Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO plus Water) Mixtures

The solubility and solution thermodynamics of isotretinoin (ITN) (3) in numerous {dimethyl sulfoxide (DMSO) (1) + water (H2O) (2)} combinations were studied at 298.2-318.2 K under fixed atmospheric pressure of 101.1 kPa. A shake flask methodology was used to determine ITN solubility, and correlations were made using the van't Hoff, Apelblat, Buchowski-Ksiazczak lambda h, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van't Hoff models. In mixtures of {(DMSO (1) + H2O (2)}, the solubility of ITN in mole fractions was enhanced with the temperature and DMSO mass fraction. The mole fraction solubility of ITN was highest in neat DMSO (1.02 x 10-1 at 318.2 K) and lowest in pure H2O (3.14 x 10-7 at 298.2 K). The output of computational models revealed good relationships between the solubility data from the experiments. The dissolution of ITN was endothermic and entropy-driven in all of the {(DMSO (1) + H2O (2)} mixtures examined, according to the positive values of measured thermodynamic parameters. Enthalpy was discovered to be the driving force behind ITN solvation in {(DMSO (1) + H2O (2)} combinations. ITN-DMSO displayed the highest molecular interactions when compared to ITN-H2O. The outcomes of this study suggest that DMSO has a great potential for solubilizing ITN in H2O.

Automated summary

The solubility and solution thermodynamics of isotretinoin in DMSO and water mixtures were studied. The results showed that the solubility of ITN increased with temperature and DMSO mass fraction. The computational models also revealed good relationships between the experimental data. The study suggests that DMSO has great potential for solubilizing ITN in water.