Tinctorin, a new spiroterpenoid from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale growing in Vietnam

A new spiroterpenoid, namely tinctorin (1), along with one known compound, norreticulatin (2), were isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established for the first time. Compound 1 was evaluated for its inhibitory activity against a-glucosidase and found to be inactive.

Automated summary

A new spiroterpenoid named tinctorin (1), along with a known compound called norreticulatin (2), was isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures were determined through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The absolute configuration of compound 2 was established for the first time. Compound 1 showed no inhibitory activity against α-glucosidase.