Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Review Biochemistry & Molecular Biology

Therapeutic Effects of Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

Daniela Mokra et al.

Summary: （

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Nutrition & Dietetics

Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women

Hiba Siblini et al.

Summary: This is an abstract of preliminary results from a clinical study on the use of EGCG for treating unexplained infertility associated with uterine fibroids. The study found that a daily dose of 800 mg of EGCG alone or in combination with clomiphene citrate or letrozole (for 5 days) is well-tolerated and not associated with liver toxicity or folate deficiency in reproductive-aged women.

NUTRIENTS (2023)

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Review Cell Biology

PD-1/PD-L1 and DNA Damage Response in Cancer

Mateusz Kciuk et al.

Summary: The application of immunotherapy for cancer treatment is expanding rapidly. Combining immunotherapeutic agents with different treatments can enhance the clinical response in patients who have developed resistance to monotherapy. Chemotherapeutic drugs that induce DNA damage often increase the expression of PD-L1, which can be used by cancer cells to evade immune surveillance. Targeting PD-L1 on cancer cells can restore the immune-reactive tumor microenvironment, making the tumor more susceptible to combined therapies. This review discusses the recent advances in understanding how DDR regulates PD-L1 expression and the impact of certain chemotherapeutic drugs on the anti-tumor immune response.

CELLS (2023)

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Article Biochemistry & Molecular Biology

EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway

Hua Wei et al.

Summary: EGCG, as an effective chemotherapeutic agent for tongue cancer, targets the Notch pathway to induce cell apoptosis and inhibit cell proliferation, thereby prolonging the lifespan of mice.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Article Biology

The Invasive Potential of Hepatoma Cells Induced by Radiotherapy is Related to the Activation of Hepatic Stellate Cells and Could be Inhibited by EGCG Through the TLR4 Signaling Pathway

Xiaoyun Shen et al.

Summary: Post-radiotherapy recurrence and metastasis of liver cancer are closely related to the increased metastatic potential of residual cancer cells mediated by radiotherapy. Changes in the liver microenvironment after radiotherapy promote the metastatic potential of hepatocellular carcinoma. Activated hepatic stellate cells (HSCs) are involved in regulating the metastatic capacity of residual cancer cells after radiotherapy. Inhibition of HSC activation can reduce liver cancer cell metastasis.

RADIATION RESEARCH (2022)

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Review Oncology

Natural-Derived Molecules as a Potential Adjuvant in Chemotherapy: Normal Cell Protectors and Cancer Cell Sensitizers

Rajib Hossain et al.

Summary: The study aimed to reduce the oxidative stress of chemotherapeutic agents in cancer and normal cells by naturally derived compounds with anti-cancer properties, and to protect normal cells from the oxidation process.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)

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Review Food Science & Technology

Chemico-biological aspects of (-)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects

Revathy Sahadevan et al.

Summary: This review comprehensively covers the development of novel techniques to improve the bioavailability of EGCG, including structural modifications, nano-carriers as efficient drug delivery systems, and synergistic studies with other bioactivities.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Article Public, Environmental & Occupational Health

Coffee and tea consumption and mortality from all causes, cardiovascular disease and cancer: a pooled analysis of prospective studies from the Asia Cohort Consortium

Sangah Shin et al.

Summary: This study examines the association between coffee and tea consumption and mortality in Asian populations. The results suggest that both coffee and green tea consumption are associated with lower risks of death from all causes and cardiovascular disease. Coffee consumption is also associated with lower risks of death from cancer.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies

Asifa Khan et al.

Summary: The study identifies two natural compounds, EGCG and quercitrin, as potential therapeutic targets for anti-cancer therapy against HK2 through virtual screening and molecular dynamics simulations.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Chemistry, Applied

Epigallocatechin 3-gallate: From green tea to cancer therapeutics

Manzar Alam et al.

Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.

FOOD CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review

Elena Ferrari et al.

Summary: This review presents evidence of autophagy modulation and anti-cancer effects induced by epigallocatechin gallate (EGCG) treatment in experimental cancer models. The study found that EGCG promotes cytotoxic autophagy through the inactivation of the PI3K/Akt/mTOR pathway, leading to apoptosis induction. Furthermore, EGCG inhibits drug-induced pro-survival autophagy and is considered a valuable agent in cancer chemoprevention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Bilal Rah et al.

Summary: The JAK/STAT signaling pathway plays an important role in regulating cellular processes such as immune regulation, cell proliferation, survival, apoptosis, and hematopoiesis. Dysregulation of this pathway is associated with various immunological disorders, hematological diseases, and solid malignancies. Understanding the intricate mechanisms of JAK/STAT signaling in solid malignancies is crucial for drug development and improving cancer therapies.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Oncology

Targeting Protein Kinase C for Cancer Therapy

Sijia He et al.

Summary: This review systematically summarizes the current findings on the architecture, activity regulation and biological functions of protein kinase C (PKC) isoforms, with a focus on their relationship with anti-cancer therapy-induced cell death. Additionally, it elaborates on the effects of PKCs on tumor metabolism and microenvironment, and highlights their implications as a target for cancer therapy.

CANCERS (2022)

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Review Oncology

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Manzar Alam et al.

Summary: Caffeic acid (CA) is a substance found in various foods and beverages, with biological activities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its potential therapeutic effects are mediated through the repression and inhibition of transcription and growth factors. The biomolecular interactions and pathways of CA have been described.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

(-)-Epigallocatechin-3-Gallate Prevents IL-1 beta-Induced uPAR Expression and Invasiveness via the Suppression of NF-kB and AP-1 in Human Bladder Cancer Cells

Dhiraj Kumar Sah et al.

Summary: EGCG can inhibit the invasion ability of bladder cancer cells induced by IL-1β by suppressing the expression of uPAR through the inhibition of ERK1/2, JNK, AP-1, and NF-κB activities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, Research & Experimental

The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis

G. D. Marijn Veerman et al.

Summary: The concomitant use of green tea extract with nintedanib may result in a clinically relevant drug interaction, leading to a 21% decrease in nintedanib exposure. Additional clinical validation is necessary to determine the impact of this interaction on treatment efficacy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Dimeric-(-)-epigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway

Xiu-Li Sun et al.

Summary: The active substance PBOG in green tea inhibits the proliferation and migration of non-small cell lung cancer cells, promotes cell apoptosis, and inhibits cell cycle progression. It can also change the secondary structure of the protein, inhibit EGFR phosphorylation, and inhibit tumor growth.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Pharmacology & Pharmacy

Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers

Shingen Misaka et al.

Summary: Green tea catechins can significantly reduce the exposure of fexofenadine, potentially by inhibiting intestinal absorption, but have no impact on the pharmacokinetics of pseudoephedrine.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Genetics & Heredity

Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)

Cecile Cieuta-Walti et al.

Summary: This study evaluated the safety and tolerability of epigallocatechin gallate (EGCG) in children with Down syndrome (DS) and examined its effects on cognitive function and functionality. The results indicated that EGCG was safe and well-tolerated in children with DS, but did not show improvement in cognitive and functional performance.

GENETICS IN MEDICINE (2022)

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Article Agriculture, Multidisciplinary

4-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling

Akane Hayashi et al.

Summary: This study reveals that sulfation is the key metabolic pathway for EGCG, with higher kinetic activity compared to methylation and glucuronidation. SULT1A1 and SULT1A3 are responsible for sulfation in the liver and intestine, respectively. Additionally, EGCG-4''-sulfate is identified as the key metabolite.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Daniela Mokra et al.

Summary: This article reviews the biological effects of (-)-Epigallocatechin-3-gallate (EGCG) in respiratory diseases, including antioxidant, anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects. EGCG may be beneficial in respiratory diseases through modulation of various intracellular signaling cascades.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

Green tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway

Qiuyun Gu et al.

Summary: This study aimed to investigate the potential regulatory pathways of EGCG in preventing obesity-related precocious puberty. The results showed that EGCG could prevent precocious puberty through the NKB/NK3R signaling pathway.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Article Oncology

EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress

Wenbing Wu et al.

Summary: This study explores the role of GRP78-mediated endoplasmic reticulum stress (ERS) in the synergistic inhibition of colorectal cancer by epigallocatechin-3-gallate (EGCG) and irinotecan (IRI). The findings demonstrate that EGCG, either alone or in combination with irinotecan, can promote GRP78 protein expression, reduce mitochondrial membrane potential and intracellular ROS, and induce apoptosis in colorectal cancer cells. Moreover, the overexpression of GRP78 enhances the efficacy of the drug combination, while the inhibition of GRP78 decreases the sensitivity of CRC cells. In vivo experiments further confirm the inhibitory effect of the EGCG and irinotecan combination on tumor growth.

JOURNAL OF ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

Sabeena Mustafa et al.

Summary: Matrix metalloproteinases (MMPs) are a group of enzymes that regulate extracellular matrix turnover and play important roles in various physiological processes. In cancer, MMP activity is critical for tumor metastasis and evasion of apoptosis.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Urology & Nephrology

Atypical small acinar proliferation and its significance in pathological reports in modern urological times

Georgios Tsampoukas et al.

Summary: Atypical small acinar proliferation is an histopathological diagnosis of unspecified importance in prostate needle-biopsy reports, and its significance in modern urological practice is discussed.

ASIAN JOURNAL OF UROLOGY (2022)

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Review Oncology

Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes

Joshua D. Greenlee et al.

Summary: Lipid rafts, enriched microdomains within the plasma membrane, play crucial roles in cancer by regulating signal transduction, cell adhesion, migration, and oncogenic signaling, while also influencing different modes of cancer cell death. Their clinical significance lies in assessing patient prognosis and evaluating metastatic potential of cancers. Understanding the intricate roles of lipid rafts in the metastatic cascade may lead to therapeutic discoveries to inhibit prometastatic processes.

CANCER RESEARCH (2021)

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Article Medicine, Research & Experimental

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Saimai Chatree et al.

Summary: EGCG decreased triglyceride and blood pressure in human subjects, but had no effects on obesity reduction, lipolysis, or browning of human white adipocytes.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Targeting the JAK/STAT Signaling Pathway for Breast Cancer

Fei Shao et al.

Summary: Breast cancer is the most common malignant tumor in women worldwide. Traditional treatments have side effects, but targeted therapies for breast cancer, focusing on the JAK/STAT signaling pathway, show promising potential. Inhibitors of JAK and STAT proteins have exhibited strong effects in inhibiting breast cancer and are being explored for clinical use.

CURRENT MEDICINAL CHEMISTRY (2021)

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Review Chemistry, Medicinal

The Role of EGCG in Breast Cancer Prevention and Therapy

Adriana Romano et al.

Summary: The polyphenolic compound EGCG in green tea shows potential chemopreventive and chemotherapeutic effects on breast cancer by exerting antioxidant or pro-oxidant properties, inducing apoptosis, and inhibiting metastasis and angiogenesis. Further in vivo investigations are necessary to determine potential toxicity at higher doses and interactions with other drugs. The data support the clinical implications of EGCG for breast cancer prevention and therapy.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

Manzar Alam et al.

Summary: Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological effects, showing potential therapeutic benefits for cancer and diabetic neuropathy diseases. Structural modifications have resulted in UA derivatives with increased potency, bioavailability, and water solubility.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Pseudophosphatases as Regulators of MAPK Signaling

Emma Marie Wilber Hepworth et al.

Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer

Cristina Minnelli et al.

Summary: The study evaluated the effect of EGCG on inhibiting NSCLC cell lines with EGFR activating mutations, demonstrating that EGCG polyphenol can inhibit cell proliferation and migration with varying efficacy and mechanisms. These findings may be of interest for evaluating the use of EGCG as an adjunct to NSCLC therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma

Alexander Ou et al.

Summary: Glioblastoma is a highly refractory and deadly human malignancy, with the dysregulated JAK/STAT signaling pathway playing a key role in tumorigenesis and resistance to therapy, influencing functions such as proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. Current understanding of JAK/STAT signaling in glioblastoma highlights the need for targeted inhibition and future research directions in the field.

CANCERS (2021)

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Article Gastroenterology & Hepatology

Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3

Ke-Wang Luo et al.

Summary: The study demonstrated that EGCG inhibits proliferation and migration of colorectal cancer cells by inducing apoptosis and downregulating the expression of STAT3, suggesting EGCG as a potential natural supplement for colon cancer treatment.

GASTROENTEROLOGY REPORT (2021)

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Article Pharmacology & Pharmacy

Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways

Feng Ding et al.

Summary: The study showed that EGCG effectively inhibited tumor growth in colon cancer cells by downregulating the Shh and PI3K pathways, leading to reduced proliferation, migration, and invasion of cancer cells with low toxicity against normal cells.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer

Gongmin Zhu et al.

Summary: KRAS is a commonly mutated oncogene in colorectal cancer, leading to aberrant activation of the KRAS protein and stimulation of downstream signaling pathways, resulting in cell proliferation and survival, ultimately leading to tumorigenesis. Patients with KRAS mutations in CRC have poor prognosis.

MOLECULAR CANCER (2021)

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Article Nutrition & Dietetics

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

Justin D. Roberts et al.

Summary: The study found that 8 weeks of dGTE+ improved maximal fat oxidation and exercise intensity, lowered LDL-c levels, but had minimal effects on body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity.

NUTRIENTS (2021)

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Article Clinical Neurology

Epigallocatechin Gallate in Progressive MS A Randomized, Placebo-Controlled Trial

Rebekka Rust et al.

Summary: In a randomized trial involving 61 patients with progressive multiple sclerosis, treatment with epigallocatechin gallate did not slow the progression of brain atrophy or improve clinical and radiologic disease activity markers, but demonstrated a good safety profile.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

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Review Biochemistry & Molecular Biology

Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

Francesco Ciscato et al.

Summary: Hexokinases, particularly Hexokinase 2 (HK2), play a critical role in glucose metabolism and are highly expressed in insulin-sensitive tissues and neoplastic cells. In addition to its enzymatic activity, HK2 can regulate autophagy and cell death, as well as intracellular Ca2+ fluxes, at the mitochondria-associated membranes (MAMs). Targeting HK2 subcellular localization in MAMs may offer a promising anti-tumor strategy by disrupting its functions in metabolic and survival pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate induces autophagy-related apoptosis associated with LC3B II and Beclin expression of bladder cancer cells

Zhaofa Yin et al.

Summary: This study demonstrated that EGCG could inhibit bladder cancer cells by inducing autophagy-related apoptosis, suggesting it as a novel therapy for bladder cancer treatment. Green tea could be considered as a tumor-preventing beverage.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Chemistry, Medicinal

EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses

Dinoop Ravindran Menon et al.

Summary: This study demonstrates that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma. It could be used as an alternative treatment strategy to target the PD-L1/PD-L2-PD-1 axis in cancers.

PHARMACEUTICALS (2021)

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Article Clinical Neurology

Epigallocatechin Gallate in Relapsing-Remitting Multiple Sclerosis A Randomized, Placebo-Controlled Trial

Judith Bellmann-Strobl et al.

Summary: In patients with RRMS, adding oral EGCG to GA did not show superiority over placebo in affecting MRI and clinical disease activity. Despite indications of EGCG bioavailability, it did not influence immune parameters. However, treatment with up to 800 mg of EGCG daily was safe and well tolerated.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

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Review Cell Biology

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?

Rosa Vona et al.

Summary: Cholesterol is crucial for cell membrane structure and plays a key role in regulating cell signaling pathways. Its homeostasis is tightly regulated and dysregulation may be linked to cardiovascular diseases and cancer development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Genetics & Heredity

Suppressing effects of green tea extract and Epigallocatechin-3-gallate (EGCG) on TGF-β- induced Epithelial-to-mesenchymal transition via ROS/Smad signaling in human cervical cancer cells

Mohammad Panji et al.

Summary: Green tea and its active substance EGCG can suppress the growth and invasion of cervical cancer cells by reducing the expression of EMT regulators, and the underlying molecular mechanism may be related to interference with ROS generation and the Smad signaling pathway.

GENE (2021)

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Article Cell Biology

EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells

Wenbing Wu et al.

Summary: The combination of EGCG and irinotecan has shown to have a stronger inhibitory effect on colorectal cancer cells compared to using either compound alone, preventing migration and invasion of tumor cells. Additionally, EGCG in combination with irinotecan could induce DNA damage and apoptosis more effectively, making it a promising strategy for colorectal cancer treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Influence of Tea Brewing Parameters on the Antioxidant Potential of Infusions and Extracts Depending on the Degree of Processing of the Leaves of Camellia sinensis

Jolanta Kowalska et al.

Summary: This study analyzed the influence of brewing process parameters on the polyphenol content, epigallocatechin gallate content, and antioxidant activity of tea leaves grown in Taiwan. Different types of tea exhibited varying characteristics under different brewing conditions.

MOLECULES (2021)

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Article Nutrition & Dietetics

Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study

Jose Enrique de la Rubia Orti et al.

Summary: The study found that administering EGCG and ketone bodies in MS patients resulted in significant decreases in inflammation markers, increased lipolytic enzyme activity, and improved functional status. BuChE appears to play a crucial role in lipid metabolism and inflammation modulation in MS patients.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

The JAK/STAT signaling pathway: from bench to clinic

Xiaoyi Hu et al.

Summary: The JAK/STAT signaling pathway is a crucial cellular signal transduction pathway, associated with various cancers and autoimmune diseases. Researchers discussed the composition, activation, and regulation of this pathway, as well as its role in diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

KRAS mutation: from undruggable to druggable in cancer

Lamei Huang et al.

Summary: This review provides the latest understanding of fundamental aspects of KRAS, the relationship between KRAS mutations and tumor immune evasion, and new progress in targeting KRAS, particularly KRAS (G12C). The possible mechanisms of resistance to KRAS (G12C) inhibitors and potential combination therapies are also summarized, aiming to offer the best personalized treatment regimen with KRAS (G12C) inhibitors and achieve truly precise treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Nutrition & Dietetics

Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management

Laura Xicota et al.

CLINICAL NUTRITION (2020)

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Article Chemistry, Medicinal

Phase II Trial of Epigallocatechin-3-Gallate in Acute Radiation-Induced Esophagitis for Esophagus Cancer

Xiaoling Li et al.

JOURNAL OF MEDICINAL FOOD (2020)

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Article Oncology

SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2

Kayla L. Steed et al.

ANTICANCER RESEARCH (2020)

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Review Cell Biology

Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases

Arezoo Hosseini et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Faustino Mollinedo et al.

JOURNAL OF LIPID RESEARCH (2020)

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Article Chemistry, Medicinal

N-Oleoyl-Phosphatidyl-Ethanolamine and Epigallo Catechin-3-Gallate Mitigate Oxidative Stress in Overweight and Class I Obese People on a Low-Calorie Diet

Roberta Cazzola et al.

JOURNAL OF MEDICINAL FOOD (2020)

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Article Pharmacology & Pharmacy

Epigallocatechin-3-gallate modulates germ cell apoptosis through the SAFE/Nrf2 signaling pathway

May Al-Maghrebi et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

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Review Food Science & Technology

Bioavailability enhancement of EGCG by structural modification and nano-delivery: A review

Wenzhong Dai et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Nutrition & Dietetics

The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients

Jose Luis Platero et al.

NUTRIENTS (2020)

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Article Oncology

Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma

Mozhdeh Sojoodi et al.

CANCER PREVENTION RESEARCH (2020)

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Review Oncology

EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways

Ammad Ahmad Farooqi et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

Bioavailability of Epigallocatechin Gallate Administered with Different Nutritional Strategies in Healthy Volunteers

Vicente Andreu Fernandez et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Boris Y. Shorning et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Role of Curcumin and (-)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

Ludwika Piwowarczyk et al.

CANCERS (2020)

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Review Oncology

DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy

Jiayu Zhang et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines

Ran Wei et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Review Biochemistry & Molecular Biology

Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer

Saleh A. Almatroodi et al.

MOLECULES (2020)

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Article Oncology

Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck

Dong M. Shin et al.

CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Fatty Acid Synthase: An Emerging Target in Cancer

Chee Wai Fhu et al.

MOLECULES (2020)

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Article Reproductive Biology

Epigallocatechin-3-gallate (EGCG) reduces apoptosis of preantral follicles through the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) signaling pathway after in vitro culture of sheep ovarian tissue

R. S. Barberino et al.

THERIOGENOLOGY (2020)

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Article Medicine, Research & Experimental

Different clinical significance of ASAP/HGPIN pattern in systematic vs. MRI-US fusion guided prostate biopsy

Iulia Andras et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Oncology

ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies

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FRONTIERS IN ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Role of Nitric Oxide in Cancer: Master Regulator or NOt?

Faizan H. Khan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation

Motofumi Kumazoe et al.

MOLECULES (2020)

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Article Nutrition & Dietetics

Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study

Maria Benlloch et al.

NUTRIENTS (2020)

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Article Cell Biology

EGCG Enhanced the Anti-tumor Effect of Doxorubicine in Bladder Cancer via NF-κB/MDM2/p53 Pathway

Ke-Wang Luo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Green Tea Catechins Induce Inhibition of PTP1B Phosphatase in Breast Cancer Cells with Potent Anti-Cancer Properties: In Vitro Assay, Molecular Docking, and Dynamics Studies

Alicja Kuban-Jankowska et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

Epigenetic alterations in cancer

Suganya Ilango et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2020)

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Review Toxicology

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

Hellen A. Oketch-Rabah et al.

TOXICOLOGY REPORTS (2020)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

Veena Somasundaram et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

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Article Pharmacology & Pharmacy

(-)-Epigallocatechin-3-gallate induces cell apoptosis in chronic myeloid leukaemia by regulating Bcr/Abl-mediated p38-MAPK/JNK and JAK2/STAT3/AKT signalling pathways

Xiang Xiao et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2019)

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Article Oncology

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway

Dongdong Wu et al.

CANCER CELL INTERNATIONAL (2019)

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Article Agriculture, Multidisciplinary

(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway

Xiaoqin La et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes

Gauri Deb et al.

MOLECULAR CARCINOGENESIS (2019)

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Article Oncology

A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy

Hanxi Zhao et al.

RADIOTHERAPY AND ONCOLOGY (2019)

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Review Chemistry, Medicinal

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

Sabrina Bimonte et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Review Chemistry, Medicinal

Natural compound inducers of immunogenic cell death

Marc Diederich

ARCHIVES OF PHARMACAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

In Silico Investigation of the Anti-Tumor Mechanisms of Epigallocatechin-3-Gallate

Wang Wang et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

Epidrugs: targeting epigenetic marks in cancer treatment

Cristiana Libardi Miranda Furtado et al.

EPIGENETICS (2019)

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Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Florian R. Greten et al.

IMMUNITY (2019)

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Review Biochemistry & Molecular Biology

Interactions of tea polyphenols with intestinal microbiota and their implication for cellular signal conditioning mechanism

Yongyong Li et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

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Review Oncology

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

Ali S. Alzahrani

SEMINARS IN CANCER BIOLOGY (2019)

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Review Cell Biology

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

Anastasiya Snezhkina et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Medicine, General & Internal

Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma?Next-Generation Sequencing and Bioinformatics Approaches

Hsiang-Ying Lee et al.

MEDICINA-LITHUANIA (2019)

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Article Nutrition & Dietetics

Protective Effect of Green Tea Consumption on Colorectal Cancer Varies by Lifestyle Factors

Hyejin Kim et al.

NUTRIENTS (2019)

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Article Oncology

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts

Ran Wei et al.

CANCERS (2019)

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Review Cell Biology

Cyclooxygenase-2 in cancer: A review

Nasser Hashemi Goradel et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Oncology

Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease

Dongmei Chen et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2019)

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Review Urology & Nephrology

Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis

Gianpaolo Perletti et al.

ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA (2019)

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Article Biotechnology & Applied Microbiology

Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25

Lingling Zan et al.

BIOENGINEERED (2019)

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Review Chemistry, Medicinal

FAK inhibitors in Cancer, a patent review

Peng-Cheng Lv et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2018)

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Article Food Science & Technology

Epigallocatechin-3-O-gallate alleviates the malignant phenotype in A-431 epidermoid and SK-BR-3 breast cancer cell lines

Alexandru Filippi et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2018)

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Article Oncology

Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells

Veronika Borutinskaite et al.

LEUKEMIA & LYMPHOMA (2018)

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Review Oncology

Emerging functions of the EGFR in cancer

Sara Sigismund et al.

MOLECULAR ONCOLOGY (2018)

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Review Cell Biology

Anti-cancer therapy with TNFα and IFNγ:A comprehensive review

Jing Shen et al.

CELL PROLIFERATION (2018)

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Review Biochemistry & Molecular Biology

Ki-67: more than a proliferation marker

Xiaoming Sun et al.

CHROMOSOMA (2018)

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Article Pharmacology & Pharmacy

Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers

Shingen Misaka et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers

Osamu Abe et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Nicholas Ekow Thomford et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Nanoscience & Nanotechnology

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Dereje Kebebe et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Review Biochemistry & Molecular Biology

In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

Koichi Saeki et al.

MOLECULES (2018)

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Review Oncology

Role of EGCG in Containing the Progression of Lung Tumorigenesis - A Multistage Targeting Approach

Sunil Kumar Dhatwalia et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

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Article Multidisciplinary Sciences

Population nutrikinetics of green tea extract

Catharina Scholl et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials

Xuan Li et al.

PLOS ONE (2018)

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Review Medicine, Legal

The safety of green tea and green tea extract consumption in adults - Results of a systematic review

Jiang Hu et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Role of the NFκB-signaling pathway in cancer

Longzheng Xia et al.

ONCOTARGETS AND THERAPY (2018)

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Article Nutrition & Dietetics

A Randomized, Placebo-Controlled Study on the Safety and Efficacy of Daily Ingestion of Green Tea (Camellia sinensis L.) cv. Yabukita and Sunrouge on Eyestrain and Blood Pressure in Healthy Adults

Mari Maeda-Yamamoto et al.

NUTRIENTS (2018)

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Article

EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K/AKT pathway

Ke-Wang Luo et al.

Oncotarget (2018)

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Article Endocrinology & Metabolism

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans

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ADIPOCYTE (2018)

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Review Biochemistry & Molecular Biology

Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies

Shogo Nakano et al.

MOLECULES (2018)

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Review Biochemistry & Molecular Biology

Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai et al.

MOLECULES (2018)

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Natural polyphenols as sirtuin 6 modulators

Minna Rahnasto-Rilla et al.

SCIENTIFIC REPORTS (2018)

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Article Environmental Sciences

Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

Fatma N. Hamed et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

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Review Public, Environmental & Occupational Health

Inflammation and cancer

Mariko Murata

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

Ran Wei et al.

FOOD & FUNCTION (2018)

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Article Environmental Sciences

Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

Chien-Han Yuan et al.

ENVIRONMENTAL TOXICOLOGY (2017)

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Article Hematology

Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis

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INTERNATIONAL JOURNAL OF HEMATOLOGY (2017)

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Article Cell Biology

Inhibition of pro-/active MMP-2 by green tea catechins and prediction of their interaction by molecular docking studies

Animesh Chowdhury et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

Wnt signaling in cancer

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ONCOGENE (2017)

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Review Environmental Sciences

Mechanisms of DNA Damage, Repair, and Mutagenesis

Nimrat Chatterjee et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2017)

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Article Food Science & Technology

Binding of tea catechins to rice bran protein isolate: Interaction and protective effect during in vitro digestion

Meng Shi et al.

FOOD RESEARCH INTERNATIONAL (2017)

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Article Oncology

Retinoic Acid Receptor: A Potential Therapeutic Target in Retinoic Acid Treatment of Endometrial Cancer

Keita Tsuji et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2017)

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Article Nutrition & Dietetics

Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial

H. Zhang et al.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2017)

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Article Biochemistry & Molecular Biology

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9

Ke-Wang Luo et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

Down-regulation of histone deacetylase 4,-5 and-6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin

Yukiko Oya et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

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Editorial Material Cell Biology

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

Bernd Groner et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

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Article Pathology

Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells

Liang Liu et al.

PATHOLOGY RESEARCH AND PRACTICE (2017)

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Review Nutrition & Dietetics

Chronic Inflammatory Diseases and Green Tea Polyphenols

Helieh S. Oz

NUTRIENTS (2017)

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Editorial Material Gastroenterology & Hepatology

Green tea and liver cancer

Francesca Bravi et al.

HEPATOBILIARY SURGERY AND NUTRITION (2017)

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Article Biochemistry & Molecular Biology

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

Daniel M. Freed et al.

CELL (2017)

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Article Oncology

Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway

L. X. Weng et al.

NEOPLASMA (2017)

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Article Oncology

A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early Breast Cancer

Matteo Lazzeroni et al.

CANCER PREVENTION RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells

Jianyun Zhu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Oncology

DNA methyltransferases and their roles in tumorigenesis

Wu Zhang et al.

BIOMARKER RESEARCH (2017)

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Review Food Science & Technology

Mechanisms of body weight reduction and metabolic syndrome alleviation by tea

Chung S. Yang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

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Article Nutrition & Dietetics

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial

Jasper Most et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2016)

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Article Medicine, Research & Experimental

Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis

Jaganmay Sarkar et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Nutrition & Dietetics

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans

Ying Hu et al.

BRITISH JOURNAL OF NUTRITION (2016)

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Article Biochemistry & Molecular Biology

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

A. Tosco et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Article Nutrition & Dietetics

Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial

I-Ju Chen et al.

CLINICAL NUTRITION (2016)

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Review Chemistry, Medicinal

Therapeutic effects of EGCG: a patent review

Leewanshi Chakrawarti et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

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Article Food Science & Technology

Inhibition of green tea polyphenol EGCG((-)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical wnt/β-catenin signalling pathway

Chenggang Yang et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2016)

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Article Oncology

Lipid Raft Integrity Is Required for Survival of Triple Negative Breast Cancer Cells

Anil Badana et al.

JOURNAL OF BREAST CANCER (2016)

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Article Oncology

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

Patricia Mucci LoRusso

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Chemistry, Applied

Combinational enhancing effects of formulation and encapsulation on digestive stability and intestinal transport of green tea catechins

Yu-Ra Son et al.

JOURNAL OF MICROENCAPSULATION (2016)

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Article Clinical Neurology

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Rafael de la Torre et al.

LANCET NEUROLOGY (2016)

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Review Biochemistry & Molecular Biology

Emerging Phytochemicals for the Prevention and Treatment of Head and Neck Cancer

Santosh K. Katiyar

MOLECULES (2016)

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Article Oncology

Effects of ω-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial

Zhenzhen Zhang et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

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Article Genetics & Heredity

Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial

Christine Chiaverini et al.

ORPHANET JOURNAL OF RARE DISEASES (2016)

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Review Cell Biology

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

Malgorzata Nita et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Plant Sciences

Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin

Yoo Seob Shin et al.

PHYTOMEDICINE (2016)

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Review Cell Biology

Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications

Xiaojun Tan et al.

TRENDS IN CELL BIOLOGY (2016)

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Review Pharmacology & Pharmacy

Targeting WEE1 Kinase in Cancer

Christopher J. Matheson et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

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Review Genetics & Heredity

Oxidative stress signaling to chromatin in health and disease

Sarah Kreuz et al.

EPIGENOMICS (2016)

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Article Oncology

Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins

Nagi B. Kumar et al.

ONCOTARGET (2016)

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Review Cell & Tissue Engineering

Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy

Lisa Y. Pang et al.

STEM CELLS INTERNATIONAL (2016)

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Article Rheumatology

Regulation of Transforming Growth Factor β-Activated Kinase 1 Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6

Anil K. Singh et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Review Medicine, Research & Experimental

Endogenous mechanisms of reactive oxygen species (ROS) generation

Agata Sarniak et al.

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2016)

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Article Nutrition & Dietetics

Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial

Anja Maehler et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)

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Article Oncology

Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention

Nagi B. Kumar et al.

CANCER PREVENTION RESEARCH (2015)

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Article Oncology

Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus

Andrew K. Joe et al.

CANCER PREVENTION RESEARCH (2015)

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Review Food Science & Technology

Tea and Its Consumption: Benefits and Risks

Khizar Hayat et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)

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Review Oncology

Tea consumption and the incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Yu-Fei Zhang et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2015)

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Article Toxicology

(-)-Epigallocatechin-3-Gallate Inhibits Osteosarcoma Cell Invasiveness by Inhibiting the MEK/ERK Signaling Pathway in Human Osteosarcoma Cells

Guoqing Tang et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2015)

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Article Food Science & Technology

Effects of different brewing conditions on catechin content and sensory acceptance in Turkish green tea infusions

Sena Saklar et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2015)

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Article Biochemistry & Molecular Biology

Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma

Rituparna Bhattacharjee et al.

JOURNAL OF MOLECULAR MODELING (2015)

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Article Clinical Neurology

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Jesus Lovera et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)

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Article Oncology

Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs

Shuntaro Tsukamoto et al.

MOLECULAR CANCER THERAPEUTICS (2015)

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Article Oncology

Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2-mediated glycolysis

Feng Gao et al.

ONCOLOGY REPORTS (2015)

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Article Oncology

(-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

Munawwar Ali Khan et al.

ONCOLOGY REPORTS (2015)

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Article Oncology

A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer

Hanxi Zhao et al.

RADIOTHERAPY AND ONCOLOGY (2015)

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Review Nutrition & Dietetics

Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome

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NUTRIENTS (2015)

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Targeting AMPK for cancer prevention and treatment

Weidong Li et al.

ONCOTARGET (2015)

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Article Biochemistry & Molecular Biology

Epigenetic Induction of Tissue Inhibitor of Matrix Metalloproteinase-3 by Green Tea Polyphenols in Breast Cancer Cells

Gauri Deb et al.

MOLECULAR CARCINOGENESIS (2015)

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Article Multidisciplinary Sciences

Investigate the Binding of Catechins to Trypsin Using Docking and Molecular Dynamics Simulation

Fengchao Cui et al.

PLOS ONE (2015)

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Article Biochemistry & Molecular Biology

Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans

Nenad Naumovski et al.

ANTIOXIDANTS (2015)

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Article Cell Biology

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

Daniela De Stefano et al.

AUTOPHAGY (2014)

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Article Nutrition & Dietetics

Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial

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BRITISH JOURNAL OF NUTRITION (2014)

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Article Cell Biology

Green Tea Polyphenol Epigallocatechin-3-Gallate Inhibits TNF-α-Induced Production of Monocyte Chemoattractant Protein-1 in Human Umbilical Vein Endothelial Cells

Ze-Mu Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

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Review Biochemistry & Molecular Biology

ROS Function in Redox Signaling and Oxidative Stress

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CURRENT BIOLOGY (2014)

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Article Food Science & Technology

Lipase-catalyzed synthesis of acetylated EGCG and antioxidant properties of the acetylated derivatives

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FOOD RESEARCH INTERNATIONAL (2014)

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Article Agriculture, Multidisciplinary

Fabrication of Self-Assembled (-)-Epigallocatechin Gal late (EGCG) Ovalbumin-Dextran Conjugate Nanoparticies and Their Transport across Mono layers of Human Intestinal Epithelial Caco-2 Cells

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

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Article Agriculture, Multidisciplinary

Characterization and Bioavailability of Tea Polyphenol Nanoliposome Prepared by Combining an Ethanol Injection Method with Dynamic High-Pressure Microfluidization

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance

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JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Food Science & Technology

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

Rafael De la Torre et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

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Natural product and natural product derived drugs in clinical trials

Mark S. Butler et al.

NATURAL PRODUCT REPORTS (2014)

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NATURE REVIEWS DRUG DISCOVERY (2014)

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ONCOGENE (2014)

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Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway

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PHYTOTHERAPY RESEARCH (2014)

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Review Pharmacology & Pharmacy

The ErbB/HER family of protein-tyrosine kinases and cancer

Robert Roskoski

PHARMACOLOGICAL RESEARCH (2014)

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A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer

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RADIOTHERAPY AND ONCOLOGY (2014)

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Receptor Tyrosine Kinases: Legacy of the First Two Decades

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

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The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

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Fabrication of coated bovine serum albumin (BSA)-epigallocatechin gallate (EGCG) nanoparticles and their transport across monolayers of human intestinal epithelial Caco-2 cells

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FOOD & FUNCTION (2014)

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CANCER IMMUNOLOGY RESEARCH (2014)

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New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

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REDOX BIOLOGY (2014)

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FRONTIERS IN ONCOLOGY (2014)

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The Effect of Three Weeks Green Tea Extract Consumption on Blood Pressure, Heart Rate Responses to a Single Bout Resistance Exercise in Hypertensive Women

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HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2014)

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Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins

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INTEGRATIVE MEDICINE RESEARCH (2014)

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Article Integrative & Complementary Medicine

PI3K/AKT/mTOR Signaling is Involved in (-)-Epigallocatechin-3-Gallate-Induced Apoptosis of Human Pancreatic Carcinoma Cells

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AMERICAN JOURNAL OF CHINESE MEDICINE (2013)

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Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis

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BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2013)

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Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

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BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

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Tea and Health: Studies in Humans

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CURRENT PHARMACEUTICAL DESIGN (2013)

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AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

D. Grahame Hardie

DIABETES (2013)

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Article Nutrition & Dietetics

Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis

R. J. Widmer et al.

EUROPEAN JOURNAL OF NUTRITION (2013)

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Article Oncology

A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer

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GYNECOLOGIC ONCOLOGY (2013)

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Article Chemistry, Multidisciplinary

Epigallocatechin-3-Gallate (EGCG) Inhibits Cell Proliferation and Migratory Behaviour of Triple Negative Breast Cancer Cells

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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2013)

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Epigallocatechin gallate attenuates interstitial cystitis in human bladder urothelium cells by modulating purinergic receptors

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JOURNAL OF SURGICAL RESEARCH (2013)

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Article Food Science & Technology

EGCG-rich green tea extract stimulates sRAGE secretion to inhibit S100A12-RAGE axis through ADAM10-mediated ectodomain shedding of extracellular RAGE in type 2 diabetes

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MOLECULAR NUTRITION & FOOD RESEARCH (2013)

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Green Tea Consumption and Risk of Esophageal Cancer: A Meta-Analysis of Published Epidemiological Studies

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2013)

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Mechanism of the inhibition of the STAT3 signaling pathway by EGCG

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ONCOLOGY REPORTS (2013)

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Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry

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TALANTA (2013)

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Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling

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ONCOTARGETS AND THERAPY (2013)

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The effects of bathing in hot springs on the absorption of green tea catechin: A pilot study

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COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2013)

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NATURE REVIEWS CANCER (2013)

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AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

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AGEING RESEARCH REVIEWS (2012)

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Article Gastroenterology & Hepatology

Green tea consumption and risk of esophageal cancer: a meta-analysis of epidemiologic studies

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BMC GASTROENTEROLOGY (2012)

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Oxidatively generated complex DNA damage: Tandem and clustered lesions

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CANCER LETTERS (2012)

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Epigenetic modifications in cancer

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CLINICAL GENETICS (2012)

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Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

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EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

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EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling

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GROWTH FACTORS (2012)

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Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

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INTERNATIONAL JOURNAL OF CANCER (2012)

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Article Medicine, Research & Experimental

Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)

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Article Oncology

Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression

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MOLECULAR MEDICINE REPORTS (2012)

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Histone deacetylases and cancer

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MOLECULAR ONCOLOGY (2012)

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EGCG Enhances the Therapeutic Potential of Gemcitabine and CP690550 by Inhibiting STAT3 Signaling Pathway in Human Pancreatic Cancer

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PLOS ONE (2012)

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Article Biochemistry & Molecular Biology

Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo

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FOOD & FUNCTION (2012)

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Article Nutrition & Dietetics

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

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NUTRIENTS (2012)

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Review Pathology

Retinoids, Retinoic Acid Receptors, and Cancer

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ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)

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Article Biochemistry & Molecular Biology

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

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The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles

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Article Oncology

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

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CARCINOGENESIS (2011)

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Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α

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CARCINOGENESIS (2011)

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Article Nutrition & Dietetics

Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process

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EUROPEAN JOURNAL OF NUTRITION (2011)

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Review Biochemistry & Molecular Biology

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

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FEBS JOURNAL (2011)

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Review Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

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Article Pharmacology & Pharmacy

Elastic liposomes as carriers for oral delivery and the brain distribution of (+)-catechin

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JOURNAL OF DRUG TARGETING (2011)

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Review Biotechnology & Applied Microbiology

Measurement of oxidatively generated base damage in cellular DNA

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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)

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Tea Polyphenols Induce Apoptosis Through Mitochondrial Pathway and by Inhibiting Nuclear Factor-kappa B and Akt Activation in Human Cervical Cancer Cells

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ONCOLOGY RESEARCH (2011)

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Review Pharmacology & Pharmacy

Tea and cancer prevention: Epidemiological studies

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PHARMACOLOGICAL RESEARCH (2011)

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Green Tea Polyphenols and Metabolites in Prostatectomy Tissue: Implications for Cancer Prevention

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CANCER PREVENTION RESEARCH (2010)

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Cell Signaling by Receptor Tyrosine Kinases

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CELL (2010)

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Successful Applications of Computer Aided Drug Discovery: Moving Drugs from Concept to the Clinic

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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)

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Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)

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Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice

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Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

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FOOD RESEARCH INTERNATIONAL (2010)

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Review Biochemistry & Molecular Biology

Oxidatively generated base damage to cellular DNA

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FREE RADICAL BIOLOGY AND MEDICINE (2010)

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Green Tea Compound in Chemoprevention of Cervical Cancer

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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2010)

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Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of γ-Interferon-Induced JAK-PKC-δ-STAT1 Signaling in Human Oral Cancer Cells

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

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Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

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JOURNAL OF CELL SCIENCE (2010)

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(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma

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BREAST CANCER RESEARCH (2010)

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Apoptosis Induction Effects of EGCG in Laryngeal Squamous Cell Carcinoma Cells through Telomerase Repression

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ARCHIVES OF PHARMACAL RESEARCH (2009)

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Induction of apoptosis in human bladder cancer cells by green tea catechins

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BIOMEDICAL RESEARCH-TOKYO (2009)

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Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro

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CANCER PREVENTION RESEARCH (2009)

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Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation

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CANCER RESEARCH (2009)

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Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia

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CANCER SCIENCE (2009)

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Article Agriculture, Multidisciplinary

Preparation and Antioxidant Activity of Green Tea Extract Enriched in Epigallocatechin (EGC) and Epigallocatechin Gallate (EGCG)

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

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Article Cell Biology

Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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Article Biochemistry & Molecular Biology

Green tea catechins in chemoprevention of cancer: A molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1)

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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2009)

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Article Food Science & Technology

Electrospun Zein Fibers as Carriers to Stabilize (-)-Epigallocatechin Gallate

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JOURNAL OF FOOD SCIENCE (2009)

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Article Oncology

Review: Green Tea Polyphenols in Chemoprevention of Prostate Cancer: Preclinical and Clinical Studies

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

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Article Pharmacology & Pharmacy

Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs

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TOXICOLOGY (2009)

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Article Cell Biology

Involvement of Members of the Cadherin Superfamily in Cancer

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

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Review Chemistry, Multidisciplinary

Tumor necrosis factor and cancer, buddies or foes?

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ACTA PHARMACOLOGICA SINICA (2008)

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Review Cell Biology

Hedgehog Signaling in Development and Cancer

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DEVELOPMENTAL CELL (2008)

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Letter Urology & Nephrology

Chemoprevention of human prostate cancer by Green Tea Catechins: Two years later. A follow-up update

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EUROPEAN UROLOGY (2008)

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Article Oncology

Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor

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INTERNATIONAL JOURNAL OF CANCER (2008)

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Article Biochemistry & Molecular Biology

(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase

Jung-Hyun Shim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation

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MOLECULAR CARCINOGENESIS (2008)

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Article Biochemistry & Molecular Biology

Green tea Polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor

Daisuke Umeda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Oncology

Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells

Rajesh L. Thangapazham et al.

CANCER BIOLOGY & THERAPY (2007)

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Article Cell Biology

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

Heinz G. Linhart et al.

GENES & DEVELOPMENT (2007)

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Review Pharmacology & Pharmacy

Tea and cancer prevention: Molecular mechanisms and human relevance

Chung S. Yang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)

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Review Medicine, Research & Experimental

Biotransformation of green tea polyphenols and the biological activities of those metabolites

Joshua D. Lambert et al.

MOLECULAR PHARMACEUTICS (2007)

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Article Endocrinology & Metabolism

Epigallocatechin-3-gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: Mechanisms of action

Curt E. Harper et al.

PROSTATE (2007)

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Article Biochemistry & Molecular Biology

A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins

Jie Qin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Article Hematology

ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

Stefania Gobessi et al.

BLOOD (2007)

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Article Oncology

Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo

Vaqar Mustafa Adhami et al.

CLINICAL CANCER RESEARCH (2007)

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Article Gastroenterology & Hepatology

(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis

Bao-He Zhu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2007)

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Article Oncology

Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours

Darci T. Butcher et al.

EUROPEAN JOURNAL OF CANCER (2007)

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Article Allergy

Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappa B in HMC-1 cells

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INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2007)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives

Dale G. Nagle et al.

PHYTOCHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells

Xinhan Zhao et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2006)

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Article Nutrition & Dietetics

Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption

Susanne M. Henning et al.

JOURNAL OF NUTRITION (2006)

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Article Biochemistry & Molecular Biology

Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer

Frank A. Sinicrope

MOLECULAR CARCINOGENESIS (2006)

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Article Gastroenterology & Hepatology

A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins

T. Nishikawa et al.

JOURNAL OF HEPATOLOGY (2006)

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Article Oncology

DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas

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CARCINOGENESIS (2006)

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Article Biochemistry & Molecular Biology

Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis

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Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity

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Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies

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FOOD AND CHEMICAL TOXICOLOGY (2006)

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Article Food Science & Technology

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: Teratogenicity and reproductive toxicity studies in rats

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FOOD AND CHEMICAL TOXICOLOGY (2006)

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Effect of liposome encapsulation of tea catechins on their accumulation in basal cell carcinomas

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JOURNAL OF DERMATOLOGICAL SCIENCE (2006)

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CANCER LETTERS (2006)

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Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study

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Review Cell Biology

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The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)

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Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)

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(-)-epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

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CLINICAL CANCER RESEARCH (2005)

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Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells

T Hussain et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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A receptor for green tea polyphenol EGCG

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The role of COX-2 inhibition in breast cancer treatment and prevention

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Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway - Evidence for direct inhibition of ERK1/2 and AKT kinases

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Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design

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Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites

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Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas

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Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists

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A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G1 arrest, and regulation of gene expression

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Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes

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Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

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Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice

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Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages

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Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

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