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Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

NANO TODAY (2023)

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Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent

Ji Yeon Hong et al.

Summary: In this study, histidine-modified hyaluronic acid (HA-His) was synthesized to quickly reduce permanganate to MnO2, resulting in the production of HA-His/MnO2 nanoparticles with good water-dispersibility and stability. These nanoparticles responded to the tumor microenvironment and were internalized into SCC7 cells with high CD44 expression. Systemically administered HA-His/MnO2 nanoparticles specifically accumulated in tumor tissues, enhancing T1 contrast in MRI.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Chemistry, Physical

Effect of Dipole Interactions on Blocking Temperature and Relaxation Dynamics of Superparamagnetic Iron-Oxide (Fe3O4) Nanoparticle Systems

Md Ehsan Sadat et al.

Summary: The effects of dipole interactions on the magnetization and relaxation dynamics of magnetic nanoparticles were studied using five different nanoparticle systems. It was found that dipole interactions play a crucial role in modifying the blocking temperature behavior of superparamagnetic nanoparticles. The frequencies of the dominant relaxation mechanisms were determined, and microwave absorption was found to depend on the local environment and dipole-dipole interactions.

MATERIALS (2023)

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Article Materials Science, Biomaterials

Multifunctional tunable ZnFe2O4@MnFe2O4 nanoparticles for dual-mode MRI and combined magnetic hyperthermia with radiotherapy treatment

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Summary: With the increase in non-communicable diseases, cancer is becoming one of the most lethal ailments of the coming decades. Significant progress has been made in the development of NPs that combine diagnostic and therapeutic properties in a single system. This study presents high-performance multifunctional NPs capable of combining different diagnostic and therapeutic methods for a full course of treatment using only one type of NP.

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Article Chemistry, Multidisciplinary

α-Fe2O3@Au-PEG-Ce6-Gd Nanoparticles as Acidic H2O2-Driven Oxygenators for Multimodal Imaging and Synergistic Tumor Therapy

Mingqian Wang et al.

Summary: In this study, a novel enhanced photothermal photodynamic antitumor nanoplatform was constructed, which has photo-thermal imaging, fluorescence imaging, and MRI-guided therapeutic capabilities. It can convert NIR light into local hyperthermia and generate singlet oxygen, further synergizing the tumor-killing effect. This nanoplatform provides a new solution for tumor imaging and treatment.

LANGMUIR (2023)

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Article Chemistry, Multidisciplinary

A tumor-associated bacteria-responsive magnetic exosome as a clearable T1 contrast agent for targeted imaging of tumors

Xiaoqing Wei et al.

Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.

NANO TODAY (2023)

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Article Engineering, Biomedical

A Strategy of Fenton Reaction Cycloacceleration for High-Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling

Lin Huang et al.

Summary: The present study proposes a strategy of Fenton reaction cycloacceleration initiated by remodeling the tumor microenvironment (TME) for magnetic resonance imaging (MRI)-guided high-performance ferroptosis therapy of tumors. The synthesized nanocomplex accumulates in carbonic anhydrase IX (CAIX)-positive tumors and increases acidification via the inhibition of CAIX, leading to the release of loaded substances for Fenton and Fenton-like reactions, generating ROS and lipid peroxides accumulation, and inducing ferroptosis of tumor cells. The detached coordination networks exhibit improved relaxivities in response to the TME. Therefore, this strategy shows promise for MRI-guided high-performance ferroptosis therapy of tumors.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Biotechnology & Applied Microbiology

Alleviating the hypoxic tumor microenvironment with MnO2-coated CeO2 nanoplatform for magnetic resonance imaging guided radiotherapy

Fen Pi et al.

Summary: To improve the efficiency of radiotherapy, a core-shell nanocomposite CeO2-MnO2 is designed as a novel radiosensitizer that can modulate the tumor microenvironment (TME) and thus improve the efficacy of radiation therapy. According to experiments, CeO2-MnO2 nanoparticles aggravate the killing effect on tumor cells by generating large amounts of ROS and disrupting the redox balance. The outer layer of MnO2 reacts with GSH and H2O2 in the tumor microenvironment to generate ROS and release oxygen, thus alleviating the hypoxic condition in the tumor area. The nanomaterial CeO2-MnO2 greatly improves the efficiency of cancer radiation therapy by improving the lack of oxygen in tumor and responding to the tumor microenvironment, providing an effective strategy for the construction of nanosystems with radiosensitizing function.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

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Article Chemistry, Multidisciplinary

Nanoprobe Based on Biominerals in Protein Corona for Dual-Modality MR Imaging and Therapy of Tumors

Peisen Zhang et al.

Summary: Researchers developed theranostic nanoprobes based on protein-corona-coated Fe3O4 nanoparticles and biomineralization. The nanoprobes showed biocompatibility, nonimmunogenicity, photothermal therapy, and the ability to target tumor cells. The released Fe3+ enhanced MR imaging, enabling improved tumor diagnosis.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Modulated Ultrasmall γ-Fe2O3 Nanocrystal Assemblies for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy

Baochan Yang et al.

Summary: Ferroptosis is a recently discovered programmed cell death induced by cellular ferrous ion bursts and subsequent Fenton reactions. In this study, hierarchically assembled gamma-Fe2O3 nanocrystal-based nanoparticles were developed, which showed switchable magnetic resonance imaging, enhanced ferroptosis efficiency, and high photothermal conversion. These nanoparticles enabled clear visualization of tissues and highly efficient photothermal therapy, achieving synergistic cancer therapy for tumor ablation. The RNA sequencing analysis revealed the multifaceted role of this therapy in cancer cell signaling, with upregulated cellular respiration and electron transport and downregulated epigenetic pathways, leading to cellular apoptosis. Gamma-Fe2O3 architectures provide a new possibility for highly efficient deep tumor treatment.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Microemulsion-Confined Assembly of Magnetic Nanoclusters for pH/H2O2 Dual-Responsive T2-T1 Switchable MRI

Wei Liu et al.

Summary: A pH/H2O2 dual-response T-2-T-1 switchable superparamagnetic iron oxide nanoprobe was obtained using a microemulsion method. The nanoprobe disassembled into small iron clusters in the tumor environment, converting the T-2 MRI signal into a T-1 MRI signal, enabling specific detection of tumors.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Integration of Au Nanosheets and GdOF:Yb,Er for NIR-I and NIR-II Light-Activated Synergistic Theranostics

Qi Cai et al.

Summary: In this study, a versatile nanosystem was constructed by encapsulating Au nanosheets in codoped gadolinium oxyfluoride (GdOF):Yb,Er spheres and decorating it with a chemotherapeutic drug, a photosensitizer, and a targeted agent. The nanosystem achieved targeted cancer treatment and real-time monitoring of curative efficacy through combining photothermal and photodynamic therapies. The nanosystem also enabled multimodal imaging.

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Article Chemistry, Multidisciplinary

An NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging-Guided Cancer Radio-Chemotherapy

Yuan Ding et al.

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Article Oncology

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Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Ashwin K. Boddeti et al.

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Simultaneous enhancement of T1 and T2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields

Huan Li et al.

Summary: This study found that a gadolinium nanoparticle, instructed by gamma-glutamyl transpeptidase (GGT) and formed intracellularly, exhibits different magnetic resonance properties at low and high magnetic fields, making it suitable for enhancing T-1 and T-2 MRI imaging of liver tumors respectively.

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A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

Xiaoge Zhang et al.

Summary: In this study, a camouflaged bionic cascaded-enzyme nanoreactor was designed for efficient tumor treatment through a series of enzymatic reactions, phototherapy, and deoxygenation-activated chemotherapy. The nanoreactor exhibited biomimetic membrane camouflage and CD47 overexpression, which enhanced tumor targeting and immune escape capabilities.

NANO-MICRO LETTERS (2022)

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Redox chemistry-enabled stepwise surface dual nanoparticle engineering of 2D MXenes for tumor-sensitive T-1 and T-2 MRI-guided photonic breast-cancer hyperthermia in the NIR-II biowindow

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Summary: In this study, a stepwise surface-functionalization strategy is developed to achieve tumor microenvironment-responsive magnetic resonance imaging-guided photothermal therapy using two-dimensional MXene nanosheets. The functionalized nanosheets exhibit high photothermal conversion efficiency and biocompatibility.

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A Valve-Closing Starvation Strategy for Amplification of Tumor-Specific Chemotherapy

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Summary: By closing the valve of glucose transported into tumor cells, the novel valve-closing starvation strategy effectively reduces glucose levels in tumor cells, induces tumor cell starvation, and enhances the cytotoxicity of chemotherapy.

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Article Chemistry, Physical

A tumor microenvironment dual responsive contrast agent for contrary contrast-magnetic resonance imaging and specific chemotherapy of tumors

Yudie Lu et al.

Summary: This research proposes a new concept of contrary contrast-MRI (CC-MRI) and develops a tumor microenvironment dual responsive contrast agent that can provide contrary MRI signals between normal tissues and diseased tissues. This contrast agent significantly enhances the contrast between tumors and normal tissues, and also has tumor targetability and controlled chemotherapy release with reduced side effects.

NANOSCALE HORIZONS (2022)

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Review Engineering, Biomedical

Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

Tianjiao Zhao et al.

Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.

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Ternary Alloy PtWMn as a Mn Nanoreservoir for High-Field MRI Monitoring and Highly Selective Ferroptosis Therapy

Guoqiang Guan et al.

Summary: Researchers have developed a novel nanoplatform for ferroptosis therapy and can monitor the process in real-time using high-field MRI.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Manganese complexes and manganese-based metal-organic frameworks as contrast agents in MRI and chemotherapeutics agents: Applications and prospects

Rouqiao Zheng et al.

Summary: Manganese-based Metal-organic Frameworks (Mn-MOFs) have significant potential in biomedical applications, especially in imaging, anti-tumor therapy, and antimicrobial applications. The low toxicity, oxidative ability, and biocompatibility of Mn-MOFs make them highly desirable in medical field. Manganese complexes also show promising prospects in drug targeting.

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Degradable Magnetic Nanoplatform with Hydroxide Ions Triggered Photoacoustic, MR Imaging, and Photothermal Conversion for Precise Cancer Theranostic

Yudan Yang et al.

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NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy

Yang Zhu et al.

Summary: In this study, a self-supply oxygen photodynamic nanomedicine system was constructed, which achieved tumor therapy by modulating the tumor microenvironment. This nanomedicine exhibited small size and high stability, leading to pronounced accumulation in the tumor, decreased expression of hypoxia-inducible factor, enhanced anti-tumor efficacy, and improved MRI imaging in the tumor.

SMALL (2022)

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A microenvironment-responsive FePt probes for imaging-guided Fenton-enhanced radiotherapy of hepatocellular carcinoma

Xingyang Zhao et al.

Summary: In this study, a microenvironment-responsive FePt probe was developed for highly efficient Fenton-enhanced radiotherapy of hepatocellular carcinoma (HCC). The probe selectively released Fe2+ in the acidic tumor microenvironment, generating a large amount of hydroxyl radicals that extended the radiotherapeutic cascade and achieved a powerful therapeutic effect. Furthermore, the probe's burst release also allowed for imaging-guided cancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Materials Science, Biomaterials

Fe-Based Theranostic Agents Respond to the Tumor Microenvironment for MRI-Guided Ferroptosis-/Apoptosis-Inducing Anticancer Therapy

Caiju Zhang et al.

Summary: We reported a pH-responsive contrast agent DFeZd NP that can map pH changes and accurately diagnose tumors by modulating MR signals in different acid-base environments. The strong T1 signals of the contrast agent distinguish malignant tumors from normal tissues and demarcate tumor boundaries. Additionally, the contrast agent can induce ferroptosis in tumor cells by facilitating Fe redox cycling and lipid peroxide formation, especially under an acidic tumor microenvironment with the presence of ascorbic acid. MRI can be used to monitor the redox cycling and ferroptosis in tumors.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

Renye Yue et al.

Summary: A tumor-microenvironment-targeted and co-activated catalytic nanoplatform (CACN) has been developed for specific ferroptosis treatment of cancer cells or tumors. The catalytic activity of CACN can be turned on by dual stimuli of ATP and slight acidity in the tumor microenvironment. The switchable MRI signal of CACN is correlated with reactive oxygen species generation and drug release, allowing for monitoring the therapeutic process.

CHEM (2022)

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Article Biology

Ensemble Deep-Learning-Enabled Clinical Decision Support System for Breast Cancer Diagnosis and Classification on Ultrasound Images

Mahmoud Ragab et al.

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BIOLOGY-BASEL (2022)

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Article Chemistry, Physical

pH-Responsive chitosan-modified gadolinium oxide nanoparticles delivering 5-aminolevulinic acid: A dual cellular and metabolic T1-T2*contrast agent for glioblastoma brain tumors detection

Elham Gholibegloo et al.

Summary: In this study, gadolinium oxide nanoparticles (Gd2O3 NPs) were loaded with 5-aminolevulinic acid (5-ALA) and assisted by intracellular iron, resulting in their ability to serve as a T1 contrast agent with T2* contrast ability. The NPs exhibited concentration-dependent toxicity against glioblastoma C6 cells and showed higher relaxation rates (R1 and R2*) compared to the controls. These findings suggest that Gd2O3 NPs loaded with 5-ALA and assisted by intracellular iron could be a promising contrast agent for glioblastoma diagnosis in MRI.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Nanoscience & Nanotechnology

Biodegradable Amorphous Copper Iron Tellurite Promoting the Utilization of Fenton-Like Ions for Efficient Synergistic Cancer Theranostics

Huyun Liu et al.

Summary: In this study, a biodegradable a-CFT@IP6@BSA agent was developed for efficient cancer therapy. The agent can release plenty of Cu+ ions in a tumor-specific manner and utilize them for the production of hydroxyl radicals. It also depletes intracellular GSH to protect the hydroxyl radicals from scavenging. The treatment with a-CFT@IP6@BSA nanoparticles leads to the downregulation of glutathione peroxidase 4 and BCL-2, indicating the induction of ferroptosis and apoptotic death of cancer cells. The nanoparticles also demonstrate excellent anticancer efficiency in vivo and have the potential for imaging-guided cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

Highly Efficient GSH-Responsive Off-On NIR-II Fluorescent Fenton Nanocatalyst for Multimodal Imaging-Guided Photothermal/ Chemodynamic Synergistic Cancer Therapy

Haimei Li et al.

Summary: Under the interference of complex and diverse tumor microenvironments, accurate diagnosis and effective treatment of malignant tumors have become the focus of research. In this study, a novel biomimetic nanocatalyst with quad-modal imaging capabilities was developed for self-enhanced photothermal/chemodynamic synergistic therapy. This nanocatalyst showed excellent tumor-targeting ability and biocompatibility, and enabled TME-responsive tumor visualization.

ANALYTICAL CHEMISTRY (2022)

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Article Nanoscience & Nanotechnology

Hypoxia-Responsive Aggregation of Iron Oxide Nanoparticles for T1-to-T2 Switchable Magnetic Resonance Imaging of Tumors

Yi Cao et al.

Summary: The newly designed hypoxia-responsive MRI contrast agent (HR-ESIONPs) utilizes extremely small iron oxide nanoparticles to switch from T1 to T2 imaging mode in the tumor microenvironment, thereby enhancing the diagnostic precision for tumors.

ACS APPLIED NANO MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Bioinspired Construction of an Enzyme-Mimetic Supramolecular Nanoagent for RNS-Augmented Cascade Chemodynamic Therapy

Shuaitian Guo et al.

Summary: Inspired by natural enzymes, specific enzyme-like cascade catalytic reactions can be obtained by imitating the metal active sites of natural enzymes and assembling inorganic materials at the molecular level via supramolecular interactions. This new material demonstrates high catalytic activity under tumor microenvironment stimulation and destroys the intratumoral redox balance by generating reactive oxygen species and reactive nitrogen species, leading to excellent cancer treatment effects.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Multifunctional Nanosnowflakes for T1-T2 Double-Contrast Enhanced MRI and PAI Guided Oxygen Self-Supplementing Effective Anti-Tumor Therapy

Yijie Lv et al.

Summary: A novel multifunctional nano-snowflake probe (USPIO@MnO2@Ce6, UMC) was developed for oxygen-enhanced photodynamic therapy. The probe efficiently degraded under high H2O2 levels in tumor cells, accelerating the production of ROS during PDT. TEM and UV-vis spectroscopy results confirmed successful synthesis of UMC, with in vitro and in vivo experiments demonstrating its imaging capabilities and enhanced treatment efficiency compared to free Ce6.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Nanoscience & Nanotechnology

Extremely Small Iron Oxide Nanoparticles with pH-Dependent Solubility Transition as T1/T2 Switchable Contrast Agents for MRI

Yilin He et al.

Summary: A pH-responsive T1/T2 switchable ESIONP contrast agent was proposed, which enables precise tumor diagnosis through signal conversion under different conditions.

ACS APPLIED NANO MATERIALS (2022)

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Article Chemistry, Analytical

Coordination-Driven Self-Assembly of Iron Oxide Nanoparticles for Tumor Microenvironment-Responsive Magnetic Resonance Imaging

Jinhong Hou et al.

Summary: In this study, pH-triggered switchable magnetic resonance imaging (MRI) nanoprobes were constructed by coordination-driven self-assembly of monodispersed iron oxide nanoparticles (MIONPs) with simple amino acid derivatives. These nanoprobes exhibited T2-weighted MRI features but could be turned into T1-weighted MRI under slightly acidic conditions at the tumor site. The dynamic assembly and disassembly properties of MIONPs enabled T2/T1 switchable contrast imaging, providing selective turn-on signals at the tumor site with high specificity.

ANALYTICAL CHEMISTRY (2022)

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Article Medicine, Research & Experimental

Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation

Lingling Lei et al.

Summary: In this study, zinc-fluorouracil metallodrug networks (Zn-Fu MNs) were designed to enhance immune activity and ROS production. Zn-Fu MNs were found to respond to acidity and ATP, releasing fluorouracil and zinc ions to induce ferroptosis in cancer cells. The synergistic effect of DNA damage and ferroptosis promoted immunogenic cell death and immune cell activation.

THERANOSTICS (2022)

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Article Medicine, Research & Experimental

Combating multidrug resistance and metastasis of breast cancer by endoplasmic reticulum stress and cell-nucleus penetration enhanced immunochemotherapy

Weixi Jiang et al.

Summary: This study developed a theranostic nanocomposite using silver nanoparticles and peptide-functionalized doxorubicin to induce organelle-mediated immunochemotherapy and drug efflux protein inhibition in drug-resistant breast cancer cells. The results showed enhanced cytotoxicity, stimulated immunogenic cell death, and potential for reversing tumor multidrug resistance and metastasis at the subcellular level.

THERANOSTICS (2022)

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Article Nanoscience & Nanotechnology

Microemulsion-Confined Assembly of Magnetic Nanoclusters for pH/H2O2 Dual-Responsive T-2-T-1 Switchable MRI

Wei Liu et al.

Summary: This work presents a switchable T-2-T-1 superparamagnetic iron oxide nanoprobe with a pH/H2O2 dual response, allowing specific detection of tumors by a pH/H2O2 dual-response T-2-T-1 MRI.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Applied

A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies

Hedieh Mansouri et al.

Summary: Fe3O4@PCD-Gd/CUR NPs, as a promising multifunctional system, showed therapeutic efficacy against tumor cells with no toxicity in vivo, making it a potential candidate for cancer diagnosis and treatment.

CARBOHYDRATE POLYMERS (2021)

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Review Nanoscience & Nanotechnology

Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

Hao Wang et al.

Summary: Nanomedicine strategies hold significant potential in smart drug delivery due to the unique composition of tumor tissue. Stimuli-responsive nanogels are increasingly important in cancer therapy, with the evolution from monoresponsive to multiresponsive systems. The properties, synthesis, and characterization of nanogels, as well as designing strategies for stimuli-response nanogels are discussed in this review, along with the potential applications of nanogel composites in constructing multistimulus-responsive nanoparticles for cancer diagnosis and therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Engineering, Biomedical

Aptamer-based ATP-responsive delivery systems for cancer diagnosis and treatment

Elham Sameiyan et al.

Summary: In recent years, many stimuli-triggered drug delivery platforms have been designed to deliver drugs accurately to specific sites and reduce their side effects, improving on-demand therapeutic efficacy. Adenosine-5'-triphosphate (ATP)-responsive drug delivery methods, combined with aptamers, offer more accurate drug delivery systems and greater control of drug release. Various nanoparticle frameworks have been utilized in the fabrication of nanocarriers for ATP-responsive drug delivery systems, with each method having its own challenges and strengths.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Analytical

Microemulsion-Confined Biomineralization of PEGylated Ultrasmall Fe3O4 Nanocrystals for T2-T1 Switchable MRI of Tumors

Wei Liu et al.

Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe

Peisen Zhang et al.

Summary: The study introduces an Fe3O4 nanoparticle-based MRI probe that can quantitatively map the heterogeneous distribution of the tumor-specific biomarker GSH in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH-Responsive Fe(III) Complex

Guohai Liang et al.

Summary: The Fe-ZDS complex developed in this study is a dual-functional agent with excellent biocompatibility and efficient renal clearance. It is capable of imaging-guided, precise photothermal therapy of tumors and exhibits higher optical absorption intensity in weakly acidic environments.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

An Acidity-Unlocked Magnetic Nanoplatform Enables Self-Boosting ROS Generation through Upregulation of Lactate for Imaging-Guided Highly Specific Chemodynamic Therapy

Linan Shi et al.

Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy

Lin Huang et al.

Summary: This study creatively utilized core/shell Fe3O4/Gd2O3 hybrid nanoparticles as gatekeepers for HMONs to achieve a large loading content of DOX, enabling active tumor-targeted drug delivery. The increased contrast provided by the modified nanoparticles in MRI guided highly efficient tumor-specific drug release and chemotherapy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Glutathione-Responsive Magnetic Nanoparticles for Highly Sensitive Diagnosis of Liver Metastases

Xiaodan Xu et al.

Summary: The study prepared glutathione-responsive hyaluronic acid-coated iron oxide nanoparticles for highly sensitive diagnosis of liver metastasis using MRI contrast, which effectively differentiates metastatic tumors from surrounding liver tissues.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Liang Jia et al.

Summary: This study presents a facile strategy to prepare cell membrane-coated nanoclusters with pH-responsiveness, which can target tumors and release drugs effectively.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

pH-responsive hollow Fe-gallic acid coordination polymer for multimodal synergistic-therapy and MRI of cancer

Congcong Liu et al.

Summary: This study successfully synthesized hollow Fe-GA/BSA nanospheres with good biocompatibility and drug release capabilities, which can be used for cancer treatment by responding to the tumor microenvironment.

NANOSCALE ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI

Alexander M. Demin et al.

Summary: The study demonstrates the use of pHLIP-modified MNPs for high-specificity nanodrug accumulation in the acidic tumor microenvironment, showing low cytotoxicity and high cellular uptake rates. In vivo experiments in BALB/c mice show a significantly higher accumulation rate of pHLIP-modified MNPs in tumors compared to PEGylated MNPs.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Biochemistry & Molecular Biology

Polymer-Functionalized Upconversion Nanoparticles for Light/Imaging-Guided Drug Delivery

Lin Zhang et al.

Summary: The strong upconversion luminescence of upconversion nanoparticles allows for light-guided drug delivery. Surface polymer coatings provide stability, prevent protein corona formation, and serve as matrices for drug delivery, enhancing the functionality of UCNPs in medicine.

BIOMACROMOLECULES (2021)

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Article Materials Science, Biomaterials

Gadolinium-doped hollow silica nanospheres loaded with curcumin for magnetic resonance imaging-guided synergistic cancer sonodynamic-chemotherapy

Ya Tian et al.

Summary: A multifunctional theranostic nanoplatform loaded with gadolinium-doped hollow mesoporous silica nanospheres has been developed for MRI-guided cancer sonodynamic-chemotherapy. By controlling drug release and releasing Gd3+ ions or oligomers, it serves as an effective contrast agent and efficiently inhibits tumor growth.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

NIR-Activated Multimodal Photothermal/Chemodynamic/Magnetic Resonance Imaging Nanoplatform for Anticancer Therapy by Fe(II) Ions Doped MXenes (Fe-Ti3C2)

Yizhang Wu et al.

Summary: In this study, Fe2+ ions were doped into 2D TC NSs to synthesize a novel FTC nanoshell, which exhibited superior PTCE due to enhanced conductivity through interlaminar ferrous ion-channels. The FTC also showed abilities of ROS releasing and GSH suppression triggered by NIR laser, making it a promising nanoplatform for biomedical applications, including bioimaging and drug loading.

SMALL (2021)

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Article Materials Science, Biomaterials

An intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy

Junlie Yao et al.

Summary: A versatile nanotheranostic agent is developed for T1/T2 dual-modal MR imaging-guided and self-augmented PTT, combining Zn0.2Fe2.8O4 nanoparticles, polydopamine, and MnO2 NPs. This agent serves as a PTT agent for effective photothermal conversion, while also consuming overexpressed GSH, generating Mn2+ and hydroxyl radicals for HSP suppression and PTT enhancement. Additionally, it strengthens T1- and T2-weighted MR contrast for tumor imaging and PTT guidance.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Fe3O4 assembly for tumor accurate diagnosis by endogenous GSH responsive T2/T1 magnetic relaxation conversion

Chengbin Wang et al.

Summary: The study introduces ultra-small Fe3O4 nanoclusters as an endogenous GSH-responsive MRI contrast agent for improved tumor diagnosis by utilizing the overexpression of GSH in tumors to achieve T-2/T-1 signal switching.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Medicine, Research & Experimental

Smart magnetic resonance imaging-based theranostics for cancer

Beatriz Brito et al.

Summary: This review introduces smart theranostics that integrate multiple functions, especially responsive agents for MRI, aiming to improve cancer therapy efficiency and diagnostic accuracy. The challenges and obstacles in the design and application are also discussed.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

Tumor microenvironment-triggered in situ cancer vaccines inducing dual immunogenic cell death for elevated antitumor and antimetastatic therapy

Binbin Ding et al.

Summary: The study proposes a strategy to develop in situ cancer vaccines by enhancing the immunomodulatory effects for immunogenic cell death, utilizing amorphous iron oxide-packaged oxaliplatin nanoprodrugs for tumor microenvironment-responsive combined treatments, promoting DCs maturity, T cell activation, and cytokine secretion.

NANOSCALE (2021)

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Review Nanoscience & Nanotechnology

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

Xiao Jin et al.

Summary: MRI is a noninvasive technique with high spatial resolution, but traditional contrast agents always have poor target-to-background signal ratio. Activatable CAs with design strategies such as ion conversion, self-assembly, and disassembly significantly improve the TBR and show advantages in biomedical applications compared to conventional CAs.

VIEW (2021)

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Article Chemistry, Multidisciplinary

An intelligent T1-T2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques

Chunshu Pan et al.

Summary: The study proposes a macrophage-targeted and in situ stimuli-triggered T-1-T-2 switchable magnetic resonance imaging (MRI) nanoprobe for non-invasive diagnosis of vulnerable plaques, which can help identify vulnerable plaques at early stages. By modifying and transforming iron oxide nanoparticles, the nanoprobe achieves a substantial non-invasive diagnosis of vulnerable plaques, contributing significantly to the application of materials science in solving clinical problems.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

Redox-triggered aggregation of ESIONPs with switchable T1 to T2 contrast effect for T2-weighted magnetic resonance imaging

Yilin He et al.

Summary: The newly designed and synthesized MRI contrast agent ESIONPs-s-s-PEG-FA can target tumor tissues and switch from a T-1 to a T-2 contrast agent in the reducing environment, showing promising targeting capacity and contrast effect in both in vitro and in vivo experiments.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Tumor microenvironment-responsive multifunctional nanoplatform based on MnFe2O4-PEG for enhanced magnetic resonance imaging-guided hypoxic cancer radiotherapy

Zhenhu He et al.

Summary: This study designed polyethylene glycol (PEG) functionalized manganese ferrite nanoparticles (MnFe2O4-PEG) to continuously catalyze the decomposition of endogenous hydrogen peroxide, enabling self-sufficiency of oxygen and reducing GSH consumption, achieving better therapeutic effects at the cellular and animal levels.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

CuFeSe2-based thermo-responsive multifunctional nanomaterial initiated by a single NIR light for hypoxic cancer therapy

Juan Lu et al.

Summary: The study developed a multifunctional therapeutic system combining photothermal therapy, chemodynamic therapy, and hypoxic therapy, showing promising results in hypoxic tumor environments. Additionally, the nanoplatform also demonstrated superior diagnostic capabilities for CT and MRI, making it a potential candidate for simultaneous diagnosis and treatment in hypoxic cancer therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Biochemical Research Methods

Redox-Sensitive Clustered Ultrasmall Iron Oxide Nanoparticles for Switchable T2/T1-Weighted Magnetic Resonance Imaging Applications

Dan Ma et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Nanoparticles for Multimodal Imaging-Guided Low-Intensity Focused Ultrasound/Immunosynergistic Retinoblastoma Therapy

Menglei Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Mesoporous carbon-manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy

Xian Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

Extremely Small Iron Oxide Nanoparticle-Encapsulated Nanogels as a Glutathione-Responsive T1 Contrast Agent for Tumor-Targeted Magnetic Resonance Imaging

Yi Cao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Multifunctional Bismuth Ferrite Nanocatalysts with Optical and Magnetic Functions for Ultrasound-Enhanced Tumor Theranostics

Lili Feng et al.

ACS NANO (2020)

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Article Chemistry, Analytical

Magnetic-Photoacoustic Dual-Mode Probe for the Visualization of H2S in Colorectal Cancer

Chenglin Yan et al.

ANALYTICAL CHEMISTRY (2020)

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Article Engineering, Environmental

Multistage tumor microenvironment-responsive theranostic nanopeanuts: Toward multimode imaging guided chemo-photodynamic therapy

Xunan Jing et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Multidisciplinary

Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

Haifeng Yuan et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Light-free Generation of Singlet Oxygen through Manganese-Thiophene Nanosystems for pH-Responsive Chemiluminescence Imaging and Tumor Therapy

Chang Lu et al.

CHEM (2020)

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Article Chemistry, Analytical

Activatable Magnetic/Photoacoustic Nanoplatform for Redox-Unlocked Deep-Tissue Molecular Imaging In Vivo via Prussian Blue Nanoprobe

Fangfang Chen et al.

ANALYTICAL CHEMISTRY (2020)

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Article Engineering, Biomedical

Tumor microenvironment responsive hollow mesoporous Co9S8@MnO2-ICG/DOX intelligent nanoplatform for synergistically enhanced tumor multimodal therapy

Junqing Huang et al.

BIOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

Tumor Acid Microenvironment-Triggered Self-Assembly of ESIONPs for T1/T2 Switchable Magnetic Resonance Imaging

Yilin He et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Synergistic regulation of longitudinal and transverse relaxivity of extremely small iron oxide nanoparticles (ESIONPs) using pH-responsive nanoassemblies

Yi Cao et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors

Fangyuan Li et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics

Maxim Shevtsov et al.

SMALL (2019)

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Article Chemistry, Multidisciplinary

A Mesoporous Nanoenzyme Derived from Metal-Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Dongdong Wang et al.

ADVANCED MATERIALS (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer

Clemens Kratochwil et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Article Chemistry, Multidisciplinary

A Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice

Guosheng Song et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Size Switchable Nanoclusters Fueled by Extracellular ATP for Promoting Deep Penetration and MRI-Guided Tumor Photothermal Therapy

Zhanwei Zhou et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Nanoscience & Nanotechnology

Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy

Xiaoxia Cai et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

Functionalized Holmium-Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia-Activated Therapy

Yanke Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

Jessica Wahsner et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

Ziliang Dong et al.

NANO LETTERS (2019)

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Article Nanoscience & Nanotechnology

Magnus nano-bullets as T1/T2 based dual-modal for in vitro and in vivo MRI visualization

Renuka Khatik et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Medicine, Research & Experimental

Gadolinium-Chelated Conjugated Polymer-Based Nanotheranostics for Photoacoustic/Magnetic Resonance/NIR-II Fluorescence Imaging-Guided Cancer Photothermal Therapy

Xiaoming Hu et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform

Xunan Jing et al.

NANOSCALE (2019)

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Article Chemistry, Inorganic & Nuclear

Combining magnetic hyperthermia and dual T1/T2 MR imaging using highly versatile iron oxide nanoparticles

Santiago Sanchez-Cabezas et al.

DALTON TRANSACTIONS (2019)

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Article Chemistry, Multidisciplinary

Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging

Guosheng Song et al.

NANO LETTERS (2018)

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Article Chemistry, Multidisciplinary

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy

Li-Sen Lin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Engineering, Biomedical

Simultaneously activating highly selective ratiometric MRI and synergistic therapy in response to intratumoral oxidability and acidity

Yuxin Liu et al.

BIOMATERIALS (2018)

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Article Medicine, Research & Experimental

Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics

Lipeng Gao et al.

THERANOSTICS (2018)

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Review Medicine, Research & Experimental

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

Wei Wu et al.

THERANOSTICS (2018)

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Article Biotechnology & Applied Microbiology

pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents

Xi Huang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Ternary-Responsive Drug Delivery with Activatable Dual Mode Contrast-Enhanced in Vivo Imaging

Shuangshuang Ren et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

Tumor-triggered transformation of chimeric peptide for dual-stage-amplified magnetic resonance imaging and precise photodynamic therapy

Jin Zhang et al.

BIOMATERIALS (2018)

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Review Chemistry, Medicinal

Redox-responsive nano-carriers as tumor-targeted drug delivery systems

Ali Raza et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies

Jingxiong Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Multidisciplinary

Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation

Lili Feng et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction

Hadi Ranji-Burachaloo et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Metalloporphyrin-Encapsulated Biodegradable Nanosystems for Highly Efficient Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy

Ping Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Review Chemistry, Multidisciplinary

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Mandi Karimi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Nanoscience & Nanotechnology

Stimuli-responsive nanocomposites for magnetic targeting synergistic multimodal therapy and T1/T2-weighted dual-mode imaging

Yinyin Chen et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Nanoscience & Nanotechnology

Oil/water nano-emulsion loaded with cobalt ferrite oxide nanocubes for photo-acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies

Raffaele Vecchione et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Chemistry, Multidisciplinary

Probing T1-T2 interactions and their imaging implications through a thermally responsive nanoprobe

J. Gallo et al.

NANOSCALE (2017)

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Article Multidisciplinary Sciences

Artificial local magnetic field inhomogeneity enhances T2 relaxivity

Zijian Zhou et al.

NATURE COMMUNICATIONS (2017)

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Article Engineering, Biomedical

A Core-Shell-Satellite Structured Fe3O4@g-C3N4-UCNPs-PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy

Lili Feng et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Review Chemistry, Multidisciplinary

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Dalong Ni et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

TaChung Yu et al.

CELL (2017)

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Article Biochemistry & Molecular Biology

Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging

Carlos Carop et al.

BIOMACROMOLECULES (2017)

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Article Chemistry, Physical

Core-Shell Metal-Organic Frameworks as Fe2+ Suppliers for Fe2+-Mediated Cancer Therapy under Multimodality Imaging

Dongdong Wang et al.

CHEMISTRY OF MATERIALS (2017)

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Article Engineering, Biomedical

Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Myeong-Hoon Kim et al.

BIOMATERIALS (2016)

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Article Chemistry, Multidisciplinary

Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis

Yue Yuan et al.

NANO LETTERS (2016)

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Article Neuroimaging

Differential diagnosis of neurodegenerative diseases using structural MRI data

Juha Koikkalainen et al.

NEUROIMAGE-CLINICAL (2016)

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Review Chemistry, Multidisciplinary

Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications

Daishun Ling et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

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Article Nanoscience & Nanotechnology

pH-Responsive Iron Manganese Silicate Nanoparticles as T1-T2* Dual-Modal Imaging Probes for Tumor Diagnosis

Jian Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Engineering, Biomedical

Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers

Ling'e Zhang et al.

BIOMATERIALS (2015)

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Review Chemistry, Multidisciplinary

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

Nohyun Lee et al.

CHEMICAL REVIEWS (2015)

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Article Chemistry, Multidisciplinary

Novel Mn3[Co(CN)6]2@SiO2@Ag Core-Shell Nanocube: Enhanced Two-Photon Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Photothermal and Chemo-therapy

Dongdong Wang et al.

SMALL (2015)

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Article Chemistry, Multidisciplinary

Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging

Huaiyong Xing et al.

ADVANCED MATERIALS (2014)

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Article Chemistry, Multidisciplinary

CXCR4-Targeted and MMP-Responsive Iron Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging

Juan Gallo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Chemistry, Multidisciplinary

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

Daishun Ling et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Chemistry, Multidisciplinary

Nanoscale Metal-Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer

Kuangda Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Chemistry, Physical

Hydration of the oxygen-evolving complex of photosystem II probed in the dark-stable S1 state using proton NMR dispersion profiles

Guangye Han et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2014)

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Article Engineering, Biomedical

Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles

Chen-Sheng Yeh et al.

BIOMATERIALS (2013)

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Article Chemistry, Multidisciplinary

Environmentally responsive MRI contrast agents

Gemma-Louise Davies et al.

CHEMICAL COMMUNICATIONS (2013)

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Article Chemistry, Multidisciplinary

Size-dependent motion of bio-functionalized magnetic nanoparticle clusters under a rotating magnetic field

Ji-Ching Lai et al.

JOURNAL OF NANOPARTICLE RESEARCH (2013)

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Article Multidisciplinary Sciences

Nanoscale Nuclear Magnetic Resonance with a Nitrogen-Vacancy Spin Sensor

H. J. Mamin et al.

SCIENCE (2013)

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Article Engineering, Biomedical

Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells

Yu Chen et al.

BIOMATERIALS (2012)

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Review Chemistry, Multidisciplinary

Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels

Jinming Hu et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Article Nanoscience & Nanotechnology

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

Shann S. Yu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

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Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

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Article Chemistry, Multidisciplinary

Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T1 Magnetic Resonance Imaging Contrast Agents

Byung Hyo Kim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Pharmacology & Pharmacy

Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement

Jolanta Kukowska-Latallo

International Journal of Nanomedicine (2010)

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Article Chemistry, Multidisciplinary

Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia

Kazuki Kiyose et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Article Chemistry, Multidisciplinary

Coating Optimization of Superparamagnetic Iron Oxide Nanoparticles for High T2 Relaxivity

Sheng Tong et al.

NANO LETTERS (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

Lung MRI for experimental drug research

Nicolau Beckmann et al.

EUROPEAN JOURNAL OF RADIOLOGY (2007)

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Article Chemistry, Multidisciplinary

Development of a T-1 contrast agent for magnetic resonance imaging using MnO nanoparticles

Hyon Bin Na et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

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