The surgical management of diffuse gliomas: Current state of neurosurgical management and future directions

Article Oncology

Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma

Shawn L. Hervey-Jumper et al.

Summary: In patients with diffuse low-grade glioma, the extent of surgical tumor resection has a controversial role in prognosis, but a randomized clinical trial is not feasible to determine different levels of resection.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Oncology

Impact of maximal extent of resection on postoperative deficits, patient functioning, and survival within clinically important glioblastoma subgroups

Jasper K. W. Gerritsen et al.

Summary: This study analyzed the impact of extent of resection, residual tumor volume, and gross-total resection on neurological and functional outcomes in patients with glioblastoma. The results showed that a larger extent of resection and smaller residual tumor volume were significantly associated with improved overall survival and progression-free survival in all patient subgroups, with residual tumor volume being a stronger prognostic factor.

NEURO-ONCOLOGY (2023)

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Article Oncology

Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group

Philipp Karschnia et al.

Summary: This study investigated the prognostic value of the extent of resection in glioblastoma, finding that smaller volumes of residual contrast-enhancing tumor were associated with better outcomes. Additionally, removing non-contrast-enhancing tumor beyond the tumor borders resulted in improved survival. These findings have significant implications for stratification in clinical trials.

NEURO-ONCOLOGY (2023)

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Article Oncology

Artificial intelligence (AI)-based decision support improves reproducibility of tumor response assessment in neuro-oncology: An international multi-reader study

Philipp Vollmuth et al.

Summary: This study aimed to assess the reproducibility and standardization of treatment response assessment using artificial intelligence (AI) decision support in MRI. The results showed that AI decision support can provide better evaluation of treatment response in patients with lower-grade gliomas compared to manual measurements.

NEURO-ONCOLOGY (2023)

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Article Clinical Neurology

Imaging-based stratification of adult gliomas prognosticates survival and correlates with the 2021 WHO classification

Akshaykumar N. Kamble et al.

Summary: Due to the lack of global accessibility, delay, and cost-effectiveness of genetic testing, there is a clinical need for an imaging-based stratification of gliomas that can prognosticate survival and correlate with the 2021-WHO classification. In this study, an imaging-based stratification system for adult gliomas (IBGS) was created and validated using MRI brain images and survival information. The IBGS system showed statistical significance in predicting survival and had good specificity in identifying different types of gliomas.

NEURORADIOLOGY (2023)

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Editorial Material Oncology

Key Clinical Principles in the Management of Glioblastoma

Rupesh Kotecha et al.

Summary: Glioblastoma is a common and aggressive primary brain tumor with a poor prognosis. The current standard treatment involves surgery, chemoradiotherapy, and maintenance chemotherapy. Clinical trials are being conducted to improve treatment outcomes. Recent research focuses on radiotherapy dose intensification, regulation of the tumor microenvironment, and exploration of immunotherapeutic approaches. This review article summarizes the current evidence-based management principles and discusses recent clinical trial data and ongoing studies.

JCO ONCOLOGY PRACTICE (2023)

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Article Clinical Neurology

Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial

Maryam Rahman et al.

Summary: This study aimed to compare the side effects of prophylactic levetiracetam treatment for 1 week versus 6 weeks in patients undergoing surgical resection. The results showed that there was no significant neurotoxicity or depression in patients treated with levetiracetam for either duration, and the incidence of seizure after surgery was low.

NEUROSURGERY (2023)

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Article Clinical Neurology

Occurrence, Risk Factors, and Consequences of Postoperative Ischemia After Glioma Resection: A Retrospective Study

Arthur T. J. van der Boog et al.

Summary: This study aimed to evaluate the incidence of postoperative ischemia and neurological deficits after glioma resection, as well as their association with potential risk factors. The results showed that 64.6% of the patients had postoperative ischemia, which was significantly associated with an insular location and intraoperative administration of vasopressors. The location of the glioma in the temporal lobe was not related to ischemia, but ischemia was significantly associated with new neurological deficits.

NEUROSURGERY (2023)

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Article Medicine, General & Internal

Vorasidenib in IDH1-or IDH2-Mutant Low-Grade Glioma

Ingo K. Mellinghoff et al.

Summary: In a phase 3 trial, vorasidenib showed significant improvement in progression-free survival and delay in the time to the next intervention for patients with grade 2 IDH-mutant glioma.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Review Clinical Neurology

Recognizing the psychological impact of a glioma diagnosis on mental and behavioral health: a systematic review of what neurosurgeons need to know

Jacob S. Young et al.

Summary: A glioma diagnosis can have a significant impact on the mental health of patients, leading to anxiety and depression. However, there is a lack of literature on therapeutic options for these behavioral health disorders. Early recognition and treatment are crucial for optimizing patients' everyday functioning.

JOURNAL OF NEUROSURGERY (2023)

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Article Clinical Neurology

Reducing complication rates for repeat craniotomies in glioma patients: a single-surgeon experience and comparison with the literature

Ramin A. Morshed et al.

Summary: The study found that in glioma patients, repeat craniotomies are not significantly more prone to complications compared to initial surgeries, and the complication rates were lower than those reported in literature. Older age and significant leukocytosis due to steroid use were identified as predictors of complications.

ACTA NEUROCHIRURGICA (2022)

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Article Oncology

Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline

Nimish A. Mohile et al.

Summary: This article provides guidance on the therapy for diffuse astrocytic and oligodendroglial tumors in adults. The recommendations are based on a systematic literature review and offer specific treatment options for different tumor grades, with reasonable alternatives. The article also provides treatment suggestions for specific patient populations.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications

Riccardo Soffietti et al.

Summary: Liquid biopsies show significant potential in the diagnosis, monitoring, and prediction of gliomas, providing valuable insights into disease progression.

NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Association of Neurological Impairment on the Relative Benefit of Maximal Extent of Resection in Chemoradiation-Treated Newly Diagnosed Isocitrate Dehydrogenase Wild-Type Glioblastoma

Alexander A. Aabedi et al.

Summary: Resection of contrast-enhanced and non-contrast-enhanced tissue affects survival outcomes in glioblastoma patients. Postoperative neurological impairment is a key factor in predicting survival outcomes.

NEUROSURGERY (2022)

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Article Oncology

Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models

Marilin S. Koch et al.

Summary: This study found that concurrent high-dose dexamethasone treatment with CAN-2409 led to significantly reduced median survival in GBM patients and inhibited the activity of immune cells. This suggests that the use of dexamethasone should be balanced between symptom control and treatment outcome when using CAN-2409 for oncolytic viral immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Review Oncology

5-Aminolevulinic Acid False-Positive Rates in Newly Diagnosed and Recurrent Glioblastoma: Do Pseudoprogression and Radionecrosis Play a Role? A Meta-Analysis

Luca Ricciardi et al.

Summary: This study conducted a systematic review and meta-analysis comparing the use of 5-ALA in newly diagnosed and recurrent GBM, with findings showing a higher fluorescence rate in recurrent GBM and no cases of radionecrosis in false-positive samples, while inflammation and signs of pseudoprogression were found in 81.4% of cases. Further clinical trials are suggested to confirm these results.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Focused ultrasound for the treatment of glioblastoma

Jill W. Roberts et al.

Summary: This article reviews the key updates from the 2021 workshop on focused ultrasound in the treatment of glioblastoma, outlines next research steps, and provides relevant references.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Oncology

Effect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP): a propensity score-matched analysis of an international, multicentre, cohort study

Jasper K. W. Gerritsen et al.

Summary: This statement indicates that the copyright belongs to Elsevier Ltd. and all rights are reserved.

LANCET ONCOLOGY (2022)

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Article Oncology

Prospective genomically guided identification of early/evolving and undersampled IDH-wildtype glioblastoma leads to improved clinical outcomes

Yalan Zhang et al.

Summary: Genomic profiling of diffuse astrocytic gliomas can better predict patient outcomes compared to histomorphology alone. This study found that the integration of genomic profiling with radiologic and histologic features can lead to improved patient management and clinical outcomes for IDH-wildtype glioblastoma. This supports the routine use of genomic profiling in accurately classifying glial neoplasms.

NEURO-ONCOLOGY (2022)

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Article Neurosciences

FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma

Alexander F. Haddad et al.

Summary: The standard treatment for IDH-wildtype glioblastoma is maximal resection followed by chemotherapy and radiation. However, the tumor also infiltrates into the peri-tumoral FLAIR abnormality, which is often not removed. Recent studies have shown a significant survival benefit associated with safe peri-tumoral FLAIR resection.

BRAIN SCIENCES (2022)

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Article Oncology

Continuous subcortical language mapping in awake glioma surgery

Hans W. Axelson et al.

Summary: This study explored the application of continuous stimulation technique in awake glioma surgery, and found that stimulation at specific subcortical locations can interfere with language performance. However, the consistency of these findings was not confirmed by bipolar stimulation method.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial

Eleonora F. Spinazzi et al.

Summary: The chronic CED of topotecan for recurrent glioblastoma was safely completed in all patients, showing potential as a safe and active therapy. This novel delivery approach overcomes limitations in drug delivery and treatment response assessment, providing a unique tissue-based evaluation of treatment response. Further studies are needed to determine the impact on clinical outcomes.

LANCET ONCOLOGY (2022)

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Meeting Abstract Oncology

Surgical management of recurrent lower-grade gliomas: analysis of oncological and functional outcomes and associated factors

L. Gay et al.

NEURO-ONCOLOGY (2022)

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Meeting Abstract Oncology

WHEN TO RESECT OR BIOPSY FOR PATIENTS WITH SUPRATENTORIAL GLIOBLASTOMA: A MULTIVARIABLE PREDICTION MODEL

I. O. Kommers et al.

NEURO-ONCOLOGY (2022)

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Article Oncology

Safety and patterns of survivorship in recurrent GBM following resection and surgically targeted radiation therapy: Results from a prospective trial

Kris Smith et al.

Summary: The use of a novel radiation device implanted in bioresorbable collagen tiles showed improved outcomes in the treatment of recurrent glioblastoma, with acceptable safety and favorable local control and survival rates.

NEURO-ONCOLOGY (2022)

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Article Oncology

Laser hyperthermia: Past, present, and future

Alexander J. Schupper et al.

Summary: Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive ablative procedure that uses laser heat to reduce tissue in intracranial lesions. Despite potentially offering a more acceptable complication profile compared to open surgery, the role of LITT in current treatment paradigms for intracranial lesions is still evolving.

NEURO-ONCOLOGY (2022)

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Meeting Abstract Oncology

RATE AND TYPE OF RECURRENCE OF LOWER-GRADE GLIOMAS SUBMITTED TO FUNCTIONAL NEUROSURGICAL APPROACH: THE IMPACT OF THE EXTENT OF RESECTION

L. Gay et al.

NEURO-ONCOLOGY (2022)

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Meeting Abstract Oncology

PROGNOSIS IN IDH-MUTANT GLIOMA: THE ROLE OF EXTENT-OF-RESECTION, AGE AND TUMOR GRADE

T. van der Vaart et al.

NEURO-ONCOLOGY (2022)

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Meeting Abstract Oncology

PHASE 1/2 CLINICAL TRIAL OF BLOOD-BRAIN BARRIER OPENING WITH THE SONOCLOUD-9 IMPLANTABLE ULTRASOUND DEVICE IN RECURRENT GLIOBLASTOMA PATIENTS RECEIVING IV CARBOPLATIN

A. Idbaih et al.

NEURO-ONCOLOGY (2022)

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Review Oncology

Stereotactic targeted radiation therapy (STaRT) trials for brain neoplasms: A comprehensive review

Yazmin Odia et al.

Summary: Radiation therapy includes external beam radiation therapy (EBRT) and brachytherapy (BT), each with different benefits and risks. GammaTile (R) Surgically Targeted Radiation Therapy (STaRT) utilizes implanted collagen tiles containing radiation sources to optimize radiation exposure. The safety and feasibility of this therapy have been established through clinical trials, and it has gained FDA approval for various brain neoplasms.

NEURO-ONCOLOGY (2022)

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Article Oncology

Turning on the light for brain tumor surgery: A 5-aminolevulinic acid story

David J. McCracken et al.

Summary: To aid in the resection of brain tumors, adjuvant technologies such as fluorescence-guided surgery have been developed. 5-aminolevulinic acid (5-ALA) is a fluorescent substance that accumulates in tumor cells, improving visualization. 5-ALA fluorescence-guided surgery can increase the extent of tumor resection and improve patient survival.

NEURO-ONCOLOGY (2022)

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Article Oncology

GammaTile® brachytherapy in the treatment of recurrent glioblastomas

Dominic J. Gessler et al.

Summary: This study reports the clinical outcomes of using GT brachytherapy platform to treat recurrent glioblastoma patients. The treatment showed good efficacy, survival rates, and local control, with no severe complications observed.

NEURO-ONCOLOGY ADVANCES (2022)

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Article Clinical Neurology

Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors

William C. Chen et al.

Summary: The study examined the safety and efficacy of salvage intracranial cesium-131 brachytherapy with resection of recurrent brain tumors. The results showed that the treatment achieved good local control with acceptable rates of complications in heavily pretreated patients.

JOURNAL OF NEUROSURGERY (2022)

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Review Medical Informatics

Radiomics in neuro-oncological clinical trials

Philipp Lohmann et al.

Summary: The development of clinical trials has greatly improved the prevention and treatment of diseases, including brain cancer. Radiomics, a method from the field of artificial intelligence, has the potential to make a significant impact on clinical trials and practice, but it is not yet widely established.

LANCET DIGITAL HEALTH (2022)

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Article Oncology

Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma

John F. de Groot et al.

Summary: Laser ablation is a viable treatment option for patients with new and recurrent glioblastoma, particularly for those with IDH wild-type newly diagnosed glioblastoma. Post-procedure radiation and chemotherapy can significantly improve survival.

NEURO-ONCOLOGY ADVANCES (2022)

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Article Clinical Neurology

Resection of supplementary motor area gliomas: revisiting supplementary motor syndrome and the role of the frontal aslant tract

Jacob S. Young et al.

Summary: This study aimed to identify which patients with SMA gliomas would develop a postoperative SMA syndrome. The results showed that more extensive resections involving the posterior SMA region and posterior cingulate gyrus increased the likelihood of postoperative SMA syndrome.

JOURNAL OF NEUROSURGERY (2022)

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Article Clinical Neurology

Mini-craniotomy for intra-axial brain tumors: a comparison with conventional craniotomy in 306 patients harboring non-dural based lesions

Sergio Paolini et al.

Summary: A study compared mini-craniotomy with conventional craniotomy for intra-axial brain tumors and found that mini-craniotomy was equally effective in terms of extent of resection, but had shorter operative time and lower rate of postoperative complications. The mini-craniotomy group also had reduced hospitalization time and faster access to adjuvant therapies.

NEUROSURGICAL REVIEW (2022)

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Review Clinical Neurology

Intraoperative ultrasound in brain tumor surgery: A review and implementation guide

Luke Dixon et al.

Summary: Accurate and reliable intraoperative neuronavigation is crucial for safe resection of brain tumors. Intraoperative MRI (iMRI) has limitations due to cost and logistics, whereas intraoperative ultrasound (ioUS) is an affordable and easily integrated tool with improved image quality and navigation features. Advanced techniques like contrast-enhanced ultrasound (CEUS) have also become clinically useful.

NEUROSURGICAL REVIEW (2022)

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Article Clinical Neurology

Influence of supramarginal resection on survival outcomes after gross-total resection of IDH-wild-type glioblastoma

Tito Vivas-Buitrago et al.

Summary: The study found that performing at least 20% SMR of the CE tumor is associated with improved OS, while over 60% SMR does not significantly influence OS.

JOURNAL OF NEUROSURGERY (2022)

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Article Clinical Neurology

On the cutting edge of glioblastoma surgery: where neurosurgeons agree and disagree on surgical decisions

Domenique M. J. Muller et al.

Summary: This study used probability maps to quantify and compare surgical decision-making for glioblastoma patients by 12 neurosurgical teams. The study found treatment variations and identified differences in patient functional outcome and survival based on biopsy and resection decisions.

JOURNAL OF NEUROSURGERY (2022)

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Review Clinical Neurology

Intraoperative MRI versus 5-ALA in high-grade glioma resection: a network meta-analysis

Danielle Golub et al.

Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.

JOURNAL OF NEUROSURGERY (2021)

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Article Clinical Neurology

Triple motor mapping: transcranial, bipolar, and monopolar mapping for supratentorial glioma resection adjacent to motor pathways

Andrew J. Gogos et al.

Summary: The study suggests that using all three mapping modalities to identify, monitor, and preserve motor systems during glioma surgery can reduce the rate of deficits without compromising the extent of resection.

JOURNAL OF NEUROSURGERY (2021)

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Article Clinical Neurology

Intraoperative MRI for newly diagnosed supratentorial glioblastoma: a multicenter-registry comparative study to conventional surgery

Amar S. Shah et al.

Summary: The study found that iMRI-assisted surgery in patients with newly diagnosed glioblastoma can increase the extent of resection and improve overall survival. However, iMRI is not an independent predictor of overall survival, and additional supporting evidence is needed to determine the clinical benefit of iMRI in the management of glioblastoma.

JOURNAL OF NEUROSURGERY (2021)

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Article Clinical Neurology

Clinical Pearls and Methods for Intraoperative Motor Mapping

Marco Rossi et al.

Summary: Resection of brain tumors involving motor areas and pathways requires the identification and preservation of various cortical and subcortical structures involved in motor control at the time of the procedure, in order to maintain the patient's full motor capacities. The use of brain mapping techniques has now been integrated into clinical practice for many years, as they help the surgeon to identify the neural structures involved in motor functions.

NEUROSURGERY (2021)

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Article Clinical Neurology

Clinical Pearls and Methods for Intraoperative Awake Language Mapping

Ramin A. Morshed et al.

Summary: Intraoperative language mapping is a well-established technique for avoiding permanent neurological deficits and maximizing extent of resection. However, there is a lack of consistency in how patients are tested and the techniques involved to ensure safety during an awake procedure. This review explores patient selection, neuroanesthetic techniques, language mapping stimulation paradigms, and the impact of electrical stimulation intensity and timing on interpretation of mapping results.

NEUROSURGERY (2021)

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Review Clinical Neurology

A Review of Cortical and Subcortical Stimulation Mapping for Language

Jacob S. Young et al.

Summary: This supplementary issue on awake intraoperative mapping reviews language processing across multiple domains, highlighting key advances in direct electrical stimulation of different cortical and subcortical regions involved in naming, repetition, reading, writing, and syntax. Various intraoperative tasks are discussed for assessing the function of a given area and avoiding injury to critical, eloquent regions.

NEUROSURGERY (2021)

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Article Oncology

Treatment of Cancer-Associated Venous Thromboembolism with Low-Molecular-Weight Heparin or Direct Oral Anticoagulants: Patient Selection, Controversies, and Caveats

Casey O'Connell et al.

Summary: Treating VTE in cancer patients is challenging due to increased risks of recurrent VTE and major bleeding. LMWH has historically been preferred, but DOACs may be used with caution, especially in patients with gastrointestinal cancer. DOACs and LMWH carry similar risks for major bleeding, with caution needed in certain cancer patients. Personalized treatment considerations and patient adherence are important factors in choosing the appropriate anticoagulant therapy.

ONCOLOGIST (2021)

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Review Clinical Neurology

Preoperative Applications of Navigated Transcranial Magnetic Stimulation

Alexander F. Haddad et al.

Summary: Preoperative mapping of cortical structures can provide neurosurgeons with a roadmap of the brain, allowing for improved operative planning, patient risk stratification, and personalized counseling. Navigated transcranial magnetic stimulation (nTMS) is a highly accurate and non-invasive modality that can differentiate between eloquent and non-eloquent cortical regions, with motor mapping being the best validated application. Language mapping is also common, but not as concordant with intraoperative mapping as motor mapping. Additionally, nTMS has been used for localizing cortical regions involved in various functions beyond motor and language processing.

FRONTIERS IN NEUROLOGY (2021)

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Review Oncology

Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients - a report of the PET/RANO group

Norbert Galldiks et al.

Summary: Management of patients with glioma usually involves multimodality treatment, with accurate neuroimaging playing a central role in radiotherapy planning and follow-up. The use of PET imaging for radiotherapy planning and monitoring in gliomas has gained interest, but Class I data is currently lacking. PET has potential for response assessment and distinguishing tumor progression from pseudoprogression or radiation necrosis in glioma patients.

NEURO-ONCOLOGY (2021)

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Article Clinical Neurology

Stimulated Raman Histology for Rapid Intraoperative Diagnosis of Gliomas

Long Di et al.

Summary: In this study, the effectiveness of Stimulated Raman Histology (SRH) was compared with conventional frozen section histology in surgeries for central nervous system tumors. The results showed that SRH significantly shortened the diagnostic time while maintaining diagnostic accuracy, and was able to quickly identify key features associated with different types of gliomas.

WORLD NEUROSURGERY (2021)

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Article Clinical Neurology

Enhanced recovery after surgery - ERAS in elective craniotomies-a non-randomized controlled trial

Anirudh Elayat et al.

Summary: The study compared the ICU/HDU stay of patients undergoing elective craniotomy for supratentorial neurosurgery with ERAS protocol versus routine care, showing a shorter stay and better pain and glycemic control in the ERAS group within the first 48 hours post-surgery, although the total hospital stay was similar.

BMC NEUROLOGY (2021)

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Review Oncology

Evidence-based recommendations on categories for extent of resection in diffuse glioma

Philipp Karschnia et al.

Summary: Surgical resection is the standard treatment for diffuse glioma, and the extent of tumor resection is associated with prognosis. Expert recommendations on different categories for extent of resection were developed based on evidence to standardize terminology. These categories may serve as a stratification factor for future clinical trials.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Oncology

Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon

Emilie Darrigues et al.

Summary: Neuro-oncology biobanks are essential for precision medicine programs. This study highlights the crucial role of neurosurgeons in diagnosis, research, and precision medicine efforts, along with successful implementation of a brain tumor biobank. The integration of standard histopathological diagnosis, next generation sequencing, and functional assays on surgical specimens in developing precision medicine protocols is emphasized.

FRONTIERS IN ONCOLOGY (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Cerebral and tumoral blood flow in adult gliomas: a systematic review of results from magnetic resonance imaging

Mueez Waqar et al.

Summary: This review of 34 studies found that high-grade gliomas increase tumor blood flow and decrease cerebral blood flow, but post-surgery, patients' cerebral blood flow can improve.

BRITISH JOURNAL OF RADIOLOGY (2021)

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Article Clinical Neurology

Optimal timing of post-operative enoxaparin after neurosurgery: A single institution experience

Robert G. Briggs et al.

Summary: Initiating prophylactic enoxaparin within 72 hours of surgery can reduce the risk of developing lower extremity DVT without increasing complication rates, based on a retrospective study.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Article Clinical Neurology

A Cohort Study on Prognostic Factors for Laser Interstitial Thermal Therapy Success in Newly Diagnosed Glioblastoma

Long Di et al.

Summary: Increased extent of ablation (EOA) is a predictor of improved progression-free survival (PFS) in the treatment of newly diagnosed glioblastoma using laser interstitial thermal therapy (LITT). Early transition to chemotherapy after LITT also improves PFS.

NEUROSURGERY (2021)

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Article Clinical Neurology

Comparison of the Safety of Prophylactic Anticoagulants After Intracranial Surgery

Joseph S. Bell et al.

Summary: The study compared the safety and efficacy of unfractionated heparin (UH) and low-molecular-weight heparin (LMWH) for prophylaxis after cranial surgery, finding that both showed similar efficacy in preventing VTE but LMWH was associated with a higher rate of intracranial hemorrhage. Reviewing existing literature and meta-analysis further supported these findings, indicating that LMWH may be associated with a greater risk of ICH compared to UH.

NEUROSURGERY (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Can Preoperative Mapping with Functional MRI Reduce Morbidity in Brain Tumor Resection? A Systematic Review and Meta-Analysis of 68 Observational Studies

Licia P. Luna et al.

Summary: The study suggests that preoperative functional MRI planning for brain tumor resection can reduce postoperative morbidity and improve patients’ performance status after surgery. Patients who underwent preoperative fMRI mapping were less likely to experience functional deterioration after surgery.

RADIOLOGY (2021)

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Article Multidisciplinary Sciences

Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology

Melike Pekmezci et al.

Summary: The study showed that fiber-laser based stimulated Raman histology (SRH) can identify residual microscopic tumor at the infiltrative glioma margin, potentially enhancing the extent of resection. Intraobserver agreements were confirmed, demonstrating the effectiveness of SRH.

SCIENTIFIC REPORTS (2021)

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Article Clinical Neurology

Unfractionated Heparin TID Dosing Regimen Is Associated With a Lower Rate of Pulmonary Embolism When Compared With BID Dosing in Patients Undergoing Craniotomy

Vineeth Thirunavu et al.

Summary: The study revealed that UFH TID dosing is associated with lower rates of PE in patients undergoing craniotomy when compared with BID dosing, while showing no significant differences in rates of DVT and reoperation for bleeding.

WORLD NEUROSURGERY (2021)

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Article Oncology

Targeting Primary Motor Cortex (M1) Functional Components in M1 Gliomas Enhances Safe Resection and Reveals M1 Plasticity Potentials

Marco Rossi et al.

Summary: The study highlights the novel technique for on-line identification of two functional components in the Primary-Motor-Cortex (M1) during tumor resection, showing the potential plasticity reorganization of M1 and its impact on tumor resection and patient motor performance. By detecting and targeting these components, complete tumor removal rate can be increased while maintaining motor function, suggesting M1 plasticity potentials.

CANCERS (2021)

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Article Oncology

Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein: Safety Study in a Porcine Model

Luca Raspagliesi et al.

Summary: This study demonstrated the safety of low-intensity ultrasound irradiation of healthy brain tissue using FDA-approved sonosensitizers in a large animal model. The results support the clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.

FRONTIERS IN ONCOLOGY (2021)

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Article Clinical Neurology

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database

Ping Zhu et al.

JOURNAL OF NEUROSURGERY (2020)

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Article Clinical Neurology

Survival benefit of lobectomy over gross-total resection without lobectomy in cases of glioblastoma in the noneloquent area: a retrospective study

Tae Hoon Roh et al.

JOURNAL OF NEUROSURGERY (2020)

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Article Clinical Neurology

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