4.7 Article

A terpyridyl functionalized rhodamine dye for viscosity sensing with fluorescence enhancement and mitochondria-targeting imaging

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A bifunctional fluorescence probe for dual-channel detecting of mitochondrial viscosity and endogenous/exogenous peroxynitrite

Minglu Li et al.

Summary: In this study, a novel fluorescence probe PV was designed and synthesized for dual-detecting mitochondrial viscosity and ONOO- levels. PV exhibited high sensitivity to viscosity and ONOO- levels with red and yellow emission, respectively. Additionally, PV was successfully applied for viscosity and ONOO- detection in living systems, and it showed the ability to track mitophagy.

BIOORGANIC CHEMISTRY (2022)

Review Chemistry, Inorganic & Nuclear

Recent advances in multifunctional fluorescent probes for viscosity and analytes

Xiaopeng Yang et al.

Summary: Viscosity plays a crucial role in biological systems and its abnormality is closely related to the development of diseases in cellular microenvironment. Fluorescence imaging, with its excellent sensitivity, non-invasive detection, high selectivity and real-time imaging, has become a powerful tool for monitoring local microviscosity and analytes changes in living cells. This review focuses on the design strategies, spectral performance, and biological applications of multifunctional probes for simultaneous detection of viscosity and analytes, and proposes new ideas to overcome the limitations of existing probes.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Chemistry, Analytical

Dual-responsive fluorescent probe for imaging NAD(P)H and mitochondrial viscosity and its application in cancer cell ferroptosis

Han Wei et al.

Summary: The dual-responsive fluorescent probe 3Q-2 can reveal dynamic changes in NAD(P)H and mitochondrial viscosity during ferroptosis, a newly discovered form of cell death. This probe displays two separate spectra in response to NAD(P)H and mitochondrial viscosity with high sensitivity and selectivity. Cancer cells exhibit distinct levels of NAD(P)H and mitochondrial viscosity during ferroptosis induced by specific inhibitors. This robust method of detecting NAD(P)H and mitochondrial viscosity simultaneously may find applications in various physiological and pathological scenarios.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Article Chemistry, Analytical

Dual-ratiometric fluorescence probe for viscosity and hypochlorite based on AIEgen with mitochondria-targeting ability

Xiaohuan Huang et al.

Summary: Viscous microenvironments can lead to common diseases, but there are currently no effective methods for dual-function detection of reactive oxygen species and viscosity. This study introduces a dual-ratiometric-response probe for ClO- and viscosity detection, which shows promising potential for clinical assays.

TALANTA (2022)

Article Engineering, Environmental

Viscosity activated NIR fluorescent probe for visualizing mitochondrial viscosity dynamic and fatty liver mice

Hongjun Song et al.

Summary: Intracellular viscosity is crucial for various biological processes, and abnormal viscosity can lead to concurrent diseases. This study presents the design and development of NIR fluorescent probes for imaging intracellular viscosity and investigating viscosity-related diseases. BP-III was identified as the most sensitive fluorescence sensor for imaging viscosity changes, and it exhibited excellent mitochondrial targetability. The probe was successfully used for imaging abnormal viscosity in fatty liver.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Chemistry, Multidisciplinary

Biological roles of sulfur dioxide and sulfite in the regulation of mitochondrial viscosity

Weijie Zhang et al.

Summary: A NIR fluorescent probe has been developed to visualize the effects of SO2/SO32- on mitochondrial viscosity. The results show that SO32- increases mitochondrial viscosity and decreases mitochondrial membrane potential (MMP). However, increasing SO2 stimulation decreases mitochondrial viscosity and causes inconspicuous changes in MMP.

CHEMICAL COMMUNICATIONS (2022)

Review Chemistry, Multidisciplinary

Small Molecular Fluorescent Probes for Imaging of Viscosity in Living Biosystems

Haibin Xiao et al.

Summary: Viscosity, as a crucial microenvironment parameter, is closely connected to various cellular processes and diseases. The visualization of viscosity has gained increasing interest in recent years, leading to the development of new fluorescence probes for mapping viscosity inside living organisms. This review comprehensively summarizes viscosity-sensitive small molecular fluorescent probes used in bioimaging, with a focus on the past three years, while also discussing the current challenges and opportunities for developing viscosity-specific fluorescent probes.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

Article Chemistry, Analytical

Real-Time Monitoring Mitochondrial Viscosity during Mitophagy Using a Mitochondria-Immobilized Near-Infrared Aggregation-Induced Emission Probe

Xiaodong Wang et al.

Summary: The study introduces a novel NIR-emissive aggregation-induced emission (AIE) probe, CS-Py-BC, which enables real-time monitoring of mitochondrial viscosity changes during mitophagy with high precision and sensitivity. The probe shows excellent mitochondrial immobilization and can successfully visualize viscosity changes during starvation or rapamycin-induced mitophagy in real time.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Revealing the Effects of Hydrogen Peroxide And Heavy Metal Ions on Viscosity

Aishan Zheng et al.

Summary: The study highlights the importance of mitochondrial viscosity in diseases, and introduces a newly designed fluorescent probe for real-time imaging and analysis. Results show that H2O2 can increase mitochondrial viscosity, while heavy metal ions decrease it, providing valuable insights into mitochondrial functions and related diseases.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Applied

Imidazole decorated dicyanomethylene-4H-pyran skeletons with aggregation induced emission effect and applications for sensing viscosity

Qi Li et al.

Summary: Two newly designed and synthesized compounds exhibit aggregation-induced emission features in THF-water mixture, along with sensitive fluorescence responses towards viscosity, suggesting potential applications in biological tracing.

DYES AND PIGMENTS (2021)

Article Chemistry, Organic

Live-cell imaging of the nucleolus and mapping mitochondrial viscosity with a dual function fluorescent probe

Tarushyam Mukherjee et al.

Summary: The study presents a fluorescent probe that allows dual imaging of mitochondria and nucleoli, providing insights into cellular processes and mechanisms. The probe also maps mitochondrial viscosity in live cells under physiological variations with minimal cytotoxicity.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Article Chemistry, Applied

Asymmetric cyanine as a far-red fluorescence probe for mitochondrial viscosity

Sang Jun Park et al.

DYES AND PIGMENTS (2020)

Article Spectroscopy

A fluoran-based viscosity probe with high-performance for lysosome-targeted fluorescence imaging

Defang Han et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

Article Multidisciplinary Sciences

A dual-labeling probe to track functional mitochondria-lysosome interactions in live cells

Qixin Chen et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

A biotin-guided fluorescent probe for dual-mode imaging of viscosity in cancerous cells and tumor tissues

Mingguang Ren et al.

CHEMICAL COMMUNICATIONS (2020)

Review Materials Science, Biomaterials

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

Chenggong Ma et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Chemistry, Multidisciplinary

Ferroptosis Accompanied by •OH Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe

Hongyu Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications

Jingjing Cui et al.

CHINESE CHEMICAL LETTERS (2019)

Review Chemistry, Multidisciplinary

Fluorescent Molecular Rotors for Viscosity Sensors

Seung-Chul Lee et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Article Chemistry, Multidisciplinary

A General Method To Increase Stokes Shift by Introducing Alternating Vibronic Structures

Tian-Bing Ren et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Chemistry, Multidisciplinary

Fluorescent Probes for Sensing and Imaging within Specific Cellular Organelles

Hao Zhu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Review Chemistry, Multidisciplinary

Macro-/micro-environment-sensitive chemosensing and biological imaging

Zhigang Yang et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Chemistry, Physical

A homodimeric BODIPY rotor as a fluorescent viscosity sensor for membrane-mimicking and cellular environments

Sangram Raut et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2014)

Article Chemistry, Multidisciplinary

Fluorescence Ratiometry and Fluorescence Lifetime Imaging: Using a Single Molecular Sensor for Dual Mode Imaging of Cellular Viscosity

Xiaojun Peng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Chemistry, Physical

Unusual large Stokes shift and solvatochromic fluorophore Synthesis, spectra, and solvent effect of 6-substituted 2,3-naphthalimide

Kishore Baathulaa et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

Imaging intracellular viscosity of a single cell during photoinduced cell death

Marina K. Kuimova et al.

NATURE CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Molecular rotor measures viscosity of live cells via fluorescence lifetime imaging

Marina K. Kuimova et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)