期刊
MOLECULAR NEUROBIOLOGY
卷 54, 期 3, 页码 1874-1886出版社
SPRINGER
DOI: 10.1007/s12035-016-9785-6
关键词
Intracerebral hemorrhage; Microglia; Inflammatory mediators
资金
- National Natural Science Foundation of China [81200885]
- Heilongjiang Postdoctoral Science-Research Foundation [LBH-Q13120]
- Natural Science Foundation of Heilongjiang Province of China [LC2013C30]
- Foundation of the First Clinical Hospital of Harbin Medical University [2012LX004]
- American Heart Association [13GRNT15730001]
- National Institutes of Health [R01NS078026, R01AT007317]
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.
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