☆ 4.5 Review

Pyroptosis and inflammation-mediated endothelial dysfunction may act as key factors in the development of erectile dysfunction (Review)

MOLECULAR MEDICINE REPORTS (2023)

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Review Andrology

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

Giuseppe Defeudis et al.

Summary: This study systematically reviewed the effects of diet and antihyperglycemic drugs on erectile function in diabetic patients. The results showed that the Mediterranean diet was effective in protecting erectile function, and antihyperglycemic drugs had an overall protective role. However, further research is needed on specific drugs.

ANDROLOGY (2023)

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Article Cell Biology

NLRP3 activation contributes to endothelin-1-induced erectile dysfunction

Rafael Sobrano Fais et al.

Summary: In this study, it was hypothesized that stimulation of endothelin receptors ETA and ETB leads to NLRP3 activation through increased calcium and ROS formation. The experiments conducted on mice demonstrated that ET-1 reduced intracavernosal pressure and the CC ACh and SNP-induced relaxation, while increasing caspase-1 expression. The use of receptor antagonists, genetic deletion, and ROS inhibitors reversed these effects, indicating that ET-1-induced erectile dysfunction involves the activation of NLRP3 via Ca2+-dependent ROS generation mediated by ETA- and ETB-receptors.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2023)

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Article Cell Biology

Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome

Longjiang Di et al.

Summary: This study investigated the specific mechanism of endothelial cell pyroptosis induced by platelet-released PMPs activated by anti-beta(2)GPI/beta(2)GPI complexes. The increased expression of NLRP3 in PMPs stimulated by anti-beta(2)GPI/beta(2)GPI complexes is closely associated with GSDMD-N, a protein involved in endothelial pyroptosis. The findings provide new insights into the mechanism of endothelial cell damage in APS and identify a potential drug target for the clinical treatment of APS.

PLATELETS (2023)

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Article Andrology

Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway

Ying Chen et al.

Summary: This study found that high-fat diet can cause erectile dysfunction, and the down-regulation of spectrin alpha, erythrocytic 1 (SPTA1) expression may lead to cell pyroptosis by activating the Hippo signaling pathway and further reducing erectile function.

ANDROLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Ticagrelor reduces doxorubicin-induced pyroptosis of rat cardiomyocytes by targeting GSK-3β/caspase-1

Shu-hui Wang et al.

Summary: This study investigated the effects of ticagrelor on Dox-induced pyroptosis in cardiomyocytes. Ticagrelor was shown to significantly improve cardiac function by inhibiting GSK-3 beta/caspase-1/GSDMD activation. In vitro experiments further demonstrated that ticagrelor reduces Dox-induced pyroptosis by targeting GSK-3 beta/caspase-1.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis

Wei Wang et al.

Summary: This study found that PINK1-mediated mitophagy and caspase-3/GSDME pathway play important roles in the pathogenesis of postoperative cognitive dysfunction (POCD). Interventional studies using PINK1 silencing and caspase-3 inhibitor showed that PINK1-regulated mitophagy regulates anesthesia and surgery-induced cognitive impairment by affecting the caspase-3/GSDME pathway, providing a promising therapeutic target for POCD.

ACS CHEMICAL NEUROSCIENCE (2023)

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Review Medicine, Research & Experimental

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

Xiaolu Zhang et al.

Summary: The NLRP3 inflammasome plays a crucial role in inflammatory diseases and has emerged as a promising therapeutic target.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2023)

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Article Dentistry, Oral Surgery & Medicine

Association of polymorphisms in Th1/Th2-related cytokines (IFN-g, TGFb1, IL-1b, IL-2, IL-4, IL-18) with oral lichen planus: A pooled analysis of case-control studies

Wei Liu et al.

Summary: This study aimed to investigate the genetic associations between SNPs in 6 cytokines (IFN-g, IL-18, TGFb1, IL-13, IL-2, IL-4) and OLP susceptibility. A significant association was found between IFN-g (874A/T) and IL-18 (137G/C) polymorphisms with OLP. A marginally significant association was found between TGFb1 (509C/T) polymorphism and OLP. However, no significant associations were found for IL-1b (3954C/T), IL-2 (330T/G), IL-4 (590C/T), and IL-18 (607C/A) polymorphisms with OLP.

JOURNAL OF DENTAL SCIENCES (2023)

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Review Cardiac & Cardiovascular Systems

The role of ROS-induced pyroptosis in CVD

Kaijiang Tian et al.

Summary: Cardiovascular disease (CVD) is the leading cause of death worldwide and poses a serious threat to human health. Pyroptosis, a newly discovered form of cell death, has been found to play a key role in CVD induced by reactive oxygen species (ROS). However, the exact signaling pathway of ROS-induced pyroptosis is not fully understood. This article reviews the specific mechanisms of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence suggests that ROS-mediated pyroptosis could be a novel target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF).

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

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Article Immunology

Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis

Changsheng Yan et al.

Summary: The study aimed to investigate the role of endoplasmic reticulum stress (ERS) in promoting caspase-1-dependent pancreatic acinar cell pyroptosis via the protein kinase R-like ER kinase (PERK) pathway to aggravate acute pancreatitis (AP). Findings showed that ERS enhances caspase-1-dependent pyroptosis and pyroptotic injury through the PERK pathway, exacerbating AP.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Immunology

Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

Miao Ren et al.

Summary: In this study, it was found that ergolide (ERG), a natural compound derived from Inula britannica, inhibits NLRP3-mediated pyroptosis by irreversibly binding to the NACHT domain of NLRP3, preventing its assembly and activation. ERG shows potential as an anti-inflammatory therapeutic agent.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Review Endocrinology & Metabolism

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Giuseppe Defeudis et al.

Summary: This study reviews the definition and prevalence of erectile dysfunction in diabetes mellitus, the impact of diabetes complications and treatment on erectile dysfunction, and current and emerging therapies for erectile dysfunction in patients with diabetes mellitus.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2022)

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Article Medicine, Research & Experimental

Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer

Aibin Liu et al.

Summary: Through comprehensive analysis, it was found that pyroptosis is aberrantly expressed in different types of cancer, attributed to CAN frequency and differences in DNA methylation levels. A pyroptosis level model was established, revealing a dual role of pyroptosis in cancers, with different levels across multiple cancers significantly associated with clinical prognosis.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Andrology

Erectile and sexual dysfunction in male and female patients with celiac disease: A cross-sectional observational study

Lorenzo Romano et al.

Summary: The study found that sexual dysfunction is prevalent in celiac disease patients. Early age at diagnosis and high body mass index appear to be predictors of sexual dysfunction. The assessment of sexual function should be included in the initial evaluation of celiac disease patients for prompt diagnosis and treatment.

ANDROLOGY (2022)

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Article Microbiology

IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

Xuemei Gou et al.

Summary: This study reveals a novel mechanism for the development of pneumosepsis caused by Streptococcus pneumoniae and the critical protective role of IL-6. IL-6 prevents macrophage death and lung inflammation injury during pneumococcal pneumosepsis. These findings are important for the early identification and treatment of pneumococcal pneumosepsis.

MICROBIOLOGY SPECTRUM (2022)

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Article Andrology

The relationship between obstructive sleep apnoea and erectile dysfunction: An underdiagnosed link? A prospective cross-sectional study

Elena Cantone et al.

Summary: This study investigated the prevalence and clinical characteristics of erectile dysfunction in patients with obstructive sleep apnoea. The results showed that 60% of patients with obstructive sleep apnoea reported erectile dysfunction. Age, hypertension, diabetes, Epworth sleepiness scale, apnoea-hypopnea index score, O-2 saturation-nadir, and oxygen desaturation index were found to have statistically significant correlations with erectile function.

ANDROLOGIA (2022)

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Article Gastroenterology & Hepatology

Sexual dysfunction in gastroenterological patients: Do gastroenterologists care enough? A nationwide survey from the Italian Society of Gastroenterology (SIGE)

Lorenzo Romano et al.

Summary: The survey found that the majority of gastroenterologists do not frequently discuss sexual dysfunction with their patients, citing reasons such as lack of knowledge, time constraints, and embarrassment. However, most respondents believed that all specialists should be able to manage sexual problems, and that attending courses on sexual dysfunction could increase awareness of the issue.

DIGESTIVE AND LIVER DISEASE (2022)

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Review Pharmacology & Pharmacy

Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells

Iara Leao Luna de Souza et al.

Summary: Erectile dysfunction is a sexual disorder characterized by the inability to generate or maintain a penile erection. It can be caused by psychosocial factors, preexisting conditions, and changes in neurotransmission and hormonal action. Current therapy involves oral vasodilators or direct injection of medications. Further research is needed to develop more effective drugs for treating this condition.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Endocrinology & Metabolism

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats

Chao Luo et al.

Summary: The study demonstrated that downregulating NLRP3 could enhance the survival of ASCs in high glucose conditions and improve DMED. Transplanting ASCs with downregulated NLRP3 could effectively suppress the development of erectile dysfunction and improve erectile function, showing promising potential for clinical applications.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

Activation and Pharmacological Regulation of Inflammasomes

Chen Chen et al.

Summary: Inflammasomes are intracellular signaling complexes involved in inflammatory reactions and cytokine release. They play a role in various diseases and have potential as therapeutic targets.

BIOMOLECULES (2022)

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Review Cardiac & Cardiovascular Systems

Non-coding RNAs in necroptosis, pyroptosis, and ferroptosis in cardiovascular diseases

Yuxi Cai et al.

Summary: Non-coding RNAs play a critical role in cardiovascular diseases, particularly in cell death. There has been a growing interest in studying their regulation of tissue homeostasis and pathophysiological conditions in CVDs. This review summarizes the functions of ncRNAs in CVDs, as well as their limitations and future prospects.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cell & Tissue Engineering

Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis

Huan Feng et al.

Summary: The study demonstrates that HUCMSCs can effectively and safely alleviate erectile dysfunction in T1DM and T2DM ED rats by attenuating diabetes-induced ferroptosis in CCSMCs. Furthermore, it provides significant evidence for the development of HUCMSCs as a viable therapeutic strategy for DMED.

STEM CELL RESEARCH & THERAPY (2022)

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Review Immunology

The role of pyroptosis and its crosstalk with immune therapy in breast cancer

Ling Wu et al.

Summary: Pyroptosis, a type of programmed cell death, has different effects on breast cancer and is associated with tumor immunotherapy. A comprehensive summary of the role of pyroptosis in cancer, specifically in breast cancer, is crucial for harnessing its potential in enhancing immunotherapy efficiency.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Role of pyroptosis in inflammation and cancer

Xiang Wei et al.

Summary: This article reviews the mechanisms, newly discovered influencing factors, anti-tumoral properties, and applications of pyroptosis in various diseases. Moreover, it provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and addresses the challenges and future directions in the field.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Review Medicine, Research & Experimental

Pyroptosis in inflammatory diseases and cancer

Zhiping Rao et al.

Summary: Pyroptosis is a critical type of programmed cell death that plays a key role in host defense against pathogen infection and can serve as a new strategy for cancer elimination. Excessive pyroptosis, however, may lead to inflammatory diseases. Therefore, it is important to fully understand the molecular mechanisms and therapeutic implications of pyroptosis.

THERANOSTICS (2022)

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Review Cell Biology

Pyroptosis: A promising therapeutic target for noninfectious diseases

Tong Li et al.

Summary: Pyroptosis is a form of programmed cell death characterized by the formation of inflammatory pores, cellular lysis, and release of pro-inflammatory cytokines, associated with intracellular pathogens-induced infection. However, it is now understood that pyroptosis also plays a role in sterile inflammation. Targeting the pyroptotic signaling pathway with specific inhibitors may offer a promising approach for the treatment of noninfective inflammatory disorders.

CELL PROLIFERATION (2021)

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Article Urology & Nephrology

Physiology of Erection and Pathophysiology of Erectile Dysfunction

Susan M. MacDonald et al.

UROLOGIC CLINICS OF NORTH AMERICA (2021)

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Article Andrology

Low androgen status inhibits erectile function by increasing pyroptosis in rat corpus cavernosum

Zhi-bin Chen et al.

Summary: The research suggests that low androgen status inhibits erectile function in rats by promoting cavernous fibrosis and decreasing NO synthesis through inducing pyroptosis of smooth muscle cells and endothelial cells in the corpus cavernosum.

ANDROLOGY (2021)

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Review Biochemistry & Molecular Biology

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie's Disease

Yasuyoshi Miyata et al.

Summary: Erectile dysfunction (ED) causes mental distress and decreases the quality of life for patients and their partners. Phosphodiesterase type 5 (PDE5) inhibitors are the standard treatment for ED, but effective in only a subgroup of patients. Macrophages play important roles in ED and Peyronie's disease (PD), but more research is needed to fully understand the pathological mechanisms involved.

BIOMEDICINES (2021)

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Review Pharmacology & Pharmacy

Gasdermin D in pyroptosis

Brandon E. Burdette et al.

Summary: Pyroptosis is a process of inflammatory cell death that defends the host against microbe infection, but excessive pyroptosis can lead to inflammatory diseases. The cleavage of GsdmD is essential for pyroptosis, releasing cytokines and causing cell death, playing a crucial role in inflammatory diseases.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Biochemistry & Molecular Biology

Anatomy, Pathophysiology, Molecular Mechanisms, and Clinical Management of Erectile Dysfunction in Patients Affected by Coronary Artery Disease: A Review

Giuseppe Sangiorgi et al.

Summary: Erectile dysfunction (ED) is the inability to achieve or maintain sufficient erection for successful sexual intercourse, significantly impacting life quality and relationships. Atherosclerosis of penile arteries is a common cause, warranting investigation for potential coexisting diseases. Understanding the pathophysiology and molecular basis has led to advancements in pharmacological and mechanical treatments for ED.

BIOMEDICINES (2021)

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Review Medicine, General & Internal

Effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews and meta-analyses

Nikolaos Pyrgidis et al.

Summary: Phosphodiesterase-type 5 inhibitors are recommended first-line treatment for erectile dysfunction, being safe and effective in various patient groups. This overview aims to summarize the existing knowledge on the efficacy and safety of PDE5i in the general population and multiple patient subgroups.

BMJ OPEN (2021)

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Review Immunology

Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Nan Ji et al.

Summary: Pyroptosis is a form of pro-inflammatory cell death mediated by the Gasdermin family and releases inflammatory cytokines. It is closely related to cardiovascular diseases such as myocardial infarction, ischemia-reperfusion, and atherosclerosis.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

Caspases in Cell Death, Inflammation, and Pyroptosis

Sannula Kesavardhana et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Article Oncology

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis

Yiyi Li et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Editorial Material Immunology

Mitochondrial GSDMD Pores DAMPen Pyroptosis

Katherine C. Barnett et al.

IMMUNITY (2020)

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Article Cell Biology

Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis

Minghao Luo et al.

INFLAMMATION (2020)

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Review Medicine, General & Internal

Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products

Karma Yeshi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Cell Biology

Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

Ming-Che Liu et al.

CELLS (2020)

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Article Cell Biology

Exosomes derived from smooth muscle cells ameliorate diabetes-induced erectile dysfunction by inhibiting fibrosis and modulating the NO/cGMP pathway

Jingyu Song et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Interleukin-18 in Health and Disease

Koubun Yasuda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Medicinal

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

Bozhi Ye et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Article Biotechnology & Applied Microbiology

Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells

Yu Song et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

Ning Li et al.

REDOX BIOLOGY (2019)

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Review Immunology

Inflammation research sails through the sea of immunology to reach immunometabolism

V. Kumar

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation

Rafael S. Fais et al.

SCIENTIFIC REPORTS (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Review Biochemistry & Molecular Biology

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

Cheng Zeng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Review Pharmacology & Pharmacy

PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery

K-E Andersson

BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Gastroenterology & Hepatology

Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease

Yuan-Yuan Yuan et al.

GASTROENTEROLOGY REPORT (2018)

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Article Pharmacology & Pharmacy

Depression induced by chronic stress leads to penile cavernosal dysfunction: protective effect of anti-TNF-α treatment

Tugce Demirtas Sahin et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018)

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Article Urology & Nephrology

Restorative effect of resveratrol on expression of endothelial and neuronal nitric oxide synthase in cavernous tissues of chronic unpredictable mild stress-exposed rats: an impact of inflammation

Yusufhan Yazir et al.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2018)

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Article Cell Biology

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

Fan Yang et al.

CELL DEATH & DISEASE (2018)

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Article Medicine, Research & Experimental

NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction

Qian Lei et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Cell Biology

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Bo Zhou et al.

CELL RESEARCH (2018)

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Article Oncology

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18-and sirtuin-1-independent pathways

Ya-feng Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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Article Urology & Nephrology

Early-stage Type 2 Diabetes Mellitus Impairs Erectile Function and Neurite Outgrowth From the Major Pelvic Ganglion and Downregulates the Gene Expression of Neurotrophic Factors

Hotaka Matsui et al.

UROLOGY (2017)

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Article Peripheral Vascular Disease

Association Between Cardiovascular Health and Endothelial Function With Future Erectile Dysfunction: The Multi-Ethnic Study of Atherosclerosis

Abbi D. Lane-Cordova et al.

AMERICAN JOURNAL OF HYPERTENSION (2017)

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Article Endocrinology & Metabolism

Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study

Shazli Azmi et al.

DIABETOLOGIA (2017)

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Article Cardiac & Cardiovascular Systems

NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage

Thiago Bruder-Nascimento et al.

CIRCULATION (2016)

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Article Andrology

Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model

Y. Hu et al.

ANDROLOGY (2016)

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Article Medicine, General & Internal

Erectile dysfunction

Faysal A. Yafi et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Multidisciplinary Sciences

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

Xingying He et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

Yang Zhang et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

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Review Andrology

Lifestyle modifications and erectile dysfunction: what can be expected?

Maria Ida Maiorino et al.

ASIAN JOURNAL OF ANDROLOGY (2015)

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Article Biochemistry & Molecular Biology

Inflammasomes: sensors of metabolic stresses for vascular inflammation

Ying Yin et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2013)

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Article Immunology

Salmonella Downregulates Nod-like Receptor Family CARD Domain Containing Protein 4 Expression To Promote Its Survival in B Cells by Preventing Inflammasome Activation and Cell Death

Araceli Perez-Lopez et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Andrology

The association between TNF-α and erectile dysfunction complaints

G. Matos et al.

ANDROLOGY (2013)

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Article Urology & Nephrology

Poly(ADP-Ribose) Polymerase Inhibition Improves Erectile Function by Activation of Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in Diabetic Rats

Wen Ji Li et al.

JOURNAL OF SEXUAL MEDICINE (2012)

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Article Endocrinology & Metabolism

Molecular and clinical characterization of Y chromosome microdeletions in infertile men: A 10-year experience in Italy

Alberto Ferlin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

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Article Cardiac & Cardiovascular Systems

Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease

Charalambos Vlachopoulos et al.

EUROPEAN HEART JOURNAL (2006)

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Review Immunology

Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells

SL Fink et al.

INFECTION AND IMMUNITY (2005)

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