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Stem-cell-like CD4(+) T cells prey on MHC class II-negative tumors

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NATURE IMMUNOLOGY
卷 -, 期 -, 页码 -

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NATURE PORTFOLIO
DOI: 10.1038/s41590-023-01563-5

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Despite the absence of MHC class II molecules on tumor cells, stem-cell-like CD4(+) T cells specific for tumor neoantigens can enhance the antitumor effects by interacting with antigen-presenting cells and promoting antitumor CD8(+) T cells in the tumor microenvironment and draining lymph nodes.
Despite the absence of MHC class II molecules on tumor cells, stem-cell-like CD4(+) T cells specific for tumor neoantigens can mediate profound antitumor effects by licensing antigen-presenting cells and augmenting antitumor CD8(+) T cells in the tumor microenvironment and draining lymph nodes.

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