期刊
MICROBIAL PATHOGENESIS
卷 181, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2023.106176
关键词
Aeromonas veronii; Virulence; ompR; Stress resistance; Biofilm
In this study, the regulatory effect of ompR gene on the biological characteristics and virulence of A. veronii TH0426 was investigated. Mutant and complement strains were constructed, and the results showed that the ompR gene deletion significantly reduced biofilm formation, osmotic stress resistance, and drug resistance of TH0426. Animal pathogenicity experiments also demonstrated a significant decrease in virulence. These findings indicate that ompR gene plays a role in regulating biofilm formation, drug sensitivity, osmotic stress resistance, and virulence of TH0426.
Aeromonas veronii (A. veronii), a highly pathogenic bacteria with a wide range of hosts, widely exists in the environment of humans, animals and aquatic animals, and can cause a variety of diseases. In this study, the receptor regulator ompR in the envZ/ompR of two-component system was selected to construct a mutant strain (& UDelta; ompR) and a complement strain (C-ompR) to explore the regulatory effect of ompR on the biological characteristics and virulence of TH0426. The results showed that the ability of biofilm formation and osmotic stress of TH0426 were significantly reduced (P < 0.001), the resistance to ceftriaxone and neomycin were slightly downregulate when the ompR gene was deleted. At the same time, animal pathogenicity experiments showed that the virulence of TH0426 was significantly down-regulated (P < 0.001). These results indicated that ompR gene regulates the biofilm formation of TH0426, and regulates some biological characteristics of TH0426, including drug sensitivity, resistance to osmotic stress, and also affects its virulence.
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