Chlorogenic Acid from Burdock Roots Ameliorates Oleic Acid-Induced Steatosis in HepG2 Cells through AMPK/ACC/CPT-1 Pathway

Article Gastroenterology & Hepatology

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

Mary P. Moore et al.

Summary: Compromised hepatic FAO and mitochondrial turnover are intimately linked to increasing NAFLD severity in patients with obesity.

HEPATOLOGY (2022)

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Article Biochemistry & Molecular Biology

The first high-quality chromosomal genome assembly of a medicinal and edible plant Arctium lappa

Yanyun Yang et al.

Summary: This study presented the first high-quality chromosome-level draft genome of Arctium lappa, including information on anchored chromosomes, repetitive sequences, protein-coding genes, and identified candidate genes related to lignan biosynthesis. Transcriptome comparisons at different developmental stages revealed differentially expressed genes. These data can be used to identify quality-related genes in A. lappa or for molecular identification and comparative genomics research.

MOLECULAR ECOLOGY RESOURCES (2022)

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Article Pharmacology & Pharmacy

The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs

Guanglu Wu et al.

Summary: GPR81 plays a critical role in hepatic lipid metabolism by modulating the transcription of PGC-1 alpha and controlling the oxidation of fatty acids. Activation of hepatic GPR81 is important for improving NAFLD.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Physiology

Polyene Phosphatidylcholine Ameliorates High Fat Diet-Induced Non-alcoholic Fatty Liver Disease via Remodeling Metabolism and Inflammation

Yang Lu et al.

Summary: This study demonstrates that polyene phosphatidylcholine (PPC) intervention can reduce fat mass and liver steatosis, improve glucose tolerance and insulin sensitivity in high-fat diet-induced NAFLD mice. Transcriptome and pathway analysis suggest that the improvement of NAFLD by PPC may be associated with reprogramming lipid metabolism and inhibiting inflammatory processes.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Nutrition & Dietetics

Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation

Ruchi Sharma et al.

Summary: This study evaluated the hepatoprotective effects of Trikatu Churna (TC) in treating alcoholic liver disease (ALD) and identified the bioactive components and mechanism of action. The results showed that TC significantly improved liver function and morphology and exerted anti-inflammatory, antioxidant, and anti-apoptotic effects by regulating multiple signaling pathways. These findings provide a basis for the potential use of TC as a therapeutic option for ALD.

FRONTIERS IN NUTRITION (2022)

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Article Biochemistry & Molecular Biology

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK/ACC/CPT-1 pathway

Kaiyang Ma et al.

Summary: Burdock root has pharmacological effects that can regulate lipid metabolism and inhibit weight gain and fatty liver caused by a high-sugar and high-fat diet.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

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Article Endocrinology & Metabolism

Atlas of metabolism reveals palmitic acid results in mitochondrial dysfunction and cell apoptosis by inhibiting fatty acid β-oxidation in Sertoli cells

Xiaoqin Xu et al.

Summary: In recent years, the impact of lipotoxicity on male fertility, especially on Sertoli cells, has been extensively studied. Researchers found that palmitic acid treatment inhibits fatty acid beta-oxidation in Sertoli cells, leading to mitochondrial dysfunction and increased apoptosis.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Chemistry, Medicinal

Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposedHepG2cells via activating autophagy mediated bySIRT1/AMPKsignaling

Deming Li et al.

Summary: The study showed that apple polyphenol extract (APE) can alleviate fatty acid-induced lipid accumulation in cells by restoring autophagy, inhibiting lipid synthesis, and promoting fatty acid oxidation. This indicates that APE has potential preventive effects on clinical hepatosteatosis by inducing autophagy.

PHYTOTHERAPY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice

Fahimeh Zamani-Garmsiri et al.

Summary: The combination of MET and CGA has shown efficacy in reducing fasting blood sugar, improving glucose tolerance, and decreasing the occurrence of NAFLD in HFD mice. It regulates fatty acid synthesis and lipid accumulation, and has anti-inflammatory effects by polarizing macrophages and reducing pro-inflammatory cytokines levels. Additionally, it increases the phosphorylation of AMP-activated protein kinase, suggesting therapeutic potential against NAFLD.

IUBMB LIFE (2021)

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Article Chemistry, Applied

Effect of in vitro gastro-intestinal digestion on the phenolic composition and antioxidant capacity of Burdock roots at different harvest time

Daniela D. Herrera-Balandrano et al.

Summary: The study demonstrated that the phenolic composition and antioxidant capacity of Burdock roots can be influenced by the harvest time, with changes observed during in vitro digestion.

FOOD CHEMISTRY (2021)

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Article Medicine, Research & Experimental

Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity

Yue Xiong et al.

Summary: Icaritin was found to have inhibitory effects on lipotoxicity and steatosis both in vitro and in vivo, mainly through promoting fatty acid oxidation and mitochondrial respiration while reducing fatty acid synthesis. ICT also significantly alleviated metabolic disorders and hepatic steatosis induced by a high-fat diet, potentially via upregulation of PPAR alpha and modulation of AKT and GSK3 beta activity.

LIFE SCIENCES (2021)

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Review Gastroenterology & Hepatology

Therapeutic pipeline in nonalcoholic steatohepatitis

Raj Vuppalanchi et al.

Summary: The therapeutic pipeline for NASH is expanding with insights into disease pathophysiology, offering potential solutions to resolve steatohepatitis or reverse fibrosis. However, there may be some clinical challenges in the use of these emerging therapies.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome

Min-Seong Ha et al.

Summary: Metabolic syndrome is on the rise among the elderly, leading to a need for new lifestyle-based treatment strategies. This study found that aquatic exercise and burdock root extract had differing effects on body composition and serum sex hormones in elderly women with MS, but their combined intervention did not show synergistic or additive effects.

SCIENTIFIC REPORTS (2021)

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Article Endocrinology & Metabolism

Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy

Jin Yoo et al.

Summary: The study demonstrates that fenofibrate can promote intracellular lipid clearance by activating TFEB and TFE3, leading to reduced hepatic fat accumulation. The lysosomal calcium signaling pathway appears to be critical in this process, suggesting a potential therapeutic target for NAFLD and cardiometabolic diseases.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Biochemistry & Molecular Biology

Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis

Heng Li et al.

Summary: NAFLD is a common chronic liver disease globally, with atherosclerotic cardiovascular disease being the leading cause of mortality in NAFLD patients. The liver plays a crucial role in cholesterol metabolism, and abnormal hepatic cholesterol metabolism can lead to NAFLD and drive the development of atherosclerosis.

PROGRESS IN LIPID RESEARCH (2021)

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Article Environmental Sciences