Epigenetic control of cancer inflammation

The interaction of non-immune and immune cells in the tumour microenvironment (TME) determines the quality of the immune attack on nascent tumour cells. A new study in melanoma cells shows that specific histone variants dampen the expression of cytokine genes in cancer-associated fibroblasts, leading to an immunosuppressive TME.

Automated summary

The interaction between non-immune and immune cells in the tumor microenvironment plays a crucial role in the immune attack on cancer cells. A recent study on melanoma cells reveals that specific histone variants can suppress the expression of cytokine genes in cancer-associated fibroblasts, resulting in an immunosuppressive tumor microenvironment.