spinal cord injury, affecting PTEN and HMGCS1 expression. Pharmacologic inhibition of PAR1 promoted neural repair, particularly by enhancing BDNF and cholesterol production after injury to improve neural resiliency.

NEUROBIOLOGY OF DISEASE (2021)

添加到收藏夹

Article Neurosciences

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Chao Wang et al.

Summary: Removing astrocytic APOE4 significantly reduces tau-mediated neurodegeneration, decreases tau pathology, lowers the levels of phosphorylated tau, and diminishes disease-associated gene expression signatures in neurons, oligodendrocytes, astrocytes, and microglia. This suggests a crucial role for astrocytic apoE in synaptic degeneration and points to the potential therapeutic implications of targeting this pathway in Alzheimer's disease.

NEURON (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease

Frank C. Church

Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.

BIOMOLECULES (2021)

添加到收藏夹

Review Immunology

Testosterone in COVID-19: An Adversary Bane or Comrade Boon

Hayder M. Al-kuraishy et al.

Summary: COVID-19 may be affected by testosterone levels, which can have both beneficial and harmful effects on the severity of the disease.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies

Irene Gracia-Rubio et al.

Summary: High levels of LDL in plasma drive the initiation and progression of CVD, while HDL is considered anti-atherogenic. SR-B1, as the high-affinity HDL receptor, plays a crucial role in the metabolism of various lipoproteins.

BIOMEDICINES (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

David K. Simon et al.

CLINICS IN GERIATRIC MEDICINE (2020)

添加到收藏夹

Review Clinical Neurology

Parkinson disease

R. Balestrino et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

添加到收藏夹

Article Neurosciences

GABAergic changes in the thalamocortical circuit in Parkinson's disease

Annelies J. M. van Nuland et al.

HUMAN BRAIN MAPPING (2020)

添加到收藏夹

Review Medicine, General & Internal

Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders

George Umemoto et al.

INTERNAL MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis

Helena C. F. Oliveira et al.

MOLECULAR ASPECTS OF MEDICINE (2020)

添加到收藏夹

Article Neurosciences

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

Wing K. Man et al.

FRONTIERS IN NEUROSCIENCE (2020)

添加到收藏夹

Review Toxicology

Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease

Zheng Mou et al.

TOXICOLOGY LETTERS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity

Mateo Amaya-Montoya et al.

LIPIDS IN HEALTH AND DISEASE (2020)

添加到收藏夹

Review Neurosciences

Potassium channels and their emerging role in parkinson's disease

Linlin Zhang et al.

BRAIN RESEARCH BULLETIN (2020)

添加到收藏夹

Review Clinical Neurology

Effects of Higher Serum Lipid Levels on the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Zheng Jiang et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Geriatrics & Gerontology

Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson's Disease

Yanxuan Li et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

添加到收藏夹

Article Cell Biology

Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson's Disease

Helena Xicoy et al.

CELLS (2020)

添加到收藏夹

Review Immunology

Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer

Maria Teresa Bilotta et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Dermatology

Statins role in vitiligo: A mini-review

Hayder M. Al-Kuraishy et al.

TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis

Lina Jiang et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)

添加到收藏夹

Review Neurosciences

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation

Bruno Lima Giacobbo et al.

MOLECULAR NEUROBIOLOGY (2019)

添加到收藏夹

Review Neurosciences

Plasma levels of brain-derived neurotrophic factor in patients with Parkinson disease: A systematic review and meta-analysis

Farzaneh Rahmani et al.

BRAIN RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Computational insights into the interaction mechanisms of estrogen-related receptor alpha with endogenous ligand cholesterol

Dongping Li et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cholesterol and the Safety Factor for Neuromuscular Transmission

Igor I. Krivoi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment

Ranl Loera-Valencia et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Effect of statins on Parkinson's disease A systematic review and meta-analysis

Junqiang Yan et al.

MEDICINE (2019)

添加到收藏夹

Article Clinical Neurology

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy

Jessica Camacho et al.

FRONTIERS IN NEUROLOGY (2019)

添加到收藏夹

Review Neurosciences

Lipid Metabolism Crosstalk in the Brain: Glia and Neurons

Casey N. Barber et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

添加到收藏夹

Review Neurosciences

Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson's Disease

Irina Alecu et al.

FRONTIERS IN NEUROSCIENCE (2019)

添加到收藏夹

Review Clinical Neurology

The role of high-intensity focused ultrasound as a symptomatic treatment for Parkinson's disease

Shayan Moosa et al.

MOVEMENT DISORDERS (2019)

添加到收藏夹

Article Immunology

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Elien Wouters et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Lipids, Apolipoproteins, and the Risk of Parkinson Disease A Prospective Cohort Study and a Mendelian Randomization Analysis

Fang Fang et al.

CIRCULATION RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?

Kevin Mouzat et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Neurosciences

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease

Shirley Yin-Yu Pang et al.

TRANSLATIONAL NEURODEGENERATION (2019)

添加到收藏夹

Article Geriatrics & Gerontology

Trends in the incidence and prevalence of Parkinson's disease in Korea: a nationwide, population-based study

Joo-Hyun Park et al.

BMC GERIATRICS (2019)

添加到收藏夹

Article Cell Biology

Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons

Maria S. Spagnuolo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Higher Serum Cholesterol and Decreased Parkinson's Disease Risk: A Statin-Free Cohort Study

Violetta Rozani et al.

MOVEMENT DISORDERS (2018)

添加到收藏夹

Article Medicine, General & Internal

Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study

Ga Eun Nam et al.

PLOS MEDICINE (2018)

添加到收藏夹

Article Neurosciences

Neuroinflammation pathways: a general review

Tara Shabab et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2017)

添加到收藏夹

Review Cell Biology

Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

Veronica Cartocci et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

添加到收藏夹

Article Oncology

The mevalonate pathway in neurons: It's not just about cholesterol

Miguel Moutinho et al.

EXPERIMENTAL CELL RESEARCH (2017)

添加到收藏夹

Article Neurosciences

A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus

Sylwia W. Brooks et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

α-Synuclein Regulates Neuronal Cholesterol Efflux

Jen-Hsiang T. Hsiao et al.

MOLECULES (2017)

添加到收藏夹

Article Clinical Neurology

Statins May Facilitate Parkinson's Disease: Insight Gained From a Large, National Claims Database

Guodong Liu et al.

MOVEMENT DISORDERS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance to Parkinson's disease

Rajib Paul et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

添加到收藏夹

Article Medicine, General & Internal

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

Marianne Benn et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

添加到收藏夹

Article Medicine, General & Internal

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

Marianne Benn et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

Tania Kollgaard et al.

PLOS ONE (2017)

添加到收藏夹

Article Nutrition & Dietetics

Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Michela Barichella et al.

CLINICAL NUTRITION (2017)

添加到收藏夹

Review Neurosciences

Coenzyme Q10 for Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

Ahmed Negida et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease

Margaux Doria et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

添加到收藏夹

Review Clinical Neurology

Cholesterol and markers of cholesterol turnover in multiple sclerosis: relationship with disease outcomes

Simon Zhornitsky et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2016)

添加到收藏夹

Review Neurosciences

The biomarkers of immune dysregulation and inflammation response in Parkinson disease

Li Chen et al.

TRANSLATIONAL NEURODEGENERATION (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

Gurdeep Marwarha et al.

EXPERIMENTAL GERONTOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

Andreas van Maarschalkerweerd et al.

FEBS LETTERS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cholesterol under oxidative stress-How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols

Waldemar Kulig et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Estrogen-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells

Juhee Lim et al.

JOURNAL OF NEUROCHEMISTRY (2015)

添加到收藏夹

Article Clinical Neurology

Statins, Plasma Cholesterol, and Risk of Parkinson's Disease: A Prospective Study

Xuemei Huang et al.

MOVEMENT DISORDERS (2015)

添加到收藏夹

Review Anatomy & Morphology

Oxidative stress and Parkinson's disease

Javier Blesa et al.

FRONTIERS IN NEUROANATOMY (2015)

添加到收藏夹

Review Cell Biology

Cholesterol metabolism and homeostasis in the brain

Juan Zhang et al.

PROTEIN & CELL (2015)

添加到收藏夹

Article Neurosciences

The serum lipid profile of Parkinson's disease patients: a study from China

Xiaoyan Guo et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2015)

添加到收藏夹

Review Immunology

Cholesterol, inflammation and innate immunity

Alan R. Tall et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Article Neurosciences

Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease

Krithika Muthukumaran et al.

BMC NEUROSCIENCE (2014)

添加到收藏夹

Article Oncology

Association of glycogen synthase kinase-3β with Parkinson's disease (Review)

Da-Wei Li et al.

MOLECULAR MEDICINE REPORTS (2014)

添加到收藏夹

Review Oncology

Inflammatory response in Parkinson's disease

Junqiang Yan et al.

MOLECULAR MEDICINE REPORTS (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease

Marianna Sikorska et al.

NEUROBIOLOGY OF AGING (2014)

添加到收藏夹

Review Neurosciences

Neuroinflammation: The role and consequences

Monty Lyman et al.

NEUROSCIENCE RESEARCH (2014)

添加到收藏夹

Article Clinical Neurology

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease No Evidence of Benefit

M. Flint Beal et al.

JAMA NEUROLOGY (2014)

添加到收藏夹

Review Physiology

Cholesterol binding to ion channels

Irena Levitan et al.

FRONTIERS IN PHYSIOLOGY (2014)

添加到收藏夹

Review Neurosciences

Brain Cholesterol Metabolism, Oxysterols, and Dementia

Timothy M. Hughes et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

添加到收藏夹

Article Clinical Neurology

Statin use and risk of Parkinson's disease: a meta-analysis of observational studies

Krishna Undela et al.

JOURNAL OF NEUROLOGY (2013)

添加到收藏夹

Article Chemistry, Applied

Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model

Hideaki Kabuto et al.

JOURNAL OF OLEO SCIENCE (2013)

添加到收藏夹

Article Clinical Neurology

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

S. Iannaccone et al.

PARKINSONISM & RELATED DISORDERS (2013)

添加到收藏夹

Review Medicine, Research & Experimental

The neuroprotective roles of BDNF in hypoxic ischemic brain injury (Review)

Ai Chen et al.

BIOMEDICAL REPORTS (2013)

添加到收藏夹

Article Neurosciences

Role of Serum Cholesterol in Parkinson's Disease: A Meta-Analysis of Evidence

Kapil Gudala et al.

JOURNAL OF PARKINSONS DISEASE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

L. Lim et al.

CELL DEATH AND DIFFERENTIATION (2012)

添加到收藏夹

Review Clinical Neurology

Olfactory dysfunction in Parkinson disease

Richard L. Doty

NATURE REVIEWS NEUROLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease

Avik Roy et al.

PLOS ONE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

Eric Frisdal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson's disease

Gurdeep Marwarha et al.

JOURNAL OF NEUROCHEMISTRY (2011)

添加到收藏夹

Article Clinical Neurology

Prospects of Statins in Parkinson Disease

Avik Roy et al.

NEUROSCIENTIST (2011)

添加到收藏夹

Article Neurosciences

Dietary intake and olfactory function in patients with newly diagnosed Parkinson's disease: a case-control study

Emma Aden et al.

NUTRITIONAL NEUROSCIENCE (2011)

添加到收藏夹

Article Clinical Neurology

Neuroinflammation in Parkinson's disease

Etienne C. Hirsch et al.

PARKINSONISM & RELATED DISORDERS (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Silencing GADD153/CHOP Gene Expression Protects against Alzheimer's Disease-Like Pathology Induced by 27-Hydroxycholesterol in Rabbit Hippocampus

Jaya R. P. Prasanthi et al.

PLOS ONE (2011)

添加到收藏夹

Review Clinical Neurology

Lipopolysaccharide Animal Models for Parkinson's Disease

Mei Liu et al.

PARKINSONS DISEASE (2011)

添加到收藏夹

Article Neurosciences

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

Andrew O. Koob et al.

EXPERIMENTAL NEUROLOGY (2010)

添加到收藏夹

Article Clinical Neurology

Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease

Paula Scalzo et al.

JOURNAL OF NEUROLOGY (2010)

添加到收藏夹

Review Sport Sciences

Neuroplasticity - Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor A Systematic Review of Experimental Studies in Human Subjects

Kristel Knaepen et al.

SPORTS MEDICINE (2010)

添加到收藏夹

Article Ophthalmology

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells

Bhanu Dasari et al.

BMC OPHTHALMOLOGY (2010)

添加到收藏夹

Article Genetics & Heredity

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

M. Futter et al.

JOURNAL OF MEDICAL GENETICS (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

Katja Nieweg et al.

JOURNAL OF NEUROCHEMISTRY (2009)

添加到收藏夹

Article Cell Biology

The role of α-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response

Mikhail Y. Golovko et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2009)

添加到收藏夹

Article Clinical Neurology

Medical records documentation of constipation preceding Parkinson disease A case-control study

R. Savica et al.

NEUROLOGY (2009)

添加到收藏夹

Review Food Science & Technology

Nourishing and health benefits of coenzyme Q(10) - a review

Martina Borekova et al.

CZECH JOURNAL OF FOOD SCIENCES (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

L. Thirumangalakudi et al.

JOURNAL OF NEUROCHEMISTRY (2008)

添加到收藏夹

Article Clinical Neurology

Total cholesterol and the risk of Parkinson disease

G. Hu et al.

NEUROLOGY (2008)

添加到收藏夹

Review Clinical Neurology

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

Claire Henchcliffe et al.

NATURE CLINICAL PRACTICE NEUROLOGY (2008)

添加到收藏夹

Article Clinical Neurology

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease

Kelly Claire Simon et al.

NEUROLOGY (2007)

添加到收藏夹

Article Neurosciences

Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development

Shingo Suzuki et al.

JOURNAL OF NEUROSCIENCE (2007)

添加到收藏夹

Review Cell Biology

Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations

Hemmi N. Bhagavan et al.

MITOCHONDRION (2007)

添加到收藏夹

Article Clinical Neurology

Serum cholesterol changes after midlife and late-life cognition -: Twenty-one-year follow-up study

A. Solomon et al.

NEUROLOGY (2007)

添加到收藏夹

Article Clinical Neurology

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Xuemei Huang et al.

MOVEMENT DISORDERS (2007)

添加到收藏夹

Article Neurosciences

Survival of adult neurons lacking cholesterol synthesis in vivo

Ursula Fuenfschilling et al.

BMC NEUROSCIENCE (2007)

添加到收藏夹

Article Neurosciences

Inhibition of glycogen synthase kinase-3 beta protects doparninergic neurons from MPTP toxicity

Wenya Wang et al.

NEUROPHARMACOLOGY (2007)

添加到收藏夹

Article Public, Environmental & Occupational Health

Serum cholesterol levels and the risk of Parkinson's disease

Lonneke M. L. de lau et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization

DA Bosco et al.

NATURE CHEMICAL BIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Coenzyme Q(10) provides neuroprotection in iron-induced apoptosis in dopaminergic neurons

P Kooncumchoo et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2006)

添加到收藏夹

Review Pharmacology & Pharmacy

Therapeutic role of coenzyme Q10 in Parkinson's disease

CW Shults

PHARMACOLOGY & THERAPEUTICS (2005)

添加到收藏夹

Article Clinical Neurology

Dietary fatty acids and the risk of Parkinson disease - The Rotterdam study

LML de Lau et al.

NEUROLOGY (2005)

添加到收藏夹

Article Clinical Neurology

Pathogenesis of nigral cell death in Parkinson's disease

S Przedborski

PARKINSONISM & RELATED DISORDERS (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone:: protective effect of coenzyme Q10

Y Moon et al.

JOURNAL OF NEUROCHEMISTRY (2005)

添加到收藏夹

Article Neurosciences

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10

M Somayajulu et al.

NEUROBIOLOGY OF DISEASE (2005)

添加到收藏夹

Review Geriatrics & Gerontology

Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease

AB Reiss et al.

NEUROBIOLOGY OF AGING (2004)

添加到收藏夹

Article Clinical Neurology

Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

M Sohmiya et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2004)

添加到收藏夹

Article Neurosciences

Lipid rafts mediate the synaptic localization of α-synuclein

DL Fortin et al.

JOURNAL OF NEUROSCIENCE (2004)

添加到收藏夹

Article Clinical Neurology

APOE-ε2 allele associated with higher prevalence of sporadic Parkinson disease

XM Huang et al.

NEUROLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uptake and transport of high-density lipoprotein (HDL) and HDL-associated α-tocopherol by an in vitro blood-brain barrier model

Z Balazs et al.

JOURNAL OF NEUROCHEMISTRY (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of cholesterol in lipid raft formation: lessons from lipid model systems

JR Silvius

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)

添加到收藏夹

Article Geriatrics & Gerontology

Combination of serum markers related to several mechanisms in Alzheimer's disease

CE Teunissen et al.

NEUROBIOLOGY OF AGING (2003)

添加到收藏夹

Article Medicine, General & Internal

Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

M Kivipelto et al.

ANNALS OF INTERNAL MEDICINE (2002)

添加到收藏夹

Article Multidisciplinary Sciences

α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

R Sharon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

添加到收藏夹

Review Neurosciences

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

MG Murer et al.

PROGRESS IN NEUROBIOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.