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Article
Radiology, Nuclear Medicine & Medical Imaging
Sanjana Ballal et al.
Summary: This study evaluated the long-term outcome of 225Ac-DOTATATE targeted alpha therapy (TAT) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) expressing somatostatin receptors. The results showed that the therapy was effective, even in patients refractory to prior treatment, with acceptable adverse effects.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Indraja D. Dev et al.
Summary: Sporadic cerebellar hemangioblastomas are rare and often associated with von Hippel-Lindau syndrome. We present an atypical case where a symptomatic sporadic cerebellar hemangioblastoma mimicked a meningioma on MRI and Ga-68-DOTANOC PET imaging.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunjuan Jiang et al.
Summary: The study demonstrates that [I-131]-labeled KN046 shows high affinity and specificity for PD-L1/CTLA-4 immune targets, with excellent intratumoral retention capability leading to good antitumor efficacy. The combination of low-dose [I-131] with KN046 significantly increases immunotherapy response rates and induces release of tumor immunogenicity-related antigens as well as significant increases in T-cell activation and tumor-infiltrating immunocytes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yutian Feng et al.
Summary: This study evaluates the therapeutic potential of single-domain antibody fragments (sdAbs) combined with alpha-particle therapy for HER2-expressing cancers. The results demonstrate that HER2-specific sdAbs, such as 5F7 and VHH_1028, show better efficacy in tumor growth inhibition compared to HER2-irrelevant VHH_2001, suggesting that combining high-affinity HER2-targeted sdAbs with a residualizing prosthetic agent is a promising strategy for targeted alpha-particle therapy.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Weihao Liu et al.
Summary: This study developed a novel heterodimeric peptide probe for glioma targeting and PET imaging. The designed probe showed good targeting ability and imaging effect, making it a potential radiopharmaceutical probe for glioma.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rie Kuroda et al.
Summary: In patients with high-risk neuroblastoma, the treatment regimen of I-131-mIBG therapy, single high-dose chemotherapy, and autologous or allogeneic stem cell transplantation is safe and effective without dose-limiting toxicity. Evaluations based on RECIST 1.1 showed stability disease and complete response rates of 87.5% and 12.5%, respectively.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Jeffrey A. Bogart et al.
Summary: Progress in the treatment of small-cell lung cancer has been slower compared to non-small-cell lung cancer. However, there have been improvements in long-term outcomes due to advances in staging, radiation treatment planning, and supportive care. Ongoing research is exploring the use of higher-dose radiotherapy and immunotherapy to further improve treatment outcomes.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasmin M. Klose et al.
Summary: The study assessed the biodistribution of various radioligand application routes in mice, and found that subcutaneous and intraperitoneal administration had comparable biodistribution to intravenous injection. Subcutaneous administration resulted in the highest tumor uptake, suggesting its potential in clinical assessment.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ebrahim S. Delpassand et al.
Summary: The targeted α-therapy with Pb-212-DOTAMTATE showed good tolerability and promising preliminary efficacy in treating patients with somatostatin receptor-positive NETs.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shimpei Iikuni et al.
Summary: A GLP-1R imaging probe [In-111]In-E4DA1 has been developed, which can detect the location of insulinomas in vivo and has reduced renal accumulation.
MOLECULAR PHARMACEUTICS
(2022)
Review
Oncology
Klaire Exarchou et al.
Summary: Gastric neuroendocrine neoplasms (g-NENs), a rare type of stomach cancer, have different pathogenesis and clinical characteristics, requiring different treatment strategies. Recent research has made progress in identifying differences between indolent and aggressive g-NENs and discovering a new mutation. Novel biomarkers have also been developed to improve diagnosis and treatment. However, the heterogeneity of g-NENs poses challenges in understanding and managing this disease, necessitating further research.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Barbara Bober et al.
Summary: The study aimed to assess the early and long-term liver complications after administration of Lutetium-177 or Lutetium-177 combined with Yttrium-90 in treating neuroendocrine neoplasms. The results showed that PRRT was a safe treatment for patients with highly or moderately differentiated, unresectable, or diffuse NENs.
NUCLEAR MEDICINE REVIEW
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anwin Joseph Kavanal et al.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Thomas Y. Wong et al.
Summary: This study evaluated the safety and efficacy of 90Y radioembolization for NELM, showing a median OS of 41 months for well-differentiated tumors and 7.6% developing grade 3 or greater hepatic toxicity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuwei Liu et al.
Summary: This study suggests the potential application of FAPI radioligand therapy in FAP-expressing pancreatic cancer, but further evaluation is needed to identify the best radionuclide with a shorter half-life, as well as combination with therapies targeting tumor cells directly.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Endocrinology & Metabolism
Guido Rindi et al.
Summary: In this review, the changes and features of neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors are detailed. The consolidation of nomenclature distinguishing different neoplasms and the importance of Ki67 as a tool for classification and grading are emphasized. The clinical relevance of proper classification and the tools available to pathologists for accurate classification are explained. The article also discusses the differential diagnoses and theranostic biomarkers for NENs, as well as the role of pathologists in identifying precursor lesions and applying molecular immunohistochemistry.
ENDOCRINE PATHOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Viviane J. Tschan et al.
Summary: This study investigated [Lu-177]Lu-Ibu-DAB-PSMA in preclinical in vivo experiments and compared its therapeutic efficacy and potential side effects with other radioligands. The results showed that [Lu-177]Lu-Ibu-DAB-PSMA was more effective in inhibiting tumor growth compared to [Lu-177]Lu-PSMA-617, and had a better safety profile than [Lu-177]Lu-PSMA-ALB-56. These findings suggest that [Lu-177]Lu-Ibu-DAB-PSMA has potential for clinical translation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Endocrinology & Metabolism
Julie Refardt et al.
Summary: Molecular imaging plays a crucial role in neuroendocrine neoplasms (NEN). By using a radiotracer, specific features of the tumor can be visualized. Somatostatin receptors are the most commonly targeted hormone receptors, while alternatives include glucose metabolism, glucagon-like peptide-1 receptors, and C-X-C motif chemokine receptor-4. There are also promising new radiopeptides awaiting further evaluation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rosa Fonti et al.
Summary: This study aimed to evaluate and quantify the heterogeneity of SSTR2 expression within primary and metastatic lesions of patients with neuroendocrine tumors. The results showed that the CoV of malignant lesions was higher than that of normal tissues, and the CoV varied with the type and site of the malignant lesions.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yuan Cheng et al.
Summary: Lung cancer, divided into small and nonsmall cell lung cancer, is a highly heterogeneous cancer. In this study, the F(ab ')(2) fragments of Durva were used to evaluate PD-L1 expression, and I-124-Durva-F(ab ')(2) was identified as a promising PD-L1 immunoPET tracer.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Martina Benesova et al.
Summary: This study investigated the impact of structural modifications of folate radioconjugates on their pharmacokinetic properties. The results showed that the linker entity in close proximity to the 4-(p-iodophenyl)butanoate entity affected the affinity to albumin. Changes in the linker entity connecting the DOTA chelator with the folate molecule did not have a major impact on the tissue distribution profile. [Lu-177]Lu-OxFol-3 showed comparable therapeutic effect to [Lu-177]Lu-OxFol-1 but appeared advantageous in preventing kidney damage.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Jiajia Zhang et al.
Summary: By designing Mn-based IRT radiosensitizers, local interstitial radiotherapy can be enhanced to address the insufficient systematic immune responses and inhibit tumor metastasis by remodeling the tumor microenvironment and activating immune responses.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Giulia Puliani et al.
Summary: This review discusses the new evidence published in 2021 on the use of Lu-177-Oxodotreotide (DOTATATE) or Y-90-Edotreotide (DOTATOC) in adult patients with NETs. The review suggests potential expansion of PRRT applications and explores the safety of PRRT, as well as the identification of prognostic and predictive factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Melpomeni Fani et al.
Summary: Somatostatin receptors (SSTs) are highly expressed in neuroendocrine tumors and neuroendocrine neoplasms, making them favorable molecular targets. Radiolabeled SST agonists, such as Ga-68-DOTA-TOC and Ga-68-DOTA-TATE, are used for PET/CT imaging and play an important role in staging and restaging these tumors. New developments, including the use of SST2 antagonists and more cytotoxic radioisotopes, show promise in enhancing diagnostic accuracy and therapeutic efficacy for SST-expressing tumors. However, further research is needed to determine if these new developments can surpass the established radiolabeled SST analogs and beta(-)-emitter PRRT.
Article
Oncology
Vandana Batra et al.
Summary: This study investigated the safety and antitumor activity of [At-211]MABG in neuroblastoma, and found that it has significant survival advantage and can effectively eradicate microscopic residual disease. An alpha particle emitting radiopharmaceutical may be effective against disseminated disease.
CLINICAL CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Marina Simon et al.
Summary: Investigating the combination of [Lu-177]Lu-DOTA-TATE PRRT and nanoshell (NS)-based PTT for treating SSTR-expressing small-cell lung tumors in mice, the study showed improved survival with the combination treatment compared to PRRT alone, highlighting the importance of treatment timing. The combination treatment was well-tolerated in the mice, suggesting the potential of NS-based PTT as an add-on to PRRT for further investigation.
Article
Medicine, Research & Experimental
Weihao Liu et al.
Summary: Targeted radionuclide therapy based on alpha-emitters is important in cancer treatment. This study proposes a new vector for At-211 radiolabeling and demonstrates its effectiveness in inhibiting tumor growth and promoting cell apoptosis without significant toxicity to normal organs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Sofia Koustoulidou et al.
Summary: Two JR11 analogs (8a and 8b) carrying an albumin binding domain were designed to prolong the blood residence time of JR11 for more effective treatment. In vitro and in vivo studies showed that [Lu-177]Lu-8a exhibited better affinity and tumor accumulation compared to [Lu-177]Lu-8b, while [Lu-177]Lu-8b did not show tumor uptake.
Article
Engineering, Biomedical
Jiajia Zhang et al.
Summary: This study demonstrates the efficacy of a tri-modal TAT-CDT-ICB strategy for inhibiting tumor metastasis and relapse. The designed radioimmunotherapy promoters, At-211-ATE-MnO2-BSA, not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. When combined with immune checkpoint inhibitors, At-211-ATE-MnO2-BSA effectively suppresses the growths of primary tumors and distant tumors. This work presents a novel approach for cancer therapy with repressed metastasis and relapse.
BIOMATERIALS RESEARCH
(2022)
Letter
Chemistry, Medicinal
Carmen Waengler et al.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Stephen Ahenkorah et al.
Summary: In this study, a novel chelator 3p-C-NETA was evaluated for its potential therapeutic and diagnostic applications. [F-18]-labeled 3p-C-NETA-TATE showed good stability and pharmacokinetic properties similar to [F-18]AlF-NOTA-Octreotide, indicating its potential as a new theranostic chelator for clinical nuclear medicine applications.
Letter
Cell Biology
Li-Nan Chen et al.
Article
Medicine, General & Internal
Charles M. Rudin et al.
Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Oncology
Apar Kishor P. Ganti et al.
Summary: The NCCN Clinical Practice Guidelines in Oncology provide recommendations for the management of SCLC, emphasizing the importance of systemic therapy for extensive-stage disease and promoting smoking cessation in patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Jonathan R. Strosberg et al.
Summary: The NETTER-1 trial did not show a significant improvement in median overall survival with Lu-177-Dotatate treatment compared to high-dose long-acting octreotide, however, there was an 11.7 month difference which could be considered clinically relevant. No new safety signals were reported during long-term follow-up.
Review
Respiratory System
Sara Tariq et al.
Summary: SCLC accounts for 14% of lung cancer cases and is highly aggressive with limited treatment options. Recent advances have identified potential therapeutic targets and subtypes, but further research is needed to improve treatment outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rahul Parghane et al.
Summary: In GEP-NET patients, Lu-177-DOTATATE therapy can convert unresectable primary tumors into resectable in a moderate fraction of cases. The treatment leads to improved survival rates and progression-free survival, suggesting its potential as a neoadjuvant therapy option.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
C. Bezzi et al.
Summary: Radiomics in the context of PanNETs focuses on methods, technical approaches, and clinical applications. Studies have shown potential in tumor grade prediction, differential diagnosis, and assessment of tumor behavior, but further validation and optimization are needed for clinical application.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narges K. Tafreshi et al.
Summary: The study demonstrates significant potential for the clinical translation of [Ac-225]Ac-DOTA-TATE for lung NENs, showing notable tumor growth delay and prolonged time to experimental endpoint.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Medicine, General & Internal
Luz Kelly Anzola et al.
Summary: Atherosclerosis, characterized by inflammatory reactions, is the main cause of heart attacks. Developing predictors for disease complications is essential due to the silent nature of the condition. Radiopharmaceuticals for PET/CT have emerged to target high-risk plaques, showing high specificity in identifying vulnerable atherosclerotic plaques.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jingjing Zhang et al.
Summary: The case study presented a patient with beta-radiation refractory metastatic thymus NET who demonstrated excellent therapy response after Ac-225-DOTATOC-targeted alpha-therapy, showing molecular and morphological remission as well as significantly improved clinical symptoms, with no adverse effects observed during treatment or follow-up.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Immunology
Mengqin Zhu et al.
Summary: Immunogenic cell death (ICD) is a regulated form of cell death induced by various stresses, which releases DAMPs such as HMGB1, CRT, ATP, and HSPs to produce antitumor immunity. Ionizing radiation (IR) has been shown to induce ICD, with factors like dose, type, and fractionation influencing its induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Alireza Karimian et al.
Review
Radiology, Nuclear Medicine & Medical Imaging
Joseph G. Jurcic
SEMINARS IN NUCLEAR MEDICINE
(2020)
Article
Hematology
Shyril O'Steen et al.
Review
Urology & Nephrology
Michael J. Morris et al.
NATURE REVIEWS UROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Bingkun Zhao et al.
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Oncology
Fei Yu et al.
Article
Oncology
Huizi Keiko Li et al.
Article
Oncology
Huizi Keiko Li et al.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cristina Mueller et al.
JOURNAL OF NUCLEAR MEDICINE
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael R. Zalutsky et al.
NUCLEAR MEDICINE AND BIOLOGY
(2007)
Article
Biochemical Research Methods
G Vaidyanathan et al.
BIOCONJUGATE CHEMISTRY
(2006)
Article
Biochemistry & Molecular Biology
G Vaidyanathan et al.
