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Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
Rafael de la Torre et al.
LANCET NEUROLOGY (2016)
Emerging Phytochemicals for the Prevention and Treatment of Head and Neck Cancer
Santosh K. Katiyar
MOLECULES (2016)
Effects of ω-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial
Zhenzhen Zhang et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)
Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial
Christine Chiaverini et al.
ORPHANET JOURNAL OF RARE DISEASES (2016)
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
Malgorzata Nita et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin
Yoo Seob Shin et al.
PHYTOMEDICINE (2016)
Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications
Xiaojun Tan et al.
TRENDS IN CELL BIOLOGY (2016)
Targeting WEE1 Kinase in Cancer
Christopher J. Matheson et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Oxidative stress signaling to chromatin in health and disease
Sarah Kreuz et al.
EPIGENOMICS (2016)
Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins
Nagi B. Kumar et al.
ONCOTARGET (2016)
Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy
Lisa Y. Pang et al.
STEM CELLS INTERNATIONAL (2016)
Regulation of Transforming Growth Factor β-Activated Kinase 1 Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6
Anil K. Singh et al.
ARTHRITIS & RHEUMATOLOGY (2016)
Endogenous mechanisms of reactive oxygen species (ROS) generation
Agata Sarniak et al.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2016)
Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial
Anja Maehler et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)
Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention
Nagi B. Kumar et al.
CANCER PREVENTION RESEARCH (2015)
Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus
Andrew K. Joe et al.
CANCER PREVENTION RESEARCH (2015)
Tea and Its Consumption: Benefits and Risks
Khizar Hayat et al.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)
Tea consumption and the incidence of cancer: a systematic review and meta-analysis of prospective observational studies
Yu-Fei Zhang et al.
EUROPEAN JOURNAL OF CANCER PREVENTION (2015)
(-)-Epigallocatechin-3-Gallate Inhibits Osteosarcoma Cell Invasiveness by Inhibiting the MEK/ERK Signaling Pathway in Human Osteosarcoma Cells
Guoqing Tang et al.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2015)
Effects of different brewing conditions on catechin content and sensory acceptance in Turkish green tea infusions
Sena Saklar et al.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2015)
Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma
Rituparna Bhattacharjee et al.
JOURNAL OF MOLECULAR MODELING (2015)
Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies
Jesus Lovera et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs
Shuntaro Tsukamoto et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2-mediated glycolysis
Feng Gao et al.
ONCOLOGY REPORTS (2015)
(-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells
Munawwar Ali Khan et al.
ONCOLOGY REPORTS (2015)
A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer
Hanxi Zhao et al.
RADIOTHERAPY AND ONCOLOGY (2015)
Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome
Samuel Legeay et al.
NUTRIENTS (2015)
Targeting AMPK for cancer prevention and treatment
Weidong Li et al.
ONCOTARGET (2015)
Epigenetic Induction of Tissue Inhibitor of Matrix Metalloproteinase-3 by Green Tea Polyphenols in Breast Cancer Cells
Gauri Deb et al.
MOLECULAR CARCINOGENESIS (2015)
Investigate the Binding of Catechins to Trypsin Using Docking and Molecular Dynamics Simulation
Fengchao Cui et al.
PLOS ONE (2015)
Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans
Nenad Naumovski et al.
ANTIOXIDANTS (2015)
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
Daniela De Stefano et al.
AUTOPHAGY (2014)
Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial
Juan Mielgo-Ayuso et al.
BRITISH JOURNAL OF NUTRITION (2014)
Green Tea Polyphenol Epigallocatechin-3-Gallate Inhibits TNF-α-Induced Production of Monocyte Chemoattractant Protein-1 in Human Umbilical Vein Endothelial Cells
Ze-Mu Wang et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
ROS Function in Redox Signaling and Oxidative Stress
Michael Schieber et al.
CURRENT BIOLOGY (2014)
Lipase-catalyzed synthesis of acetylated EGCG and antioxidant properties of the acetylated derivatives
Song Zhu et al.
FOOD RESEARCH INTERNATIONAL (2014)
Fabrication of Self-Assembled (-)-Epigallocatechin Gal late (EGCG) Ovalbumin-Dextran Conjugate Nanoparticies and Their Transport across Mono layers of Human Intestinal Epithelial Caco-2 Cells
Zheng Li et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)
Characterization and Bioavailability of Tea Polyphenol Nanoliposome Prepared by Combining an Ethanol Injection Method with Dynamic High-Pressure Microfluidization
Li-qiang Zou et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)
67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance
Shuntaro Tsukamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
Rafael De la Torre et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2014)
Natural product and natural product derived drugs in clinical trials
Mark S. Butler et al.
NATURAL PRODUCT REPORTS (2014)
Therapeutic modulation of Notch signalling - are we there yet?
Emma R. Andersson et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Protein kinase C and cancer: what we know and what we do not
R. Garg et al.
ONCOGENE (2014)
Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway
Laddawan Senggunprai et al.
PHYTOTHERAPY RESEARCH (2014)
The ErbB/HER family of protein-tyrosine kinases and cancer
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2014)
A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer
Hanxi Zhao et al.
RADIOTHERAPY AND ONCOLOGY (2014)
Evaluating Medicinal Plants for Anticancer Activity
Elisha Solowey et al.
TheScientificWorldJOURNAL (2014)
Receptor Tyrosine Kinases: Legacy of the First Two Decades
Joseph Schlessinger
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases
Mark A. Lemmon et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Fabrication of coated bovine serum albumin (BSA)-epigallocatechin gallate (EGCG) nanoparticles and their transport across monolayers of human intestinal epithelial Caco-2 cells
Zheng Li et al.
FOOD & FUNCTION (2014)
NF-κB, an Active Player in Human Cancers
Yifeng Xia et al.
CANCER IMMUNOLOGY RESEARCH (2014)
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
Hae-Suk Kim et al.
REDOX BIOLOGY (2014)
Targeting PI3K/Akt/mTOR signaling in cancer
Camillo Porta et al.
FRONTIERS IN ONCOLOGY (2014)
The Effect of Three Weeks Green Tea Extract Consumption on Blood Pressure, Heart Rate Responses to a Single Bout Resistance Exercise in Hypertensive Women
Hamid Arazi et al.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2014)
Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins
Jae-Hwan Chung et al.
INTEGRATIVE MEDICINE RESEARCH (2014)
PI3K/AKT/mTOR Signaling is Involved in (-)-Epigallocatechin-3-Gallate-Induced Apoptosis of Human Pancreatic Carcinoma Cells
Shi Liu et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2013)
Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis
Yuhi Sakamoto et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2013)
Bioavailability of bioactive food compounds: a challenging journey to bioefficacy
Maarit J. Rein et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)
Tea and Health: Studies in Humans
Naghma Khan et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
D. Grahame Hardie
DIABETES (2013)
Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis
R. J. Widmer et al.
EUROPEAN JOURNAL OF NUTRITION (2013)
A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer
Dominique Trudel et al.
GYNECOLOGIC ONCOLOGY (2013)
Epigallocatechin-3-Gallate (EGCG) Inhibits Cell Proliferation and Migratory Behaviour of Triple Negative Breast Cancer Cells
Cornelia Braicu et al.
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2013)
Epigallocatechin gallate attenuates interstitial cystitis in human bladder urothelium cells by modulating purinergic receptors
Min Liu et al.
JOURNAL OF SURGICAL RESEARCH (2013)
EGCG-rich green tea extract stimulates sRAGE secretion to inhibit S100A12-RAGE axis through ADAM10-mediated ectodomain shedding of extracellular RAGE in type 2 diabetes
Shang-Ming Huang et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2013)
Green Tea Consumption and Risk of Esophageal Cancer: A Meta-Analysis of Published Epidemiological Studies
Li-Xuan Sang et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2013)
Mechanism of the inhibition of the STAT3 signaling pathway by EGCG
Yang Wang et al.
ONCOLOGY REPORTS (2013)
Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry
Hui Chen et al.
TALANTA (2013)
Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling
Heiying Jin et al.
ONCOTARGETS AND THERAPY (2013)
The effects of bathing in hot springs on the absorption of green tea catechin: A pilot study
Shinya Hayasaka et al.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2013)
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas et al.
NATURE REVIEWS CANCER (2013)
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
Antero Salminen et al.
AGEING RESEARCH REVIEWS (2012)
Green tea consumption and risk of esophageal cancer: a meta-analysis of epidemiologic studies
Ping Zheng et al.
BMC GASTROENTEROLOGY (2012)
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Jean Cadet et al.
CANCER LETTERS (2012)
Epigenetic modifications in cancer
R. Kanwal et al.
CLINICAL GENETICS (2012)
Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy
Libero Santarpia et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2012)
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling
Kristy J. Wilson et al.
GROWTH FACTORS (2012)
Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
Su-Ni Tang et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation
Seung Bin Park et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)
Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression
Jie Qin et al.
MOLECULAR MEDICINE REPORTS (2012)
Histone deacetylases and cancer
Bruna Barneda-Zahonero et al.
MOLECULAR ONCOLOGY (2012)
EGCG Enhances the Therapeutic Potential of Gemcitabine and CP690550 by Inhibiting STAT3 Signaling Pathway in Human Pancreatic Cancer
Su-Ni Tang et al.
PLOS ONE (2012)
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo
Piwen Wang et al.
FOOD & FUNCTION (2012)
Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea
Guang-Jian Du et al.
NUTRIENTS (2012)
Retinoids, Retinoic Acid Receptors, and Cancer
Xiao-Han Tang et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
Glenn S. Van Aller et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles
Dar-Shih Hsieh et al.
BIOMATERIALS (2011)
(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells
Vijayalakshmi Nandakumar et al.
CARCINOGENESIS (2011)
Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α
Hong Wang et al.
CARCINOGENESIS (2011)
Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process
Triparna Sen et al.
EUROPEAN JOURNAL OF NUTRITION (2011)
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Chrisostomi Gialeli et al.
FEBS JOURNAL (2011)
Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?
Derliz Mereles et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)
Elastic liposomes as carriers for oral delivery and the brain distribution of (+)-catechin
Yaw-Bin Huang et al.
JOURNAL OF DRUG TARGETING (2011)
Measurement of oxidatively generated base damage in cellular DNA
Jean Cadet et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
Tea Polyphenols Induce Apoptosis Through Mitochondrial Pathway and by Inhibiting Nuclear Factor-kappa B and Akt Activation in Human Cervical Cancer Cells
Madhulika Singh et al.
ONCOLOGY RESEARCH (2011)
Tea and cancer prevention: Epidemiological studies
Jian-Min Yuan et al.
PHARMACOLOGICAL RESEARCH (2011)
Green Tea Polyphenols and Metabolites in Prostatectomy Tissue: Implications for Cancer Prevention
Piwen Wang et al.
CANCER PREVENTION RESEARCH (2010)
Cell Signaling by Receptor Tyrosine Kinases
Mark A. Lemmon et al.
CELL (2010)
Successful Applications of Computer Aided Drug Discovery: Moving Drugs from Concept to the Clinic
Tanaji T. Talele et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
Alexander Schultze et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice
Joshua D. Lambert et al.
FOOD AND CHEMICAL TOXICOLOGY (2010)
Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea
Catrina M. Peters et al.
FOOD RESEARCH INTERNATIONAL (2010)
Oxidatively generated base damage to cellular DNA
Jean Cadet et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Green Tea Compound in Chemoprevention of Cervical Cancer
Changping Zou et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2010)
Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of γ-Interferon-Induced JAK-PKC-δ-STAT1 Signaling in Human Oral Cancer Cells
Chieh-Wen Cheng et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
Michael D. Schaller
JOURNAL OF CELL SCIENCE (2010)
(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma
Ting Luo et al.
BREAST CANCER RESEARCH (2010)
Apoptosis Induction Effects of EGCG in Laryngeal Squamous Cell Carcinoma Cells through Telomerase Repression
Xi Wang et al.
ARCHIVES OF PHARMACAL RESEARCH (2009)
Induction of apoptosis in human bladder cancer cells by green tea catechins
Brian J. Philips et al.
BIOMEDICAL RESEARCH-TOKYO (2009)
Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro
Jerry McLarty et al.
CANCER PREVENTION RESEARCH (2009)
Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation
Kyung-Chul Choi et al.
CANCER RESEARCH (2009)
Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia
Reo Iwasaki et al.
CANCER SCIENCE (2009)
Preparation and Antioxidant Activity of Green Tea Extract Enriched in Epigallocatechin (EGC) and Epigallocatechin Gallate (EGCG)
Jianhui Hu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)
Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response
Jiao Wang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Green tea catechins in chemoprevention of cancer: A molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1)
Roberto Artali et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2009)
Electrospun Zein Fibers as Carriers to Stabilize (-)-Epigallocatechin Gallate
Y. Li et al.
JOURNAL OF FOOD SCIENCE (2009)
Review: Green Tea Polyphenols in Chemoprevention of Prostate Cancer: Preclinical and Clinical Studies
Naghma Khan et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)
Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs
I. M. Kapetanovic et al.
TOXICOLOGY (2009)
Involvement of Members of the Cadherin Superfamily in Cancer
Geert Berx et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Tumor necrosis factor and cancer, buddies or foes?
Xia Wang et al.
ACTA PHARMACOLOGICA SINICA (2008)
Hedgehog Signaling in Development and Cancer
Jin Jiang et al.
DEVELOPMENTAL CELL (2008)
Chemoprevention of human prostate cancer by Green Tea Catechins: Two years later. A follow-up update
Maurizio Brausi et al.
EUROPEAN UROLOGY (2008)
Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor
Xin Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase
Jung-Hyun Shim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation
Zhiwei He et al.
MOLECULAR CARCINOGENESIS (2008)
Green tea Polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor
Daisuke Umeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells
Rajesh L. Thangapazham et al.
CANCER BIOLOGY & THERAPY (2007)
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
Heinz G. Linhart et al.
GENES & DEVELOPMENT (2007)
Tea and cancer prevention: Molecular mechanisms and human relevance
Chung S. Yang et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)
Biotransformation of green tea polyphenols and the biological activities of those metabolites
Joshua D. Lambert et al.
MOLECULAR PHARMACEUTICS (2007)
Epigallocatechin-3-gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: Mechanisms of action
Curt E. Harper et al.
PROSTATE (2007)
A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
Jie Qin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
Stefania Gobessi et al.
BLOOD (2007)
Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo
Vaqar Mustafa Adhami et al.
CLINICAL CANCER RESEARCH (2007)
(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis
Bao-He Zhu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2007)
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours
Darci T. Butcher et al.
EUROPEAN JOURNAL OF CANCER (2007)
Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappa B in HMC-1 cells
Hye-Young Shin et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2007)
Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives
Dale G. Nagle et al.
PHYTOCHEMISTRY (2006)
Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells
Xinhan Zhao et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2006)
Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
Susanne M. Henning et al.
JOURNAL OF NUTRITION (2006)
Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer
Frank A. Sinicrope
MOLECULAR CARCINOGENESIS (2006)
A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins
T. Nishikawa et al.
JOURNAL OF HEPATOLOGY (2006)
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
Dun-Fa Peng et al.
CARCINOGENESIS (2006)
Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis
G Peng et al.
MOLECULAR CARCINOGENESIS (2006)
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity
R. A. Isbrucker et al.
FOOD AND CHEMICAL TOXICOLOGY (2006)
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies
R. A. Isbrucker et al.
FOOD AND CHEMICAL TOXICOLOGY (2006)
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: Teratogenicity and reproductive toxicity studies in rats
R. A. Isbrucker et al.
FOOD AND CHEMICAL TOXICOLOGY (2006)
Effect of liposome encapsulation of tea catechins on their accumulation in basal cell carcinomas
Jia-You Fang et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2006)
TNF-α in cancer treatment:: Molecular insights, antitumor effects, and clinical utility
Remco van Horssen et al.
ONCOLOGIST (2006)
Oncogenic rearrangements of the NTRK1/NGF receptor
MA Pierotti et al.
CANCER LETTERS (2006)
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study
S Bettuzzi et al.
CANCER RESEARCH (2006)
TNF-alpha in promotion and progression of cancer
Frances Balkwill
CANCER AND METASTASIS REVIEWS (2006)
Notch signalling: a simple pathway becomes complex
Sarah J. Bray
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway
BT Wu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways
PF Hung et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
(-)-epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells
M Shimizu et al.
CLINICAL CANCER RESEARCH (2005)
Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells
T Hussain et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
PI3K/Akt/mTOR pathway as a target for cancer therapy
D Morgensztern et al.
ANTI-CANCER DRUGS (2005)
A receptor for green tea polyphenol EGCG
H Tachibana et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
The role of COX-2 inhibition in breast cancer treatment and prevention
B Arun et al.
SEMINARS IN ONCOLOGY (2004)
Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway - Evidence for direct inhibition of ERK1/2 and AKT kinases
JF Sah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design
DM Smith et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
Oxygen, reactive oxygen species and tissue damage
CM Bergamini et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Role of cyclooxygenase-2 in colorectal cancer
FA Sinicrope et al.
CANCER AND METASTASIS REVIEWS (2004)
Hedgehog signalling in cancer formation and maintenance
MP di Magliano et al.
NATURE REVIEWS CANCER (2003)
Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites
J Hong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
Y Saito et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists
R Deana et al.
THROMBOSIS AND HAEMOSTASIS (2003)
A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G1 arrest, and regulation of gene expression
WS Ahn et al.
DNA AND CELL BIOLOGY (2003)
Cancer chemopreventive activity and bioavailability of tea and tea polyphenols
JD Lambert et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
KM Ferguson et al.
MOLECULAR CELL (2003)
Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes
S Ahmed et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
COX-2 inhibitors in cancer treatment and prevention, a recent development
XC Xu
ANTI-CANCER DRUGS (2002)
Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
J Jodoin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2002)
Mammalian MAP kinase signalling cascades
LF Chang et al.
NATURE (2001)
Untangling the ErbB signalling network
Y Yarden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice
JD Liu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages
C Lakenbrink et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
Expression of the 37-kDa laminin binding protein in murine lung tumor cell correlates with tumor angiogenesis
M Tanaka et al.
CANCER LETTERS (2000)