期刊
MOLECULAR BIOLOGY OF THE CELL
卷 34, 期 10, 页码 -出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E22-11-0519
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Condensates have emerged as a new way to understand cell organization and are believed to play important roles in all cellular processes. However, current visual representations of condensates do not effectively communicate the growing knowledge about their formation and function. This limitation can lead to biased interpretations of results and hinder the generation of new hypotheses.
Condensates have emerged as a new way to understand how cells are organized, and have been invoked to play crucial roles in essentially all cellular processes. In this view, the cell is occupied by numerous assemblies, each composed of member proteins and nucleic acids that preferentially interact with each other. However, available visual representations of condensates fail to communicate the growing body of knowledge about how condensates form and function. The resulting focus on only a subset of the potential implications of condensates can skew interpretations of results and hinder the generation of new hypotheses. Here we summarize the discussion from a workshop that brought together cell biologists, visualization and computation specialists, and other experts who specialize in thinking about space and ways to represent it. We place the recent advances in condensate research in a historical perspective that describes evolving views of the cell; highlight different attributes of condensates that are not well-served by current visual conventions; and survey potential approaches to overcome these challenges. An important theme of these discussions is that the new understanding on the roles of condensates exposes broader challenges in visual representations that apply to cell biological research more generally.
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