Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence?

Article Clinical Neurology

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria

Brenda Banwell et al.

Summary: Serum antibodies against MOG can help diagnose MOGAD, which is distinct from multiple sclerosis and neuromyelitis optica. The presence of MOG-IgG is a core criterion for the diagnosis. MOGAD can present with various symptoms and can be either monophasic or relapsing, and diagnostic accuracy relies on MOG-IgG cell-based assays.

LANCET NEUROLOGY (2023)

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Article Immunology

A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma: Case report on diagnostic challenge

Yasunori Uzura et al.

Summary: This case report describes a 52-year-old woman with right hemiparesis caused by a mass lesion in the left parietal white matter and corpus callosum. The patient was initially diagnosed with anti-myelin oligodendrocyte glycoprotein-associated disease and showed improvement with steroid treatment, but was later diagnosed with B cell lymphoma through cerebrospinal fluid examination.

JOURNAL OF NEUROIMMUNOLOGY (2022)

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Editorial Material Clinical Neurology

Editorial: Antibody-Mediated Autoimmune Diseases of the CNS: Challenges and Approaches to Diagnosis and Management

Yin-Xi Zhang et al.

FRONTIERS IN NEUROLOGY (2022)

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Article Clinical Neurology

Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MS

Samantha A. Banks et al.

Summary: The study found that involvement of the brainstem or cerebellum is common in MOGAD, usually occurring as part of a multifocal central nervous system attack rather than in isolation. Compared to AQP4-IgG-NMOSD and MS, MOGAD patients are younger and exhibit specific MRI characteristics.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

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Article Clinical Neurology

Inflammatory Demyelinating Lesions: True Sentinel Lesion or Immune-Mediated Response to Lymphoma?

Tianming Qiu et al.

Summary: Inflammatory demyelinating changes referred to as sentinel lesions in PCNSL may lead to misdiagnosis, highlighting the importance of targeting the most enhanced region on MRI for biopsy when there is high suspicion for PCNSL.

WORLD NEUROSURGERY (2021)

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Article Pathology