New Mechanical Markers for Tracking the Progression of Myocardial Infarction

Review Cardiac & Cardiovascular Systems

Transforming growth factor-β in myocardial disease

Nikolaos G. Frangogiannis

Summary: Transforming growth factor-beta (TGF beta) plays an important role in myocardial diseases, regulating the phenotype and function of cardiovascular cells, participating in cardiac repair and remodeling.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Cell Biology

Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization

Arthur T. Molines et al.

Summary: The concentration of the cytoplasm has a linear and inverse relationship with the rates of microtubule polymerization and depolymerization, indicating that changes in cytoplasmic viscosity play a key role in modulating these reactions.

DEVELOPMENTAL CELL (2022)

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Review Cardiac & Cardiovascular Systems

The microtubule cytoskeleton in cardiac mechanics and heart failure

Matthew A. Caporizzo et al.

Summary: The microtubule network of cardiac muscle cells plays a crucial role in cardiac mechanics and heart diseases. Understanding the contribution and remodeling of microtubules can provide insights into potential therapies for acquired heart diseases.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Multidisciplinary Sciences

Frequency-dependent transition in power-law rheological behavior of living cells

Jiu-Tao Hang et al.

Summary: Living cells exhibit diverse mechanical behaviors at different time scales. A self-similar hierarchical model is used in this study to capture the power-law rheological characteristics of cells in different frequency scales. The transition between low- and high-frequency scales is defined by a transition frequency based on cell's mechanical parameters. The differences in cytoskeletal properties of different cell types or states can be characterized by changes in mechanical parameters in the model.

SCIENCE ADVANCES (2022)

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Article Multidisciplinary Sciences

Extracellular fluid viscosity enhances cell migration and cancer dissemination

Kaustav Bera et al.

Summary: Cells can respond to changes in extracellular fluid viscosity, and higher viscosity can increase cell motility and dissemination. This is achieved through the formation of a dense actin network and the activation of specific signaling pathways. Additionally, cancer cells exposed to high viscosity can acquire mechanical memory and enhance migration and metastasis through transcriptional control.

NATURE (2022)

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Article Physics, Multidisciplinary

Intracellular softening and increased viscoelastic fluidity during division

Sebastian Hurst et al.

Summary: During cell division, the cell cortex stiffens while the rest of the cell interior softens, possibly due to a role switch between microtubules and actin.

NATURE PHYSICS (2021)

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Article Multidisciplinary Sciences

A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells

Jiu-Tao Hang et al.

Summary: The mechanical responses of cells are primarily dependent on their generic architectural mechanism, rather than specific molecular properties. The power-law exponent of cell rheology can be quantitatively tuned by varying the stiffness or architecture of the cytoskeleton. The proposed self-similar hierarchical cellular model can naturally reproduce the universal power-law characteristics of cell rheology.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models

Maria Villalba-Orero et al.

Summary: Brillouin microspectroscopy (mBS) is a valuable tool for assessing the viscoelastic properties of cardiac tissue and has important clinical application prospects for heart diseases. The study found that mBS can directly detect changes in stiffness in healthy myocardium, but the association is disrupted under pathological conditions.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Rheology of rounded mammalian cells over continuous high-frequencies

Gotthold Flaeschner et al.

Summary: Understanding the viscoelastic properties of living cells and their relation to cell state and morphology remains challenging. Higher frequencies could elucidate the link between cellular and molecular properties. The new assay introduced in this study can measure cell mechanical response in the frequency range of approximately 1-40kHz, revealing an uncorrelated relationship between cell size and viscoelasticity.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

The viscoelasticity of adherent cells follows a single power-law with distinct local variations within a single cell and across cell lines

Juan G. Sanchez et al.

Summary: The study utilized AFM to measure and analyze the nanomechanical properties of live cells, revealing limitations in traditional elastic and viscoelastic models to characterize the mechanical response of cells under micrometer-scale deformations.

NANOSCALE (2021)

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Review Oncology

The matrix in cancer

Thomas R. Cox

Summary: Alterations in the extracellular matrix play a crucial role in the development and progression of solid tumours, and our understanding of matrix biology is expanding. New approaches targeting the matrix in cancer are being developed.

NATURE REVIEWS CANCER (2021)

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Article Cardiac & Cardiovascular Systems

The compendium of matrix metalloproteinase expression in the left ventricle of mice following myocardial infarction

Amanda R. Kaminski et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Review Nanoscience & Nanotechnology

The stiffness of living tissues and its implications for tissue engineering

Carlos F. Guimaraes et al.

NATURE REVIEWS MATERIALS (2020)

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Article Multidisciplinary Sciences

Double power-law viscoelastic relaxation of living cells encodes motility trends

J. S. de Sousa et al.

SCIENTIFIC REPORTS (2020)

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Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Signe Holm Nielsen et al.

MATRIX BIOLOGY (2019)

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Article Engineering, Biomedical

A viscoelastic adhesive epicardial patch for treating myocardial infarction

Xiao Lin et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Review Biology

Tissue mechanics, an important regulator of development and disease

Nadia M. E. Ayad et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)

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Review Cell Biology

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

Farzaneh G. Tahrir et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Physics, Applied

Resonance compensating chirp mode for mapping the rheology of live cells by high-speed atomic force microscopy

Marc Schaechtele et al.

APPLIED PHYSICS LETTERS (2018)

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Article Biochemical Research Methods

Quantitative proteomic changes during post myocardial infarction remodeling reveals altered cardiac metabolism and Desmin aggregation in the infarct region

Kaberi Datta et al.

JOURNAL OF PROTEOMICS (2017)

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Review Medicine, General & Internal

Acute myocardial infarction

Grant W. Reed et al.

LANCET (2017)

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Article Physics, Multidisciplinary

High-frequency microrheology reveals cytoskeleton dynamics in living cells

Annafrancesca Rigato et al.

NATURE PHYSICS (2017)

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Article Multidisciplinary Sciences

Size- and speed-dependent mechanical behavior in living mammalian cytoplasm

Jiliang Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Medicine, Research & Experimental

Characterization of Cardiac Dynamics in an Acute Myocardial Infarction Model by Four-Dimensional Optoacoustic and Magnetic Resonance Imaging

Hsiao-Chun Amy Lin et al.

THERANOSTICS (2017)

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Article Cardiac & Cardiovascular Systems

Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis

Abhijit Takawale et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

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Article Nanoscience & Nanotechnology

Atomic force microscopy as a tool to evaluate the risk of cardiovascular diseases in patients

Ana Filipa Guedes et al.

NATURE NANOTECHNOLOGY (2016)

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Article Multidisciplinary Sciences

Local viscoelasticity of living cells measured by rotational magnetic spectroscopy

J. -F. Berret

NATURE COMMUNICATIONS (2016)

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Article Chemistry, Physical

Imaging viscoelastic properties of live cells by AFM: power-law rheology on the nanoscale

Fabian M. Hecht et al.

SOFT MATTER (2015)

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Review Cardiac & Cardiovascular Systems

MicroRNAs in myocardial infarction

Reinier A. Boon et al.

NATURE REVIEWS CARDIOLOGY (2015)

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Article Chemistry, Physical

Imaging viscoelastic properties of live cells by AFM: power-law rheology on the nanoscale

Fabian M. Hecht et al.

SOFT MATTER (2015)

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Article Engineering, Biomedical

Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts

Ion Andreu et al.

ACTA BIOMATERIALIA (2014)

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Article Chemistry, Physical

The cytoplasm of living cells behaves as a poroelastic material

Emad Moeendarbary et al.

NATURE MATERIALS (2013)

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Article Cardiac & Cardiovascular Systems

Myocardial tissue elastic properties determined by atomic force microscopy after stromal cell-derived factor 1α angiogenic therapy for acute myocardial infarction in a murine model

William Hiesinger et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2012)

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Review Materials Science, Multidisciplinary

Linear and Nonlinear Rheology of Living Cells

Philip Kollmannsberger et al.

ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 41 (2011)

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Article Materials Science, Multidisciplinary

Characterizing the elastic properties of tissues

Riaz Akhtar et al.

MATERIALS TODAY (2011)

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Article Cardiac & Cardiovascular Systems

Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat

Gregory M. Fomovsky et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Article Nanoscience & Nanotechnology

Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy

Martin Stolz et al.

NATURE NANOTECHNOLOGY (2009)

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Article Multidisciplinary Sciences

Physical plasticity of the nucleus in stem cell differentiation

J. David Pajerowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Cardiac & Cardiovascular Systems

Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance

Mark F. Berry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

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New Mechanical Markers for Tracking the Progression of Myocardial Infarction

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