Targeting NLRP3 inflammasome for neurodegenerative disorders

Article Chemistry, Multidisciplinary

Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease

An-Qi Dong et al.

Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.

ACTA PHARMACOLOGICA SINICA (2023)

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Article Cell Biology

Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes

Xi-Lei Liu et al.

Summary: This study demonstrates that maraviroc can mitigate TBI-induced neuroinflammation by reducing NLRP3 inflammasome activation, modulating microglial polarization, and inhibiting the release of inflammatory factors. Additionally, maraviroc has neuroprotective effects and improves neurological recovery in TBI patients. Therefore, maraviroc may be a potential pharmacotherapeutic strategy for TBI.

NEURAL REGENERATION RESEARCH (2023)

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Article Allergy

NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome

Katerina Theodoropoulou et al.

Summary: This study investigates the mutations in NLRP3 gene and its regulation on inflammatory responses in a rare autoinflammatory disease called CAPS. The researchers discovered various splice variants of NLRP3 and found that some of them may regulate NLRP3 activation through alternative splicing. They also observed the importance of different coding exons in the LRR domain for inflammasome function.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Article Neurosciences

Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy

Carolina A. Moraes et al.

Summary: This study investigated the role of the NLRP3 inflammasome in microglial activation and synaptic loss related to sepsis. The results showed increased expression of NLRP3 inflammasome in the brains of septic mice, specifically in microglial cells. In vitro experiments also revealed that LPS-stimulated microglia produced mitochondrial reactive oxygen species, recruited NLRP3 complex, and released IL-1β. Inhibition of NLRP3, caspase-1, and mitochondrial ROS decreased IL-1β secretion by microglial cells.

MOLECULAR NEUROBIOLOGY (2023)

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Article Immunology

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease

Alexander Grotemeyer et al.

Summary: Inhibition of the NLRP3 inflammasome can reduce neuroinflammation and prevent the death of dopaminergic neurons in a human α-synuclein mouse model of progressive Parkinson's disease (PD). Repeat administration of the NLRP3 inhibitor MCC950 decreased the infiltration of T cells into the substantia nigra and mitigated microglial activation and α-synuclein protein aggregation in dopaminergic neurons. This treatment also resulted in less neurodegeneration of dopaminergic neurons and improved motor behavior related to PD.

JOURNAL OF NEUROINFLAMMATION (2023)

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Article Immunology

The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice

Jia-Mei Li et al.

Summary: Inhibiting NLRP3 inflammasome expression can improve depressive-like behaviors in mice and this study aimed to understand its impact on cognitive decline in depression and explore the common neuro-immunological mechanisms of depression and Alzheimer's disease (AD).

JOURNAL OF NEUROINFLAMMATION (2023)

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Article Biochemistry & Molecular Biology

HDAC Inhibitor SAHA Alleviates Pyroptosis by up-regulating miR-340 to Inhibit NEK7 Signaling in Subarachnoid Hemorrhage

Kui Luo et al.

Summary: HDAC inhibitor SAHA ameliorates microglia pyroptosis in SAH through triggering miR-340 expression to suppress NEK7 signaling.

NEUROCHEMICAL RESEARCH (2023)

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Article Clinical Neurology

Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons

Sebastiaan Moonen et al.

Summary: The study investigated the contribution of pyroptosis, a pro-inflammatory mechanism of cell death downstream of the inflammasome, to neurodegeneration in Alzheimer's disease (AD). The findings suggest the activation of pyroptosis in specific cell types and its potential link to neuron death in AD.

ACTA NEUROPATHOLOGICA (2023)

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Article Chemistry, Multidisciplinary

Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration

Xinxin Ma et al.

Summary: This study demonstrates that Prussian blue nanozyme (PBzyme) can act as a pyroptosis inhibitor to alleviate neurodegeneration in mouse and cell models of Parkinson's disease. By scavenging reactive oxygen species, inhibiting activation of the inflammasome, and reducing the production of inflammatory factors, PBzyme exerts neuroprotective effects.

ADVANCED MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

Ting Xu et al.

Summary: The membrane-bound E3 ubiquitin ligase gp78 mediates mixed ubiquitination of NLRP3, restraining inflammasome activation by inhibiting NLRP3 oligomerization and subcellular translocation. Insig-1, an endoplasmic reticulum membrane protein, is required for the gp78-NLRP3 interaction and gp78-mediated NLRP3 ubiquitination. Deficiency of gp78 or Insig-1 in myeloid cells leads to exacerbated NLRP3 inflammasome-dependent inflammation in vivo.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Immunology

Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease

Adrianne F. Pike et al.

Summary: This study reveals that dopamine inhibits the activation of NLRP3 inflammasome in primary human microglia, providing insights into the potential therapeutic target for Parkinson's disease.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Oncology

NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis

Poulomi Banerjee et al.

Summary: This article explores the molecular mechanisms underlying cognitive dysfunction in patients with amyotrophic lateral sclerosis. It identifies significantly dysregulated genes between cognitively affected and unaffected brain regions, as well as macromolecular complex regulation associated with cognitive resilience.

JOURNAL OF PATHOLOGY (2022)

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Article Biochemistry & Molecular Biology

Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via Pituitary Adenylate Cyclase-Activating Polypeptide

Kai Wang et al.

Summary: This study found that Hyperoside can inhibit the activation of the NLRP3 inflammasome by reducing the secretion of inflammatory factors, protecting dopaminergic neurons, and reversing motor dysfunction caused by MPTP. Hyperoside achieves this by upregulating PACAP levels.

NEUROCHEMISTRY INTERNATIONAL (2022)

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Article Geriatrics & Gerontology

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis

Yawen Cai et al.

Summary: This study found that Salidroside can slow down the progression of Alzheimer's disease by inhibiting NLRP3 inflammasome-mediated pyroptosis.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Immunology

Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation

Hyun-ju Lee et al.

Summary: This study explores the effects of idebenone on neuroinflammatory responses, cognitive function, and underlying molecular mechanisms. The results suggest that idebenone can enhance neuroprotective NRF2 expression, reduce neuroinflammation, and improve learning and memory in mice. It also targets NLRP3 inflammasome activation and decreases gliosis and proinflammatory cytokine levels. In a mouse model of Alzheimer's disease, idebenone improves cognitive dysfunction and inhibits neuroinflammation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

Cong Li et al.

Summary: Activation of NLRP3 inflammasome leads to cell pyroptosis and inflammatory cytokine secretion, and is involved in the development of various diseases. Manoalide, identified as a selective small molecule inhibitor of NLRP3, can inhibit NLRP3 activation through multiple mechanisms and alleviate the pathogenesis of related diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation

Yu Ren et al.

Summary: The study investigated the pharmacological effects of the NLRP3 inflammasome inhibitor MCC950 in a DLB mouse model, showing that MCC950 improved cognitive dysfunction symptoms without affecting motor coordination, indicating its potential therapeutic value for DLB.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Investigating the NLRP3 inflammasome and its regulator miR-223-3p in multiple sclerosis and experimental demyelination

Dylan A. Galloway et al.

Summary: This study investigated the expression of NLRP3 inflammasome and its endogenous regulator microRNA-223-3p in the demyelinated central nervous system (CNS) and found that they were upregulated at sites of myelin injury, playing a critical role in the inflammatory response following demyelination. It was also found that both microRNA-223-3p and a small-molecule NLRP3 inhibitor, MCC950, could suppress inflammasome activation in macrophages and microglia. Furthermore, systemic delivery of MCC950 in mice significantly reduced axonal injury within demyelinated lesions.

JOURNAL OF NEUROCHEMISTRY (2022)

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Article Cell Biology

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis

Yueting Zhang et al.

Summary: Ischemic stroke is a challenging condition to treat, and reoxygenation after the ischemic event can cause detrimental effects on the brain. This study explores the role of XBP-1 in regulating pyroptosis, a form of cell death, in the context of cerebral ischemia/reperfusion injury.

MEDIATORS OF INFLAMMATION (2022)

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Article Immunology

Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

Julien Moretti et al.

Summary: Caspase-11 can detect intracellular lipopolysaccharide (LPS) produced by invasive Gram-negative bacteria, leading to noncanonical activation of the NLRP3 inflammasome. This study found that bacterial mRNA signaling is necessary for the noncanonical activation of NLRP3 inflammasome in macrophages. Concurrent detection of bacterial RNA and LPS binding to pro-caspase-11 mediates the interaction between pro-caspase-11 and NLRP3, triggering the activation of the inflammasome.

NATURE IMMUNOLOGY (2022)

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Article Neurosciences

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Nikhil Panicker et al.

Summary: Parkinson's disease is caused by alpha-synuclein accumulation and death of dopamine neurons in the substantia nigra pars compacta, with NLRP3 inflammasome hyperactivation playing a role in the disease. Loss of parkin activity leads to spontaneous assembly of NLRP3 inflammasome in dopamine neurons, which is further exacerbated by mitochondrial-derived reactive oxygen species. Inhibition of neuronal NLRP3 inflammasome assembly can prevent degeneration of dopamine neurons in PD models.

NEURON (2022)

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Article Neurosciences

Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB

Yajiao Hu et al.

Summary: Hypoxia and ischemia can lead to neonatal encephalopathy and brain injury, causing cerebral palsy, cognitive impairment, growth restriction, and epilepsy. This study explores the neuroprotective effects of hydrogen against perinatal hypoxic-ischaemic encephalopathy (HIE) and identifies the involvement of the Nrf2-mediated NLRP3 and NF-jB pathways in mitigating cellular injury, apoptosis, neurobehavioral deficits, inflammation, and oxidative stress.

NEUROSCIENCE (2022)

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Article Pharmacology & Pharmacy

The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson's Disease by Inhibiting the NF-?B/NLRP3 Pathway

Shuhan Liu et al.

Summary: This study demonstrates that KPT-8602 has potent anti-inflammatory effects and could be used as a novel therapeutic agent for inflammasome-related diseases, such as Parkinson's disease, through the regulation of the NF-kappa B signaling pathway and the NLRP3 inflammasome.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell Biology

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Feng Yao et al.

Summary: This study found that HDAC11 is involved in endothelial cell pyroptosis in atherosclerosis (AS). TNF-α induces pyroptosis in HUVECs through TNFR1-mediated upregulation of HDAC11. Knockdown of HDAC11 suppresses pyroptosis in TNF-α-induced HUVECs by inhibiting both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways. Furthermore, HDAC11 affects pyroptosis by regulating the acetylation levels of ERG.

CELL DEATH DISCOVERY (2022)

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Article Immunology

β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson's disease models via inhibiting STAT3/NLRP3/GSDMD pathway

Ziying Jiang et al.

Summary: The study found that beta-hydroxybutyrate (BHB) has anti-inflammatory effects on Parkinson's disease (PD) and inhibits the inflammatory response by regulating the STAT3/NLRP3/GSDMD signaling pathway, providing new interventions and therapeutic targets.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages

Yanhui Duan et al.

Summary: The LRR domain plays a critical role in the activation of NLRP3 inflammasome, and its deletion inhibits the activation of NLRP3 inflammasome.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Clinical Neurology

Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex

Evelien Van Schoor et al.

Summary: This study found that the activation of inflammasomes and pyroptosis in microglia plays an important role in neuronal degeneration in ALS patients and transgenic mice. Inhibition of microglial inflammasome/pyroptosis activation may be a potential therapeutic strategy for ALS.

ACTA NEUROPATHOLOGICA (2022)

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Article Neurosciences

Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model

Haoyun Zhang et al.

Summary: The study found early activation of the canonical NLRP3 inflammasome induced pyroptosis in ventral horn neurons in ALS mice, which may participate in motor neuron degeneration and initiate neuroinflammatory processes during ALS progression.

BMC NEUROSCIENCE (2022)

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Editorial Material Neurosciences

Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson's disease

Kristine E. Zengeler et al.

Summary: The study reveals that NLRP3, previously believed to mainly function in microglia, is also present in neurons and plays a significant role in the pathogenesis of Parkinson's disease.

NEURON (2022)

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Article Neurosciences

Novel inflammasome and oxidative modulators in Parkinson's disease: A prospective study

Akash Roy et al.

Summary: This study found that serum NLRP3 inflammasome and IL-113 levels significantly increased in PD patients over a year, while the average enzymatic activity of serum SOD1 also increased at the one-year follow-up. Concurrently, the mean motor severity of this patient cohort worsened over the study period.

NEUROSCIENCE LETTERS (2022)

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Article Cell Biology

C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect

Ru-Huei Fu et al.

Summary: This study identified the association between PR50, C1QBP, and NLRP3 inflammasome activity in microglia, providing potential therapeutic strategies for intervention in C9-ALS using syringin.

CELLS (2022)

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Article Biochemistry & Molecular Biology

CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity

Liliang Li et al.

Summary: This study found that NLRP3 inflammasome-mediated pyroptosis is a major cause of cardiotoxicity in multiple antipsychotics. CB1R serves as an upstream regulator of the NLRP3 inflammasome and competitively binds to antipsychotics, stabilizing the inflammasome. These findings suggest that small-molecule inhibitors targeting the CB1R/NLRP3 signaling pathway may be attractive approaches to rescue cardiac side effects of antipsychotics.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Biochemistry & Molecular Biology

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Swagata Ghatak et al.

Summary: Early stages of human Alzheimer's disease (AD) show hyperexcitability in the brain, leading to extensive synapse loss and cognitive dysfunction, with no current disease-modifying therapy available. Utilizing human iPSC models may be a valuable tool for screening drugs to treat hyperexcitability and synaptic damage in AD, potentially increasing the chances of success in treatment.

MOLECULAR PSYCHIATRY (2021)

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Article Cell Biology

1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation

Mario A. Lauterbach et al.

Summary: The study reveals that deoxysphingolipids have an impact on autophagy, potentially leading to inflammation and abnormalities in the innate immune system.

AUTOPHAGY (2021)

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Article Immunology

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease

Yue Qin et al.

Summary: The study found that impaired microglial autophagy exacerbates neuroinflammation and dopaminergic neurodegeneration by modulating NLRP3 inflammasome responses. Enhancing microglial autophagy may be a promising new therapeutic strategy for PD.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Immunology

USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy

Tao Liu et al.

Summary: The study reveals that USP19 acts as an anti-inflammatory switch promoting M2-like macrophage polarization and inhibiting inflammatory responses by affecting NLRP3 activity through various mechanisms.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

Liudmila Andreeva et al.

Summary: The NLRP3 protein forms a double-ring structure held together by LRR-LRR interactions, predominantly localized on the cell membrane, ready to sense various signals to induce inflammasome activation.

CELL (2021)

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Article Oncology

NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury

Xubiao Ji et al.

Summary: NEK7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia cells post-SCI, and targeting NEK7/NLRP3 signaling shows promise in treating inflammatory response after spinal cord injury.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Shi Yu et al.

Summary: The inhibition of V-ATPase has been shown to exacerbate LPS-induced NLRP3 inflammasome activation in primary human monocytes, leading to an alternative pathway characterized by NLRP3-dependent, K+ efflux-independent, ASC oligomerization and caspase-1 activation. This suggests that V-ATPases play additional roles during NLRP3 inflammasome activation in primary human monocytes.

FEBS JOURNAL (2021)

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Article Biochemistry & Molecular Biology

ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by Interfering with Canonical, Non-Canonical, and Alternative Routes of Inflammasome Activation in Human THP1 Cells

Letizia Mezzasoma et al.

Summary: Dysregulated inflammasome activation and IL-1 beta production are linked to inflammatory disorders. Natriuretic Peptides (NPs) inhibit IL-1 beta secretion by activating NPR-1/cGMP/PKG-I axis, interfering with both Gasdermin D and Caspase-8 cleavage. This suggests a potential treatment strategy for diseases related to dysregulated inflammasome activation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Jargalsaikhan Dagvadorj et al.

Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Neurosciences

Electroacupuncture Ameliorates Neuroinflammation-Mediated Cognitive Deficits through Inhibition of NLRP3 in Presenilin1/2 Conditional Double Knockout Mice

Kun Li et al.

Summary: Neuroinflammation is a crucial pathogenesis in Alzheimer's disease, and electroacupuncture (EA) has shown potential as a therapy for anti-inflammation. This study found that EA improved memory deficits and impaired synaptic plasticity in AD-like mice, possibly through suppression of NLRP3 inflammasome activation. However, EA treatment did not further improve the cognitive deficits when combined with MCC950 administration.

NEURAL PLASTICITY (2021)

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Article Immunology

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

Jialong Chen et al.

Summary: The study found that the p38-TFEB signaling pathway promotes neuroinflammation in Parkinson's disease by inhibiting CMA-mediated NLRP3 degradation. Inhibition of p38 has a protective effect in PD models, preventing neurodegeneration and alleviating movement impairments. This research suggests that targeting the p38-TFEB pathway could be a potential therapeutic strategy for Parkinson's disease.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Immunology

HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury

Si-Wei Tan et al.

Summary: The study found that the continuous activation of the NLRP3 inflammasome and release of HMGB1 are closely related to cognitive impairment in the late stage of traumatic brain injury (TBI). Inhibition of HMGB1 improved long-term potentiation reduction and cognitive function by reducing NLRP3 inflammasome activation. This provides insights into the mechanism of cognitive dysfunction progression in TBI.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Neurosciences

NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi

Eliana Cristina de Brito Toscano et al.

Summary: In patients with mesial temporal lobe epilepsy, up-regulation of NLRP1 and NLRP3 in sclerotic hippocampi is associated with elevated levels of IL-1 beta and caspase-1, while increased levels of peripheral caspase-1 are related to bilateral hippocampal sclerosis. The findings suggest a role for inflammasome activation in both central and peripheral inflammation in TLE.

BRAIN RESEARCH (2021)

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Article Cell Biology

The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome

Joseph S. Bednash et al.

Summary: STAM-binding protein (STAMBP) has been identified as a negative regulator of the NLRP3 inflammasome, limiting excessive inflammasome activation and reducing injurious IL-1 beta signaling through a non-degradative ubiquitination mechanism.

CELLULAR SIGNALLING (2021)

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Article Biochemistry & Molecular Biology

Inflammasome in ALS Skeletal Muscle: NLRP3 as a Potential Biomarker

Leticia Moreno-Garcia et al.

Summary: The study indicated significant alterations in NLRP3 inflammasome gene and protein levels in the skeletal muscle of SOD1G93A mice, with a positive correlation between Nlrp3 transcriptional levels and longevity. NLRP3 mRNA levels were elevated in the blood of ALS patients compared to healthy controls, suggesting a potential role of NLRP3 in ALS pathogenesis in skeletal muscle.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Tingting Niu et al.

Summary: Activation of Nlrp3 inflammasome requires recruitment of Nek7 for ASC speck formation. The phosphorylation status of NLRP3 S803 controls this recruitment, playing a crucial role in inflammasome assembly. These findings suggest that targeting NLRP3 S803 phosphorylation may be a potential strategy for controlling inflammasome-related inflammatory responses.

NATURE COMMUNICATIONS (2021)

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Article Neurosciences

Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice

Guohua Li et al.

Summary: The study revealed that SEVO exposure significantly impaired spatial reference memory, sensorimotor, and cognitive function in mice. Mechanistically, SEVO induced the formation of NLRP3 inflammasome, leading to neurodegeneration.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Clinical Neurology

P2X7 receptor/NLRP3 inflammasome complex and α-synuclein in peripheral blood mononuclear cells: a prospective study in neo-diagnosed, treatment-naive Parkinson's disease

Anna Solini et al.

Summary: Newly diagnosed PD patients exhibit systemic overexpression of the P2X7R/NLRP3 inflammasome platform, likely regulating cellular α-synuclein content, which is significantly reduced after a year of PD treatment. This inflammatory platform may be mediated by impaired JNK phosphorylation and undergoes epigenetic regulation by miR-7 and miR-30.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Dorit Trudler et al.

Summary: Parkinson's disease is associated with the accumulation of alpha-synuclein and activation of microglia, potentially leading to neuronal death. This study shows that alpha-synuclein can activate NLRP3 inflammasome in human microglia and that alpha-synuclein-antibody complexes can exacerbate inflammation in a human context.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Clinical Neurology

Intracerebral Injection of Heme Induces Lipid Peroxidation, Neuroinflammation, and Sensorimotor Deficits

Luiz Ricardo C. Vasconcellos et al.

Summary: The study established a model in mice for intrastriatal heme injection, causing lipid peroxidation, neuroinflammation, and sensorimotor deficits. Heme induced brain damage and reactive astrogliosis, along with behavior deficits. NLRP3 was found to play a role in heme-induced behavior deficits in this model.

STROKE (2021)

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Article Neurosciences

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

Keith E. Campagno et al.

Summary: The P2X(7) receptor modulates the clearance of extracellular debris by microglial cells and mediates lysosomal damage that can activate the NLRP3 inflammasome.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Cell Biology

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Bowen Zhou et al.

Summary: Gasdermin E (GSDME) functions as an independent conduit for interleukin-1b (IL-1b) release in cellular inflammasome activation, regardless of its cell death ability. Our study reveals that both NLRP3 and NLRP1 inflammasomes depend on both gasdermins for IL-1b processing and release, apart from their ability to induce cell lysis.

CELL REPORTS (2021)

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Article Neurosciences

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients

Federica Piancone et al.

Summary: While alpha-syn did not activate the NLRP3 inflammasome, neuroinflammation in PD patients may be related to an imbalance between proinflammatory and anti-inflammatory cytokines.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Clinical Neurology

Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer's disease

Dawn C. Matthews et al.

Summary: This study evaluated the potential efficacy and safety of riluzole in patients with Alzheimer's disease compared to placebo using neuroimaging biomarkers, showing that riluzole-treated participants had better preserved cerebral glucose metabolism compared to placebo group, with positive correlation between cognitive performance and regional cerebral glucose metabolism, as well as potential engagement of the glutamatergic system by riluzole in the posterior cingulate. These findings support further powered, longer duration studies of riluzole as a potential intervention for Alzheimer's disease.

BRAIN (2021)

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Article Immunology

Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies

Hannah Scheiblich et al.

Summary: Research has shown that microglia react differently to various forms of α-syn, with NLRP3 inflammasome playing a crucial role in this process, and NLRP3 inhibition can improve the clearance efficiency of α-syn oligomers.

JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

TBK1 and IKKe act like an OFF switch to limit NLRP3 inflammasome pathway activation

Fabian A. Fischer et al.

Summary: The activation of NLRP3 inflammasome is regulated by multiple mechanisms, including a posttranslational phospho-switch described in this study. This phospho-switch involves the protein phosphatase 2A (PP2A) as an ON switch and the kinases TANK-binding kinase 1 (TBK1) and I-kappa-B kinase epsilon (IKKe) as an OFF switch. Understanding these regulatory mechanisms could provide new insights for disease interventions related to NLRP3 activation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cell Biology

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88-and NLRP3-ASC-inflammasome pathway

Shanya Jiang et al.

Summary: Pathological hyperphosphorylation and aggregation of tau, along with neuroinflammation driven by IL-1 beta, are key features of tauopathies. Research shows that pTau primes and activates IL-1 beta through MyD88- and NLRP3-ASC-dependent pathways in myeloid cells, including microglia, leading to tau pathology and cognitive dysfunction.

CELL REPORTS (2021)

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Article Cell Biology

Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

Chinmaya Panda et al.

Summary: This study demonstrates that aggregated PHF6 peptide upregulates NLRP3 inflammasome expression and induces IL-1β and IL-18 expression in HMC3 cells, as well as affecting other inflammation and microglial polarization markers. Furthermore, the aggregated PHF6 also influences Beclin-1 expression and autophagy in a time-dependent manner. Overall, the study provides insights into the complex interplay between Alzheimer's PHF6 peptide aggregation and microglial inflammation, polarization, and autophagy.

CELLS (2021)

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Article Biochemistry & Molecular Biology

2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway

Ruixue Huang et al.

Summary: Chronic exposure to n-hexane can cause sensorimotor neuropathy mediated by the toxic metabolite 2,5-hexanedione. The activation of NLRP3 inflammasome has been associated with various neurodegenerative diseases, and in this study, it was found that HD-induced neurotoxicity involves the activation of NLRP3 inflammasome. Inhibition of NADPH oxidase can mitigate the activation of NLRP3 inflammasome and subsequent neurodegeneration, suggesting a critical role of NADPH oxidase-dependent activation of microglial NLRP3 inflammasome in HD-induced neurotoxicity.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling

Shuting Zhang et al.

MOLECULAR PSYCHIATRY (2020)

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Article Neurosciences

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Vandana Deora et al.

GLIA (2020)

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Article Cell Biology

Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice

Jinbo Cheng et al.

AUTOPHAGY (2020)

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Article Cell Biology

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

Ming He et al.

CELL METABOLISM (2020)

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Article Immunology

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

Juan Tang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

Asta Luciunaite et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Immunology

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease

Zheng Fan et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Geriatrics & Gerontology

A novel role for SHARPIN in amyloid-O phagocytosis and inflammation by peripheral blood -derived macrophages in Alzheimer's disease

Dhanya Krishnan et al.

NEUROBIOLOGY OF AGING (2020)

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Article Cell Biology

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Xue Zhang et al.

AGING-US (2020)

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Article Clinical Neurology

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

Sunny Malhotra et al.

BRAIN (2020)

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Article Physiology

Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

Camila A. Pereira et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Neurosciences

Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer's Disease

Weigang Cui et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Clinical Neurology

NLRP3 level in cerebrospinal fluid of patients with neuromyelitis optica spectrum disorders: Increased levels and association with disease severity

Yu Peng et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

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Article Cardiac & Cardiovascular Systems

Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis

Suwen Chen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Immunology

NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease

Hayate Javed et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Signaling Through Purinergic Receptor P2Y2Enhances Macrophage IL-1β Production

Gonzalo de la Rosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Clinical Neurology

NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice

Gen Li et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Neurosciences

Effects of Chronic Masitinib Treatment in APPswe/PSEN1dE9 Transgenic Mice Modeling Alzheimer's Disease

Tengfei Li et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Cell Biology

Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer's Disease Patients

Filomena Iannuzzi et al.

CELLS (2020)

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Article Immunology

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants

Elisabeth Mulazzani et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Cell Biology

Klotho overexpression improves amyloid-beta clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Yue Zhao et al.

AGING CELL (2020)

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Article Clinical Neurology

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

Heping Shen et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2020)

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Article Immunology

Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy

Hui Hu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Immunology

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology

Daniel C. Shippy et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

Yang Liu et al.

NEUROSCIENCE LETTERS (2020)

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Article Neurosciences

NLRP3 Is Involved in the Maintenance of Cerebral Pericytes

Wenqiang Quan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Cell Biology

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease

Xiao-fei He et al.

CELL DEATH & DISEASE (2020)

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Article Neurosciences

Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice

Jie Li et al.

EXPERIMENTAL BRAIN RESEARCH (2020)

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Article Biology

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

Wenbiao Wang et al.

BMC BIOLOGY (2020)

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Article Multidisciplinary Sciences

Galactosaminogalactan activates the inflammasome to provide host protection

Benoit Briard et al.

NATURE (2020)

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Article Multidisciplinary Sciences

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease

Niklas Lonnemann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll -like receptors 2 and 4

Pedro M. Moraes-Vieira et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

Hui Song et al.

NATURE COMMUNICATIONS (2020)

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Article Biology

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Jack P. Green et al.

ELIFE (2020)

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Article Multidisciplinary Sciences

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease

Xinwen Zhang et al.

SCIENCE ADVANCES (2020)

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Article Clinical Neurology

Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?

Jack Rivers-Auty et al.

BRAIN COMMUNICATIONS (2020)

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Article Immunology

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons

Diana F. Silva et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Clinical Neurology

Diclofenac reduces the risk of Alzheimer's disease: a pilot analysis of NSAIDs in two US veteran populations

Olaf Stuve et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2020)

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Article Cell Biology

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

Tao Pan et al.

NEURAL REGENERATION RESEARCH (2020)

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Article Chemistry, Multidisciplinary

A novel artificial intelligence protocol to investigate potential leads for Parkinson's disease

Zhi-Dong Chen et al.

RSC ADVANCES (2020)

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Article Biochemistry & Molecular Biology

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Biochemistry & Molecular Biology

ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Guangming Ren et al.

EMBO JOURNAL (2019)

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Correction Biochemistry & Molecular Biology

ApoE attenuates unresolvable inflammation by complex formation with activated C1q (vol 25, pg 496, 2019)

Changjun Yin et al.

NATURE MEDICINE (2019)

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Article Cell Biology

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

Xiaojuan Han et al.

AUTOPHAGY (2019)

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Article Biochemistry & Molecular Biology

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

Tam T. T. Tran et al.

FASEB JOURNAL (2019)

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Article Multidisciplinary Sciences

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

Humayun Sharif et al.

NATURE (2019)

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Article Neurosciences

The relationship between inflammasomes and the endoplasmic reticulum stress response in the injured spinal cord

Sho Yanagisawa et al.

NEUROSCIENCE LETTERS (2019)

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Article Multidisciplinary Sciences

Alternative splicing regulates stochastic NLRP3 activity

Florian Hoss et al.

NATURE COMMUNICATIONS (2019)

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Article Clinical Neurology

Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease

Si Zhang et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

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Article Clinical Neurology

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease A Randomized Clinical Trial

Christopher H. van Dyck et al.

JAMA NEUROLOGY (2019)

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Article Multidisciplinary Sciences

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

Parimal Samir et al.

NATURE (2019)

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Article Neurosciences

EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

Yuhua Chen et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

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Article Neurosciences

Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia

Pratima Rawat et al.

GLIA (2019)

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Article Immunology

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

Koustav Chatterjee et al.

JOURNAL OF NEUROIMMUNOLOGY (2019)

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Article Clinical Neurology

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Ilie-Cosmin Stancu et al.

ACTA NEUROPATHOLOGICA (2019)

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Article Cell Biology

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

Agnese Gugliandolo et al.

INFLAMMATION (2018)

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Article Psychiatry

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression

Claudia Bartels et al.

AMERICAN JOURNAL OF PSYCHIATRY (2018)

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Article Behavioral Sciences

Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NF kappa B

Manish Kumar et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

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Review Geriatrics & Gerontology

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

Ruth Knight et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2018)

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Article Neurosciences

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

Francois Mouton-Liger et al.

GLIA (2018)

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Article Immunology

HSP60 critically regulates endogenous IL-1 beta production in activated microglia by stimulating NLRP3 inflammasome pathway

Shalini Swaroop et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Neurosciences

NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo

Yingjie Qi et al.

NEUROBIOLOGY OF DISEASE (2018)

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Article Neurosciences

Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway

Bingqing Cao et al.

NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Tali Lang et al.

NATURE COMMUNICATIONS (2018)

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Article Geriatrics & Gerontology

Fasudil in Combination With Bone Marrow Stromal Cells (BMSCs) Attenuates Alzheimer's Disease-Related Changes Through the Regulation of the Peripheral Immune System

Jiezhong Yu et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

Jack P. Green et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

Rachael Barry et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

Jueqi Chen et al.

NATURE (2018)

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Article Cell Biology

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Richard Gordon et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Immunology

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Ayaka Nakanishi et al.

INFLAMMATION AND REGENERATION (2018)

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Article Neurosciences

NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease

Katharine M. von Herrmann et al.

NPJ PARKINSONS DISEASE (2018)

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Article Clinical Neurology

Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice

Berthold Debye et al.

BRAIN PATHOLOGY (2018)

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Article Neurosciences

Prevention of Amyloid-β and Tau Pathologies, Associated Neurodegeneration, and Cognitive Deficit by Early Treatment with a Neurotrophic Compound

Narjes Baazaoui et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Immunology

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Andrea Stutz et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Immunology

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Zhirong Zhang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Biochemistry & Molecular Biology

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

Nan Song et al.

MOLECULAR CELL (2017)

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Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats

Zhijuan Mao et al.

NEUROCHEMICAL RESEARCH (2017)

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Article Critical Care Medicine

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

Jessica S. Wallisch et al.

NEUROCRITICAL CARE (2017)

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Review Neurosciences

Islet amyloid polypeptide: Another key molecule in Alzheimer's pathogenesis?

Yun Zhang et al.

PROGRESS IN NEUROBIOLOGY (2017)

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Article Multidisciplinary Sciences

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Xuan Li et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

Tiantian Tang et al.

NATURE COMMUNICATIONS (2017)

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Article Medicine, Research & Experimental

[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease

Michelle L. James et al.

THERANOSTICS (2017)

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Article Clinical Neurology

Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound

Narjes Baazaoui et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

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Article Neurosciences

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease

Souvarish Sarkar et al.

NPJ PARKINSONS DISEASE (2017)

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Article Immunology

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice

Juan Zhuang et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Article Immunology

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

C. Dempsey et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Article Immunology

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Christina J. Gross et al.

IMMUNITY (2016)

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Article Neurosciences

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease

Marina Saresella et al.

MOLECULAR NEURODEGENERATION (2016)

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Article Multidisciplinary Sciences

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Mausita Karmakar et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Michael J. D. Daniels et al.

NATURE COMMUNICATIONS (2016)

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Article Clinical Neurology

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

Adam C. Kaufman et al.

ANNALS OF NEUROLOGY (2015)

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Article Biochemistry & Molecular Biology

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

Adelin Gustot et al.

BIOCHEMICAL JOURNAL (2015)

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Article Biochemistry & Molecular Biology

FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity

Yan-Le Xin et al.

BIOSCIENCE REPORTS (2015)

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Article Biochemistry & Molecular Biology

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan et al.

CELL (2015)

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Article Cell Biology

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Wan-ting He et al.

CELL RESEARCH (2015)

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Article Neurosciences

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

Weihua Zhao et al.

EXPERIMENTAL NEUROLOGY (2015)

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Article Neurosciences

NLRP3 Inflammasome Is Expressed by Astrocytes in the SOD1 Mouse Model of ALS and in Human Sporadic ALS Patients

Sonja Johann et al.

GLIA (2015)

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Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Control of repeat-protein curvature by computational protein design

Keunwan Park et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Neurosciences

Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production

Li Wang et al.

NEUROSCIENCE LETTERS (2015)

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Article Cell Biology

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

J. R. Yaron et al.

CELL DEATH & DISEASE (2015)

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Article Biochemistry & Molecular Biology

Control of repeat-protein curvature by computational protein design

Keunwan Park et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Alvin Lu et al.

CELL (2014)

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Article Endocrinology & Metabolism

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

Islam N. Mohamed et al.

DIABETOLOGIA (2014)

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Article Immunology

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Alberto Baroja-Mazo et al.

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Targeting NLRP3 inflammasome for neurodegenerative disorders

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