Hematomyelia associated with coronavirus disease 2019: A rare case report

Article Immunology

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

Valeria Fumagalli et al.

Summary: In this study, researchers described a method using an inhalation tower system to expose unanesthetized transgenic mice to aerosolized virus. This approach has advantages in simulating COVID-19 pathogenesis and provides a useful tool for studying viral transmission, disease pathogenesis, and therapeutic interventions.

SCIENCE IMMUNOLOGY (2022)

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Review Clinical Neurology

Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)

Biyan Nathanael Harapan et al.

Summary: The novel coronavirus SARS-CoV-2 causing COVID-19 has become a significant global challenge. In addition to respiratory symptoms, COVID-19 can also lead to neurological symptoms and complications. Further research is needed to understand the impact of neurological symptoms on the disease progression.

JOURNAL OF NEUROLOGY (2021)

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Review Clinical Neurology

Cerebrospinal fluid in COVID-19: A systematic review of the literature

Ariane Lewis et al.

Summary: The detection of SARS-CoV-2 in cerebrospinal fluid or evaluation for intrathecal antibody synthesis appears to be rare in COVID-19 patients. Most neurological complications associated with SARS-CoV-2 are unlikely to be related to direct viral neuroinvasion.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Role of SARS-CoV-2 and ACE2 variations in COVID-19

Priya Antony et al.

Summary: COVID-19, caused by SARS-CoV-2, has become one of the worst medical emergencies in almost a century, with the virus mutating and adapting continuously. Variations in ACE2 gene could also impact susceptibility to the virus. A deeper understanding of genetic variations in SARS-CoV-2 and ACE2 is crucial for the development of effective treatments and preventive measures.

BIOMEDICAL JOURNAL (2021)

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Review Peripheral Vascular Disease

Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update

Ashwin Kumar Shukla et al.

Summary: COVID-19 has affected more than 26 million individuals worldwide, with patients with diabetes mellitus or other major complications at high risk. ACE2 receptor plays a key role in the virus entry, leading to more severe disease outcomes. Treatment strategies for COVID-19 target either the virus-ACE2 interaction or the human immune system.

HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2021)

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Article Medicine, General & Internal