期刊
NEUROBIOLOGY OF DISEASE
卷 187, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2023.106296
关键词
Multiple system atrophy; Gastrointestinal dysfunction; Intestinal permeability; Enteric nervous system; Gut
This article provides an in-depth exploration of the physiological, structural, and immunological changes theorised to underpin gastrointestinal dysfunction in patients with Multiple system atrophy (MSA). It also highlights areas for future research in order to identify more suitable pharmaceutical treatments for gastrointestinal symptoms in MSA patients.
Multiple system atrophy (MSA) is a rare, progressive neurodegenerative disorder characterised by autonomic, pyramidal, parkinsonian and/or cerebellar dysfunction. Autonomic symptoms of MSA include deficits associated with the gastrointestinal (GI) system, such as difficulty swallowing, abdominal pain and bloating, nausea, delayed gastric emptying, and constipation. To date, studies assessing GI dysfunctions in MSA have primarily focused on alterations of the gut microbiome, however growing evidence indicates other structural components of the GI tract, such as the enteric nervous system, the intestinal barrier, GI hormones, and the GI-driven immune response may contribute to MSA-related GI symptoms. Here, we provide an in-depth exploration of the physiological, structural, and immunological changes theorised to underpin GI dysfunction in MSA patients and highlight areas for future research in order to identify more suitable pharmaceutical treatments for GI symptoms in patients with MSA.
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