☆ 4.5 Article

Efficacy and safety of diacerein and celecoxib combination therapy for knee osteoarthritis: A double-blind, randomized, placebo-controlled prospective study

MEDICINE (2023)

Diacerein versus non-steroidal anti-inflammatory drugs in the treatment of knee osteoarthritis: a meta-analysis

Fan Zeng et al.

Summary: This systematic review and meta-analysis evaluated the efficacy and safety of diacerein in patients with knee osteoarthritis (KOA). The results showed that diacerein had comparable efficacy to non-steroidal anti-inflammatory drugs (NSAIDs) in reducing pain indicators. Diacerein also outperformed NSAIDs in terms of global efficacy assessment and sustained effectiveness, with no significant difference in adverse events incidence. However, the majority of evidence quality was low, indicating the need for further high-quality studies.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2023)

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