Electrochemical sensor using cobalt oxide-modified porous carbon for uric acid determination

An electrochemical sensor for the detection of uric acid was constructed using cobalt oxide-modified porous carbon@multi-walled carbon nanotube (MWCNTs) composite material for the modification of the electrode. Firstly, ZIF-67 is generated on carbon nanotubes using the surfactant cetylammonium bromide (CTAB) as template. The vesicles generated by CTAB act as nucleation sites for the in situ growth of ZIF-67. Then, cobalt oxide-modified porous carbon was obtained after high-temperature carbonization of ZIF-67, leading to the formation of cobalt oxide-modified porous carbon@MWCNT composite materials. Co-N and Co-O active sites on the composite material can improve the oxidation of uric acid on the electrode surface, leading to enhanced sensitivity and selectivity for uric acid detection. The sensor has a good linear range from 1 to 40 & mu;M for uric acid detection with a detection limit of 0.09 & mu;M. The sensor was utilized for determination of uric acid in actual serum samples.

Automated summary

An electrochemical sensor for uric acid detection was developed using cobalt oxide-modified porous carbon@multi-walled carbon nanotubes composite material. The sensor exhibited a good linear range and detection limit, making it suitable for the determination of uric acid in actual serum samples.