☆ 4.7 Article

Curcumin-reduced gold nanoparticles facilitate IL-12 delivery to a cervical cancer in vitro cell model

NANOMEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pharmacology & Pharmacy

Liposomes in the Targeted Gene Therapy of Cancer: A Critical Review

Ashish Akkewar et al.

Summary: Cancer immunotherapy has made significant progress in recent years with the help of nanocarriers like liposomes that improve immune responses through targeted distribution. Liposomes, lipid bilayer vesicles, have been used as smart delivery systems for hydrophobic and hydrophilic bioactive substances since the 1960s, and advancements in drug entrapment and manufacturing have continued. Understanding the mechanisms and interactions involved in liposome-mediated transmission of genetic material is crucial for successful gene delivery. This analysis focuses on ligand-targeted liposomes and theranostic liposomes for cancer diagnosis and treatment, highlighting their benefits and potential applications.

CURRENT DRUG DELIVERY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

The Optimized Formulation of Tamoxifen-Loaded Niosomes Efficiently Induced Apoptosis and Cell Cycle Arrest in Breast Cancer Cells

Iman Akbarzadeh et al.

Summary: The study aimed to optimize niosomal formulations of tamoxifen for the treatment of breast cancer. The optimized formulation showed improved stability and pH-dependent drug release, making it a promising candidate for drug delivery in breast cancer treatment. The tamoxifen-loaded niosomes exhibited high biocompatibility with healthy cells and remarkable inhibitory effects on cancer cells, as well as changes in gene expression patterns associated with cell cycle arrest, decreased migration capacity, increased caspase activity, and apoptosis induction.

AAPS PHARMSCITECH (2022)

添加到收藏夹

Article Oncology

Global distribution, risk factors, and recent trends for cervical cancer: A worldwide country-level analysis

Junjie Huang et al.

Summary: This study evaluated the global distribution, risk factors, and temporal trends of cervical cancer. Results showed higher burden in regions with low and medium HDI and associated with higher alcohol consumption. The overall burden of cervical cancer is decreasing, but some populations show increasing trend in incidence and mortality.

GYNECOLOGIC ONCOLOGY (2022)

添加到收藏夹

Article Immunology

Borrelia burgdorferi Is a Poor Inducer of Gamma Interferon: Amplification Induced by Interleukin-12

Frederik R. van de Schoor et al.

Summary: This study investigates the regulation of interferon-gamma (IFN-gamma) during early Lyme borreliosis (LB) and provides insights into the host response to B. burgdorferi. The study finds that the addition of interleukin-12 (IL-12) amplifies the IFN-gamma response in cells exposed to B. burgdorferi, and the response is significantly higher in LB patients. The study also identifies a single nucleotide polymorphism associated with increased IFN-gamma production.

INFECTION AND IMMUNITY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Poly-L-Lysine-Lactobionic Acid-Capped Selenium Nanoparticles for Liver-Targeted Gene Delivery

Shaigan Naidoo et al.

Summary: This study designed and characterized functionalized selenium nanoparticles that efficiently bind, protect, and deliver DNA to liver cancer cells, exhibiting favorable features as gene nanocarriers for liver cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Progress in gene therapy treatments for prostate cancer

Jingxin Xue et al.

Summary: Prostate cancer, a prevalent cancer affecting men, has been widely reported. Gene therapy is considered an optimal treatment with targeted delivery of complementary gene sequences showing promise in certain instances. Various gene therapies have been established for a wide range of diseases, with several gene therapy clinical trials at various phases currently underway.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Histidine-Tagged Folate-Targeted Gold Nanoparticles for Enhanced Transgene Expression in Breast Cancer Cells In Vitro

Calrin Joseph et al.

Summary: This study successfully prepared functionalized gold nanoparticles for targeted gene delivery in breast cancer cells. The nanoparticles exhibited favorable size and negative charge, effectively protecting the gene from degradation and showing good cellular compatibility and enhanced transgene activity. Folate-targeted nanoparticles demonstrated better gene delivery efficiency in specific types of breast cancer cells.

PHARMACEUTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anticancer Effects of Gold Nanoparticles by Inducing Apoptosis in Bladder Cancer 5637 Cells

Sajedeh Daei et al.

Summary: Gold nanoparticles have shown promising anticancer properties by inducing ROS production, regulating apoptosis-related gene expression, and promoting apoptosis in bladder cancer cells, while also inhibiting cell migration.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

添加到收藏夹

Review Oncology

Localized Nano-mediated Interleukin-12 Gene Therapy: Promising Candidate for Cancer Immunotherapeutics

Jeaneen Venkatas et al.

Summary: This article discusses the application and potential of interleukin-12 (IL-12) as an antitumor immunotherapeutic agent, emphasizing the need for localized gene therapy and the development of nano-delivery strategies for IL-12 in cancer treatment. The findings suggest that IL-12 has promising prospects in cancer immunotherapy, but its systemic delivery has limitations due to severe side effects. The use of nanomedicine provides new avenues to enhance therapeutic indices with minimal side effects, and combination therapy with other anticancer molecules can further potentiate the activity of IL-12. The results will aid researchers in developing immunotherapeutic nanovectors that synergistically enhance the therapeutic effect of the IL-12 gene to eliminate cancer cells.

CURRENT CANCER DRUG TARGETS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gold nanoparticles induce apoptosis in HCT-116 colon cancer cell line

Atefeh Maddah et al.

Summary: This study investigated the apoptotic and anti-cancer effect of gold nanoparticles on HCT-116 colon cancer cells. The results showed that treatment with nanoparticles led to an increase in the expression of Bax and P53 genes, a decrease in the expression of Bcl-2 and CCNB1 genes, and an increase in the level of apoptosis.

MOLECULAR BIOLOGY REPORTS (2022)

添加到收藏夹

Article Polymer Science

Dendrimers as prospective nanocarrier for targeted delivery against lung cancer

Virali Arora et al.

Summary: Dendrimers are synthetic nano-molecules with a spherical structure and a stardust topology. They are effective in solving the solubility problem in drug delivery and have been successfully used in chemotherapeutic drug delivery. Research has shown that dendrimers have potential in treating lung cancer and outperform other nanoparticles in terms of bioavailability and stability.

EUROPEAN POLYMER JOURNAL (2022)

添加到收藏夹

Article Medicine, General & Internal

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Khanh Bao Tran et al.

LANCET (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Novel strategies exploiting interleukin-12 in cancer immunotherapy

Assunta Cirella et al.

Summary: Interleukin-12 is a potent agent for enhancing antitumor immune responses. Localized delivery methods such as electroporation and genetic engineering can significantly improve treatment outcomes, and combining IL-12 with checkpoint inhibitors shows promising results.

PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Editorial Material Biotechnology & Applied Microbiology

Green synthesis of gold nanoparticles using plant products and plants extracts aiming for cancer therapy: helping the beauty to beat 'cure' the beast

Rania M. Hathout

Summary: This article emphasizes the importance of using green synthesis methods for the preparation of gold nanoparticles, and introduces various methods and application examples.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Potential of Curcumin-Capped Nanoparticle Synthesis in Cancer Therapy: A Green Synthesis Approach

Jeaneen Venkatas et al.

Summary: Cancer nanotherapeutics, using nanomaterials as a form of cancer therapy, is an important and promising field of research. Nanoparticles have unique properties that make them excellent vehicles for delivering therapeutic genes and drugs to tumors. However, there is also concern about the potential long-term side effects of nanoparticles on the environment and human health. Using curcumin-capped nanoparticles as a green and sustainable alternative shows potential for effective and targeted cancer treatment.

NANOMATERIALS (2022)

添加到收藏夹

Review Materials Science, Biomaterials

Recent advances in nanotechnology approaches for non-viral gene therapy

Yihang Jiang et al.

Summary: Gene therapy has shown great potential in the treatment of various diseases by regulating the expression of specific genes. Non-viral vector-based gene therapy is being explored as an important approach to overcome the limitations of viral vector-based gene therapy, with enhanced gene stability, treatment efficiency, tumor targeting, and biocompatibility. This review discusses different non-viral vector-mediated gene therapy approaches using various nanocarriers, including nanoparticles, carbon nanotubes, and gold nanoparticles. The construction strategies, cellular uptake pathways, multifunctional gene therapy, and safety of non-viral vector-based gene therapy are comprehensively discussed.

BIOMATERIALS SCIENCE (2022)

添加到收藏夹

Review Oncology

Cancer gene therapy goes viral: viral vector platforms come of age

Urban Bezeljak

Summary: Viral vector gene therapy has great potential in cancer treatment and has played an important role in CAR-T cell therapy, cancer vaccines, and targeted oncolytic therapy. Recent advances in production platforms have enabled the widespread adoption of viral vectors, making them a promising tool in standard cancer treatment.

RADIOLOGY AND ONCOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Gelatin-coated gold nanoparticles as an effective pH-sensitive methotrexate drug delivery system for breast cancer treatment

B. Khodashenas et al.

Summary: This study investigated the synthesis and effectiveness of gold/gelatin nanoparticles as a carrier for methotrexate drug. The size and shape of AuNPs were found to affect the entrapment efficiency, drug release rate, and cellular uptake, with AuNPs showing higher EE than AuNRs. MTX loaded AuNR2-gelatin exhibited the highest cytotoxic effect on MCF-7 breast cancer cells.

MATERIALS TODAY CHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Design and fabrication of novel multi-targeted magnetic nanoparticles for gene delivery to breast cancer cells

Amin Amani et al.

Summary: Novel multi-targeted magnetic nanoparticles (MTMNPs) were synthesized for DNA protection and targeted gene delivery to breast cancer cells. The MTMNPs significantly reduced PEI-associated toxicity and improved gene delivery efficiency compared to PEI/DNA complex.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Photoluminescent carbon quantum dot/poly-L-Lysine core-shell nanoparticles: A novel candidate for gene delivery

Akbar Hasanzadeh et al.

Summary: This study developed a novel gene delivery vehicle by combining carbon quantum dots (CQDs) with poly-L-lysine (PLL) to form core-shell nanoparticles with a hybrid nanostructure. These nanoparticles exhibited narrow size distribution, average diameter under 10 nm, non-toxicity to human cells, and promising optical properties. These CQD/PLL core-shell nanoparticles have great potential as a non-toxic and efficient gene delivery vector.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor-Associated Macrophage and Tumor-Cell Dually Transfecting Polyplexes for Efficient Interleukin-12 Cancer Gene Therapy

Nasha Qiu et al.

Summary: A novel IL12 gene-delivery vector was designed to efficiently transfect both cancer cells and TAMs, turning them into a factory for IL12 production, which effectively activates anticancer immune responses and remodels the tumor microenvironment. The intravenously administered vector slows tumor growth and doubles survival in three animal models with minimal systemic toxicities.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Clinical Neurology

Using viral vectors to deliver local immunotherapy to glioblastoma

Alexander F. Haddad et al.

Summary: Glioblastoma treatment has not significantly improved in recent years, with limited efficacy of immunotherapies due to concerns surrounding systemic toxicities and blood-brain barrier penetration. Using viral vectors to deliver immunotherapies directly to tumor cells shows promise in increasing treatment efficacy and reducing systemic toxicities.

NEUROSURGICAL FOCUS (2021)

添加到收藏夹

Article Toxicology

Cellular uptake and toxicity of gold nanoparticles on two distinct hepatic cell models

Maria Enea et al.

Summary: The study compared the cytotoxic effects of gold nanoparticles with different size, shape, and capping on liver cells, finding that smaller 15 nm spheres displayed the highest toxicity. Toxicological effects were influenced by capping, size, and cell type, with citrate-capped nanoparticles more toxic than MUA, 15 nm nanoparticles more toxic than 60 nm ones, and primary rat hepatocytes more sensitive than HepaRG cells. The presence of FBS significantly influenced toxicity outcomes, with higher internalization of AuNPs in PRH compared to HepaRG cells.

TOXICOLOGY IN VITRO (2021)

添加到收藏夹

Article Chemistry, Applied

Multi-functional carboxymethyl chitin-based nanoparticles for modulation of tumor-associated macrophage polarity

Yunfeng Wan et al.

Summary: The use of tumor-targeted and microenvironment-responsive nanocarriers (TRN) can effectively address the issues of poor distribution and systemic side effects associated with cytokines, demonstrating significant anti-tumor efficacy in mice models.

CARBOHYDRATE POLYMERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer's and Parkinson's Diseases

Keelan Jagaran et al.

Summary: Neurodegenerative disorders result in the gradual degeneration of axons and neurons in the central nervous system, causing major disruptions in patients' lives. Current treatments are only palliative, highlighting the need for a therapeutic strategy targeting the root cause of the diseases. The synergistic use of gene therapy and nanomedicine shows promise in effectively treating these diseases by targeting the causative mutated genes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Nanomedicine-mediated optimization of immunotherapeutic approaches in cervical cancer

Jeaneen Venkatas et al.

Summary: Cervical cancer presents immense complexity at the molecular level, limiting traditional treatment methods. Immunotherapy and nanotechnology offer new hope for cancer treatment, but their efficacy varies depending on the patient population, requiring further research and improvement.

NANOMEDICINE (2021)

添加到收藏夹

Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

添加到收藏夹

Proceedings Paper Materials Science, Multidisciplinary

Biocompatibility of gold nanoparticles: In-vitro and In-vivo study

Rua J. Kadhim et al.

Summary: The study examined the toxicity of gold nanoparticles in both in-vitro and in-vivo settings. Results indicated that GNPs exhibited no toxic effects on REF cells and did not cause significant pathological changes in mice after being injected intraperitoneally.

MATERIALS TODAY-PROCEEDINGS (2021)

添加到收藏夹

Review Food Science & Technology

Antimicrobial and anticancer applications and related mechanisms of curcumin-mediated photodynamic treatments

Qiong-Qiong Yang et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

pH-Responsive charge switchable PEGylated ε-poly-L-lysine polymeric nanoparticles-assisted combination therapy for improving breast cancer treatment

Zhihao Guo et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Immunology

Localized Interleukin-12 for Cancer Immunotherapy

Khue G. Nguyen et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer

Bee Ling Tan et al.

MOLECULES (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Sterically stabilized siRNA:gold nanocomplexes enhance c-MYC silencing in a breast cancer cell model

Aliscia N. Daniels et al.

NANOMEDICINE (2019)

添加到收藏夹

Review Oncology

Cytokines in clinical cancer immunotherapy

Pedro Berraondo et al.

BRITISH JOURNAL OF CANCER (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Folate-tagged chitosan-functionalized gold nanoparticles for enhanced delivery of 5-fluorouracil to cancer cells

Jude Akinyelu et al.

APPLIED NANOSCIENCE (2019)

添加到收藏夹

Article Chemistry, Medicinal

Folate-Targeted mRNA Delivery Using Chitosan-Functionalized Selenium Nanoparticles: Potential in Cancer Immunotherapy

Fiona Maiyo et al.

PHARMACEUTICALS (2019)

添加到收藏夹

Review Engineering, Biomedical

Recent advances in the development of gene delivery systems

Y. K. Sung et al.

BIOMATERIALS RESEARCH (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

PEGylated dendrimer-entrapped gold nanoparticles with low immunogenicity for targeted gene delivery

Bei Xu et al.

RSC ADVANCES (2018)

添加到收藏夹

Review Clinical Neurology

Gold Nanoparticles for Brain tumor imaging: a Systematic Review

Antonio Meola et al.

FRONTIERS IN NEUROLOGY (2018)

添加到收藏夹

Article Oncology

Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells

Keunok Jung et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Synthesis of curcumin-functionalized gold nanoparticles and cytotoxicity studies in human prostate cancer cell line

Shruti Nambiar et al.

APPLIED NANOSCIENCE (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Therapeutic gene editing: delivery and regulatory perspectives

Gayong Shim et al.

ACTA PHARMACOLOGICA SINICA (2017)

添加到收藏夹

Review Immunology

Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12

Ruben Hernandez-Alcoceba et al.

IMMUNOTHERAPY (2016)

添加到收藏夹

Article Polymer Science

Synthesis of PEGylated chitosan copolymers as efficiently antimicrobial coatings for leather

Quanqing Luo et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2016)

添加到收藏夹

Article Chemistry, Physical

NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors

Flavio Curnis et al.

NANO RESEARCH (2016)

添加到收藏夹

Article Optics

Understanding the shape effect on the plasmonic response of small ligand coated nanoparticles

Xing Chen et al.

JOURNAL OF OPTICS (2016)

添加到收藏夹

Article Chemistry, Physical

Characterization of citrates on gold and silver nanoparticles

Priastuti Wulandari et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biocompatibility Assessment of Polyethylene Glycol-Poly L-Lysine-Poly Lactic-Co-Glycolic Acid Nanoparticles In Vitro and In Vivo

Liting Guo et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2015)

添加到收藏夹

Article Nanoscience & Nanotechnology

Green Synthesis of Curcumin Capped Gold Nanoparticles and Evaluation of Their Cytotoxicity

Ch. Sreelakshmi et al.

NANOSCIENCE AND NANOTECHNOLOGY LETTERS (2013)

添加到收藏夹

Article Oncology

Cytokines in Cancer Immunotherapy

Sylvia Lee et al.

Cancers (2011)

添加到收藏夹

Article Pharmacology & Pharmacy

Lipoplexes with biotinylated transferrin accessories: Novel, targeted, serum-tolerant gene carriers

Moganavelli Singh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

添加到收藏夹

Article Engineering, Biomedical

Physicochemical model of alginate-poly-L-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS

SK Tam et al.

BIOMATERIALS (2005)

添加到收藏夹

Review Genetics & Heredity

Towards safe, non-viral therapeutic gene expression in humans

DJ Glover et al.

NATURE REVIEWS GENETICS (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.