A comprehensive review on the utility of resonance Rayleigh scattering in pharmaceutical analysis; with emphasis on nanostructure role in analyte probing

The present article summarizes the use of resonance Rayleigh scattering (RRS) as a versatile tool in pharma-ceutical analysis. RRS was applied for the determination of about 110 pharmaceutical compounds belonging to more than 12 therapeutical groups. The analyte plays an essential role in affecting the RRS signal through different approaches. Ion associate complex formation was the most commonly applied approach. The ability of the analyte to induce aggregation of certain nanoparticles was another approach. Few methods were based on the role of the analyte on the formation of the nanoparticles, in addition to a minor approach relied on RRS quenching. The widely used RRS probes were organic dyes, while neutralization indictors, surfactants, nano -particles, and inorganic compounds were also utilized. In all approaches, there were evidence for the role of nanostructure in the occurrence of RRS. In addition to the direct RRS measurements, RRS was coupled with HPLC or flow injection as a detection system.

Automated summary

The present article summarizes the use of resonance Rayleigh scattering (RRS) as a versatile tool in pharmaceutical analysis. RRS was applied to determine about 110 pharmaceutical compounds belonging to more than 12 therapeutic groups. Various approaches, including ion associate complex formation, aggregation of nanoparticles induced by analyte, the role of analyte in the formation of nanoparticles, and RRS quenching, were used to affect the RRS signal. Organic dyes were widely used as RRS probes, while neutralization indicators, surfactants, nanoparticles, and inorganic compounds were also utilized. There was evidence for the role of nanostructure in the occurrence of RRS in all approaches. Additionally, RRS was coupled with HPLC or flow injection as a detection system.