期刊
MOLECULAR MEDICINE
卷 22, 期 -, 页码 643-652出版社
FEINSTEIN INST MED RES
DOI: 10.2119/molmed.2016.00034
关键词
-
资金
- National Natural Science Foundation of China [81572353, 81372639, 81160255, 81472243, 81460423]
- Innovation Program of Guangxi Municipal Education Department [201204LX674]
- Innovation Program of Shanghai Municipal Education Commission [13YZ035]
- Natural Science Foundation of Guangxi [2015GXNSFAA139223, 2013GXNSFAA019251, 2014GXNSFDA118021, 2014GXNSFAA118144]
- Key Discipline and Specialty Foundation of Shanghai Municipal Commission of Health and Family Planning
- Shu Guang project (Shanghai Municipal Education Commission and Shanghai Education Development Foundation) [13SG19]
- Recruitment Program of Youjiang Medical University for Nationality [yy2015hsky03]
Acute pancreatitis is characterized by zymogen preactivation. Severe inflammation caused by zymogen activation can eventually lead to multiple organ dysfunctions which contribute to the high mortality rate of severe acute pancreatitis. However, there is no specific treatment available for acute pancreatitis therapy. Here, we show that spautin-1, which effectively inhibits autophagy flux, ameliorated the pathogenesis of acute pancreatitis induced by cerulein or L-arginine. CaMKII phosphorylation due to cytosolic calcium overload was revealed in this paper. It was also demonstrated that autophagic protein aggregates degradation blockade accompanied by impaired autophagy correlated positively with intra-acinar cell digestive aymogen activation stimulated by cerulein or L-arginine. The role of spautin-1 in ameliorating acute pancreatitis was shown here to be associated with impaired autophagy inhibition and Ca2+ overload alleviation. We provide a promising therapy for acute pancreatitis through targeting both impaired autophagy and increased cytosolic calcium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据