☆ 4.7 Article

Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis

MOLECULAR PHARMACEUTICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Bioactive inorganic nanomaterials for cancer theranostics

Zifan Pei et al.

Summary: Bioactive inorganic nanomaterials have attracted wide attention in cancer theranostics due to their unique physical and chemical properties, strong mechanical stability, and easy compounding with various carriers to achieve specific antitumor efficacy.

CHEMICAL SOCIETY REVIEWS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The endocytosis of nano-Pt into non-small cell lung cancer H1299 cells and intravital therapeutic effect in vivo

Zhongqing Xiao et al.

Summary: In this study, platinum nanoclusters were used for optical imaging and demonstrated targeted antitumor activity with low systemic toxicity. The research revealed that the nanoclusters entered non-small cell lung cancer cells predominantly through macropinocytosis and clathrin-dependent endocytosis pathway, showing significant antitumor efficiency and targeting properties. These findings suggest the great potential of platinum nanoclusters for clinical diagnosis and therapy of non-small cell lung cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Targeted nanomedicine in cisplatin-based cancer therapeutics

Yu Han et al.

Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Oncology

Biomarking and Induction of Apoptosis in Ovarian Cancer Using Bifunctional Polyethyleneimine-Caged Platinum Nanoclusters

Mengjun Zhang et al.

Summary: Ovarian cancer, ranking eighth in terms of tumor incidence, has the highest mortality rate among all gynecological tumors. Platinum-based drugs are commonly used in its treatment, but resistance and toxicity limit their effectiveness. In this study, bifunctional ultrafine polyethyleneimine caged platinum nanoclusters (PEI-Pt NCs) were developed to overcome the challenges associated with platinum drugs. Results showed that PEI-Pt NCs can inhibit proliferation and migration, as well as induce apoptosis in ovarian cancer cells.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Deficiency of kin17 Facilitates Apoptosis of Cervical Cancer Cells by Modulating Caspase 3, PARP, and Bcl-2 Family Proteins

Bingsen Su et al.

Summary: This study found that knockdown of KIN17 gene can facilitate apoptosis of cervical cancer cells by targeting caspase 3, PARP, and Bcl-2 family proteins. In addition, KIN17 can regulate cancer cell apoptosis through the mitochondrial pathway and could be used as a novel therapeutic target for the regulation of cell apoptosis in cervical cancer.

JOURNAL OF ONCOLOGY (2022)

添加到收藏夹

Review Multidisciplinary Sciences

Cisplatin for cancer therapy and overcoming chemoresistance

Ranmali Ranasinghe et al.

Summary: Cisplatin is a leading chemotherapy drug for cancer treatment, but its acute toxicity remains a major challenge. While efforts are ongoing to discover more effective drugs, nothing has surpassed the benefits of cisplatin so far. Oxaliplatin is considered superior in colorectal cancer, but cisplatin still has a wide application in treating gynaecological cancers.

HELIYON (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma

Georgia Zoumpoulidou et al.

Summary: RB1 loss-of-function mutations in osteosarcoma exhibit selective hypersensitivity to PARP inhibitors, independent of canonical homologous recombination defect signatures.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Oncology

Long Non-coding RNAs in Cisplatin Resistance in Osteosarcoma

Valeria A. Ferretti et al.

Summary: Osteosarcoma is a common malignant bone tumor with poor prognosis despite therapeutic progress. Cisplatin is a key drug for treatment, but drug resistance remains a serious issue. Understanding the molecular mechanisms and genes involved in cisplatin resistance in Osteosarcoma is crucial for developing more effective treatments.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies

Ingrid Lilienthal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

Shuying Shen et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-α4β7 monoclonal antibody-conjugated nanoparticles block integrin α4β7 on intravaginal T cells in rhesus macaques

Sidi Yang et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Review Materials Science, Biomaterials

Recent advancements in polyethyleneimine-based materials and their biomedical, biotechnology, and biomaterial applications

Zhonghui Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Autophagy Modulated by Inorganic Nanomaterials

Lingling Guo et al.

THERANOSTICS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting BAX to drug death directly

Loren D. Walensky

NATURE CHEMICAL BIOLOGY (2019)

添加到收藏夹

Article Oncology

Incidence and Mortality of Sarcomas in Shanghai, China, During 2002-2014

Bao Pingping et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities

Fatemeh Farjadian et al.

NANOMEDICINE (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Delivery technologies for cancer immunotherapy

Rachel S. Riley et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Maire F. Osborn et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Selective bio-labeling and induced apoptosis of hematopoietic cancer cells using dual-functional polyethylenimine-caged platinum nanoclusters

Xing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Fluorescent gold nanoclusters for efficient cancer cell targeting

Rahul Purohit et al.

International Journal of Nanomedicine (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting BCL-2 regulated apoptosis in cancer

Kirsteen J. Campbell et al.

OPEN BIOLOGY (2018)

添加到收藏夹

Article Materials Science, Biomaterials

Phenanthriplatin(IV) conjugated multifunctional up-converting nanoparticles for drug delivery and biomedical imaging

Bo Teng et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Nanotechnology: Revolutionizing the Science of Drug Delivery

Mohini Mishra et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

添加到收藏夹

Article Chemistry, Applied

Polyethyleneimine modified poly(Hyaluronic acid) particles with controllable antimicrobial and anticancer effects

Nurettin Sahiner et al.

CARBOHYDRATE POLYMERS (2017)

添加到收藏夹

Review Chemistry, Medicinal

Direct Activation of Bax Protein for Cancer Therapy

Zhiqing Liu et al.

MEDICINAL RESEARCH REVIEWS (2016)

添加到收藏夹

Article Biochemical Research Methods

N-Heterocyclic Carbene-Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy

Neila Chekkat et al.

BIOCONJUGATE CHEMISTRY (2016)

添加到收藏夹

Review Oncology

Platinum-based drugs: past, present and future

Shahana Dilruba et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

添加到收藏夹

Review Oncology

Finally, An Apoptosis-Targeting Therapeutic for Cancer

Carlo M. Croce et al.

CANCER RESEARCH (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Cisplatin resistance and opportunities for precision medicine

Lauren Amable

PHARMACOLOGICAL RESEARCH (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma

Hongping Xia et al.

ACS CENTRAL SCIENCE (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Polyethyleneimine-Based Nanocarriers for Gene Delivery

Xia Wang et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lipid Metabolism, Apoptosis and Cancer Therapy

Chunfa Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Nanomedicine therapeutic approaches to overcome cancer drug resistance

Janet L. Markman et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ajay Ummat et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of cisplatin resistance

L. Galluzzi et al.

ONCOGENE (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cisplatin resistance: Preclinical findings and clinical implications

Beate Koeberle et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.