期刊
MOLECULES
卷 28, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules28196918
关键词
non-alcoholic fatty liver disease; glucosamine; inflammation; liver lipid metabolism; intestinal barrier
This study investigated the therapeutic effect of GLC in NAFLD and its underlying mechanisms. The results demonstrated that GLC attenuated insulin resistance, inflammation, and liver lipid metabolism disorder in NAFLD mice. GLC treatment improved liver lipid metabolism, relieved insulin resistance and oxidative stress, increased intestinal barrier function, and reduced liver inflammation by inhibiting the activation of the LPS/TLR4/NF-kappa B pathway.
Non-alcoholic fatty liver disease (NAFLD) is a liver disease syndrome. The prevalence of NAFLD has continued to increase globally, and NAFLD has become a worldwide public health problem. Glucosamine (GLC) is an amino monosaccharide derivative of glucose. GLC has been proven to not only be effective in anti-inflammation applications, but also to modulate the gut microbiota effectively. Therefore, in this study, the therapeutic effect of GLC in the NAFLD context and the mechanisms underlying these effects were explored. Specifically, an NAFLD model was established by feeding mice a high-fat and high-sugar diet (HFHSD), and the HFHSD-fed NAFLD mice were treated with GLC. First, we investigated the effect of treating NAFLD mice with GLC by analyzing serum- and liver-related indicator levels. We found that GLC attenuated insulin resistance and inflammation, increased antioxidant function, and attenuated serum and liver lipid metabolism in the mice. Then, we investigated the mechanism underlying liver lipid metabolism, inflammation, and intestinal barrier function in these mice. We found that GLC can improve liver lipid metabolism and relieve insulin resistance and oxidative stress levels. In addition, GLC treatment increased intestinal barrier function, reduced LPS translocation, and reduced liver inflammation by inhibiting the activation of the LPS/TLR4/NF-kappa B pathway, thereby effectively ameliorating liver lesions in NAFLD mice.
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