4.6 Article

Astrocyte Responses Influence Local Effects of Whole-Brain Magnetic Stimulation in Parkinsonian Rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Endocannabinoid signaling in astrocytes

Abel Eraso-Pichot et al.

Summary: The study of astrocytic contribution to brain functions has gained popularity in neuroscience. Recent discoveries have shown the involvement of astrocytes in synaptic functions and revealed their previously unimaginable multiple functions. Additionally, research on cannabinoids has identified different ways they interact with astrocytes, modify their functions, alter their communication with neurons, and impact behavior. This review discusses the expression of endocannabinoid system members in astrocytes and the latest findings on cannabinoid modulation of important astroglial functions, such as calcium dynamics, gliotransmission, metabolism, and inflammation.
Article Multidisciplinary Sciences

Quartile coefficient of variation is more robust than CV for traits calculated as a ratio

Zoltan Botta-Dukat

Summary: Comparing variations of traits within species can test ecological theories. Measures of relative variation, such as the coefficient of variation (CV), are commonly used to remove the effect of mean trait differences. However, using CV may result in differences in interpretation, especially with outlier trait values. The quartile coefficient of variation is a better alternative as it gives the same value for a trait and its inverse and is not sensitive to outliers.

SCIENTIFIC REPORTS (2023)

Review Radiology, Nuclear Medicine & Medical Imaging

PET imaging of reactive astrocytes in neurological disorders

Yu Liu et al.

Summary: Reactive astrocytes play a critical role in neurological diseases, and PET imaging can help visualize the biological activities of these cells. Future studies should focus on the development of specific imaging agents for astrocytes to further explore the role of reactive astrocytes in various diseases.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

Review Neurosciences

Imaging of Reactive Astrogliosis by Positron Emission Tomography

Ryuichi Harada et al.

Summary: Neurodegenerative diseases are characterized by neuronal loss, gliosis, and the deposition of misfolded proteins. Imaging the glial response in vivo using PET combined with A beta and tau PET can provide insights into the disease process and aid in diagnosis and monitoring of therapeutic response.

FRONTIERS IN NEUROSCIENCE (2022)

Review Neurosciences

Striatal glutamatergic hyperactivity in Parkinson's disease

F. Campanelli et al.

Summary: This paper provides an overview of the critical mechanism of glutamatergic hyperactivity in the early and advanced stages of Parkinson's disease. Synaptic dysfunction is the primary target in the early stages of the disease, leading to alterations in other neurotransmitter systems and persistent modifications that generate movement disorders.

NEUROBIOLOGY OF DISEASE (2022)

Article Multidisciplinary Sciences

Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression

Jessica Moretti et al.

Summary: LI-rTMS modulates neuronal activity and functional connectivity, with widespread effects throughout the brain. Acute stimulation leads to changes in c-Fos positive cell densities, while chronic stimulation decreases parvalbumin interneuron activity and increases anti-correlated functional connectivity effects.

SCIENTIFIC REPORTS (2022)

Review Biochemical Research Methods

Non-invasive brain stimulation for Parkinson's disease: Clinical evidence, latest concepts and future goals: A systematic review

Julian Madrid et al.

Summary: Parkinson's disease is a growing public health concern in aging populations, with current treatments having limitations and the need for new therapies. Non-invasive brain stimulation offers a potential complementary approach, showing promising outcomes in recent trials but with only a few paradigms improving PD symptoms. Advancements in technology may soon allow for longer and deeper brain stimulation.

JOURNAL OF NEUROSCIENCE METHODS (2021)

Article Clinical Neurology

Low intensity repetitive magnetic stimulation reduces expression of genes related to inflammation and calcium signalling in cultured mouse cortical astrocytes

Darren Clarke et al.

Summary: This study investigated the effects of low intensity repetitive magnetic stimulation (LI-rMS) on RNA and protein levels in cultured mouse astrocytes, finding that 10Hz rMS significantly reduced specific protein levels while 1Hz rMS had an impact on the expression of certain genes, potentially contributing to changes in astrocytic phenotype.

BRAIN STIMULATION (2021)

Article Engineering, Biomedical

Effect of skin conductivity on the electric field induced by transcranial stimulation techniques in different head models

Micol Colella et al.

Summary: This study uses numerical simulations to demonstrate the significant impact of using different skin conductivity values on estimating the induced E-field distribution in the brain during TMS and tDCS applications. Skin conductivity variations can lead to up to a 70% impact on the local E-field induced by tDCS, and around 20% in TMS, specifically in regions where potential side effects may occur. Therefore, an accurate model of the skin is crucial for precise estimation of the induced E-field in such applications.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

Article Immunology

Early life stress exposure worsens adult remote microglia activation, neuronal death, and functional recovery after focal brain injury

Clarissa Catale et al.

Summary: The study found that early life stress permanently alters microglial responses, leading to exaggerated inflammation and worse functional recovery. Treatment with GW2580 during early life stress exposure can reduce inflammation and cell death, improving functional recovery.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Clinical Neurology

Transcranial Magnetic Stimulation Exerts Rejuvenation Effects on Corticostriatal Synapses after Partial Dopamine Depletion

Giuseppina Natale et al.

Summary: This study suggests that acute iTBS treatment can alleviate corticostriatal dysfunctions in a rat model of early parkinsonism by modulating NMDAR-dependent plasticity, leading to structural changes and striatal compensatory adaptation.

MOVEMENT DISORDERS (2021)

Review Neurosciences

CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions

Ana Covelo et al.

Summary: The endocannabinoid system plays a crucial role in various brain functions by activating CB1R, impacting synaptic activity and behavior. In recent years, astrocytes have been recognized as significant players in brain physiology due to their involvement in the tripartite synapse and metabolic interactions with neurons. Evidence suggests that astrocytes may serve as important sources of endocannabinoid synthesis and release, adding complexity to the understanding of ECS in brain functions.

NEUROPHARMACOLOGY (2021)

Article Clinical Neurology

Conditions for numerically accurate TMS electric field simulation

Luis J. Gomez et al.

BRAIN STIMULATION (2020)

Article Neurosciences

A novel approach to localize cortical TMS effects

Konstantin Weise et al.

NEUROIMAGE (2020)

Review Pharmacology & Pharmacy

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

L. Iovino et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

Article Multidisciplinary Sciences

Individual head models for estimating the TMS-induced electric field in rat brain

Lari M. Koponen et al.

SCIENTIFIC REPORTS (2020)

Review Clinical Neurology

Noninvasive Stimulation of the Human Brain: Activation of Multiple Cortical Circuits

Vincenzo Di Lazzaro et al.

NEUROSCIENTIST (2018)

Article Clinical Neurology

Where and what TMS activates: Experiments and modeling

Ilkka Laakso et al.

BRAIN STIMULATION (2018)

Article Neurosciences

Frequency-specific effects of repetitive magnetic stimulation on primary astrocyte cultures

Darren Clarke et al.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE (2017)

Article Neurosciences

Glia: A Neglected Player in Non-invasive Direct Current Brain Stimulation

Anne-Kathrin Gellner et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

Review Neurosciences

How Does Transcranial Magnetic Stimulation Influence Glial Cells in the Central Nervous System?

Carlie L. Cullen et al.

FRONTIERS IN NEURAL CIRCUITS (2016)

Article Engineering, Electrical & Electronic

A Computational Model for Real-Time Calculation of Electric Field due to Transcranial Magnetic Stimulation in Clinics

Alessandra Paffi et al.

INTERNATIONAL JOURNAL OF ANTENNAS AND PROPAGATION (2015)

Article Neurosciences

Network Connectivity and Individual Responses to Brain Stimulation in the Human Motor System

Lizbeth Cardenas-Morales et al.

CEREBRAL CORTEX (2014)

Article Clinical Neurology

Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)

Jean-Pascal Lefaucheur et al.

CLINICAL NEUROPHYSIOLOGY (2014)

Article Neurosciences

Waxholm Space atlas of the Sprague Dawley rat brain

Eszter A. Papp et al.

NEUROIMAGE (2014)

Article Neurosciences

Theta-burst stimulation and striatal plasticity in experimental parkinsonism

Veronica Ghiglieri et al.

EXPERIMENTAL NEUROLOGY (2012)

Article Biochemistry & Molecular Biology

GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes

Eunsook Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Pharmacology & Pharmacy

Endocannabinoid-dopamine interactions in striatal synaptic plasticity

Brian N. Mathur et al.

FRONTIERS IN PHARMACOLOGY (2012)

Article Neurosciences

Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Alia Benali et al.

JOURNAL OF NEUROSCIENCE (2011)

Review Clinical Neurology

Astrocytes: biology and pathology

Michael V. Sofroniew et al.

ACTA NEUROPATHOLOGICA (2010)

Review Biochemistry & Molecular Biology

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

Amanda L. Sheldon et al.

NEUROCHEMISTRY INTERNATIONAL (2007)

Article Multidisciplinary Sciences

Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling

Henry H. Yin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Clinical Neurology

Basic mechanisms of TMS

Y Terao et al.

JOURNAL OF CLINICAL NEUROPHYSIOLOGY (2002)

Article Biochemistry & Molecular Biology

The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms

G Gegelashvili et al.

NEUROCHEMISTRY INTERNATIONAL (2000)