期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 61, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.201500815
关键词
Binge eating; Metabolic disease; Microbiota; Obesity; Western cafeteria diet
资金
- National Health and Medical Research Council of Australia
Scope: Overconsumption of energy-rich food is a major contributor to the obesity epidemic. The eating habits of many people are characterized by the cycling between overconsumption of energy-rich foods and dieting, the effects of which on the microbiota are currently unknown. Methods and results: We compared the fecal microbiota of rats either continuously fed chow or palatable cafeteria diet to a cycled group switched between the two diets (chow for 4, cafeteria for 3 days/wk, n=12/group) over 16 wk. Enriched bacterial metabolic pathways were predicted, and a range of metabolic parameters was correlated to microbial taxa and pathways. Cycled rats showed large excursions in food intake on each diet switch. When switched from chow to cafeteria, they overconsumed, and when switched back to chow they underconsumed relative to those maintained on the two diets. Metabolic parameters of cycled rats were intermediate between those of the other diet groups (p < 0.05). The microbiota of cycled rats was nearly indistinguishable from rats under constant cafeteria diet, and both groups were significantly different to the chow group. Correlation analyses identified microbial metabolic pathways associated with an obese phenotype. Conclusion: These data suggest that continuous or intermittent exposure to palatable foods have similar effects on the gut microbiota.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据