☆ 4.5 Article

OmpR (TCS response regulator) of Aeromonas veronii plays a major role in drug resistance, stress resistance and virulence by regulating biofilm formation

MICROBIAL PATHOGENESIS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Agriculture, Dairy & Animal Science

The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses

Dandan Fu et al.

Summary: In this study, the researchers found that deletion of the envZ gene in APEC significantly reduced biofilm formation, resistance to stress conditions, and pathogenicity. They also found that EnvZ influenced the adhesion ability of APEC to chicken embryonic fibroblast cells and the expression of inflammatory cytokines. Transcriptome analysis revealed the involvement of outer membrane proteins, stress response systems, and TCSs in the regulatory role of EnvZ. This study provides compelling evidence for the contribution of EnvZ to APEC pathogenicity.

POULTRY SCIENCE (2023)

添加到收藏夹

Article Microbiology

Virulence, Antibiotic Resistance, and Phylogenetic Relationships of Aeromonas spp. Carried by Migratory Birds in China

Bing Liang et al.

Summary: This study evaluated antimicrobial resistance, virulence, and genetic diversity of Aeromonas isolated from migratory birds in different regions of China. The results showed that these birds carry multidrug-resistant Aeromonas strains with various virulence factors, and the biofilms formed by these strains pose a potential threat to public health.

MICROORGANISMS (2023)

添加到收藏夹

Article Microbiology

The Essential Role of OmpR in Acidithiobacillus caldus Adapting to the High Osmolarity and Its Regulation on the Tetrathionate-Metabolic Pathway

Linxu Chen et al.

Summary: This study reveals that the osmotic stress response two-component system EnvZ-OmpR is widely distributed in Acidithiobacillus spp., and OmpR plays an essential role in the adaptation of Acidithiobacillus caldus to high osmotic stress. Transcriptome analysis shows that OmpR has a significant impact on the various metabolic and regulatory systems of A. caldus.

MICROORGANISMS (2023)

添加到收藏夹

Article Medicine, General & Internal

Severe skin and soft tissue infection in the left upper limb caused by Aeromonas veronii: a case report

Linhui Li et al.

Summary: This article reports a case of severe skin and soft tissue infection caused by Aeromonas veronii. The patient was a 50-year-old Chinese woman with a history of cardiac disease and type 2 diabetes mellitus, who accidentally injured her left thumb. Early antibiotic therapy and surgical debridement were performed, and whole-genome sequencing confirmed the pathogen and revealed drug resistance and virulence genes. After 1 month of treatment, the wound gradually healed, and after 3 months of rehabilitation, the left hand recovered well in appearance and function.

JOURNAL OF MEDICAL CASE REPORTS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Two-Component System Response Regulator ompR Regulates Mussel Settlement through Exopolysaccharides

Wei Ma et al.

Summary: In this study, the function of the two-component system response regulator ompR on biofilm formation and mussel settlement was investigated. The deletion of the ompR gene in Pseudoalteromonas marina resulted in increased motility, decreased biofilm-forming capacity, and reduced induction of plantigrade settlement in mussels. The levels of extracellular polysaccharides were also decreased in the delta ompR strain. Addition of recombinant OmpW protein restored biofilm-inducing activities and upregulated exopolysaccharides. These findings contribute to a better understanding of the regulatory mechanism of bacterial two-component systems and benthic animal settlement.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Living together: The role of Candida albicans in the formation of polymicrobial biofilms in the oral cavity

Maria Rapala-Kozik et al.

Summary: The oral cavity of humans is colonized by a variety of microbial community, including bacteria and fungi such as Candida albicans. Under certain conditions, C. albicans can transform into an invasive pathogen that causes mucosal infections. This transformation is associated with changes in cell morphology and the expression of virulence factors. C. albicans can also interact with different bacterial species, producing biofilms that enhance colonization and resistance to antimicrobial agents. However, these microbial relationships are influenced by the complexity of host conditions and microbial dominance in vivo.

YEAST (2023)

添加到收藏夹

Review Immunology

Understanding bacterial biofilms: From definition to treatment strategies

Ailing Zhao et al.

Summary: Bacterial biofilms are complex microbial communities surrounded by extracellular polymeric substances. They are a significant problem in treating bacterial infections and can exhibit increased resistance to antibiotics, causing device-related and non-device infections and posing a serious threat to global health. Therefore, early detection and search for new treatments are essential. This paper systematically reviews the formation, infections, detection methods, and potential treatment strategies of bacterial biofilms, aiming to provide researchers with the latest progress in their detection and treatment.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

添加到收藏夹

Article Microbiology

Synergistic interactions in multispecies biofilm combinations of bacterial isolates recovered from diverse food processing industries

Faizan Ahmed Sadiq et al.

Frontiers in Microbiology (2023)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Occurrence of potential virulence determinants in Aeromonas spp. isolated from different aquatic environments

Sana Majeed et al.

Summary: Aeromonas species are bacterial pathogens that cause economic losses in aquaculture and pose a threat to public health. They are widely distributed and can cause diseases in both humans and aquatic animals. The presence of virulent Aeromonas spp. in aquatic environments predisposes infections. Researchers have found various virulence factors and toxin genes of Aeromonas spp. in aquatic environments, which enhance their pathogenic ability. The high prevalence of Aeromonas spp. in the aquatic environment is of concern due to the potential for transmission to humans through contaminated food and water. This review highlights the risks associated with Aeromonas species' virulence properties for both aquaculture and public health.

JOURNAL OF APPLIED MICROBIOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Regulatory Circuit Underlying Downregulation of a Type III Secretion System in Yersinia enterocolitica by Transcription Factor OmpR

Marta Nieckarz et al.

Summary: This study investigates the role of the transcriptional regulator OmpR in membrane protein expression and secretion in Yersinia enterocolitica. The findings show that OmpR negatively affects the levels of Ysc-Yop proteins, particularly YopD, and represses the expression of yopD. OmpR also has a positive role in the expression of the master regulator of the flagellar-associated T3SS, flhDC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Microbiology

Prevalence and genetic diversity of Aeromonas veronii isolated from aquaculture systems in the Poyang Lake area, China

Xiandong Xu et al.

Summary: This study conducted genotyping, virulence gene and antimicrobial resistance gene detection, and drug susceptibility tests on Aeromonas veronii isolates from aquaculture systems in the Poyang Lake area. The results revealed high genetic diversity among the strains and the presence of multiple virulence and antimicrobial resistance genes. Some strains also showed resistance to traditionally effective drugs for Aeromonas. The study provides insights into the impact of aquaculture in the Poyang Lake area on public health.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Fisheries

Essential role of ascO for virulence of Aeromonas veronii and inducing apoptosis

Tong Zhao et al.

Summary: The mutation of the ascO gene in A. veronii reduces its adhesion and toxicity to EPC cells, as well as the level of apoptosis induced by the bacteria. These findings are significant for further understanding the function of the ascO gene and the pathogenesis of A. veronii.

JOURNAL OF FISH DISEASES (2022)

添加到收藏夹

Article Fisheries

The role and mechanisms of the two-component system EnvZ/OmpR on the intracellular survival of Aeromonas hydrophila

Ziyan Du et al.

Summary: Aeromonas hydrophila infections are common in aquaculture. The two-component system EnvZ/OmpR plays an important role in the intracellular survival of A. hydrophila. Silencing the genes of envZ/ompR significantly decreases the survival rates and escape ability of the bacteria. The two-component system EnvZ/OmpR regulates the expression of molecular chaperones and maintains ion homeostasis to affect the bacterial survival in macrophages.

JOURNAL OF FISH DISEASES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues

David Lopez-Escarpa et al.

Summary: This study reveals that Salmonella enterica serovar Typhimurium can properly divide and elongate inside acidic phagosomes by regulating the protein levels of PBP3. Meanwhile, exposure to phagosome cues leads to abnormal cell division and morphology in Escherichia coli.

MOLECULAR MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Contribution of the EnvZ/OmpR two-component system to growth, virulence and stress tolerance of colistin-resistant Aeromonas hydrophila

Gang Xiao et al.

Summary: This study revealed the significant role of the EnvZ/OmpR TCS in the growth, motility, virulence, and stress response of A. hydrophila, providing important insights for the development of novel antibacterial and vaccine therapies targeting EnvZ/OmpR against A. hydrophila.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Review Infectious Diseases

Aeromonas veronii cellulitis, bacteremia, and sepsis in a patient with liver cirrhosis and end-stage renal disease following a minor abrasion with exposure to pond water: A case report and literature review

Charlotte L. Stanbaugh et al.

Summary: Aeromonads are known to cause gastrointestinal illness, but recent reports show that they can also cause extra-intestinal infections, especially in immunocompromised individuals. Patients with liver cirrhosis are particularly susceptible to severe infections caused by Aeromonas spp. We report a rare case of A. veronii septicemia in a patient with liver cirrhosis and end-stage renal disease after exposure to pond water.

IDCASES (2022)

添加到收藏夹

Review Microbiology

Community-wide changes reflecting bacterial interspecific interactions in multispecies biofilms

Faizan Ahmed Sadiq et al.

Summary: Most bacterial species exist in the form of surface-adhered communities or biofilms in various environments. Researchers are now focusing on studying multispecies biofilms and revealing interspecific interactions due to the coexistence of numerous bacterial species. Emergent properties in multispecies biofilms are triggered by bacterial social interactions, which are important for controlling and manipulating microbial communities.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

Network-based analysis of virulence factors for uncovering Aeromonas veronii pathogenesis

Hong Li et al.

Summary: This study constructed a genome-wide PPI network for Aeromonas veronii and found that its virulence factors had higher degree and betweenness centrality, tended to interact with each other, and were enriched in specific modules. The virulence factors may regulate A. veronii's virulence through signal transduction pathways and manipulate host biological processes by mimicking and competitively binding to host proteins.

BMC MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

Identification of Essential Genes Associated With Prodigiosin Production in Serratia marcescens FZSF02

Xianbo Jia et al.

Summary: Prodigiosin, a promising secondary metabolite produced mainly by Serratia strains, was studied through mutagenesis library construction with EZ-Tn5 transposon, revealing 33 genes involved in prodigiosin production can be classified into transcription-regulating, membrane protein-encoding, and metabolism enzyme-encoding genes. The downregulation of pigA gene transcription in mutants with different inserted genes corresponded to decreased prodigiosin production, while functional confirmation of mutant genes in the pyrimidine nucleotide biosynthesis pathway was conducted by adding orotate and uridylate to the medium. Gene complementation confirmed the regulatory role of EnvZ/OmpR two-component regulatory system genes envZ and ompR in prodigiosin production.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Functional analysis of hisJ in Aeromonas veronii reveals a key role in virulence

Hai-peng Zhang et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Cadaverine reverse transporter (CadB protein) contributes to the virulence of Aeromonas veronii TH0426

LuoTao Tao et al.

INTERNATIONAL MICROBIOLOGY (2020)

添加到收藏夹

Article Microbiology

Inactivation of the T6SS inner membrane protein DotU results in severe attenuation and decreased pathogenicity of Aeromonas veronii TH0426

Haichao Song et al.

BMC MICROBIOLOGY (2020)

添加到收藏夹

Article Immunology

Vibrio cholerae OmpR Contributes to Virulence Repression and Fitness at Alkaline pH

D. E. Kunkle et al.

INFECTION AND IMMUNITY (2020)

添加到收藏夹

Article Immunology

Nucleoside Diphosphate Kinases (ndk) reveals a key role in adhesion and virulence of Aeromonas veronii

Lei Zhang et al.

MICROBIAL PATHOGENESIS (2020)

添加到收藏夹

Review Microbiology

Signal Transduction Proteins in Acinetobacter baumannii: Role in Antibiotic Resistance, Virulence, and Potential as Drug Targets

P. Malaka De Silva et al.

FRONTIERS IN MICROBIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Comparative genomics of Aeromonas veronii: Identification of a pathotype impacting aquaculture globally

Hasan C. Tekedar et al.

PLOS ONE (2019)

添加到收藏夹

Article Microbiology

The OmpR Regulator of Burkholderia multivorans Controls Mucoid-to-Nonmucoid Transition and Other Cell Envelope Properties Associated with Persistence in the Cystic Fibrosis Lung

Ines N. Silva et al.

JOURNAL OF BACTERIOLOGY (2018)

添加到收藏夹

Article Chemistry, Physical

Physico-chemistry from initial bacterial adhesion to surface-programmed biofilm growth

Vera Carniello et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2018)

添加到收藏夹

Article Microbiology

A New Role of OmpR in Acid and Osmotic Stress in Salmonella and E-coli

Smarajit Chakraborty et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Article Microbiology

Phosphorylated OmpR Is Required for Type 3 Fimbriae Expression in Klebsiella pneumoniae Under Hypertonic Conditions

Ten-Huang Lin et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Bacterial Virulence Factors: Secreted for Survival

Aditya Kumar Sharma et al.

INDIAN JOURNAL OF MICROBIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Smarajit Chakraborty et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Revealing genome-scale transcriptional regulatory landscape of OmpR highlights its expanded regulatory roles under osmotic stress in Escherichia coli K-12 MG1655

Sang Woo Seo et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Microbiology

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

Sandeep Tiwari et al.

FRONTIERS IN MICROBIOLOGY (2017)

添加到收藏夹

Review Microbiology

Impact of OmpR on the membrane proteome of Yersinia enterocolitica in different environments: repression of major adhesin YadA and heme receptor HemR

Marta Nieckarz et al.

ENVIRONMENTAL MICROBIOLOGY (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Complete genome sequence of the fish pathogen Aeromonas veronii TH0426 with potential application in biosynthesis of pullulanase and chitinase

Yuanhuan Kang et al.

JOURNAL OF BIOTECHNOLOGY (2016)

添加到收藏夹

Article Cell Biology

Expanded roles of two-component response regulator OmpR in Escherichia coli: genomic SELEX search for novel regulation targets

Tomohiro Shimada et al.

GENES TO CELLS (2015)

添加到收藏夹

Article Ecology

High prevalence of biofilm synergy among bacterial soil isolates in cocultures indicates bacterial interspecific cooperation

Dawei Ren et al.

ISME JOURNAL (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

High Salt Concentrations Increase Permeability through OmpC Channels of Escherichia coli

Seiji Kojima et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Article Immunology

Yersinia pestis Requires the 2-Component Regulatory System OmpR-EnvZ to Resist Innate Immunity During the Early and Late Stages of Plague

Angeline Reboul et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

添加到收藏夹

Article Genetics & Heredity

Bacterial Regulon Evolution: Distinct Responses and Roles for the Identical OmpR Proteins of Salmonella Typhimurium and Escherichia coli in the Acid Stress Response

Heather J. Quinn et al.

PLOS GENETICS (2014)

添加到收藏夹

Article Microbiology

OmpR and RcsB abolish temporal and spatial changes in expression of flhD in Escherichia coli Biofilm

Priyankar Samanta et al.

BMC MICROBIOLOGY (2013)

添加到收藏夹

Article Infectious Diseases

Biliary tract infections caused by Aeromonas species

C. M. Chao et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2013)

添加到收藏夹

Review Multidisciplinary Sciences

Pivoting the Plant Immune System from Dissection to Deployment

Jeffery L. Dangl et al.

SCIENCE (2013)

添加到收藏夹

Article Microbiology

Proteomic analysis of Campylobacter jejuni 11168 biofilms reveals a role for the motility complex in biofilm formation

Martin Kalmokoff et al.

JOURNAL OF BACTERIOLOGY (2006)

添加到收藏夹

Review Microbiology

Regulation of bacterial virulence by two-component systems

D Beier et al.

CURRENT OPINION IN MICROBIOLOGY (2006)

添加到收藏夹

Review Microbiology

Advances in understanding bacterial outer-membrane biogenesis

N Ruiz et al.

NATURE REVIEWS MICROBIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12

T Oshima et al.

MOLECULAR MICROBIOLOGY (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

EnvZ-OmpR interaction and osmoregulation in Escherichia coli

SJ Cai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

添加到收藏夹

Article Microbiology

OmpR regulates the stationary-phase acid tolerance response of Salmonella enterica serovar Typhimurium

IS Bang et al.

JOURNAL OF BACTERIOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.