Single-cell multiomic analyses sheds light on mitochondrial mutational selection

Single large-scale mitochondrial DNA deletions cause a spectrum of disease with differing severities and tissue expressivity. Quantification of single-cell deletion levels with multi-modal cellular readouts provides insights into hematopoietic cell fate and disease manifestation.

Automated summary

Single large-scale mitochondrial DNA deletions result in a range of diseases with varying levels of severity and tissue expression. Examining single-cell deletion levels through multi-modal cellular readouts allows for better understanding of hematopoietic cell fate and disease manifestation.