4.6 Review

The Role and Mechanism of Perilla frutescens in Cancer Treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Agriculture, Multidisciplinary

Characterization of a Group of 2,3-Oxidosqualene Cyclase Genes Involved in the Biosynthesis of Diverse Triterpenoids of Perilla frutescens

Ruoshi Huang et al.

Summary: In this study, nine putative 2,3-oxidosqualene cyclase (OSC) genes were identified and characterized in Perilla frutescens. Camelliol C, a triterpenol with pharmacological effect, and its synthetic enzyme PfOSC7 were first identified in P. frutescens. Additionally, cycloartenol, lupeol, and beta-amyrin synthases were identified as PfOSC2, PfOSC4, and PfOSC9, respectively. Molecular docking and site-directed mutagenesis revealed potential variations in catalytic specificity or efficiency caused by specific mutations in PfOSC4, PfOSC7, and PfOSC9. These findings provide valuable insights into the biosynthetic pathways of triterpenoids and have significant implications for germplasm breeding in P. frutescens.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Review Oncology

Research and Patents Status of Selected Phytochemicals Against Cancer: How Close and How Far?

Homa Fatma et al.

Summary: Phytochemicals have shown promise in cancer prevention and chemosensitization, but their poor bioavailability and rapid excretion are limitations. Analogues have been introduced to enhance bioavailability and efficacy. Research and patents demonstrate the potential of phytochemicals for anti-cancer and chemosensitizing roles.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2023)

Review Plant Sciences

A comprehensive review of the botany, ethnopharmacology, phytochemistry, pharmacology, toxicity and quality control of Perillae Fructus

Suyi Liu et al.

Summary: This article summarizes the botany, ethnopharmacology, phytochemistry, pharmacology, toxicity, and quality control of Perilla frutescens, providing scientific evidence for its development and utilization.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Article Biochemistry & Molecular Biology

An Ethanol Extract of Perilla frutescens Leaves Suppresses Adrenergic Agonist-Induced Metastatic Ability of Cancer Cells by Inhibiting Src-Mediated EMT

Jae-Hoon Jeong et al.

Summary: Previous studies have shown that the adrenergic receptor signaling pathway plays a significant role in chronic stress-induced cancer metastasis. This study investigates whether an ethanol extract of Perilla frutescens leaves (EPF) can regulate the metastatic ability of cancer cells induced by adrenergic agonists. The results demonstrate that EPF can suppress the adrenergic agonist-promoted metastatic ability of cancer cells by inhibiting Src-mediated epithelial-mesenchymal transition (EMT).

MOLECULES (2023)

Article Biotechnology & Applied Microbiology

Perilla pomace obtained from four different varieties have different levels and types of polyphenols and anti-allergic activity

Yuba Raj Gaihre et al.

Summary: This study analyzed the nutritional composition and anti-allergic properties of different varieties of perilla pomace with different photoperiod responses. Flavonoids apigenin and luteolin found in the pomace from Japanese varieties may contribute to anti-allergic response. Extracts from varieties originating from Nepal reduced phosphorylation of proteins involved in degranulation signaling pathway.

CYTOTECHNOLOGY (2022)

Article Biochemistry & Molecular Biology

Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients

Hechun Liu et al.

Summary: This study investigated the different effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acid (n-3 PUFA) on the fatty acids of erythrocytes and glycolipid metabolism in patients with type 2 diabetes mellitus (T2DM). The results showed that supplementation with perilla oil decreased fasting blood glucose (FBG) levels, while fish oil supplementation decreased serum triglyceride (TG) levels. Marine-based and plant-based n-3 PUFAs exhibited different effects on the fatty acid compositions of erythrocytes and regulated glycolipid metabolism.

LIPIDS IN HEALTH AND DISEASE (2022)

Review Cell Biology

The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer

Yingying Hu et al.

Summary: Artemisinin and its derivatives have shown antitumor effects in addition to their antimalarial properties. The mechanisms of antitumor activity involve cell cycle regulation, inhibition of tumor angiogenesis, DNA damage, and induction of ferroptosis. This review focuses on the potential of artemisinin derivatives in regulating ferroptosis and provides a basis for their use as anticancer drugs in clinical practice.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Review Food Science & Technology

Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review

Famous Erhunmwunsee et al.

Summary: Perillaldehyde (PAE), a major component of perilla plants, has antifungal and antimicrobial properties, as well as potential health benefits. It is used in various industries including food, perfume, and traditional medicine. Animal studies have shown PAE's anticancer, anti-depressant, and anti-inflammatory effects, but caution is advised due to potential adverse effects at high doses. Further research and clinical trials are needed to fully understand its properties and potential applications.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Article Biotechnology & Applied Microbiology

Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines

Zhuoyuan Lin et al.

Summary: Perillaldehyde (PAH), an active ingredient of Perilla frutescens, has been shown to inhibit proliferation, invasion and migration of prostate cancer cells. It also prevents stem cell characteristics and inhibits bone metastasis and osteoclastogenesis by suppressing the activation of NF-kappa B pathway and RANKL.

BIOENGINEERED (2022)

Review Oncology

Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against Cancer

Roohi Mohi-Ud-Din et al.

Summary: Flavonoids, a class of polyphenolic compounds, are widely found in food and beverages. They possess anticancer activities by modulating various signaling pathways to interrupt cancer progression.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Perilla frutescens: A Rich Source of Pharmacological Active Compounds

Tianyu Hou et al.

Summary: This review summarizes the latest research findings on the phytochemistry and pharmacological activities of Perilla frutescens. The plant contains approximately 400 different bioactive compounds and exhibits various pharmacological properties such as anti-inflammatory, antidepressant, anticancer, and antioxidant effects. It has potential applications in the treatment of diabetes and its complications, prevention of hyperuricemia, and management of allergic conditions.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Comparative Analysis of Polycyclic Aromatic Hydrocarbons and Halogenated Polycyclic Aromatic Hydrocarbons in Different Parts of Perilla frutescens (L.) Britt.

Pengfei Wang et al.

Summary: Perilla frutescens is a popular medicinal herb and edible plant in East Asia. The study found that the leaves, stems, and seeds of Perilla frutescens contain polycyclic aromatic hydrocarbons (PAHs) but no halogenated PAHs. The distribution of PAHs in the different parts of Perilla frutescens varied significantly. Based on the toxic equivalent quantity (TEQ) and incremental lifetime cancer risk (ILCR), the cancer risk from consuming Perilla frutescens was assessed to be low.

MOLECULES (2022)

Review Cell Biology

Cell cycle on the crossroad of tumorigenesis and cancer therapy

Jing Liu et al.

Summary: Cell cycle aberrancy is a fundamental mechanism underlying tumorigenesis, and therapies targeting cell cycle machinery components can not only suppress cancer cell division but also reverse cancer metabolism and restore cancer immune surveillance. Recently, proteolysis targeting chimeras (PROTACs) have been used to target oncogenic proteins related to cell cycle progression for more effective tumor suppression.

TRENDS IN CELL BIOLOGY (2022)

Review Cell Biology

Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action

Abdul Waheed Khan et al.

Summary: Despite advancements in conventional therapies, cancer remains a leading cause of death globally. Plant-based medicines have been used since ancient times and have shown promising results with minimal side effects. Discovery of more plant-derived bioactive compounds is encouraged to prevent and treat cancer without significant adverse effects.
Article Food Science & Technology

Protective Effect of Diet-Supplemented and Endogenously Produced Omega-3 Fatty Acids against HFD-Induced Colon Inflammation in Mice

Shalom Sara Thomas et al.

Summary: Perilla frutescens oil can reduce colon inflammation induced by a high-fat diet by suppressing the NF-kappa B pathway. Both fat-1 transgenic mice that produce omega-3 fatty acids endogenously and wild-type mice supplemented with perilla oil showed improvements in body weight and serum lipid levels. Additionally, perilla oil supplementation and omega-3 fatty acids production in transgenic mice were associated with increased colon length, reduced inflammation markers, and improved epithelial integrity barrier markers.
Review Integrative & Complementary Medicine

Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone

Ruo Wang et al.

Summary: Perilla ketone and isoegomaketone, important active components of Perilla frutescens, have been shown to exhibit various pharmacological activities such as antitumor, antifungal, anti-inflammatory effects, and potential in combating toxicity from immunotherapy. However, there is a lack of reviews on the pharmacological activities and effects of these compounds.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Review Chemistry, Medicinal

Roles of plant-derived bioactive compounds and relatedmicroRNAsin cancer therapy

Heng Zou et al.

Summary: Plant-derived bioactive compounds can inhibit tumor growth and metastasis by regulating miRNA expression, influencing tumor progression, microenvironment, and drug resistance in various cancers. This review aims to provide a new understanding of the targeting of miRNAs by plant-derived bioactive compounds and shed light on their potential clinical applications.

PHYTOTHERAPY RESEARCH (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Integrative & Complementary Medicine

Extracts of Perilla frutescens var. Acuta (Odash.) Kudo Leaves Have Antitumor Effects on Breast Cancer Cells by Suppressing YAP Activity

Cho-Long Kim et al.

Summary: The study shows that Perilla frutescens var. acuta (Odash.) Kudo leaf extract inhibits tumor cell growth and migration by phosphorylating YAP/TAZ and disrupting their interaction with the TEAD complex. This antitumor effect was demonstrated in triple-negative breast cancer cells through induced apoptosis and reduced migration, with the inhibition of migration being primarily regulated by YAP activity.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells

Payungsak Tantipaiboonwong et al.

Summary: The research demonstrates that perilla seed oil (PSO) and rosmarinic acid-rich fraction (RA-RF) act as antioxidants to scavenge TNF-alpha induced reactive oxygen species (ROS) levels, resulting in decreased expression of inflammatory cytokines and modulation of multiple signaling pathways, showing a potential role in preventing oxidative stress and inflammation.

MOLECULES (2021)

Review Biochemistry & Molecular Biology

Unsaturated fatty acids as a co-therapeutic agents in cancer treatment

Zahra Asefy et al.

Summary: Many clinical studies have shown the beneficial effects of -3 and -6 fatty acids on various diseases, including cardiovascular disorders, asthma, rheumatoid arthritis, osteoporosis, and most cancers. Polyunsaturated fatty acids (PUFAs) have been shown to have a toxic effect on cancer cells, although the exact mechanism is still unknown.

MOLECULAR BIOLOGY REPORTS (2021)

Article Immunology

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

Lei Chu et al.

Summary: The study found that perillaldehyde (PAH) derived from Perilla frutescens can suppress cytosolic-DNA-induced innate immune responses by inhibiting cGAS activity, potentially benefiting the treatment of autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy

Sadegh Rajabi et al.

Summary: Cancer is a challenging global health problem, and understanding the six cancer hallmarks is crucial in developing novel therapies. Apoptosis, involving intrinsic and extrinsic signaling pathways, plays a critical role in cancer treatment, and targeting multiple molecules in these pathways may offer new treatment options and prevent resistance. Plant extracts and plant-derived molecules have shown potential in activating apoptosis pathways in human cancer cells, making them promising candidates for cancer treatment.

BIOMOLECULES (2021)

Article Nutrition & Dietetics

Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats

Napapan Kangwan et al.

Summary: The study found that PSO and metformin can effectively improve gut dysbiosis, inflammation, and metabolic disturbance in HFD-fed rats, with metformin showing greater benefits.

NUTRIENTS (2021)

Article Cell Biology

The Cancer SENESCopedia: A delineation of cancer cell senescence

Fleur Jochems et al.

Summary: The study comprehensively analyzed the transcriptome and senolytic responses in 13 cancer cell lines induced to undergo senescence, showing that the response to senolytic agents and the composition of the senescence-associated secretory phenotype in cancer cells are more influenced by the cell of origin than by the senescence trigger. Using machine learning, a gene expression classifier called SENCAN was established for detecting senescence in cancer cell samples, with the expression profiles and classifier accessible online as Cancer SENESCopedia.

CELL REPORTS (2021)

Article Plant Sciences

Identifying SSR Markers Related to Seed Fatty Acid Content in Perilla Crop (Perilla frutescens L.)

Hyeon Park et al.

Summary: Perilla seed oil, a popular health food in South Korea, contains various fatty acids. By using association analysis of SSR markers, several markers associated with fatty acid content in Perilla seed oil were identified, which can be useful for improving seed oil quality in Perilla crops through MAS breeding programs.

PLANTS-BASEL (2021)

Review Biochemistry & Molecular Biology

Tropane alkaloid biosynthesis: a centennial review

Jian-Ping Huang et al.

Summary: Tropane alkaloids are a remarkable class of plant secondary metabolites, with a long history of being used as poisons, hallucinogens, and anaesthetic agents. The complete biosynthetic route of hyoscyamine and scopolamine was only clarified in 2020 after many years of research. The study emphasizes the biomimetic nature of Robinson's total synthesis of tropinone and highlights the importance of total synthesis in natural product biosynthesis research.

NATURAL PRODUCT REPORTS (2021)

Review Oncology

Oxidative stress and its role in cancer

Marija Dragan Jelic et al.

Summary: Reactive oxygen species (ROS) can damage biomolecules and lead to oxidative stress, potentially causing various diseases. Research focuses on 8-OHdG and antioxidative enzymes as biomarkers for oxidative stress in cancer, with results indicating lower levels of antioxidative enzymes in cancer patients and higher levels of 8-OHdG and MDA.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2021)

Article Oncology

The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Abu Hazafa et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2020)

Article Oncology

Progress in cancer mortality, incidence, and survival: a global overview

Claudia Santucci et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2020)

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Oncology

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Marek Samec et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Review Nutrition & Dietetics

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications

Raquel D. S. Freitas et al.

NUTRIENTS (2019)

Article Biochemistry & Molecular Biology

Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy

Yu Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

TRENDS IN CELL BIOLOGY (2019)

Review Cell Biology

Medicinal Plants in the Prevention and Treatment of Colon Cancer

Paola Aiello et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Chemistry, Applied

Role of Omega-3 Polyunsaturated Fatty Acids in Mental Health-Studies from Japan

Kei Hamazaki

JOURNAL OF OLEO SCIENCE (2019)

Review Biotechnology & Applied Microbiology

Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics

Mallappa Kumara Swamy et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

Article Agriculture, Multidisciplinary

Intestinal Anti-Inflammatory Activity of Perillaldehyde

Takuya Uemura et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites

Seong-Ah Shin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Anthocyanins in perilla plants and dried leaves

Yumi Fujiwara et al.

PHYTOCHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Polyphenols in Food: Cancer Prevention and Apoptosis Induction

Ashita Sharma et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Xu Hu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Food Science & Technology

Perilla Oil Supplementation Improves Hypertriglyceridemia and Gut Dysbiosis in Diabetic KKAy Mice

Feng Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

Review Pharmacology & Pharmacy

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Bee Ling Tan et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Chemistry, Medicinal

Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens

Yang Liu et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2017)

Article Chemistry, Medicinal

Perillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens

Yang Liu et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2017)

Review Biotechnology & Applied Microbiology

New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles

M. A. Zaimy et al.

CANCER GENE THERAPY (2017)

Article Biochemistry & Molecular Biology

A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions

Rikiya Kamei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Oncology

Global Cancer Incidence and Mortality Rates and Trends-An Update

Lindsey A. Torre et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2016)

Review Nutrition & Dietetics

Anticancer Efficacy of Polyphenols and Their Combinations

Aleksandra Niedzwiecki et al.

NUTRIENTS (2016)

Review Oncology

Cancer and cure: A critical analysis

P. S. Roy et al.

INDIAN JOURNAL OF CANCER (2016)

Review Biotechnology & Applied Microbiology

Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance

Sanjeev K. Srivastava et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemistry & Molecular Biology

A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes

Ayaka Nakajima et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2015)

Article

Finding cancer’s weakest link

Nicole Michel Sodir et al.

Oncotarget (2015)

Article Biochemistry & Molecular Biology

Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves

In Hwa Jeon et al.

MOLECULES (2014)

Article Nutrition & Dietetics

Dietary PUFA and cancer

S. Abel et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2014)

Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Review Cell Biology

The Hippo pathway: regulators and regulations

Fa-Xing Yu et al.

GENES & DEVELOPMENT (2013)

Article Agriculture, Multidisciplinary

Metabolite Profiling Based on Lipophilic Compounds for Quality Assessment of Perilla (Perilla frutescens) Cultivars

Jae Kwang Kim et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Article Geriatrics & Gerontology

Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons

Gang Zhao et al.

NEUROBIOLOGY OF AGING (2012)

Article Biochemistry & Molecular Biology

Isoegomaketone Induces Apoptosis through Caspase-Dependent and Caspase-Independent Pathways in Human DLD1 Cells

Byoung Ok Cho et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)

Article Medicine, Research & Experimental

Effect of Perilla frutescens var. acuta Kudo and rosmarinic acid on allergic inflammatory reactions

Hyun-A Oh et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

Review Immunology

Targeting the tumor microenvironment by immunotherapy: part 2

Judith Leibovici et al.

IMMUNOTHERAPY (2011)

Review Oncology

Apoptosis in cancer: from pathogenesis to treatment

Rebecca S. Y. Wong

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

Article Pharmacology & Pharmacy

Health effects of omega-3,6,9 fatty acids: Perilla frutescens is a good example of plant oils

Mohammad Asif

ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE (2011)

Review Oncology

Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention

Wu-Yang Huang et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2010)

Article Biochemistry & Molecular Biology

Antioxidant Activities of Polyphenols Extracted from Perilla frutescens Varieties

Linghua Meng et al.

MOLECULES (2009)

Review Oncology

Tumour necrosis factor and cancer

Frances Balkwill

NATURE REVIEWS CANCER (2009)

Article Chemistry, Medicinal

Perilla frutescens var. frutescens in northern Laos

Michiho Ito et al.

JOURNAL OF NATURAL MEDICINES (2008)

Article Gastroenterology & Hepatology

Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin

Do Y. Lim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Review Medicine, General & Internal

Gene Therapy for Cancer Treatment: Past, Present and Future

Deanna Cross et al.

CLINICAL MEDICINE & RESEARCH (2006)

Article Biochemistry & Molecular Biology

Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects

N Banno et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Metabolomics and differential gene expression in anthocyanin chemo-varietal forms of Perilla frutescens

M Yamazaki et al.

PHYTOCHEMISTRY (2003)

Article Pharmacology & Pharmacy

Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice

H Takeda et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2002)

Article Biochemistry & Molecular Biology

Antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria

H Yamamoto et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2002)