Temozolomide and flavonoids against glioma: from absorption and metabolism to exosomal delivery

Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide increases GBM patient survival, it has also been connected to negative immune-related adverse effects. Numerous research investigations have shown that flavonoids have strong antioxidant and chemo-preventive effects. Consequently, it might lessen chemotherapeutic medicines' side effects while also increasing therapeutic effectiveness. The need for creating innovative, secure, and efficient drug carriers for cancer therapy has increased over time. Recent research indicates that exosomes have enormous potential to serve as carriers and cutting-edge drug delivery systems to the target cell. In recent years, researchers have been paying considerable attention to exosomes because of their favorable biodistribution, biocompatibility, and low immunogenicity. In the present review, the mechanistic information of the anti-glioblastoma effects of temozolomide and flavonoids coupled with their exosomal delivery to the targeted cell has been discussed. In addition, we discuss the safety aspects of temozolomide and flavonoids against glioma. The in-depth information of temozolomide and flavonoids action via exosomal delivery can unravel novel strategies to target Glioma.

Automated summary

Patients with glioblastoma and anaplastic astrocytoma are treated with temozolomide, which has been shown to increase patient survival but may also have negative immune-related effects. Flavonoids have antioxidant and chemo-preventive effects, and may reduce side effects of chemotherapy while increasing effectiveness. Exosomes have potential as drug carriers for cancer therapy due to their favorable biodistribution, biocompatibility, and low immunogenicity.