4.3 Article

A single-dose strategy for immunization with live attenuated vaccines is an effective option before treatment initiation in multiple sclerosis patients

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis

Carmen Tur et al.

Summary: Progression independent of relapse activity (PIRA) is the main event responsible for irreversible disability accumulation in relapsing multiple sclerosis (MS). This cohort study investigated the predictors of PIRA at the time of the first demyelinating attack and factors associated with long-term clinical outcomes. The findings suggest that presenting with PIRA after a first demyelinating event is associated with an unfavorable prognosis.

JAMA NEUROLOGY (2023)

Article Clinical Neurology

European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

Susana Otero-Romero et al.

Summary: This study developed a European consensus on vaccination strategies for people with multiple sclerosis (pwMS) who are candidates for disease-modifying therapies (DMTs). A multidisciplinary working group used formal consensus methodology to formulate recommendations based on the quality of evidence and risk-benefit balance. A total of 53 recommendations were agreed upon, aiming to homogenize immunization practices in pwMS.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Review Clinical Neurology

ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

Susana Otero-Romero et al.

Summary: This study aims to develop an evidence-based vaccination strategy for pwMS who are candidates for disease-modifying therapies. A multidisciplinary working group conducted a systematic literature search and formulated 53 recommendations based on the quality of evidence. The goal of this study is to homogenize immunization practices in pwMS.

MULTIPLE SCLEROSIS JOURNAL (2023)

Review Clinical Neurology

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021

Carmen Tur et al.

Summary: In recent years, there have been rapid developments in the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), with a wide range of disease-modifying treatments (DMTs) now available. However, most DMTs come with the risk of adverse events, particularly infections. To address this, an international workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) was held in April 2021 to review the current knowledge on infection risks associated with DMT use in MS and NMOSD patients, and to discuss strategies for risk mitigation. The workshop also explored specific populations, such as children, pregnant women, individuals with comorbidities, and those living in regions with high infection burden, as well as the impact of the ongoing SARS-CoV-2 pandemic on DMT-associated infectious risks.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Immunology

Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

Huy Quang Quach et al.

Summary: The study found that even in a highly vaccinated population, a significant proportion of adults lack immunity to measles, with gender and age influencing the immune response.

VACCINES (2022)

Article Immunology

The Effectiveness of Varicella Vaccine: 25 Years of Postlicensure Experience in the United States

Eugene D. Shapiro et al.

Summary: This study summarizes the effectiveness of varicella vaccine in preventing varicella and the lessons learned from the first 25 years of the vaccination program in the United States. One dose of the vaccine provides moderate protection against varicella of any severity and high protection against severe varicella. The two-dose vaccine program further improves the vaccine's effectiveness and reduces the incidence, severity, and outbreaks of varicella.

JOURNAL OF INFECTIOUS DISEASES (2022)

Review Clinical Neurology

Vaccinations in multiple sclerosis patients receiving disease-modifying drugs

Susana Otero-Romero et al.

Summary: New evidence supports the lack of causal link between MS and vaccination, with consensus statements emphasizing the importance of starting vaccination early. Timing adjustments for vaccine administration are necessary to ensure safety and optimize vaccine responses in light of potential interference from DMDs. Patients on B-cell depleting therapies like Ocrelizumab are at risk of reduced immunogenicity to vaccines, highlighting the implications for upcoming SARS-CoV-2 vaccination.

CURRENT OPINION IN NEUROLOGY (2021)

Review Immunology

Assessing and mitigating risk of infection in patients with multiple sclerosis on disease modifying treatment

Susana Otero-Romero et al.

Summary: The field of multiple sclerosis treatment has seen significant development in recent years, but also faces new challenges such as increased risk of infections. MS specialist neurologists need to pay more attention to infection risks in treatments and be familiar with new mitigation strategies.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2021)

Article Biotechnology & Applied Microbiology

Long-term immunogenicity after measles vaccine vs. wild infection: an Italian retrospective cohort study

Francesco Paolo Bianchi et al.

Summary: The study found that individuals vaccinated for measles are more likely to lose protective antibodies in the years following vaccination compared to those who had a natural infection. Only 92% of individuals seroconverted after receiving one or two doses of the vaccine. This finding should be considered in the early phase of measles elimination efforts.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Immunology

Correlation of protection against varicella in a randomized Phase III varicella-containing vaccine efficacy trial in healthy infants

Md Ahsan Habib et al.

Summary: This study investigated the relationship between varicella-specific antibody concentrations and protection against chickenpox, finding a positive correlation between antibody concentrations and protection, with increased concentrations reducing the probability of chickenpox breakthrough.

VACCINE (2021)

Review Immunology

A guide to vaccinology: from basic principles to new developments

Andrew J. Pollard et al.

Summary: Immunization is vital for public health policy and there are challenges ahead for immunologists in developing new vaccines. Although immunology has not contributed significantly to vaccine development so far, a better understanding of protective immunity is urgently needed to tackle difficult-to-target pathogens.

NATURE REVIEWS IMMUNOLOGY (2021)

Editorial Material Clinical Neurology

Time matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis?

Joao J. Cerqueira et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Review Pediatrics

Global Varicella Vaccine Effectiveness: A Meta-analysis

Mona Marin et al.

PEDIATRICS (2016)

Review Immunology

Correlates of Protection Induced by Vaccination

Stanley A. Plotkin

CLINICAL AND VACCINE IMMUNOLOGY (2010)