Pioneer factor competing for fate change

Pioneer transcription factors bind closed chromatin regions, alter local accessibility and activate target genes. A study reveals that the SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers via sequestration of epigenetic factors.

Automated summary

A study uncovers that Pioneer transcription factors can bind closed chromatin regions, modify local accessibility, and activate target genes. The SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers through sequestration of epigenetic factors.