Optimization of the Green Extraction of Red Araca (Psidium catteyanum Sabine) and Application in Alginate Membranes for Use as Dressings

In this research, the aim was to introduce innovation to the pharmaceutical field through the exploration of an underutilized plant matrix, the red araca, along with the utilization of sodium alginate for the development of membranes designed for active topical dressings. Within this context, optimal extraction conditions were investigated using the central composite rotational statistical design (CCRD) to obtain a red araca epicarp extract (RAEE) rich in bioactive compounds utilizing the maceration technique. The extract acquired under the optimized conditions (temperature of 66 degree celsius and a hydroalcoholic solvent concentration of 32%) was incorporated into a sodium alginate matrix for the production of active membranes using a casting method. Characterization of the membranes revealed that the addition of the extract did not significantly alter its morphology. Furthermore, satisfactory results were observed regarding mechanical and barrier properties, as well as the controlled release of phenolic compounds in an environment simulating wound exudate. Based on these findings, the material produced from renewable matrices demonstrates the promising potential for application as a topical dressing within the pharmaceutical industry.

Automated summary

This research aims to introduce innovation to the pharmaceutical field by exploring the use of red araca and sodium alginate for the development of active membranes. The study found that red araca extract could be successfully incorporated into the membranes without altering their morphology. Additionally, the membranes demonstrated satisfactory mechanical and barrier properties, as well as controlled release of phenolic compounds in wound exudate simulation. The material produced from renewable matrices shows promising potential as a topical dressing in the pharmaceutical industry.