The Role and Mechanism of Perilla frutescens in Cancer Treatment

Perilla frutescens is an annual herb of the Labiatae family and is widely grown in several countries in Asia. Perilla frutescens is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that Perilla frutescens has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of Perilla frutescens for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of Perilla frutescens for cancer treatment. It was found that the main active components of Perilla frutescens producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of Perilla frutescens are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to Perilla frutescens.

Automated summary

Perilla frutescens is a widely grown herb in Asia with various medicinal uses. It has been found to have pharmacological effects such as anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective properties. This review summarizes the chemical composition and molecular mechanisms of Perilla frutescens for cancer treatment, with perilla aldehyde, rosmarinic acid, lignan, isoestrogen, and perilla seed oil identified as the main active components. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to Perilla frutescens.