Research Progress in Oxygen Carrier Design and Application

Ischemia or hypoxia can lead to pathological changesin the metabolismand function of tissues and then lead to various diseases. Timelyand effective blood resuscitation or improvement of hypoxia is veryimportant for the treatment of diseases. However, there is a needto develop stable, nontoxic, and immunologically inert oxygen carriersdue to limitations such as blood shortages, different blood types,and the risk of transmitting infections. With the development of varioustechnologies, oxygen carriers based on hemoglobin and perfluorocarbonhave been widely studied in recent years. This paper reviews the developmentand application of hemoglobin and perfluorocarbon oxygen carriers.The design of oxygen carriers was analyzed, and their applicationas blood substitutes or oxygen carriers in various hypoxic diseaseswas discussed. Finally, the characteristics and future research ofideal oxygen carriers were prospected to provide reference for follow-upresearch.

Automated summary

Ischemia or hypoxia can cause pathological changes in tissue metabolism and function, leading to various diseases. Timely and effective blood resuscitation or improvement of hypoxia is crucial for disease treatment. However, the development of stable, non-toxic, and immunologically inert oxygen carriers is necessary due to limitations such as blood shortages and the risk of infections. Hemoglobin and perfluorocarbon-based oxygen carriers have been widely studied, and this paper reviews their development and applications as blood substitutes or oxygen carriers in hypoxic diseases. The design of oxygen carriers, their characteristics, and future research prospects are also discussed to provide a reference for further studies.