☆ 4.3 Review

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

MOLECULAR DIAGNOSIS & THERAPY (2023)

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Diet in Dermatology: Review of Diet's Influence on the Conditions of Rosacea, Hidradenitis Suppurativa, Herpes Labialis, and Vitiligo

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Summary: This review investigates the modification of diet for the treatment of cutaneous diseases such as rosacea, hidradenitis suppurativa, herpes labialis, and vitiligo. The findings suggest that elimination diets may not improve rosacea symptoms, but have low risk of harm. Zinc and vitamin D supplementation have been found to be beneficial for treating hidradenitis suppurativa. L-lysine supplementation is effective for prophylaxis but not for decreasing duration of active lesions in herpes labialis. The use of Polypodium leucotomos and vitamin D supplementation can increase repigmentation in vitiligo.

AMERICAN JOURNAL OF LIFESTYLE MEDICINE (2023)

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Article Dermatology

GATA3 ameliorates melanocyte injuries in vitiligo through SIRT3-mediated HMGB1 deacetylation

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Summary: Vitiligo is a skin depigmentation disorder characterized by downregulation of GATA3 and upregulation of HMGB1. H2O2 treatment inhibits cell survival, proliferation, and melanin secretion while inducing cell apoptosis. GATA3 overexpression can reverse the effects of H2O2 by decreasing HMGB1 expression and acetylation, which is mediated by SIRT3. These findings provide new evidence for the treatment of vitiligo.

JOURNAL OF DERMATOLOGY (2023)

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Editorial Material Medicine, General & Internal

Uses of Polypodium leucotomos Extract in Oncodermatology

Paolo Calzari et al.

Summary: The extract of Polypodium leucotomos plays a vital role in preventing skin cancers and photoaging, and it can be effective when taken orally or applied topically. Its mechanisms include antioxidant, photoprotective, antimutagenic, anti-inflammatory, and immunoregulatory effects. In addition, it has potential uses in non-neoplastic diseases such as pigmentary disorders, photosensitivity, and atopic dermatitis.

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Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening

Young Yun Jung et al.

Summary: Yuja has antioxidant, anti-wrinkle, moisturizing, and whitening effects. It inhibits collagen degradation, induces moisturizing factors, and decreases melanin content. These findings contribute to the development of skin-improving cosmetics and pharmaceuticals.

ANTIOXIDANTS (2023)

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Article Dermatology

Influence of Oral Supplementation of Vitamins A and E on the Effectiveness of Vitiligo Treatment

Laura Nowowiejska et al.

Dermatologic Therapy (2023)

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Review Cell Biology

The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications

Wei-Ling Chang et al.

Summary: Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing melanocytes which are attacked by immune cells. Oxidative stress is considered to play a crucial role in activating consequent autoimmune responses related to vitiligo. This report provides new perspectives and advances our understanding of interrelationships between oxidative stress and autoimmunity in the pathogenesis of vitiligo. Progress with targeted antioxidant therapy is described, with the aim of providing potential therapeutic approaches.

CELLS (2023)

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Article Dermatology

The Role of Dietary Antioxidants in Melanoma and Nonmelanoma Skin Cancer

Kimberly A. Sable et al.

Summary: Dietary supplements, such as vitamins, have been used in dermatology to treat various skin conditions. Antioxidants can prevent cellular damage caused by free radicals and potentially prevent DNA damage from UV radiation. Studies suggest that antioxidants and vitamins may play a role in chemoprevention of melanoma and NMSC in humans.

CUTIS (2023)

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Article Dermatology

Comparison of the efficacy of Tacrolimus 0.1% ointment and Tacrolimus 0.1% plus topical pseudocatalase/superoxide dismutase gel in children with limited vitiligo: a randomized controlled trial

Diala M. Alshiyab et al.

Summary: This study aimed to assess the synergic effect of pseudocatalase/superoxide dismutase (PSD) gel when combined with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone for the treatment of vitiligo. The results showed that adding PSD to Tacrolimus ointment did not provide any additional therapeutic benefit in children with limited vitiligo.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Article Biochemistry & Molecular Biology

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Laura Lossi

BIOCHEMICAL JOURNAL (2022)

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Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process

Monika Michalak

Summary: This review focuses on the importance of plant compounds in skin care, particularly the role of plant compounds as antioxidants in protecting skin health and combating harmful factors such as UV radiation and free radicals.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

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Summary: This article reviews the role of mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) in metabolic regulation, aging, and aging-related diseases. By understanding how sirtuins regulate metabolic processes and their functional differences in canonical pathways and signaling networks, a deeper understanding of the mechanisms underlying the delay or acceleration of biological aging can be achieved.

JOURNAL OF GENETICS AND GENOMICS (2022)

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Review Cell Biology

The Role of Oxidative Stress in the Pathogenesis of Vitiligo: A Culprit for Melanocyte Death

Yijie Xuan et al.

Summary: This review summarizes the role of oxidative stress in the pathogenesis of vitiligo and discusses the mechanisms of interaction between oxidative stress and various modes of cell death. The findings suggest that oxidative stress acts as an initiator for different cell death modes through complex mechanisms, such as autophagy, apoptosis, and ferroptosis. These insights provide new ideas for exploring the pathogenesis and potential therapeutic targets of vitiligo.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response

Shan He et al.

Summary: Vitiligo is a chronic autoimmune skin disorder characterized by depigmented patches and destruction of melanocytes. Oxidative stress, as a key factor, leads to melanocyte loss by altering the redox status and impairing the defense mechanism. There is a connection between oxidative stress and autoimmunity in vitiligo, with chemokines playing a role in disease progression.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

Ferroptosis: A New Regulatory Mechanism in Osteoporosis

Pan Liu et al.

Summary: This review discusses the role of ferroptosis in the pathogenesis of osteoporosis, as well as its relationship with osteoclasts, osteoblasts, diabetic osteoporosis, steroid-induced osteoporosis, and postmenopausal osteoporosis. Emerging biomedical research provides new insights into the roles of ferroptosis and osteoporosis, helping broaden our understanding of iron metabolism and immune regulation. Further studies using animal models and cell models will contribute to clarifying the relationship between ferroptosis and osteoporosis, and may lead to the development of new mechanisms and treatments for osteoporosis in the future.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

Xiaoxue Xing et al.

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Cell Biology

Oxeiptosis: a novel pathway of melanocytes death in response to oxidative stress in vitiligo

Pan Kang et al.

Summary: This study found that in addition to apoptosis and necroptosis, other cell death modalities may exist in melanocytes under oxidative stress. Furthermore, it was demonstrated that Oxeiptosis occurs in oxidative stress-induced melanocyte death and contributes to the pathogenesis of vitiligo.

CELL DEATH DISCOVERY (2022)

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The Current Status of Antioxidants in the Treatment of Vitiligo in China

Ying Zhou et al.

Summary: Little is known about the use of antioxidants in the clinical treatment of vitiligo. A study conducted in China found that while the majority of dermatologists recognized the potential of antioxidants for treating vitiligo, their actual usage rates were low. Insufficient knowledge was identified as a significant factor influencing the frequency of antioxidant usage. The stage, type, severity, age, and method of using antioxidants were also found to affect the curative efficacy of antioxidants in treating vitiligo.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Research Progress on Targeted Antioxidant Therapy and Vitiligo

Jingzhan Zhang et al.

Summary: Vitiligo, a common skin condition characterized by depigmentation, poses significant challenges for treatment due to its long duration and slow results. The role of oxidative stress in the development of vitiligo has been recognized, leading to the exploration of antioxidant therapy. This article provides a brief overview of the relationship between oxidative stress and vitiligo, as well as advancements in targeted antioxidant treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Altered expression of ferroptosis markers and iron metabolism reveals a potential role of ferroptosis in vitiligo

Xiuyi Wu et al.

Summary: The expression of ferroptosis markers is altered in the epidermis of vitiligo patients and iron deficiency is revealed in their blood. Erastin induces ferroptosis in human epidermal MCs in vitro, while NAC protects MCs from ferroptosis.

PIGMENT CELL & MELANOMA RESEARCH (2022)

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Chuwen Tian et al.

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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Necroptosis: A Pathogenic Negotiator in Human Diseases

Hitesh Singh Chaouhan et al.

Summary: This review focuses on the mechanisms underlying programmed cell death pathways, including apoptosis and necroptosis. It discusses the functions of necroptosis-associated proteins and their impact on disease progression. Furthermore, it explores the potential benefits of natural and chemical compounds, as well as novel targeted therapies, in inducing necroptotic cell death in malignant cells and overcoming drug resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biotechnology & Applied Microbiology

Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy

Xiaoqing Liu et al.

Summary: This review provides a brief summary of mitochondrial-endoplasmic reticulum communication-mediated oxidative stress and autophagy. The mitochondria and endoplasmic reticulum, as important organelles in cells, are connected to each other and jointly regulate oxidative stress and autophagy. The review explores the mutual connection of mitochondria and endoplasmic reticulum in mediating oxidative stress and autophagy through ROS and Ca2+ and aims to provide part of the theoretical basis for alleviating oxidative stress through autophagy mediated by mitochondrial-endoplasmic reticulum communication.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Dermatology

Serum Copper and Zinc Levels Among Iranian Vitiligo Patients

Zahra Khoshdel et al.

Summary: This study aimed to evaluate the changes in serum Cu and Zn levels among Iranian vitiligo patients. The results showed significantly lower Cu and Zn levels in vitiligo patients compared to healthy controls, as well as lower Cu and Zn concentrations in young patients and those with generalized vitiligo.

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Review Immunology

Immunometabolism in the pathogenesis of vitiligo

Chen Lyu et al.

Summary: Vitiligo is a skin disorder characterized by the loss of melanocytes. The pathogenesis of vitiligo involves immunometabolism, including mitochondrial dysfunction, oxidative stress, and defects in metabolic pathways. These abnormalities are influenced by genetic and epigenetic factors and are associated with glucose and lipid metabolism. Melanocytes, keratinocytes, and tissue-resident memory T cells play important roles in the dysregulation of metabolic pathways in vitiligo.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Dermatology

Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study

Sinu Rose Mathachan et al.

Summary: Oxidative stress likely plays a pathogenic role in vitiligo, with significantly raised levels of oxidative damage marker and decreased levels of antioxidants observed in patients. Generalized and active disease groups showed more derangement in oxidative stress parameters compared to localized and stable disease groups.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium

Katherine G. Thompson et al.

Summary: Dietary supplements like zinc, biotin, and vitamin D are commonly recommended by dermatologists, but the evidence for their safety and efficacy is limited. Nicotinamide shows promising evidence in preventing nonmelanoma skin cancers, while further high-quality studies are needed for biotin and zinc.

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Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Yi Yu et al.

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CELL DEATH DISCOVERY (2021)

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HLA-Cw1 and Psoriasis

Yi-Wei Huang et al.

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AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

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Article Dermatology

NB-UVB plus oral Polypodium leucotomos extract display higher efficacy than NB-UVB alone in patients with vitiligo

Alessia Pacifico et al.

Summary: Combination treatment with oral supplementation of Polypodium leucotomos and NB-UVB phototherapy can enhance repigmentation and improve response rate in patients with vitiligo, suggesting a potential therapeutic strategy for the disease.

DERMATOLOGIC THERAPY (2021)

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Randomized clinical trial of combined therapy with oral α-lipoic acid and NB-UVB for nonsegmental stable vitiligo

Yan Sun et al.

Summary: This study did not find additional benefit of oral ALA in combination with NB-UVB phototherapy in the treatment of nonsegmental stable vitiligo. There were no significant differences between treatment group and control group for patients of different ages and genders. More studies should be conducted to identify other protocols of ALA or other types of antioxidants for the treatment of stable vitiligo.

DERMATOLOGIC THERAPY (2021)

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The relationship between non-segmental Vitiligo, HLA genotype and oxidative stress

Yildiz Hayran et al.

Summary: The study revealed that HLA-A*02 increased, HLA-A*11 and HLA-DRB1*01 decreased susceptibility to vitiligo in Turkish patients, along with a potential relationship between HLA and TAC.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid

Fanni Toth et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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A Systematic Review of Nutrition, Supplement, and Herbal-Based Adjunctive Therapies for Vitiligo

Anastasia Shakhbazova et al.

Summary: Vitiligo is an autoimmune skin condition that destroys skin melanocytes, causing depigmentation of the skin. Nutritional supplements and diet may have a potential impact on managing the disease, but further research is needed to explore this area.

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2021)

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Review Dermatology

Vitiligo: A focus on pathogenesis and its therapeutic implications

Christina Bergqvist et al.

Summary: Vitiligo is a common depigmenting disorder caused by genetic and environmental factors. Significant progress has been made in understanding its pathogenesis as an autoimmune disease in the past decade.

JOURNAL OF DERMATOLOGY (2021)

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Mechanisms of melanocyte death in vitiligo

Jianru Chen et al.

Summary: Vitiligo is an autoimmune depigment disease caused by the destruction of melanocytes due to various factors, including genetic susceptibility, oxidative stress, and immune dysfunction. Research suggests that most melanocyte deaths are a result of abnormal immune responses, including heightened innate immunity, skewed T helper cells, and cytotoxic T lymphocytes.

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Article Dermatology

Oxidative stress and the cholinergic system in non-segmental vitiligo: Effect of narrow band ultraviolet b

Eman Raafat Said et al.

Summary: The study found that levels of cholinergic system and oxidative stress in the skin of vitiligo patients significantly changed before and after phototherapy, indicating their important role in the development of vitiligo.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2021)

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The fate of melanocyte: Mechanisms of cell death in vitiligo

Xiuyi Wu et al.

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PIGMENT CELL & MELANOMA RESEARCH (2021)

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Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

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NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Yaoying Lu et al.

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BIOSCIENCE REPORTS (2021)

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Clinical Significance of Serum Oxidative Stress Markers to Assess Disease Activity and Severity in Patients With Non-Segmental Vitiligo

Shuli Li et al.

Summary: This study found dysregulated oxidative stress status in patients with non-segmental vitiligo (NSV), with antioxidant enzymes, total antioxidant capacity, and oxidative biomarkers showing significant differences compared to healthy controls. These serum markers were correlated with disease activity and severity, indicating their potential for assessing the condition in NSV patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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The Cross-Link between Ferroptosis and Kidney Diseases

Jingyu Wang et al.

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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RIP1-Mediated Necroptosis Facilitates Oxidative Stress-Induced Melanocyte Death, Offering Insight into Vitiligo

Bowei Li et al.

Summary: This study found evidence of necroptosis in melanocytes from vitiligo perilesional skin, and oxidative stress was shown to trigger melanocyte death. The RIP1 signaling pathway plays a crucial role in this process.

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Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Fabrizio Guarneri et al.

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Fas-FasL interaction in cytotoxic T cell-mediated vitiligo: The role of lesional expression of tumor necrosis factor-α and interferon-γ in Fas-mediated melanocyte apoptosis

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Homocysteine induces melanocytes apoptosis via PERK-eIF2α-CHOP pathway in vitiligo

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Vitiligo: A Review

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DERMATOLOGY (2020)

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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Therapeutic implications of assessment of serum zinc levels in patients with vitiligo: A patient controlled prospective study

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Serum level of antioxidant vitamins and minerals in patients with vitiligo, a systematic review and meta-analysis

Jing Huo et al.

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Functional nutrition as integrated approach in vitiligo management

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Cell death: a review of the major forms of apoptosis, necrosis and autophagy

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Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo

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Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar

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RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

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Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy

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IL-17 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo

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HMGB1 deficiency reduces H2O2-induced oxidative damage in human melanocytes via the Nrf2 pathway

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Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

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NATURE IMMUNOLOGY (2018)

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Article Dermatology

Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde

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CLINICAL AND EXPERIMENTAL DERMATOLOGY (2017)

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Article Biochemistry & Molecular Biology

Levels of oxidative damage and proinflammatory cytokines are enhanced in patients with active vitiligo

Sneha Mitra et al.

FREE RADICAL RESEARCH (2017)

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Article Allergy

Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes

Shuli Li et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

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TRENDS IN BIOCHEMICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

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NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo

Yuanmin He et al.

SCIENTIFIC REPORTS (2017)

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Article Dermatology

Impact of high-mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo

J. Y. Kim et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Article Biochemistry & Molecular Biology

Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo

Q. Shi et al.

CELL DEATH AND DIFFERENTIATION (2016)

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Article Dermatology

Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and inhibition of endoplasmic reticulum stress

L. Lu et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2016)

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Article Pharmacology & Pharmacy

Evaluation of cellular antioxidant and antiproliferative activities of five main phyllanthus emblica L. cultivars in China

D Liu et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Article Dermatology

Triple-combination treatment with oral α-lipoic acid, betamethasone injection, and NB-UVB for non-segmental progressive vitiligo

Li Li et al.

JOURNAL OF COSMETIC AND LASER THERAPY (2016)

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Review Dermatology

Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?

Heng Xie et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

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Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

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Review Biotechnology & Applied Microbiology

Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis

Bi-huan Xiao et al.

BIOMED RESEARCH INTERNATIONAL (2016)

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Review Immunology

Pyroptotic cell death defends against intracellular pathogens

Ine Jorgensen et al.

IMMUNOLOGICAL REVIEWS (2015)

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Oxidative Stress-Induced Chemokine Production Mediates CD8+ T Cell Skin Trafficking in Vitiligo

Shuli Li et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2015)

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Review Biochemistry & Molecular Biology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L. Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2015)

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Article Dermatology

Evaluation of an oral supplement containing Phyllanthus emblica fruit extracts, vitamin E, and carotenoids in vitiligo treatment

Roberta Colucci et al.

DERMATOLOGIC THERAPY (2015)

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Article Dermatology

Decreased copper and zinc in sera of Chinese vitiligo patients: A meta-analysis

Qinghai Zeng et al.

JOURNAL OF DERMATOLOGY (2014)

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Review Dermatology

Melanocytes as Instigators and Victims of Oxidative Stress

Laurence Denat et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Review Dermatology

Guidelines for the management of vitiligo: the European Dermatology Forum consensus

A. Taieb et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Article Dermatology

Q10-triggered facial vitiligo

K. U. Schallreuter

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Article Cell Biology

Caspase Functions in Cell Death and Disease

David R. McIlwain et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Article Dermatology

Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo

Ravinder Kumar et al.

EXPERIMENTAL DERMATOLOGY (2012)

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Article Integrative & Complementary Medicine

Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial

Orest Szczurko et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

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Article Dermatology

Heme Oxygenase-1 Protects Human Melanocytes from H2O2-Induced Oxidative Stress via the Nrf2-ARE Pathway

Zhe Jian et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Dermatology

Hypothesis: Zinc can be effective in treatment of vitiligo

Nooshin Bagherani et al.

INDIAN JOURNAL OF DERMATOLOGY (2011)

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Review Dermatology

Role of antioxidants in the skin: Anti-aging effects

Hitoshi Masaki

JOURNAL OF DERMATOLOGICAL SCIENCE (2010)

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Article Dermatology

Circulatory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligo

Rehan Khan et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2009)

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Article Dermatology

A randomized, double-blinded, placebo-controlled trial of pseudocatalase cream and narrowband ultraviolet B in the treatment of vitiligo

S. Bakis-Petsoglou et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Article Dermatology

Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin

P. V. Sravani et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2009)

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Article Pharmacology & Pharmacy

Response of Vitiligo to Narrowband Ultraviolet B and Oral Antioxidants

Maha Elgoweini et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2009)

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Article Dermatology

From basic research to the bedside:: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo

Karin U. Schallreuter et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2008)

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Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

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Article Dermatology

A comparative study of oxidant-antioxidant status in stable and active vitiligo patients

Dammak Ines et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2006)

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Review Dermatology

Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance

M Campioni et al.

EXPERIMENTAL DERMATOLOGY (2005)

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Article Dermatology

A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients

E Hazneci et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2005)

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Article Dermatology

Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo

D Parsad et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2003)

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Article Dermatology

Topical pseudocatalase mousse and narrowband UVB phototherapy is not effective for vitiligo: an open, single-centre study

DC Patel et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2002)

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Article Dermatology

The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis

M Raisova et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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