☆ 4.8 Editorial Material

Establishing the fundamental rules for genetic code expansion

NATURE CHEMISTRY (2023)

Machines on Genes through the Computational Microscope

Souvik Sinha et al.

Summary: This article reports the increasing role of computational biophysics in characterizing the mechanisms of gene machines, focusing on innovative applications of computational methods and their integration with structural and biophysical experiments. Advanced computational methods reveal the biophysical function that is unseen through experimental techniques, accomplishing the power of the computational microscope. Bridging the gap between experimentally obtained macroscopic observables and the molecular principles playing at the microscopic level is crucial for harnessing molecular machines for medical, pharmaceutical, and biotechnological purposes.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2023)

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Article Chemistry, Multidisciplinary

Atomistic simulations oftheEscherichia coli ribosome provide selection criteria for translationally active substrates

Zoe L. Watson et al.

Summary: As genetic code expansion progresses, it is still a challenge to determine the substrates the ribosome can accommodate. This study provides insights into how the E. coli ribosome incorporates non-?-a-amino acids, using high-resolution cryogenic electron microscopy and metadynamics simulations. The findings suggest that reactive monomers prefer a specific conformational space for efficient bonding, which could facilitate the synthesis of non-peptide heterooligomers.

NATURE CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology