Natural Polysaccharide Delivery Platforms with Multiscale Structure Used for Cancer Chemoimmunotherapy

Article Surgery

A Phase 3 Randomized Clinical Trial of Chemotherapy With or Without Algenpantucel-L (HyperAcute-Pancreas) Immunotherapy in Subjects With Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer

Daniel Brock Hewitt et al.

Summary: In patients with borderline resectable or locally advanced unresectable pancreatic ductal adenocarcinoma, Algenpantucel-L immunotherapy did not improve overall survival and showed similar safety profile compared to standard treatment.

ANNALS OF SURGERY (2022)

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Article Engineering, Biomedical

Cryogel vaccines effectively induce immune responses independent of proximity to the draining lymph nodes

Alexander J. Najibi et al.

Summary: Cryogel-based cancer vaccines can induce potent antigen-specific immune responses regardless of the distance to the draining lymph nodes. The vaccination location flexibility of scaffold-based vaccines demonstrates their ability to generate strong immune responses independent of draining lymph nodes.

BIOMATERIALS (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Review Chemistry, Multidisciplinary

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

Sajal Sen et al.

Summary: Cancer is the second deadliest disease worldwide, and immunotherapy using immunogenic cell death (ICD) shows promise in overcoming treatment limitations. Metal-based complexes have been identified as potential ICD inducers. This review assesses the progress in this field and sets the stage for future advances.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Urology & Nephrology

Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes

Gottfrid Sjodahl et al.

Summary: This study investigates the impact of molecular subtypes on pathological response and survival in patients with muscle-invasive bladder cancer (MIBC) receiving preoperative cisplatin-based chemotherapy. The results suggest that patients with certain molecular subtypes, such as genomically unstable (GU) and urothelial-like (Uro) tumors, are more responsive to cisplatin-based neoadjuvant chemotherapy and have improved survival compared to those with the basal/squamous (Ba/Sq) subtype. The study highlights the potential of subtype-specific biomarkers, such as osteopontin (SPP1), for developing a more precision-based treatment approach for neoadjuvant chemotherapy in MIBC.

EUROPEAN UROLOGY (2022)

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Review Immunology

Immunogenic cell stress and death

Guido Kroemer et al.

Summary: Immunogenic cell death (ICD) plays an important role in therapy and disease, as dying mammalian cells release signals that interact with the host to determine the immunological correlates of cellular stress and death. ICD is crucial in immunosurveillance and is related to strategies evolved by pathogens and cancer cells. Additionally, normal cell death can also initiate antigen-specific immune responses.

NATURE IMMUNOLOGY (2022)

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Article Oncology

Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies

Hanxin Liu et al.

Summary: The tumor microenvironment plays a major role in the malignancy and therapeutic resistance of cancer, with intercellular communication contributing to this process. Immune evasion, extracellular matrix remodeling, and therapy-induced senescence (TIS) all contribute to cancer resistance and disease progression. The senescence-associated secretory phenotype (SASP) of senescent cells drives inflammation and promotes tumor relapse and distant metastasis. selectively removing senescent cells may be a promising strategy to prevent drug resistance associated with the remodelled tumor microenvironment.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

Biological functions of therapy-induced senescence in cancer

Eleni Fitsiou et al.

Summary: Therapy-induced cellular senescence is a stable growth arrest state caused by common cancer treatments such as chemotherapy and radiation. Its consequences in an oncogenic context can vary, acting as both a tumor suppressive mechanism and a tumor promoting factor due to differential expression and secretion of specific cytokines and factors.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Pharmacology & Pharmacy

Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

Man Kyu Shim et al.

Summary: This review outlines the trends and advances in tumor immunotherapy using carrier-free prodrug nanoparticles (PDNPs). PDNPs have shown great potential in reversing immunosuppressive tumor microenvironment and enhancing the response to immune checkpoint blockade therapy. This strategy provides a safe and effective drug delivery method with improved therapeutic outcomes.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Smart μ-Fiber Hydrogels with Macro-Porous Structure for Sequentially Promoting Multiple Phases of Articular Cartilage Regeneration

Zhijie Ma et al.

Summary: In this study, a macro-porous hydrogel was developed for articular cartilage regeneration. The hydrogel incorporated exosomes derived from lipopolysaccharide-activated cells stimulated with bioglass extract, as well as poly(lactic-co-glycolic acid) microspheres containing kartogenin. This hydrogel not only improved tissue infiltration, but also sequentially delivered different bioactive substances to enhance cartilage regeneration.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Applied

Chitosan-gum arabic embedded alizarin nanocarriers inhibit biofilm formation of multispecies microorganisms

Vinit Raj et al.

Summary: This study synthesized chitosan-gum arabic-coated liposomes-alizarin nanocarriers (CGL-Alz NCs) to improve the release and penetration of alizarin in biofilms. The CGL-Alz NCs acted against biofilms caused by Candida albicans or Staphylococcus aureus and exerted long-term antibiofilm effects through sustained release of alizarin.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Epigallocatechin 3-gallate: From green tea to cancer therapeutics

Manzar Alam et al.

Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.

FOOD CHEMISTRY (2022)

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Article Biotechnology & Applied Microbiology

Targeting of pancreatic cancer cells and stromal cells using engineered oncolytic Salmonela typhimurium

Wenzhi Tan et al.

Summary: Pancreatic cancer is resistant to conventional therapies due to abundant stromal cells and poor immune cell infiltration. This study used engineered Salmonella typhimurium expressing ClyA to target cancer stromal cells and cancer cells, effectively treating pancreatic cancer in mice. The bacteria accumulated in tumor tissues and secreted ClyA into the tumor microenvironment, leading to inhibition of cancer growth and increased immune cell infiltration. This approach provides a novel strategy for treating pancreatic cancer by combining anticancer and antistromal therapy.

MOLECULAR THERAPY (2022)

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Article Chemistry, Physical

A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair

Zejun Xu et al.

Summary: A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity has been developed for enhanced diabetic wound repair. The hydrogel platform shows remarkable biocompatibility and antioxidant properties, as well as the ability to regulate blood glucose levels, promote angiogenesis, and effectively treat inflammation.

NANO RESEARCH (2022)

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Article Engineering, Biomedical

Microfluidized Dextran Microgels Loaded with Cisplatin/SPION Lipid Nanotherapeutics for Local Colon Cancer Treatment via Oral Administration

I. -Lin Lu et al.

Summary: A multifunctional sequential targeted delivery system has been developed for efficient treatment of malignant tumors with selective accumulation and minimal systemic drug absorption. This system consists of microfluidized dextran microgels encapsulating LNPs and SPIONs, which achieve hierarchical dual targeting and enhance the retention and cellular uptake of therapeutic LNPs in the colon. The system demonstrates a strong therapeutic effect and reduces unnecessary drug absorption and side effects.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy

Yu Zhang et al.

Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Article Materials Science, Multidisciplinary

Highly antifouling double network hydrogel based on poly(sulfobetaine methacrylate) and sodium alginate with great toughness

Jing Zhang et al.

Summary: A newly developed double network hydrogel based on SBMA and SA exhibits excellent mechanical properties, biocompatibility, and antifouling properties, making it a promising candidate for biomedical applications. The hybrid crosslinked structure of the DN hydrogel provides it with unique characteristics suitable for artificial connective tissues, implantable devices, and underwater equipment.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

Biological drug and drug delivery-mediated immunotherapy

Qingqing Xiao et al.

Summary: The onset and progression of inflammatory diseases such as cancer, vascular inflammation, and autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy plays a critical role in combating these diseases, while drug delivery strategies are potent in promoting their delivery.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Biochemistry & Molecular Biology

Zwitterionic Hydrogel with High Transparency, Ultrastretchability, and Remarkable Freezing Resistance for Wearable Strain Sensors

Qin Jiao et al.

Summary: This study presents the development of an ultrastretchable, highly transparent, and antifreezing zwitterionic-based electronic sensor that can maintain its toughness and transparency down to -40 degrees C. The zwitterionic hydrogel exhibits good biocompatibility and protein adsorption resistance. Such zwitterionic hydrogel-based strain sensors could be highly valuable for wearable electronic devices, especially in extreme environment applications.

BIOMACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity

Lele Sun et al.

Summary: A smart hydrogel has been developed to release immune adjuvants in response to repeated low-dose chemo/radiotherapies, enhancing antitumor immunity. By synchronizing the release of immune adjuvants with tumor cell death, the hydrogel demonstrates remarkable synergistic effects in eliminating established tumors and promoting immune memory.

ADVANCED MATERIALS (2021)

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Article Chemistry, Applied

Highly antifouling, biocompatible and tough double network hydrogel based on carboxybetaine-type zwitterionic polymer and alginate

Jing Zhang et al.

Summary: This study prepared a new hybrid ionic-covalent cross-linked double network hydrogel with good mechanical properties by a one-pot method, exhibiting high elastic modulus, tensile strength, self-recovery capability, outstanding antifouling property, and biocompatibility. This provides a new strategy for preparing antifouling hydrogels for different applications like tissue scaffolds, wound dressings, and implantable devices.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy

Baicheng Wei et al.

Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.

NANO LETTERS (2021)

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Article Engineering, Biomedical

Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion

Jinfeng Liao et al.

Summary: Osteosarcoma, a malignant bone tumor that often occurs in adolescents, poses challenges in complete surgical removal leading to high recurrence rates and metastasis. A novel hydrogel with photothermal properties has been developed for postoperative tumor eradication and bone regeneration, showing promising dual functions in tumor therapy and tissue repair.

BIOACTIVE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Jingjing Huo et al.

Summary: Given the challenges of bacterial resistance and biofilm protection, photothermal therapy (PTT)-derived multimodal synergistic treatments have emerged as a promising approach to combat bacterial infections. By combining PTT with chemotherapy, photo-dynamic/catalytic therapy, immunotherapy, and sonodynamic therapy, enhanced bactericidal activity can be achieved while minimizing potential side effects.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Biotechnology & Applied Microbiology