期刊
MOLECULAR NEUROBIOLOGY
卷 54, 期 2, 页码 1254-1262出版社
SPRINGER
DOI: 10.1007/s12035-016-9740-6
关键词
Stroke; Neural stemcells; Kunming mice model; NSCs transplantation
资金
- National Natural Science Foundation of Gansu, China [1506RJZA222]
- Lanzhou Science and Technology Bureau Project [2015-2-55]
Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In this study, we explore the transplantation of exogenous neural stem cells (NSCs) as the potential therapy for the photothrombotic ischemia stroke in a Kunming mice model. After stroke, mice receiving NSC transplantation demonstrated a better recovery of brain function during the neurobehavioral tests. Histology analysis of the brain samples from NSC transplanted mice demonstrated a reduction of brain damage caused by stroke. Moreover, immunofluorescence assay for biomarkers in brain sections confirmed that transplanted NSCs indeed differentiated to neurons and astrocytes, consistent with the improved brain function after stroke. Taken together, our data suggested that exogenous NSC transplantation could be a promising therapy for stroke.
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