Drug Delivery and Therapy Strategies for Osteoporosis Intervention

Article Chemistry, Multidisciplinary

Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro

Kosheli Thapa Magar et al.

Summary: Macrophages play a crucial role in inflammation, and the use of AND-MPN Ns shows potential for treating inflammatory diseases.

CHINESE CHEMICAL LETTERS (2023)

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Article Cell & Tissue Engineering

Nanoparticles Targeting Delivery Antagomir-483-5p to Bone Marrow Mesenchymal Stem Cells Treat Osteoporosis by Increasing Bone Formation

Li-Bin Sun et al.

Summary: This study demonstrates that miR-483-5p inhibits osteogenic differentiation of BMSCs and delivering miR-483-5p inhibitor to BMSCs via nanoparticles is a potential treatment for osteoporosis. The research identifies miR-483-5p as a target for regulating BMSC osteoblastic differentiation and provides a novel candidate for clinical prevention and treatment of osteoporosis.

CURRENT STEM CELL RESEARCH & THERAPY (2023)

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Article Pharmacology & Pharmacy

Oral delivery of calcitonin-ion pairs: In vivo proof of concept for a highly lipophilic counterion

Richard Wibel et al.

Summary: Hydrophobic ion pairing and incorporation into SEDDS is a promising strategy for oral delivery of hydrophilic macromolecular drugs. In this study, hydrophobic ion pairs (HIP) between sCT and highly lipophilic sulfosuccinate counterions were formed. The use of bis(isotridecyl) sulfosuccinate resulted in the highest lipophilicity and improved solubility in lipophilic co-solvents. The HIP-loaded SEDDS showed excellent pharmacological activity in rats, with a relative hypocalcaemic effect of 13.8 +/- 5.6%.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Engineering, Biomedical

Additive manufacturing of PLA-Mg composite scaffolds for hard tissue engineering applications

Rasoul Bakhshi et al.

Summary: Polylactic acid (PLA) is a promising option for hard tissue engineering due to its biocompatibility and processability, but its weak mechanical properties and biodegradability restrict its usage. To overcome these limitations, micrometric magnesium particles were incorporated into the PLA matrix via fused deposition modeling (FDM). The PLA-Mg composites exhibited improved mechanical, physical, chemical, and biological characteristics, with the PLA-6Mg composite scaffold showing the best cellular response. 3D-printed PLA-Mg composite scaffold shows great potential for hard tissue engineering applications.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2023)

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Review Pharmacology & Pharmacy

Lipid carriers for mRNA delivery

Wanting Zhang et al.

Summary: This study provides an overview of the applications of lipid carriers in mRNA delivery and the development of lipid-based formulations as vaccine delivery systems, with a focus on the recent advancements in COVID-19 mRNA vaccines. It highlights the significance of these advancements in developing effective vaccines and treatment methods.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Engineering, Biomedical

A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration

Lingbin Che et al.

Summary: Osteoporosis is a serious consequence of aging, leading to disability and death. This study develops a biomimetic drug delivery system that can release medication in a sensitive and short-term manner, providing an effective treatment for osteoporosis.

BIOACTIVE MATERIALS (2023)

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Review Instruments & Instrumentation

Management of bone diseases: looking at scaffold-based strategies for drug delivery

Myriam Bordone et al.

Summary: The bone tissue has the ability to regenerate itself, but in certain cases, strategic approaches are needed for bone reconstruction and regeneration. Bone scaffolds, which have been used as synthetic bone grafts, are now being explored as drug delivery systems. Targeted drug delivery to the bone can enhance treatment effectiveness and minimize side effects, but more research is needed in this area.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2023)

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Article Pharmacology & Pharmacy

Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator

Qingqing Xiao et al.

Summary: In this study, researchers combined a targeted diterpenoid derivative with an anti-CTLA-4 checkpoint blockade to improve immunotherapy. The use of thermosensitive liposomes as carriers allowed for the co-delivery of the two drug payloads into the tumor, resulting in enhanced immune response and therapeutic effect. Additionally, the diterpenoid derivative also improved the immunotherapeutic effect of the anti-PD-1 checkpoint antibody.

ACTA PHARMACEUTICA SINICA B (2023)

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Review Endocrinology & Metabolism

Scaffolds: a biomaterial engineering in targeted drug delivery for osteoporosis

Safoora Poorirani et al.

Summary: This review explains the role of scaffolds in targeted drug delivery for the treatment of osteoporosis.

OSTEOPOROSIS INTERNATIONAL (2023)

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Article Biotechnology & Applied Microbiology

Customized flexible hollow microneedles for psoriasis treatment with reduced-dose drug

Yingjie Ren et al.

Summary: Microneedles, especially hollow microneedles (HMNs), are crucial for drug delivery. However, current HMNs are mainly manufactured using silicon microfabrication, which lacks a low-cost and batch-scale customized approach, especially for flexible substrate HMNs. This study proposes using a high-precision 3D printed master mold and a dual-molding process to prepare HMNs with different shapes and sizes. The reuse of the molds significantly reduces costs. The drug delivery efficiency of the fabricated HMNs was verified through in situ treatment of psoriasis in mice, which resulted in reduced side effects and drug toxicity. This dual-molding process can revitalize HMNs development.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

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Article Engineering, Multidisciplinary

Blending strategy to modify PEEK-based orthopedic implants

Zhiyong Chen et al.

Summary: Polyetheretherketone (PEEK) is a thermoplastic polymer widely used in orthopedic implants due to its strong mechanical properties, good chemical stability, and excellent biocompatibility. However, its low elastic modulus limits its application to low-modulus areas of human bone. This review discusses various strategies to modify PEEK-based implants, including blending with reinforcing materials to enhance mechanical strength and incorporating bioactive additives to promote osteogenic activity and bone integration. The challenges and future development of PEEK-based composites are also highlighted.

COMPOSITES PART B-ENGINEERING (2023)

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Article Pharmacology & Pharmacy

Dissolving microneedle transdermal patch loaded with Risedronate sodium and Ursolic acid bipartite nanotransfersomes to combat osteoporosis: Optimization, characterization, in vitro and ex vivo assessment

Niha Sultana et al.

Summary: Osteoporosis is a fatal bone disease that contributes significantly to human mortality and economic burden. A microneedle transdermal patch loaded with optimized formulation nanotransfersomes containing Risedronate Sodium and Ursolic acid has been developed to improve osteoporosis treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Review Medicine, Research & Experimental

Advances in microneedle-based therapy for bone disorders

Zengping Lin et al.

Summary: Treatment of bone-related disorders is a major public health concern with significant social and economic burden. Conventional drug delivery systems face challenges in achieving efficient and specific drug absorption for bone diseases. Microneedle-based therapy offers a safe and less invasive approach for treating bone disorders, improving delivery efficiency and therapeutic impact. This review summarizes the progress and potential of microneedle-based therapy, discussing its benefits, challenges, and future perspectives in bone treatment.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Pharmacology & Pharmacy

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Deepak Kulkarni et al.

Summary: Microneedles are increasingly popular in transdermal drug delivery for biomedical and healthcare applications due to their efficient and minimally invasive drug delivery capabilities. Polymeric microneedles offer advantages such as biocompatibility, biodegradability, and non-toxicity compared to inorganic microneedles. The use of a wide variety of polymers provides a broad scope for drug delivery and other biomedical applications. Advanced 3D and 4D printing technology is shifting the fabrication of polymeric microneedles. The multifaceted biomedical applications of polymeric microneedles include drug delivery, vaccine delivery, biosensing, and diagnostics.

SCIENTIA PHARMACEUTICA (2023)

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Article Cell & Tissue Engineering

Nanoparticles Targeting Delivery Antagomir-483-5p to Bone Marrow Mesenchymal Stem Cells Treat Osteoporosis by Increasing Bone Formation

Yue Zhou et al.

Summary: This study demonstrates that miR-483-5p inhibits the osteogenic differentiation of BMSCs, and selectively delivering antagomir-483-5p to BMSCs using nanoparticles can promote osteoblastic differentiation and prevent osteoporosis. The research also identified MAPK1 and Smad5 as direct targets of miR-483-5p in regulating BMSC osteoblastic differentiation and osteoporosis.

CURRENT STEM CELL RESEARCH & THERAPY (2023)

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Article Endocrinology & Metabolism

Trends in postmenopausal osteoporosis treatment in France during the period 2007-2016: A nationwide claims database analysis

Bernard Cortet et al.

Summary: The trends in pharmacological management of postmenopausal osteoporosis in France from 2007 to 2016 showed marked changes, with a slight increase followed by a rapid decrease in the rates of women receiving any anti-osteoporosis medications. The use of calcium/vitamin D as the only prevention and exclusive intervention for postmenopausal osteoporosis significantly increased. Patients initiating anti-osteoporosis medications showed a shift towards higher risk individuals with more severe chronic comorbidities, history of fractures, and high-dose steroid use over the 10-year period.

BONE (2022)

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Article Chemistry, Multidisciplinary

Liposome-based anchoring and core-encapsulation for combinatorial cancer therapy

Qingqing Xiao et al.

Summary: In this study, a liposome-based co-delivery system was developed to simultaneously deliver pro-apoptotic protein and cytotoxic drug for synergistic cancer treatment. The system improved the solubility of the drug and achieved efficient drug delivery by targeting receptors on cancer cells. In vivo experiments demonstrated that the co-delivery system significantly inhibited tumor growth.

CHINESE CHEMICAL LETTERS (2022)

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Article Pharmacology & Pharmacy

Fabrication and optimization of raloxifene loaded spanlastics vesicle for transdermal delivery

Iram Khan et al.

Summary: This research aims to develop and optimize Raloxifene HCL loaded spanlastics. A nanocarrier was prepared using ethanol injection method and optimized using Box Behnken design. The effects of independent variables on vesicle size, polydispersity index, and encapsulation efficiency were evaluated. The optimized spanlastics formulation showed suitable particle size for skin permeation. Various characterization and release studies were performed. The result indicated that Raloxifene HCL loaded spanlastics could be a better approach for delivering drugs in deeper layers of the skin.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Review Endocrinology & Metabolism

Pregnancy and Lactation Associated Osteoporosis

Sarah A. Hardcastle

Summary: Pregnancy-associated osteoporosis is a rare condition affecting women in pregnancy or the postpartum period, characterized by skeletal fragility and vertebral fractures. The etiology is poorly understood, and management is challenging due to limited evidence and potential spontaneous improvement in bone density post-pregnancy and lactation.

CALCIFIED TISSUE INTERNATIONAL (2022)

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Review Instruments & Instrumentation

Lipid-based emulsion drug delivery systems - a comprehensive review

Mori Dhaval et al.

Summary: Lipid-based emulsion systems have gained popularity for improving solubility of water-insoluble drugs, along with advantages such as enhanced permeability and protection against pre-systemic metabolism. This article provides a comprehensive review of critical properties of lipid-based emulsion systems, including different types of emulsions, stabilization mechanisms, preparation methods, and evaluation techniques.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Liposome-based delivery of biological drugs

Kosheli Thapa Magar et al.

Summary: Biological drugs are limited in their application due to their inherent properties, but liposome-based drug delivery systems provide a promising solution to improve drug delivery.

CHINESE CHEMICAL LETTERS (2022)

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Article Chemistry, Multidisciplinary

Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes

George Frimpong Boafo et al.

Summary: A targeted co-delivery system of daunorubicin and cytarabine was developed, showing good stability and endocytosis capability, which could be utilized for the treatment of breast cancer.

CHINESE CHEMICAL LETTERS (2022)

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Article Engineering, Multidisciplinary

Icariin-releasing 3D printed scaffold for bone regeneration

Lin Zou et al.

Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.

COMPOSITES PART B-ENGINEERING (2022)

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Review Biochemistry & Molecular Biology

The Role of Testosterone in the Elderly: What Do We Know?

Biagio Barone et al.

Summary: Testosterone is the most important hormone in male health, and aging can result in testosterone deficiency. Testosterone replacement therapy can restore testosterone levels in men, improving sexual dysfunction, increasing bone density and muscle strength, and providing cardioprotective effects. However, it may be contraindicated in men with untreated prostate cancer and may have other potential side effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Dentistry, Oral Surgery & Medicine

RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway

D. D. Liu et al.

Summary: This study reveals that RUNX2 regulates the BMP4 pathway by inhibiting CHRDL1 transcription, which has important implications for the treatment of bone diseases.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Transdermal formulations and strategies for the treatment of osteoporosis

Angelica Villanueva-Martinez et al.

Summary: Osteoporosis is a major health issue due to its association with fractures, morbidity, mortality, and re-hospitalization. Transdermal delivery may be an attractive alternative for the treatment of osteoporosis.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs

Arvind Sharma et al.

Summary: This review addresses the latest developments in supersaturated drug delivery systems.

MOLECULES (2022)

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Article Chemistry, Multidisciplinary

The Relationship between the Drug Delivery Properties of a Formulation of Teriparatide Microneedles and the Pharmacokinetic Evaluation of Teriparatide Administration in Rats

Yu-Jeong Oh et al.

Summary: This study examines the relationship between the drug delivery properties of the solid formulation with teriparatide and the pharmacokinetic properties of teriparatide in vivo. The results demonstrate that the release rate of the solid formulation determines the drug's pharmacokinetic properties.

PHARMACEUTICAL RESEARCH (2022)

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Article Materials Science, Characterization & Testing

Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Chunlan Jing et al.

Summary: Bone-targeted polymeric nanoparticles for alendronate delivery were fabricated and shown to have sustained release and good cytocompatibility, with high affinity to bone cells.

POLYMER TESTING (2022)

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Article Chemistry, Physical

Aminopropyltriethoxysilane (APTES)-Modified Nanohydroxyapatite (nHAp) Incorporated with Iron Oxide (IO) Nanoparticles Promotes Early Osteogenesis, Reduces Inflammation and Inhibits Osteoclast Activity

Krzysztof Marycz et al.

Summary: Osteoporosis poses challenges and economic burden to healthcare systems. Personalized biomaterials can restore bone balance. In this study, APTES-stabilized nanometer crystalline hydroxyapatite and iron oxide nanoparticles were found to modulate bone cell metabolism and be useful in the fabrication of personalized materials.

MATERIALS (2022)

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Review Medicine, General & Internal

Secondary Osteoporosis and Metabolic Bone Diseases

Mahmoud M. Sobh et al.

Summary: Secondary osteoporosis is a global problem caused by osteoporosis and can be triggered by various reasons. Kidney, diabetes, thyroid and parathyroid disorders, gastrointestinal diseases, liver disease, inflammatory disorders, and medications can all contribute to the development of secondary osteoporosis.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Deepak Kulkarni et al.

Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.

PHARMACEUTICS (2022)

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Article Chemistry, Physical

Laboratory determination and thermodynamic analysis of alendronate solubility in supercritical carbon dioxide

Mohammed A. S. Abourehab et al.

Summary: Alendronic acid, a bisphosphonate medicine, can be enhanced in bioavailability by using supercritical carbon dioxide as a solvent. This study experimentally determined the solubility of Alendronate in scCO2 and correlated the data using different models, finding the most accurate fit with the experimental data.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Pharmacology & Pharmacy

A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture

Changxin Liu et al.

Summary: Osteoporotic fractures are a common bone disease that is difficult to cure. The Mg-based MAO-MT-PLGA drug/ion delivery system shows potential in treating osteoporotic fractures by promoting bone formation, inhibiting bone resorption, and improving skeletal condition.

PHARMACEUTICS (2022)

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Review Chemistry, Multidisciplinary

Overcoming skin barriers through advanced transdermal drug delivery approaches

Vivek Phatale et al.

Summary: Transdermal drug delivery system (TDDS) is a potential approach for effective drug delivery, with advantages such as easy administration, controlled release, and prolonged therapeutic effect. Poor skin permeability is a primary challenge, but can be overcome through fusion with other methods. This article summarizes the fundamental features, components, and design of TDDS, as well as methods for assessing skin permeability. It also explores the application of active methods and passive methods in transdermal drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Mucoadhesive carriers for oral drug delivery

Raj Kumar et al.

Summary: Oral medicine has benefits such as ease of administration and patients' compliance, but many drugs cannot be taken orally due to their physicochemical properties. Mucoadhesive formulations show potential for improving oral drug retention and absorption for targeted treatment of gastrointestinal diseases.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Biotechnology & Applied Microbiology

Dual drug delivery platforms for bone tissue engineering

Devi V. K. Anupama et al.

Summary: The dual delivery platforms in bone tissue engineering can provide supplementary bioactive compounds for enhanced bone regeneration. The delivery time of these compounds can be adjusted by altering parameters of the carrier platform. This review article focuses on the concept of dual drug delivery platform, classifies various platforms for bone tissue engineering, and highlights the future direction of these techniques.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Composite Separable Microneedles for Transdermal Delivery and Controlled Release of Salmon Calcitonin for Osteoporosis Therapy

Yao Li et al.

Summary: A composite separable microneedles system consisting of silk fibroin needle tips and hyaluronic acid base is developed for transdermal delivery of salmon calcitonin for therapy of osteoporosis. The release of salmon calcitonin can be controlled by modulating the conformation structure of silk fibroin and the interaction between salmon calcitonin peptide and silk fibroin proteins.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Chemistry, Multidisciplinary

Recent advances in nanoparticle-based drug delivery systems for rheumatoid arthritis treatment

Simran Nasra et al.

Summary: Nanotechnology offers new treatment options for rheumatoid arthritis by using nanoparticles to directly deliver drugs to the inflamed joints, avoiding adverse effects. Current treatments have shown significant progress in slowing disease progression and improving patients' lives, but new medication options are still needed.

NANOSCALE ADVANCES (2022)

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Review Rheumatology

Osteoporosis in 10 years time: a glimpse into the future of osteoporosis

Giovanni Adami et al.

Summary: The number of patients with osteoporosis is projected to increase dramatically in the next decade, leading to a crisis of fractures and increased societal and economic burden. However, there will be novel pharmacological treatment as well as new optimized treatment strategies to address this crisis. Fracture liaison services are likely to be implemented on a large scale globally to prevent additional fractures in high-risk patients. Advances in diagnostic tools and more precise fracture risk assessment tools will improve our ability to detect patients at high risk of fractures. The use of big data and artificial intelligence will aid in the development of precision medicine. This review discusses the future epidemiology, costs, early and accurate diagnosis, fracture risk assessment, and treatment of osteoporosis.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2022)

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Article Engineering, Environmental

Photothermally triggered biomimetic drug delivery of Teriparatide via reduced graphene oxide loaded chitosan hydrogel for osteoporotic bone regeneration

Xiaoting Wang et al.

Summary: The study introduces a novel local delivery system for Teriparatide using photothermal conversion to mimic pulsatile secretion, promoting bone tissue regeneration. The optimal dose and time for the system in enhancing osteogenic activity on bone marrow mesenchymal stem cells derived from ovariectomized rats are evaluated.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Analysis of the bone fracture targeting properties of osteotropic ligands

Jeffery J. Nielsen et al.

Summary: The study aimed to improve bone fracture management by continuously applying bone anabolic agents to the fracture surface. Short oligopeptides of acidic amino acids were found to significantly increase localization of peptide payload to bone fractures, offering a promising strategy for enhancing fracture healing.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Endocrinology & Metabolism

Risks vs. benefits of switching therapy in patients with postmenopausal osteoporosis

Hotaka Ishizu et al.

Summary: Switching therapy is an important strategy in the treatment of postmenopausal osteoporosis. Understanding the characteristics of each drug, including limitations, side effects, compliance, and fracture prevention abilities, is crucial. The order of drug administration is important when switching therapy, and routine monitoring should be continued to ensure effectiveness and safety.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment

Xiao-Yu He et al.

Summary: Osteoporosis is a severe public health concern among the elderly and postmenopausal adults, with related fractures posing a major cause of morbidity and mortality. Emerging technologies for treating osteoporosis, such as mesenchymal stem cells, exosomes, and biomimetic materials, have received increasing research attention and shown significant progress in reconstruction and repair of bones affected by osteoporosis-related fractures.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

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Review Pharmacology & Pharmacy

Liposomes as multifaceted delivery system in the treatment of osteoporosis

Nikita Nirwan et al.

Summary: Liposomes-based bone-targeted delivery of therapeutics shows promise for treating osteoporosis effectively. However, despite extensive in vitro and in vivo research on liposomes, significant progress in their clinical translation has not been achieved. Successful translation from bench to bedside requires interdisciplinary collaboration between preclinical and clinical experts at different stages of liposomes development.

EXPERT OPINION ON DRUG DELIVERY (2021)

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Article Biochemistry & Molecular Biology

Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy

Lorena del Pozo-Acebo et al.

Summary: miRNAs are potential mediators of gene expression in therapeutic strategies, but the instability of extracellular RNAs limits their biological function. Strategies to enhance miRNA therapeutic potential include developing efficient, tissue-specific delivery methods using exosomes. However, a standard, reproducible, and cost-effective protocol for exosome isolation and extracellular RNA delivery is currently lacking.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Medicinal

Targeted nanomedicines for the treatment of bone disease and regeneration

Farideh Ordikhani et al.

Summary: Targeted drug delivery to the bone through passive or active targeting is an attractive treatment option for various bone related diseases, with the potential to increase therapeutic efficacy and minimize side effects. The development of nanocarrier delivery systems offers opportunities for more effective therapies, although further research is necessary to progress towards clinical applications.

MEDICINAL RESEARCH REVIEWS (2021)

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Review Materials Science, Multidisciplinary

Poly(N-isopropylacrylamide)-based smart hydrogels: Design, properties and applications

Lin Tang et al.

Summary: PNIPAM-based smart hydrogels are important smart materials with unique thermo-responsive properties and promising applications. This review summarizes the development, fundamental design, synthetic strategies, and potential applications of these materials in various fields.

PROGRESS IN MATERIALS SCIENCE (2021)

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Article Pharmacology & Pharmacy

Supramolecular assembly of rifampicin and PEGylated PAMAM dendrimer as a novel conjugate for tuberculosis

Rami Ahmed et al.

Summary: The study successfully developed PEGylated G4 PAMAM dendrimers as a suitable drug carrier for rifampicin, with negligible cytotoxicity, high loading potential, and prolonged-release behavior. PEGylated dendrimers exhibited a slower release rate compared to the native/unmodified formulation and free drug, with significantly improved toxicity after PEGylation, and negligible toxicity detected for formulations with 100% functionalization.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Exploration of a transdermal nanoemulgel as an alternative therapy for postmenopausal osteoporosis

Foziyah Zakir et al.

Summary: The study demonstrated the enhanced bioavailability and anti-osteoporotic efficacy of raloxifene hydrochloride (RH) using a transdermal nanoemulgel formulation. The improved pharmacokinetic and pharmacodynamic performance suggest it may serve as a safe and effective alternative to current marketed products.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

Yingxiao Sun et al.

Summary: The study investigated the loading of strontium ranelate onto sulfonated three-dimensional PEEK porous structures, showing enhanced cell adhesion and improved bioactivity of MC3T3-E1 cells.

REGENERATIVE BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Maurice N. Collins et al.

Summary: Bone tissue engineering aims to create biofunctional tissue for treating diseases, with scaffold fabrication techniques and biomaterial selection being crucial. Vascularization and immunomodulation are major challenges in this field.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Pharmacology & Pharmacy

Microneedle array systems for long-acting drug delivery

Lalit K. Vora et al.

Summary: The development of microneedles (MNs) assisted drug delivery technologies has been active for over two decades. Different types of MNs are designed to deliver therapeutic materials directly into the dermal and ocular space for sustained or controlled release of active ingredients. Challenges lie ahead in realizing the full potential of sustained-release long-acting MNs in clinical applications.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Advances of Microneedles in Biomedical Applications

Jie Xu et al.

Summary: This article discusses the applications of microneedles in biomedical areas, including their classification, manufacturing, drug delivery systems, disease diagnoses, wound repair, and cancer therapy. It also delves into the safety and future prospects of microneedles.

MOLECULES (2021)

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Review Pharmacology & Pharmacy

Hollow microneedles: A perspective in biomedical applications

Alvaro Carcamo-Martinez et al.

Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Ji-Bong Choi et al.

Summary: The study involved fabricating a composite hydrogel by incorporating BCP into GelMA, resulting in a material with excellent mechanical properties, high cell viability, and strong bone differentiation ability for bone regeneration. The hydrogel also offers advantages for clinical use due to its customizable structure.

NANOMATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC

Hongying Chen et al.

Summary: A dual targeting nano-biomimetic drug delivery vehicle was designed for efficient treatment of malignancies in jaw bones, showing excellent bone and cancer targeting abilities. The nanoparticles were camouflaged with a hybrid membrane of head and neck squamous cell carcinoma WSU-HN6 cells and red blood cells, modified with oligopeptides of aspartate acid, which resulted in enhanced uptake and effective cancer growth inhibition properties.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Materials Science, Ceramics

3D printing and osteogenesis of loofah-like hydroxyapatite bone scaffolds

Qinghua Chen et al.

Summary: The study successfully reconstructed porous bone scaffolds using hydroxyapatite and natural loofah, with appropriate pore size and ideal porosity, promoting in vivo osteogenesis.

CERAMICS INTERNATIONAL (2021)

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Review Microbiology

Highlighting the use of micro and nanoparticles based-drug delivery systems for the treatment of Helicobacter pylori infections

Mauricio Palmeira Chaves de Souza et al.

Summary: This article emphasizes the use of micro and nanoparticles as important technological tools for the treatment of H. pylori infections, focusing on main nanotechnological systems and microtechnological systems that can improve drug delivery and treatment outcomes.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Review Pharmacology & Pharmacy

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

Sofia Lara-Ochoa et al.

Summary: Hydroxyapatite is the gold standard in the biomedical field due to its composition and similarity to human bone, with properties that can be tailored through different synthesis techniques and compounds. However, the correlation with biological response is still uncertain, necessitating a focus on the most desirable properties for an appropriate biological response.

PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M. Ghezzi et al.

Summary: Polymeric micelles, innovative aggregation colloids formed by self-assembling of amphiphilic polymers in solution, offer advantages in drug administration but also face challenges such as lower stability and complex characterization. Understanding their interaction with the biological environment is crucial, and a combination of different characterization techniques can provide a deeper insight into their in vivo behavior.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biochemistry & Molecular Biology

Osteoblast role in the pathogenesis of rheumatoid arthritis

S. Berardi et al.

Summary: In rheumatic diseases, such as rheumatoid arthritis, the dysregulation of osteoblasts plays a crucial role in bone loss. Resolving inflammation is essential for bone healing, and understanding the mechanisms involved in osteoblast dysfunction could lead to new therapeutic strategies.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Cell Biology

Circ-ITCH sponges miR-214 to promote the osteogenic differentiation in osteoporosis via upregulating YAP1

Da Zhong et al.

Summary: This study elucidated the functional roles and mechanisms of circ-ITCH in regulating osteogenic differentiation in osteoporosis, showing that circ-ITCH upregulates YAP1 expression to promote osteogenic differentiation via sponging miR-214. Circ-ITCH could potentially serve as a novel therapeutic target for osteoporosis.

CELL DEATH & DISEASE (2021)

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Review Materials Science, Biomaterials

Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration

Hui Jin et al.

Summary: Simvastatin-incorporated drug delivery systems show potential in enhancing bone regeneration by inducing osteogenesis and angiogenesis, with various loading methods and materials being explored. Further research is needed to address current shortcomings and define future development directions in this field.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Engineering, Biomedical

Precise in-situ release of microRNA from an injectable hydrogel induces bone regeneration

Minfeng Gan et al.

Summary: The study demonstrates the effective delivery and precise release of cholesterol-modified non-coding microRNA in bone defects using an injectable poly(ethylene glycol) hydrogel, showing significantly improved bone regeneration outcomes.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential

Hadeel Kheraldine et al.

Summary: Traditional drug delivery systems typically use carriers to improve drug efficacy, but recent research has shown that polymeric drug delivery systems may have intrinsic biological actions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Stimulus-responsive liposomes for biomedical applications

Antonia Antoniou et al.

Summary: Liposomes are lipidic supramolecular aggregates with the ability to encapsulate and carry molecules of various natures, making them ideal for drug delivery systems. Recent advancements in chemical modifications have led to the development of smart liposome-based drug delivery systems with tunable features and disease-directed capabilities.

DRUG DISCOVERY TODAY (2021)

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Review Biochemistry & Molecular Biology

Targeting Drug Delivery in the Elderly: Are Nanoparticles an Option for Treating Osteoporosis?

Gudrun C. Thurner et al.

Summary: Nanoparticles with specific targeting groups have the potential to accumulate at specific lesion sites and release therapeutic agents, but face challenges in crossing blood-tissue barriers in living organisms. However, if their targets are directly accessible from the blood, nanoparticles can avoid these barriers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Facilitated and Controlled Strontium Ranelate Delivery Using GCS-HA Nanocarriers Embedded into PEGDA Coupled with Decortication Driven Spinal Regeneration

Chih-Wei Chiang et al.

Summary: The study aimed to develop an effective SrR carrier system for spinal bone regeneration, with in vitro and in vivo studies confirming its biocompatibility and therapeutic efficacy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Cell Biology

Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway

Jianye Yang et al.

Summary: Astragalus polysaccharide (APS) has demonstrated the ability to inhibit osteoclast formation and differentiation, regulate inflammatory osteolysis, and potentially become an effective treatment for disorders associated with osteoclasts.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats

Yuanyuan Guo et al.

Summary: This study developed a drug delivery system using PLGA nanoparticles to co-load E-2 and Fe3O4, modified with AL for bone targeting and magnetically controlled drug release. The NPs showed good stability, biocompatibility, encapsulation ability of E-2, and magnetic properties. The NPs effectively ameliorated OVX-induced bone loss and had less side effects on non-skeletal tissues.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

T-Cell Mediated Inflammation in Postmenopausal Osteoporosis

Di Wu et al.

Summary: Osteoporosis, a common metabolic bone disease, particularly affects middle-aged and elderly women. Menopause is a leading cause of primary osteoporosis in women, and there is a growing recognition of the role of the adaptive immune system in the development of postmenopausal osteoporosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics

Kai K. Ewert et al.

Summary: Cationic liposomes have been explored as effective carriers for various therapeutics, particularly nucleic acids, with recent milestones in the approval of siRNA therapeutic patisiran and mRNA vaccines against COVID-19. Understanding the structure of these carriers and their interactions with cell membranes is crucial for optimizing their use in medical applications, including targeted delivery of nucleic acids in vivo.

PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Injectable Hydrogel with NIR Light-Responsive, Dual-Mode PTH Release for Osteoregeneration in Osteoporosis

Lijun Kuang et al.

Summary: A study has developed an injectable multifunctional hydrogel for bone repair that releases PTH to achieve bone regeneration. The platform has shown to enhance both osteoblast and osteoclast activity, successfully repairing bone defects in experimental models.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Proceedings Paper Materials Science, Multidisciplinary

A historical perspective of liposomes-a bio nanomaterial

Vikash Kumar Sharma et al.

Summary: Liposomes, as a bio nanomaterial, are known as drug delivery agents due to their unique properties. They encapsulate an aqueous solution in a hydrophobic membrane, enabling the solubilization of both hydrophilic and hydrophobic molecules, and are used as artificial cell models.

MATERIALS TODAY-PROCEEDINGS (2021)

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Article Materials Science, Biomaterials

An oligopeptide/aptamer-conjugated dendrimer-based nanocarrier for dual-targeting delivery to bone

Mingxing Ren et al.

Summary: A new dual-targeting nanocarrier, CH6-PAMAM-C11, was synthesized by covalently modifying G4.0 PAMAM dendrimer with C11 peptide and CH6 aptamer, showing successful accumulation in bone cells, mineralized areas, and tissues. Both in vitro and in vivo experiments confirmed the efficient bone targeting ability of CH6-PAMAM-C11, suggesting potential for drug delivery to bone tissues for osteoporosis treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration

Hongjie Zhang et al.

Summary: A multifunctional hydrogel with injectability, adhesivity and osteogenic activity was successfully prepared for bone regeneration by grafting dopamine to alginate and incorporating strontium ions. This simple hydrogel, constructed with a binary component, is expected to be used as a scaffold for bone tissue engineering in clinical applications, as it achieved necessary functions and showed promising results in animal experiments.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Multidisciplinary

An overview of polymeric nanomicelles in clinical trials and on the market

Xue Zheng et al.

Summary: Polymeric nanomedicine, especially polymeric micelles (PM) with nanoscale size, shows promising physical and biological advantages such as excellent solubility, pharmacokinetics, efficacy, and lower toxicity. PM has garnered increasing interest in research and clinical applications, with good clinical outcomes but also facing challenges.

CHINESE CHEMICAL LETTERS (2021)

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Article Engineering, Biomedical

Construction of multilayered molecular reservoirs on a titanium alloy implant for combinational drug delivery to promote osseointegration in osteoporotic conditions

Maohua Chen et al.

ACTA BIOMATERIALIA (2020)

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Article Nanoscience & Nanotechnology

Bone targeted delivery of salmon calcitonin hydroxyapatite nanoparticles for sublingual osteoporosis therapy (SLOT)

Darsheen J. Kotak et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Review Pharmacology & Pharmacy

Recent advances in bone-targeted therapy

Chen Shi et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Pharmacology & Pharmacy

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

D. J. Brayden et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Cell & Tissue Engineering

Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice

Zebing Hu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Endocrinology & Metabolism

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS—2020 UPDATE

Pauline M. Camacho et al.

Endocrine Practice (2020)

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Article Pharmacology & Pharmacy

Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate

Angelica Villanueva-Martinez et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Spray-dried raloxifene submicron particles for pulmonary delivery: Development and in vivo pharmacokinetic evaluation in rats

Marcia Camponogara Fontana et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Biotechnology & Applied Microbiology

Design and development of a commercially viable in situ nanoemulgel for the treatment of postmenopausal osteoporosis

Foziyah Zakir et al.

NANOMEDICINE (2020)

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Article Materials Science, Multidisciplinary

Thermal characterization of hydroxyapatite or carbonated hydroxyapatite hybrid composites with distinguished collagens for bone graft

Monica Rufino Senra et al.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2020)

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Review Pharmacology & Pharmacy

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Antonio Jose Guillot et al.

PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Enhanced osteogenesis and therapy of osteoporosis using simvastatin loaded hybrid system

Tao Wu et al.

BIOACTIVE MATERIALS (2020)

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Article Medicine, Research & Experimental

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules

Akmal Sabri et al.

MOLECULAR PHARMACEUTICS (2020)

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Review Pharmacology & Pharmacy

Current trends in polymer microneedle for transdermal drug delivery

Khater Ahmed Saeed AL-Japairai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Engineering, Chemical

Comparison of surfactants at solubilizing, forming and stabilizing nanoemulsion of hesperidin

Yanmei Liao et al.

JOURNAL OF FOOD ENGINEERING (2020)

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Review Biochemistry & Molecular Biology

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Aleksandra Zielinska et al.

MOLECULES (2020)

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Review Biochemistry & Molecular Biology

Applications and Limitations of Dendrimers in Biomedicine

Adriana Aurelia Chis et al.

MOLECULES (2020)

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Review Endocrinology & Metabolism

Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders

Kazuki Sawamoto et al.

CURRENT OSTEOPOROSIS REPORTS (2020)

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Review Pharmacology & Pharmacy

Transdermal delivery of peptide and protein drugs: Strategies, advantages and disadvantages

Lin-yu Long et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Chemistry, Physical

Sustainable technologies for liposome preparation

Maja Leitgeb et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2020)

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Review Biology

The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

Yang Yang et al.

BIOLOGICAL RESEARCH (2020)

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Article Materials Science, Biomaterials

Biodegradable nano-organosilica gene carrier for high-efficiency gene transfection

Kun Zeng et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Multidisciplinary Sciences

Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model

Enas A. Fouad-Elhady et al.

HELIYON (2020)

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Review Pharmacology & Pharmacy

Adapting liposomes for oral drug delivery

Haisheng He et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Review Cell Biology

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Youqiang Sun et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence

Kok-Yong Chin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pharmacology & Pharmacy

Enhancement of oral bioavailability of salmon calcitonin through chitosan-modified, dual drug-loaded nanoparticles

Lin Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Biochemistry & Molecular Biology

Medical Treatment for Osteoporosis: From Molecular to Clinical Opinions

Li-Ru Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pharmacology & Pharmacy

Novel chitosan based nanoparticles as gene delivery systems to cancerous and noncancerous cells

Soheila Rahmani et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Nanoscience & Nanotechnology

Targeted siRNA delivery using aptamer-siRNA chimeras and aptamer-conjugated nanoparticles

Padmanaban Sivakumar et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

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Review Pharmacology & Pharmacy

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Ana Claudia Lima et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Chemistry, Applied

Improved treatment efficacy of risedronate functionalized chitosan nanoparticles in osteoporosis: formulation development, in vivo, and molecular modelling studies

Shivalingappa Santhosh et al.

JOURNAL OF MICROENCAPSULATION (2019)

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Review Pharmacology & Pharmacy

Drug Delivery Based on Nanotechnology for Target Bone Disease

Xiaosong Yang et al.

CURRENT DRUG DELIVERY (2019)

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Review Medicine, General & Internal

Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly

Rossella Cannarella et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Materials Science, Biomaterials

Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies

Sanjay Sharma et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Review Medicine, Research & Experimental

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Tejashree Waghule et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Pharmacology & Pharmacy

Pharmacology of bisphosphonates

Serge Cremers et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

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Article Materials Science, Biomaterials

(Trans) dermal insulin delivery based on polymeric systems

Shiva Darvishha et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Review Cell Biology

Prospect of mesenchymal stem cells in therapy of osteoporosis: A review

Leili Aghebati-Maleki et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Physiology

THE ACTIVITY OF PEPTIDES OF THE CALCITONIN FAMILY IN BONE

Dorit Naot et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Biotechnology & Applied Microbiology

Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis

Xiaoduan Sun et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration

Zhong-Wei Luo et al.

NANOSCALE (2019)

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Review Dentistry, Oral Surgery & Medicine

Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ)

Hiromitsu Kishimoto et al.

JAPANESE DENTAL SCIENCE REVIEW (2019)

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Article Biophysics

Migration critically meditates osteoblastic differentiation of bone mesenchymal stem cells through activating canonical Wnt signal pathway

Jing He et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Review Biochemistry & Molecular Biology

Microneedles: A versatile strategy for transdermal delivery of biological molecules

Dong-Jin Lim et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Editorial Material Medicine, General & Internal

Treatment of Osteoporosis

Kamala Gullapalli Cotts et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Review Chemistry, Multidisciplinary

Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses

Pedro Lavrador et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Pharmacology & Pharmacy

Modulation of transdermal drug delivery with coated microneedles

Kevin Ita

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

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Review Immunology

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

Ander Abarrategi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Surgery

Effect of the vascularized bone components on the survival of vascularized composite allografts

Jianwu Chen et al.

JOURNAL OF SURGICAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Exendin-4-encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

Shayan Fakhraei Lahiji et al.

SCIENTIFIC REPORTS (2018)

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Article Polymer Science

Antibacterial Capability, Physicochemical Properties, and Biocompatibility of nTiO2 Incorporated Polymeric Scaffolds

Cijun Shuai et al.

POLYMERS (2018)

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Article Pharmacology & Pharmacy

Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles

Zhenyang Mao et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Instruments & Instrumentation

Individually coated microneedles for co-delivery of multiple compounds with different properties

Song Li et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Article Instruments & Instrumentation

Bone-targeted delivery of simvastatin-loaded PEG-PLGA micelles conjugated with tetracycline for osteoporosis treatment

Yonghui Xie et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Article Cell Biology

Syringic acid, a phenolic acid, promotes osteoblast differentiation by stimulation of Runx2 expression and targeting of Smad7 by miR-21 in mouse mesenchymal stem cells

B. Arumugam et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

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Review Medical Laboratory Technology

The bone remodelling cycle

J. S. Kenkre et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2018)

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Review Chemistry, Physical

Strategies to improve micelle stability for drug delivery

Yang Lu et al.

NANO RESEARCH (2018)

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Article Pharmacology & Pharmacy

Self-Dissolving Microneedle Arrays for Transdermal Absorption Enhancement of Human Parathyroid Hormone (1-34)

Chihiro Naito et al.

PHARMACEUTICS (2018)

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Article Biotechnology & Applied Microbiology

Polyurethane/hydroxypropyl cellulose electrospun nanofiber mats as potential transdermal drug delivery system: characterization studies and in vitro assays

A. Gencturk et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Development of Bone Targeting Drugs

Molly Stapleton et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Nanoscience & Nanotechnology

A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy

Mingxiang Cai et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Chemistry, Multidisciplinary

Microneedle, bio-microneedle and bio-inspired microneedle: A review

Guojun Ma et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Chemistry, Multidisciplinary

Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases

Shugo Yamashita et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Materials Science, Biomaterials

Scaffolds for Bone Tissue Engineering: State of the art and new perspectives

Livia Roseti et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Medicine, General & Internal

Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone A Controlled Clinical Trial

Peter J. Snyder et al.

JAMA INTERNAL MEDICINE (2017)

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Review Endocrinology & Metabolism

Aging, Osteocytes, and Mechanotransduction

Haniyeh Hemmatian et al.

CURRENT OSTEOPOROSIS REPORTS (2017)

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Article Pharmacology & Pharmacy

Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

Hidemasa Katsumi et al.

PHARMACEUTICS (2017)

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Article Pharmacology & Pharmacy

Atorvastatin-loaded micelles with bone-targeted ligand for the treatment of osteoporosis

Yonghui Xie et al.

DRUG DELIVERY (2017)

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Review Rheumatology

An overview and management of osteoporosis

Tumay Sozen et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2017)

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Article Pharmacology & Pharmacy

Biodegradable intranasal nanoparticulate drug delivery system of risedronate sodium for osteoporosis

Mohammad Fazil et al.

DRUG DELIVERY (2016)

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Article Chemistry, Multidisciplinary

Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery

Yao Sun et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Effective delivery of bone morphogenetic protein 2 gene using chitosan-polyethylenimine nanoparticle to promote bone formation

Liang Zhao et al.

RSC ADVANCES (2016)

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Article Pharmacology & Pharmacy

Pharmacokinetics of Oral Recombinant Human Parathyroid Hormone [rhPTH(1-31)NH2] in Postmenopausal Women with Osteoporosis

Amy Sturmer et al.

CLINICAL PHARMACOKINETICS (2013)

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Article Chemistry, Multidisciplinary

Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats

K. Gradauer et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Endocrinology & Metabolism

Androgen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes

Kristine M. Wiren et al.

BONE (2012)

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Article Pharmacology & Pharmacy

Delivery of salmon calcitonin using a microneedle patch

Cetin Tas et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Chemistry, Medicinal

In vivo iontophoretic delivery of salmon calcitonin across microporated skin

Viswatej Vemulapalli et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Article Chemistry, Medicinal

Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate: Evaluation of transdermal absorption, safety, and pharmacological effects after application in rats

Hidemasa Katsumi et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Article Chemistry, Multidisciplinary

Prevention of Orthopedic Device-Associated Osteomyelitis Using Oxacillin-Containing Biomineral-Binding Liposomes

Xin-Ming Liu et al.

PHARMACEUTICAL RESEARCH (2012)

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Article Pharmacology & Pharmacy

Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo

Liting Guo et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Review Endocrinology & Metabolism

The Amazing Osteocyte

Lynda F. Bonewald

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

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Article Chemistry, Multidisciplinary

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