4.2 Review

Killing in the name of: T6SS structure and effector diversity

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Summary: The T6SS is a multiprotein weapon evolved by Gram-negative bacteria to deliver effectors into cells. The interactions between the TssK baseplate component and the TssL inner membrane protein are important for T6SS activity. In this study, mutagenesis and cross-linking analyses were used to investigate the structural details and propose a model for the baseplate-membrane complex interface.

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A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

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A binary effector module secreted by a type VI secretion system

Yasmin Dar et al.

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Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP

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Multiple T6SSs, Mobile Auxiliary Modules, and Effectors Revealed in a Systematic Analysis of the Vibrio parahaemolyticus Pan-Genome

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An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

Marcos H. de Moraes et al.

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Plant holobiont interactions mediated by the type VI secretion system and the membrane vesicles: promising tools for a greener agriculture

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EMBO JOURNAL (2009)

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