☆ 4.7 Review

Hepatic insulin receptor: new views on the mechanisms of liver disease

METABOLISM-CLINICAL AND EXPERIMENTAL (2023)

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Article Gastroenterology & Hepatology

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

Mary E. Rinella et al.

HEPATOLOGY (2023)

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Review Biochemistry & Molecular Biology

GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives

Riccardo Nevola et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, affecting 70% of patients with diabetes. There are currently no specific drugs available for its treatment. GLP-1 receptor agonists (GLP-1 RAs) have shown significant impact on body weight and markers of fatty liver and fibrosis in NAFLD patients, in addition to their anti-hyperglycemic effect. This review aims to summarize the available evidence on the role of GLP-1 RAs in NAFLD treatment and propose potential future scenarios.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease

Evelyn A. A. Bates et al.

Summary: By using GNUR treatment in mice with NAFLD, the study found that it can increase plasma bilirubin levels, decrease plasma urobilin levels, reduce liver fat content and ceramide production, lower blood glucose and insulin levels, and decrease inflammatory mediators, thus improving overall liver health.

BIOMOLECULES (2023)

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Article Biochemistry & Molecular Biology

Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance

Zachary A. Kipp et al.

Summary: This study found that bilirubin levels are lower in obese individuals compared to lean individuals. Obesity leads to an increase in the UGT1A1 enzyme, which clears bilirubin from the blood. As a result, more conjugated bilirubin enters the intestine and is converted into urobilin, which is then absorbed through the hepatic portal vein. The study also revealed a negative correlation between bilirubin levels and BMI and adiposity in obese individuals, while urobilin levels were positively associated with BMI and adiposity. Obese women were found to have higher insulin resistance, and urobilin levels showed a stronger linear correlation with insulin resistance in women compared to men. These findings suggest that plasma urobilin levels are associated with obesity and its comorbidities such as insulin resistance.

ANTIOXIDANTS (2023)

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Article Biochemistry & Molecular Biology

Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content

Zachary A. Kipp et al.

Summary: Studies show that increasing plasma bilirubin levels can help prevent and treat hepatic lipid accumulation in metabolic diseases like obesity and diabetes. Using mice on a high-fat diet, researchers found that bilirubin nanoparticles effectively reduce liver fat content by inhibiting the accumulation of ceramides and lowering the expression of enzymes responsible for ceramide production. These findings suggest that bilirubin nanoparticles have potential for improving metabolic health.

METABOLITES (2023)

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Review Peripheral Vascular Disease

Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease

Olufunto O. Badmus et al.

Summary: Purpose of this review is to highlight the cardiovascular complications in MAFLD patients, discuss the potential mechanisms linking MAFLD to the development of cardiovascular disease, and suggest therapeutic approaches for treating cardiovascular diseases in patients with MAFLD.

CURRENT HYPERTENSION REPORTS (2023)

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Editorial Material Physiology

Powering the powerhouse: Heme oxygenase-1 regulates mitochondrial function in non-alcoholic fatty liver disease (NAFLD)

Terry D. Hinds Jr et al.

ACTA PHYSIOLOGICA (2023)

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Article Physiology

Loss of hepatic PPAR alpha in mice causes hypertension and cardiovascular disease

Olufunto O. Badmus et al.

Summary: Cardiovascular disease (CVD) is the leading cause of death in patients with nonalcoholic fatty liver disease (NAFLD). A study using mice deficient in hepatic proliferator-activated receptor-alpha (PPAR alpha) found that the lack of PPAR alpha led to increased liver fat content and higher risk of NAFLD, as well as impaired cardiovascular function and enhanced vascular stiffness.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2023)

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Article Cell Biology

Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue

Terry D. Hinds et al.

Summary: This study established the first adipose-specific PPAR alpha knockout mice and found that PPAR alpha plays a significant role in adipose tissue expansion during obesity, protecting against lipogenesis, inflammation, and cholesterol ester accumulation, especially in male mice.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease

Juan Moreno-Vedia et al.

Summary: Metabolic-associated fatty liver disease (MAFLD) is a common chronic liver disease, but it is often underestimated due to the lack of effective diagnostic methods. Fatty acid binding protein 4 (FABP4) plays an important role in the progression of fatty liver disease and may be a potential therapeutic target.

BIOMEDICINES (2022)

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Review Gastroenterology & Hepatology

Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH)

Rocio Gallego-Duran et al.

Summary: This is a meeting report of the 3rd Translational Hepatology Meeting held in Alicante, Spain, in October 2021. The meeting, organized by the Spanish Association for the Study of the Liver (AEEH), provided updates on recent advances in basic and translational hepatology, focusing on the molecular and cellular mechanisms and therapeutic targets involved in metabolic-associated fatty liver disease (MAFLD), metabolic-associated steatohepatitis (MASH), cirrhosis, and end-stage hepatocellular carcinoma (HCC).

GASTROENTEROLOGIA Y HEPATOLOGIA (2022)

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Article Gastroenterology & Hepatology

Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents

Justin F. Creeden et al.

Summary: This study explores the similarities in fibrotic signaling networks in humans and rodents, identifying potential antifibrotic effects that may improve outcomes in liver diseases. The activation of certain protein kinases, such as the insulin receptor, is found to be hyperactive in fibrotic liver disease in both species. The findings establish a comprehensive kinase atlas for liver fibrosis, identifying analogous signaling events conserved among humans and rodents.

HEPATOLOGY (2022)

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Article Endocrinology & Metabolism

Serum Thrombospondin-2 Levels Are Closely Associated With the Severity of Metabolic Syndrome and Metabolic Associated Fatty Liver Disease

Xuerui Wu et al.

Summary: The study found that serum thrombospondin-2 (TSP2) is closely associated with the severity and progression of obesity-related metabolic syndrome (MetS) and metabolic associated fatty liver disease (MAFLD). Serum TSP2 is a promising noninvasive biomarker for differentiating metabolic associated steatohepatitis (MASH) and identifying at-risk patients.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Gastroenterology & Hepatology

Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial

Naim Alkhouri et al.

Summary: This study evaluated the safety and efficacy of combining semaglutide with cilofexor and/or firsocostat in patients with NASH. The combination therapy was generally well tolerated and resulted in additional benefits over semaglutide monotherapy, including improvements in liver steatosis and biochemistry. Double-blind placebo-controlled trials with larger patient numbers are needed to further assess the efficacy and safety of these combination therapies in NASH.

JOURNAL OF HEPATOLOGY (2022)

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Article Endocrinology & Metabolism

Association between use of liraglutide and liver fibrosis in patients with type 2 diabetes

Yijiong Tan et al.

Summary: This study found that the use of Liraglutide treatment is associated with a reduced risk of liver fibrosis in patients with type 2 diabetes.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

NAFLD: Mechanisms, Treatments, and Biomarkers

Fatiha Nassir

Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic-associated fatty liver disease (MAFLD), is a common liver disease worldwide that is closely linked to the obesity epidemic. Currently, there is no specific pharmacological treatment available for NAFLD due to incomplete understanding of its mechanisms, lack of accurate and inexpensive imaging tools, and inadequate non-invasive biomarkers. NAFLD can lead to metabolic-associated steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma.

BIOMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Regulation of Insulin Clearance by Non-Esterified Fatty Acids

Sonia M. Najjar et al.

Summary: Insulin stores lipid in adipocytes and prevents lipolysis and the release of NEFA. Excessive release of NEFA and increased abdominal adiposity trigger insulin resistance, leading to reduced insulin clearance in the liver. Conversely, reduced insulin clearance in the liver can cause chronic hyperinsulinemia and insulin resistance. This review discusses the impact of NEFA mobilization on the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and its implications in the pathogenesis of non-alcoholic fatty liver disease.

BIOMEDICINES (2022)

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Review Medicine, Research & Experimental

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Olufunto O. Badmus et al.

Summary: Metabolic-associated fatty liver disease (MAFLD) is a condition characterized by fat accumulation in the liver along with metabolic dysfunction, leading to an increased risk of cardiovascular diseases. The regulation of hepatic lipid metabolism involves various pathways, and imbalances in these pathways can result in hepatic lipid accumulation and the progression of inflammation and fibrosis. This review explores the molecular mechanisms involved in the regulation of hepatic lipids and discusses emerging therapies that target these pathways as potential future treatments for MAFLD.

CLINICAL SCIENCE (2022)

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Article Endocrinology & Metabolism

Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance

Amalia Gastaldelli et al.

Summary: The development of insulin resistance leads to increased plasma insulin response to offset the defect in insulin action, maintaining normal glucose tolerance. Metabolic clearance rate of insulin (MCRI) is closely related to insulin resistance, showing different patterns in individuals with different glucose tolerance and diabetes statuses.

DIABETES (2021)

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Review Gastroenterology & Hepatology

Antidiabetic drugs and non-alcoholic fatty liver disease: A systematic review, meta-analysis and evidence map

Jai Kumar et al.

Summary: The meta-analysis revealed significant efficacy of pioglitazone and novel antidiabetic agents in treating NAFLD, with pioglitazone showing remarkable improvements in liver function and steatosis.

DIGESTIVE AND LIVER DISEASE (2021)

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Article Gastroenterology & Hepatology

Randomised clinical trial: Semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non-alcoholic fatty liver disease assessed by magnetic resonance imaging

Anne Flint et al.

Summary: In patients with NAFLD, the change in liver stiffness between semaglutide and placebo was not significantly different, but semaglutide significantly reduced liver fat content compared to placebo. Additionally, semaglutide also led to decreases in liver enzymes, body weight, and HbA(1c) levels.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Review Endocrinology & Metabolism

Bilirubin as a metabolic hormone: the physiological relevance of low levels

Justin F. Creeden et al.

Summary: Recent research indicates that bilirubin may have a new role as a metabolic hormone, potentially leading to cardiovascular complications for patients with low levels. Protective mechanisms at mildly elevated levels of bilirubin could offer treatment possibilities for those with hypobilirubinemia.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Article Endocrinology & Metabolism

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

Kasper W. ter Horst et al.

Summary: In obese patients with NAFLD, impaired insulin-mediated suppression of glucose production and no increase in glucose-stimulated/high-insulin lipogenesis were observed, indicating a proximal block in insulin signaling pathways in hepatocytes.

DIABETES CARE (2021)

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Article Endocrinology & Metabolism

Lower insulin clearance is associated with increased risk of type 2 diabetes in Native Americans

Mujtaba H. Shah et al.

Summary: The study found that lower MCRI is associated with an unfavorable metabolic phenotype and an increased risk of incident type 2 diabetes.

DIABETOLOGIA (2021)

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Article Gastroenterology & Hepatology

Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real-world data analysis

Santo Colosimo et al.

Summary: The study showed that GLP-1 receptor agonists and SGLT-2 inhibitors can improve biomarkers of steatosis and fibrosis, therefore slowing down the progression of liver disease.

LIVER INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis

Injoo Hwang et al.

Summary: Reducing TIF1 gamma in HSCs leads to the transfer of retinol to hepatocytes, promoting fat deposition and damage, ultimately leading to liver fibrosis.

CELL AND BIOSCIENCE (2021)

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Review Medicine, Research & Experimental

Severe insulin resistance syndromes

Angeliki M. Angelidi et al.

Summary: Severe insulin resistance syndromes are a group of rare and heterogeneous disorders with complex etiologies. While advances in medical technology have provided insights into their pathophysiological pathways, the exact cellular and molecular mechanisms of insulin resistance still need further elucidation. Early identification and personalized clinical management are crucial for these syndromes.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Cell Biology

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

Lykke Sylow et al.

Summary: Skeletal muscle is crucial for insulin-stimulated glucose disposal and overall glycemic control. Insulin regulates glucose uptake in skeletal muscle through complex signaling cascades. Understanding insulin's actions in muscle can provide insights into addressing issues with glucose uptake in conditions like diabetes and obesity.

CELL METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance

Weiyu Chen et al.

Summary: The study using Bvra gene knockout mice found that BVRA deficiency makes mice susceptible to oxidative stress-induced hepatic steatosis without insulin resistance. Alpha-tocopherol supplementation reversed the hepatic phenotype and observed biochemical changes in Bvra(-/-) mice.

REDOX BIOLOGY (2021)

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Article Endocrinology & Metabolism

Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits

Diego O. Borges et al.

Summary: The study suggests that IDE plays a crucial role in regulating postprandial insulin clearance and liver metabolic resilience. Dysfunctional IDE regulation directly impairs postprandial hepatic glucose disposal and increases susceptibility to dysmetabolic conditions.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Biochemistry & Molecular Biology

Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha)

Darren M. Gordon et al.

Summary: This study revealed that bilirubin interacts with threonine 283 (T283) and alanine 333 (A333) in the ligand-binding pocket of PPAR alpha. Mutational analysis showed significantly reduced bilirubin binding with T283 and A333 mutations. Bilirubin did not show any interaction with PPAR gamma.

MOLECULES (2021)

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Article Medicine, General & Internal

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Philip N. Newsome et al.

Summary: This phase 2 trial demonstrated that treatment with semaglutide resulted in a significantly higher percentage of patients with NASH resolution compared to placebo in patients with NASH, but did not show a significant between-group difference in the percentage of patients with an improvement in fibrosis stage.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Gastroenterology & Hepatology

Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis?

Fu-Shun Yen et al.

Summary: A study comparing the risks of mortality, liver-related complications, and cardiovascular events between type 2 diabetes mellitus (T2DM) patients with compensated liver cirrhosis who use insulin and those who do not found that insulin users had higher risks of death, liver-related complications, cardiovascular events, and hypoglycemia.

BMC GASTROENTEROLOGY (2021)

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Article Endocrinology & Metabolism

New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms

Roberto Bizzotto et al.

Summary: The study found that insulin sensitivity is the strongest determinant of EICISR, being approximately four times more influential than insulin resistance-related hypersecretion. EICISR is positively associated with factors such as M/I, fasting and mean OGTT glucose, and beta-cell glucose sensitivity, while negatively associated with African American or Hispanic race, female sex, and female age. Oral glucose ingestion reduces insulin clearance, and there are two adaptive processes involving insulin clearance that are dysregulated in type 2 diabetes.

DIABETES CARE (2021)

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Article Endocrinology & Metabolism

Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1

Raghd Abu Helal et al.

Summary: The study revealed that reconstituting CEACAM1 in the liver of Cc1(-/-) mice can reverse diet-induced liver dysfunction and NASH, including hepatic fibrosis. Treatment with nicotinic acid failed to eliminate hepatic fibrosis in HF-fed Cc1(-/-) mice.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Endocrinology & Metabolism

FKBP51 and the molecular chaperoning of metabolism

Kathryn B. Smedlund et al.

Summary: FK506-binding protein 51 (FKBP51) is becoming recognized as a significant biomarker of metabolic dysfunction, with diverse regulatory roles in lipid metabolism, protein catabolism, and dermal adipocytes. The signaling mechanisms of FKBP51 and potential therapeutic compounds targeting it are currently being explored.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Medicine, Research & Experimental

Effects of obesity and 10 weeks metformin treatment on liver steatosis

Reza Hakkak et al.

Summary: The study showed that short-term metformin treatment decreased liver steatosis, but did not affect serum markers of liver steatosis.

BIOMEDICAL REPORTS (2021)

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Editorial Material Gastroenterology & Hepatology

Redefining non-alcoholic fatty liver disease: what's in a name?

[Anonymous]

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Biochemistry & Molecular Biology

Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice

David E. Stec et al.

BIOMOLECULES (2020)

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Article Endocrinology & Metabolism

Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross-sectional and longitudinal study from the Yale Pediatric NAFLD cohort

Domenico Trico et al.

DIABETES OBESITY & METABOLISM (2020)

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Article Biochemistry & Molecular Biology

Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator?activated receptor ?

Darren M. Gordon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Editorial Material Medicine, Research & Experimental

Insulin-stimulated lipogenesis gets an epigenetic makeover

Clarence R. Manuel et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

Metabolic control analysis of hepatic glycogen synthesis in vivo

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Gastroenterology & Hepatology

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Mohammed Eslam et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Multidisciplinary Sciences

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Marion Regnier et al.

SCIENTIFIC REPORTS (2020)

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Review Endocrinology & Metabolism

NAFLD as a continuum: from obesity to metabolic syndrome and diabetes

Amelio F. Godoy-Matos et al.

DIABETOLOGY & METABOLIC SYNDROME (2020)

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Review Biochemistry & Molecular Biology

Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease

David E. Stec et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Saroglitazar in patients with non-alcoholic fatty liver disease and diabetic dyslipidemia: a prospective, observational, real world study

Omesh Goyal et al.

SCIENTIFIC REPORTS (2020)

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Article Pharmacology & Pharmacy

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate

Terry D. Hinds et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Endocrinology & Metabolism

Pathophysiological mechanisms underlying MAFLD

Mohammad Shafi Kuchay et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Public, Environmental & Occupational Health

Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends

Moien Abdul Basith Khan et al.

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH (2020)

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Article Cell Biology

RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin

Darren M. Gordon et al.

PHYSIOLOGICAL GENOMICS (2019)

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Review Cell Biology

The cell biology of the hepatocyte: A membrane trafficking machine

Ryan J. Schulze et al.

JOURNAL OF CELL BIOLOGY (2019)

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Article Physiology

Loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity

David E. Stec et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation

Darren M. Gordon et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Endocrinology & Metabolism

Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes

Richard N. Bergman et al.

DIABETES (2019)

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Article Cell Biology

The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition

Qiqi Li et al.

CELL REPORTS (2019)

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Article Cell Biology

TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats

Daisuke Kaya et al.

CELLS (2019)

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Review Peripheral Vascular Disease

Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health

Terry D. Hinds et al.

CURRENT HYPERTENSION REPORTS (2019)

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Article Endocrinology & Metabolism

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis

Hilda E. Ghadieh et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

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Article Medicine, General & Internal

Projected US State-Level Prevalence of Adult Obesity and Severe Obesity

Zachary J. Ward et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Gastroenterology & Hepatology

Resolving the Paradox of Hepatic Insulin Resistance

Dominic Santoleri et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Medicine, General & Internal

Diabetes drugs for nonalcoholic fatty liver disease: a systematic review

Ian Blazina et al.

SYSTEMATIC REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer

Rosa Divella et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Review Gastroenterology & Hepatology

Biliverdin reductase and bilirubin in hepatic disease

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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Thiazolidinediones as antidiabetic agents: A critical review

M. J. Nanjan et al.

BIOORGANIC CHEMISTRY (2018)

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JOURNAL OF CELL BIOLOGY (2018)

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Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

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JOURNAL OF HEPATOLOGY (2018)

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Bilirubin in the Liver-Gut Signaling Axis

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Exenatide Induces Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Expression to Prevent Hepatic Steatosis

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Article Endocrinology & Metabolism

Adapting to insulin resistance in obesity: role of insulin secretion and clearance

Sang-Hee Jung et al.

DIABETOLOGIA (2018)

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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca A. Lotta et al.

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Article Gastroenterology & Hepatology

Metabolic and Histological Implications of Intrahepatic Triglyceride Content in Nonalcoholic Fatty Liver Disease

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HEPATOLOGY (2017)

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Review Medicine, General & Internal

Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus A meta-analysis

Wenjie Dai et al.

MEDICINE (2017)

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The Correlation Between Body Fat, Visceral Fat, and Nonalcoholic Fatty Liver Disease

Yun-Huei Ko et al.

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Review Endocrinology & Metabolism

Unraveling the Regulation of Hepatic Metabolism by Insulin

Paul M. Titchenell et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

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Review Medicine, Research & Experimental

Deciphering the Roles of Thiazolidinediones and PPARγ in Bladder Cancer

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PPAR RESEARCH (2017)

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Review Endocrinology & Metabolism

Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease

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Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

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Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women

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Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis

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Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα

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De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose

Francis W. B. Sanders et al.

BIOLOGICAL REVIEWS (2016)

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The glucocorticoid receptor: cause of or cure for obesity?

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FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone

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ENDOCRINOLOGY (2016)

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Article Gastroenterology & Hepatology

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

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GUT (2016)

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PPAR (Peroxisome Proliferator-activated Receptor ) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition

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Article Biochemistry & Molecular Biology

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

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JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

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JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor?

Terry D. Hinds et al.

MEDICAL HYPOTHESES (2016)

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Genetics of Insulin Resistance and the Metabolic Syndrome

Audrey E. Brown et al.

CURRENT CARDIOLOGY REPORTS (2016)

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Bilirubin Binding to PPARα Inhibits Lipid Accumulation

David E. Stec et al.

PLOS ONE (2016)

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Review Biochemistry & Molecular Biology

Regulation of glucose metabolism from a liver-centric perspective

Hye-Sook Han et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

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Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα

Michiharu Komatsu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

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PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

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JOURNAL OF HEPATOLOGY (2015)

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Review Endocrinology & Metabolism

Biliverdin reductase isozymes in metabolism

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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

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PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

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NATURE COMMUNICATIONS (2015)

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A 5-Day High-Fat, High-Calorie Diet Impairs Insulin Sensitivity in Healthy, Young South Asian Men but Not in Caucasian Men

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DIABETES (2014)

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Article Endocrinology & Metabolism

Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells

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DIABETES (2014)

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Article Endocrinology & Metabolism

Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation

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ENDOCRINOLOGY (2014)

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Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

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Relationship Between Disease Severity, Hyperinsulinemia, and Impaired Insulin Clearance in Patients With Nonalcoholic Steatohepatitis

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Classes of phosphoinositide 3-kinases at a glance

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Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways

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Letter Gastroenterology & Hepatology

Effect of exenatide therapy on hepatic fat quantity and hepatic biomarkers in type 2 diabetic patients

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CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2014)

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Review Medicine, General & Internal

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism

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JOURNAL OF CLINICAL MEDICINE (2014)

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Review Gastroenterology & Hepatology

Insulin sensitizers for the treatment of non-alcoholic fatty liver disease

Zeynel Abidin Ozturk et al.

WORLD JOURNAL OF HEPATOLOGY (2014)

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Obesity and Severe Obesity Forecasts Through 2030

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2012)

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Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Joshua L. Owen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Review Endocrinology & Metabolism

Role of ceramides in nonalcoholic fatty liver disease

Mangesh Pagadala et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

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The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

Wonae Lee

DIAGNOSTIC PATHOLOGY (2011)

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Review Endocrinology & Metabolism

Genetic Syndromes of Severe Insulin Resistance

Robert K. Semple et al.

ENDOCRINE REVIEWS (2011)

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Article Biochemistry & Molecular Biology

Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)

Terry D. Hinds et al.

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Review Pharmacology & Pharmacy

Insulin Resistance in Nonalcoholic Fatty Liver Disease

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CURRENT PHARMACEUTICAL DESIGN (2010)

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Article Gastroenterology & Hepatology

Epidemiology of Non-Alcoholic Fatty Liver Disease

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DIGESTIVE DISEASES (2010)

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

Shijie Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Hepatic insulin resistance, metabolic syndrome and cardiovascular disease

Reza Meshkani et al.

CLINICAL BIOCHEMISTRY (2009)

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Case series of liver failure associated with rosiglitazone and pioglitazone

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PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2009)

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Article Gastroenterology & Hepatology

Development of Nonalcoholic Steatohepatitis in Insulin-Resistant Liver-Specific S503A Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Mutant Mice

Sang Jun Lee et al.

GASTROENTEROLOGY (2008)

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Review Physiology

Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver

Scott L. Friedman

PHYSIOLOGICAL REVIEWS (2008)

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Editorial Material Biochemistry & Molecular Biology

It's Not How Fat You Are, It's What You Do with It That Counts.

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PLOS BIOLOGY (2008)

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Article Biochemistry & Molecular Biology

SREBP-1-independent regulation of lipogenic gene expression in adipocytes

Motohiro Sekiya et al.

JOURNAL OF LIPID RESEARCH (2007)

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

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CELL METABOLISM (2007)

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Insulin acutely decreases hepatic fatty acid synthase activity

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CELL METABOLISM (2005)

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Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans

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DIABETES (2005)

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Article Endocrinology & Metabolism

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

E Bugianesi et al.

DIABETOLOGIA (2005)

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Review Medicine, General & Internal

Drug therapy: Thiazolidinediones

H Yki-Jarvinen

NEW ENGLAND JOURNAL OF MEDICINE (2004)

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Article Multidisciplinary Sciences

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

WM He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Endocrinology & Metabolism

Regulation of insulin action by CEACAM1

SM Najjar

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)

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Article Genetics & Heredity

CEACAM1 regulates insulin clearance in liver

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NATURE GENETICS (2002)

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Peroxisome proliferator-activated receptors and hepatic stellate cell activation

T Miyahara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Gastroenterology & Hepatology

Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

F Marra et al.

GASTROENTEROLOGY (2000)

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