期刊
MOLECULES
卷 28, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/molecules28155775
关键词
Ru(III) complexes; amphiphilic compounds; nucleolipids; lipoic acid; chemical synthesis; half-life time
Recently, we have focused on the preparation of nucleolipid-based Ru(III) complexes that can form supramolecular aggregates under physiological conditions. These complexes can prevent metal deactivation and efficiently deliver Ru(III) into cells for its therapeutic activity.
Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supramolecular aggregates which can efficiently prevent metal deactivation and convey Ru(III) inside the cells where it exerts its activity. Within an interdisciplinary program for the development of multifunctional nanoparticles for theranostic applications, we here report the design, synthesis, and characterization of a novel functionalized Ru(III) salt, carrying a lipoic acid moiety in the nucleolipid-based scaffold to allow its incorporation onto metal-based nanoparticles.
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